Name : Farghaly A. Omar
Date of Birth : 03/5/1951 , Place of Birth: Suhag
Academic affiliation: Professor of Pharmaceutical and
medicinal Chemistry
Head of the dept. ofmedicinal Chemistry
Mailing Address: Dept. of Medicinal Chemistry, Faculty of Pharmacy
AssiutUniversity, 71526 Assiut, Egypt.
Phone : +2088-2327315 (home), +2088-2411329 (office).
Fax: +2088-2332776 E-Mail:
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Scientific qualifications and employments:
1) Head of the department of Medicinal Chemistry, Faculty of pharmacy, AssiutUniversity, 0ct.
2010
2) Coordinator of the department of Pharmaceutical chemistry, College of Pharmacy, King
KhalidUniversity (October 2007)
3) Professor of medicinal Chemistry, KingKhaledUniversity, Abha/kingdom of Saudi Arabia
(October 2005 – July 2010).
4) Professor of medicinal chemistry, Addis AbabaUniversity, Addis Ababa/Ethiopia (October
2004 – July 2005).
5) Vice Dean of Faculty of Pharmacy/ AssiutUniversity (for students and education affairs (Oct.
2000 – Oct. 2004).
6) Director of the Center for Drug Discovery/Assiut University (Nov. 1999 – Oct. 2004).
7) Professor of Medicinal Chemistry (September 1999).
8) Head of the Department of Pharmaceutical and Medicinal Chemistry; Assiut Universty (Sept.
1999 – Sept. 2000)
9) Associate Professor of Pharm. Chem. (June 1994)
10) Research fellowship: Center for drug Discovery; Faculty of Pharmacy; FloridaUniversity
(Gainsville/Florida- USA 1992).
11) Lecturer of Pharmaceutical Chemistry (June 1987); Dept. of Pharmaceutical Chemistry;
Faculty of Pharmacy, AssiutUniversity.
12) Ph. D. Studies; BonnUniversity (1982 – 1987)
“Die Asymmetrische Synthese von GABA-verwandeter Cycloaliphatisher Aminosauren und bicyclishe Lactame”
13) M.Sc. Pharm. Chem. (Assiut University; May 1979).
“Synthesis of Some Nitrobenzimidazole Acrylic Acid Derivatives of potential Antiparasitic Activity”.
14) B.Sc. Pharm. Sci. (Assiut university; June 1974).
Professional and Social Activities:
1) Member of the Egyptian Pharmacist Syndicate
2) Member of the Egyptian Pharmaceutical Society.
3) Member of the Egyptian Society for Electron Microscopy.
4) Member of the New YorkAcademy of Science.
5) Participant of several conferences for Pharmaceutical Sciences in Egypt;
Germany and Austria.
1)Symbosium on" Naturstufe als Leitsubstanzen fuer neue Arzneistufe" Deutsche Pharmazeutische Gesellschaft, Bonn/Germany 18 -19 March 1988.
2)Conference of the American Chemical Society, Chicago, USA, Feb. 1992.
3)XXII Conference of pharmaceutical Sciences, The Egyptian Pharmaceutical Society,
Cairo/Egypt Dec. 17 – 19 (1991).
4)XXIV Conference of pharmaceutical Sciences, The Egyptian Pharmaceutical Society,
Cairo/Egypt Dec. 22 – 24 (1994).
5)Egyptian-German Conference on Medicinal Plants, Assiut/Egypt Nov. 27(1995).
6)Workshop on Environmental Pollution and health problems, Faculty of Medicine/ AssiutUniversity, Assiut/Egypt, May 18 – 23 (1996).
7)Training courses on Electron microscopy (Technique and Applications), AssiutUniversity, Assiut/Egypt March 30 – April 4 (1996).
8)Symposium on "Antioxidants in medical practice" faculty of Medicine, AssiutUniversity, Assiut/Egypt Nov. 5th (1996).
9)Training Courses in Molecular Biology, Molecular biology and genetic engineering center, Assiut University, Assiut/Egypt May, 3 – 6 (1997).
10) AssiutUniversity 1st International Conferenc of Pharmaceutical Sciences, Assiut/Egypt March 4 – 5 (1998).
11) XIV Wissenschaftliche Tagung der Oesterreichischen Pharmazeutischen Gesellschaft, Graz/Austeria June 11 – 13 (1998).
12) AssiutUniversity 2nd International Conference of Pharmaceutical Sciences, Assiut /Egypt March 2- 4 (1998).
13)AssiutUniversity 3rd International Conference of Pharmaceutical Sciences, Assiut/ Egypt March 4 – 5 (2002).
14)Symposium on"Red Sea Marine plants as Natural Leads for new Drugs" Faculty of Pharmacy, Suez canal University, Ismailia/Egypt Dec. 3 – 5 (2003).
15)AssiutUniversity 4th International Conference of Pharmaceutical Sciences, Assiut /Egypt March 4 – 5 (2004).
16)The 7th International Saudi Pharmaceutical Conference; 19-21 March (2007); Riyadh,
Saudi Arabia
17) Workshop on “Conducting Initial Quality Evaluation” 17th April 2007; Centre for
Academic Assessment and Development; KKU; Abha/ Saudi Arabia.
18) Workshop on “Multiple Choice Questions” 19th April 2007; Medical Education
Development Centter (MEDC); Abha/Saudi Arabia.
19)Training program” Blackboard Academic Suite- Learning System” 21/01/2009; KingKhalidUniversity, Abha- KSA.
20)Training program on” Academic leadership” 1 – 3 Nov. 2009; Abha/ Saudi Arabia.
21)Training programs on “E-Learning” King Khalid university; Abha/Saudi Arabia (2009).
22)Training Programm on” Working Tward Program Accreditation” conducted by Prince Naif institute for research and consulting services. 25/12/1430 – 27/12/1430 H, KKU; Abha-KSA>
23)Coordinator of the following committees of faculty of pharmacy – King Khalid university; Abha/Saudi Arabia:
a)Committee of training program for graduated pharmacists.
b)Committee of the study plan and courses.
c)Committee of Academic Accreditation and Quality Assessment.
24)Reviewer in several Journals and Bulletins:
- Bulletin of Pharmaceutical Sciences; AssiutUniversity.
- Journal of Pharmaceutical Sciences, CairoUniversity.
- Al-MansouraUniversity Scientic Award.
- Saudi Pharmaceutical Journal.
- Spectrochimica Act Part A: Biomolecular Spectroscopy.
- KingAbdulAzizUniversity; Deanship of Scientific Research.
Teaching Activities:
Teaching of the different topics of Medicinal chemistry for the graduate and postgraduate students in the Faculties of Pharmacy, AssiutUniversity, TantaUniversity (1999/2000), and Al-AzharUniversity (Assiut), Addis AbabaUniversity/ Ethiopia, and KingKhaledUniversity, Abha/KSA.
Good experience in applications and teaching medicinal Chemistry trhough E-Learning.
The teaching courses include the following topics:
1)Medicinal Chemistry:
2)Drug Design and drug Development.
3)Pharmaceutical Organic chemistry:
4)Pharmaceutical Analytical Chemistry.
5)Instrumental Analysis.
6)Quality assurance and quality control of medicines.
Postgraduate coarses:
1) Designing organic synthesis.
2) Reaction mechanisms in organic synthesis.
3) Combinatorial chemistry.
4) Advanced NMR methods in structure elucidation.
5) Biochemical basis of drugs actions.
6) Drug Design
7) Chemical Aspects in Quality Assurance of Drugs.
Reviews Articles and Books:
1)Review Article on "Recombinant DNA Technology in Drug Discovery",
AssiutUniversity September 1999.
2)Review Article on "Peptidomimetics and their Applications in Drug
Design" AssiutUniversity September, September 2001.
3)Topics In Medicinal Chemistry vol. I and II.
4)Practical Pharmaceutical Chemistry vol. I and II.
5)Drug Design"Principles, Approaches and Methodologies".
Research Acivities
1) Drug Design
2) Asymmetric Synthesis of biologically active substances
3) Design and synthesis of Prodrugs of Non-Steroidal antiinflammatory agents with improved therapeutic index.
4) Synthesis and Design of biologically active compounds including: NSAIDs;
Antiparasitic agents; Antifungal agents.
5) Pharmacokinetic studies using HPLC.
6) Design and Synthesis of Dopamine Chemical Delivery system to the brain.
7) Design and synthesis of Cytrabine (Ara-C) prodrugs.
8) Quantitative-Structure Activity Relationship Studies of newly synthesized antitubercular agents.
9) Review Article on “Recombinant DNA Technology in Drug Discovery”.
10) Supervisor of several Theses for Master and Ph.D degrees in AssiutUniversity and
Al-AzharUniversity (Assiut).
List of Thesis Supervised:
1) Synthesis and Investigation N4-substituted Cytarabine Derivatives as prodrugs. (Ph. D thesis, Assiut University 1994)
2) Design, Synthesis and antidepressant activity of Some N2-substituted Nalidixic Acid hydrazides and their Cyclized Analogues. (M. Sc thesis, Assiut University 1998)
3) Synthesis and antibacterial activity of some 2,5,7-Triazolo[1,5-a]Pyrimidines (M. Sc thesis, Assiut University 2002)
4) Design and Synthesis of some p-substituted Styrylisoxazole carboxylic Acid Derivatives as Antiinflammatory agents. (M. Sc thesis, Assiut University 2004)
5) Comparative in vitro quality Evaluation of tablets of commonly prescribed Antiepileptic Drugs, Carbamazepine and Phenobarbital, from drug retail outlets in Addis Ababa. (M. Sc thesis, Addis Ababa University 2005)
6) Comparative in vitro evaluation of Antihypertensive Drugs (Methyldopa, Furosemide, and propranolo) from local market, Addis Ababa (M. Sc thesis, Addis Ababa University 2005)
7) Assessment on the Quality and Influence of the tropical Storage Conditions on Certain Amoxicillin Formulations marketed in Ethiopia.(M. Sc thesis, Addis Ababa University 2005)
8) Biotransformation Studies of Prednisone and Prednisolone using human intestinal bacteria. (M. Sc thesis, Assiut University 2006).
List of Thesis Evaluated (Referant):
1) Design and Synthesis of Some triazolquinazolines as antibacterial and anti-inflammatory agents. (Ph. D thesis, Cairo University 2001).
2) Synthesis, Antihypertensive and antibacterial activity of some Thiazolo- and midazo-pyrimidines. (M. Sc thesis, Al-Azhar University 2004).
3) Synthesis and Investigation N4-substituted Cytarabine Derivatives as prodrugs. (Ph. D thesis, Assiut University 1994)
4) Design, Synthesis and antidepressant activity of Some N2-substituted Nalidixic Acid hydrazides and their Cyclized Analogues. (M. Sc thesis, Assiut University 1998)
5) Synthesis and antibacterial activity of some 2,5,7-Triazolo[1,5-a]Pyrimidines (M. Sc thesis, Assiut University 2002)
6) Design and Synthesis of some p-substituted Styrylisoxazole carboxylic Acid Derivatives as Antiinflammatory agents. (M. Sc thesis, Assiut University 2004)
7) Comparative in vitro quality Evaluation of tablets of commonly prescribed
Antiepileptic Drugs, Carbamazepine and Phenobarbital, from drug retail outlets in Addis Ababa. (M. Sc thesis, Addis Ababa University 2005)
8) Comparative in vitro evaluation of Antihypertensive Drugs (Methyldopa, Furosemide, and propranolo) from local market, Addis Ababa (M. Sc thesis, Addis Ababa University 2005)
9) Assessment on the Quality and Influence of the tropical Storage Conditions on Certain Amoxicillin Formulations marketed in Ethiopia.(M. Sc thesis, Addis Ababa University 2005)
10) Biotransformation Studies of Prednisone and Prednisolone using human intestinal bacteria. (M. Sc thesis, Assiut University 2006)
11) Stress Decomposition Studies and Development of validated stability indicating Assay method for Lamivudine. (M. Sc. thesis, Addis Ababa University 2005)
12) Descriptive quantitative Structure-Radical Scavenging Activity Relationship Study of Flavonoids. (M. Sc thesis, Addis Ababa University 2005)
13) Synthesis of somw shiff’s bases of indoline-2,3-dione and quinoline carboxylic acid
derivatives with potential antitubercular activity.(M.Sc. thesis, Knig Saud University 2010)
List of Publications
1- Biotransformation studies of prednisone using human intestinal bacteria; Part II: Anaerobic
incubation and docking studies. Mohamed M. Al-Sanea, Atef A. Abdel-Hafez, Farghaly A. Omar
and Adel F. Youssef Accepted for publication:13 February 2009. Journal of Enzyme Inhibition
and Medicinal Chemistry.
2- Biotransformation Studies of Prednisone Using Human Intestinal Bacteria; Part I: Aerobic
Incubation. Mohammed M. Al-Sanea, Atef A. Abdel-Hafez, Farghaly A. Omar and Adel F.
Youssef. Bull. Pharm. Sci., AssiutUniversity, Vol. 31, Part 2, 2008, pp. 215-228.
3- Design and Synthesis of some p-Substituted Styrylisoxazole Carboxylic Acid Derivatives as
Antiinflammatory Agents. Farghaly A. Omar1, Atef A. Abdel-Hafez, and Montaser S. Bull.
Pharm.Sci.AssiutUniversity, 27, 171-186(2004).
4- Synthesis and antibacterial screening of Some 2,5,7-Triaryl-1,2,4-Triazolo[1,5-a]pyrimidines.
Farghaly A. Omar1, Nawal A. El-Koussi1, Mohamed F. Radwan2 and Salah A.
Abdel-Aziz. Bull. Pharm.Sci.AssiutUniversity, 27, 141-154(2004).
5- Cyclic Amide Derivatives as Potential Prodrugs: N-Hydroxymethyl-succinimide- / Isatin Esters of
some Non-steroidal Anti-inflammatory Carboxylic Acids as Prodrugs with Improved Therapeutic
Index. Nadia M. Mahfouz, Farghaly A. Omar and Tarek A. Fadl
Eur. J. Med. Chem. 34,551 - 562(1999).
6- Synthesis and in vitro antifungal activity of some N,N-disubstituted dithiocarbamic acid esters
derived from 2-methylquinazolinones.
Farghaly A. Omar and Ahmed M. Moharram. Boll. Chim. Farmaceutico 138, 273 – 282(1999)
7- Syntesis of Some 6-Bromo Nalidixic Acid Hydrazides As potential Antidepressants
A.F. Youssef, Farghaly A. Omar, H.A. El-Sherief and G.A. Ahmad
Proceedings of AssiutUniv. 1st Pharm. Sci. Conf. 20 - 34(1998).
8- Design, Synthesis and Antidepressant Activity of Some N2-substituted Nalidixic Acid Hydrazides
and their Cyclized Analogues
A.F. Youssef, Farghaly A. Omar, H.A. El-sherief and G.A. Abou-Rahma. Bull. Pharm. Sci.,
AssiutUniversity, 21,15 -26(1998)
9- Molecular Structural Parameters in Tuberculostatic Activity of Polyhydroxy Xanthones
Hassan H. Farag, Farghaly A. Omar and Nadia M. Mahfouz. Bull. Pharm. Sci., AssiutUniversity,
21,7 - 14(1998).
10- Paracetamol (Acetaminophen) Esters of Some Non-steroidal Anti-inflammatory Carboxylic Acids as
Mutual Prodrugs with Improved Therapeutic Index. T. A. Fadl and F. A. Omar
J. Inflammopharmacolgy, 6(2), 143-157(1998)
11- Cyclic amide derivatives as potentialpProdrugs: Synthesis and evaluation of N-hydroxy-
methylphthalimide esters of some non-steroidal anti-inflammatory carboxylic acid drugs
Farghaly A. Omar. Eur. J. Med. Chem. 33, 123-131(1998)
12- Design, Synthesis and Anti-inflammatory Activity of Some1,3,4-Oxadiazole Derivatives
F.A. Omar, N.M. Mahfouz and M.A. Rahman. Eur. J. Med. Chem. 31, 819-825(1996)
13- Steric Parameters in PLE Catalyzed Hydrolysis of N4-Substitued Cytarabine
ester prodrugs. T. Kawaguchi, A.F. Youssef, T.A. Fadl, F.A. Omar, H.H. Farag and T.Hasegawa,
Pharmazie 51, 718(1996)
14- Synthesis and Investigation of N4-Substituted Cytarabine Derivatives as Prodrugs
T.A. Fadl, T. Hasegawa, A.F. Youssef, H.H. Farag, F.A. Omar and T. Kawaguchi
Pharmazie 50, 382-387(1995)
15- Spectrophotometric Determination of Piroxicam Using 2,2-Diphenyl-1-Picrylhydrazyl
Kamla M. Emara and Farghaly A. Omar. Alex. J. Pharm. Sci. 8, 24-28(1994)
16- Synthesis of Some Nalidixic Acid Derivatives. Farghaly A. Omar. Alex. J. Pharm. Sci. 8, 65-
68(1994)
17- Synthesis and Evaluation of Redox Chemical Delivery System for Brain Enhanced Dopamine
Containing an Activated Carbamate-type Ester.
Farghaly A. Omar, Hassan H. Farag and N. Bodor. J. Drug Targeting 2,309-316(1994)
18- Improved Delivery Through Biological Membranes: Preparation and Investigation of Stable
Dopamine Chemical Delivery System Samples. N. Bodor, Hassan H. Farag and Farghaly A. Omar.
Bull. Pharm. Sci., AssiutUniversity, 16, 175-182(1993)
19- Niridazole Prodrugs: Synthesis, Characterization and Hydrolysis Kinetics of some N-Acyloxymethyl
Niridazoles. Farghaly A. Omar; Nadia M. Mahfouz; Hassan H. Farag and SalehI. Saleh
Saudi Pharmaceutical Journal, 1, 62-69(1993)
20- Preparation and Evaluation of isoniazid Microcapsules. S.M. Safwat and Farghaly A. Omar.
S.T.P. Pharma Sciences 3,398-403(1993).
21- Synthesis and Antibacterial Activity of Certain Quinoline and Quinazoline Derivatives
Containing Sulfide and Sulfone Moieties. Maher F. Elzohry; Abdel-Hameed N. Ahmed; Faghaly
A. Omar and Mohamed A. Abd-Alla. J. Chem. Tech. and Biotecnol. 53,329-336(1992)
22- EPC-Synthese cis-Bicyclischer Lactame und Amine. Farghaly Omar und August W. Frahm. Arch.
Pharm. (Weinheim) 323, 923-928(1990)
23- Die Asymmetrische Synthese von GABA-verwandter Cycloaliphatischer Aminosauren
Farghaly Omar und August W. Frahm. Arch. Pharm. (Weinheim) 322, 461-471(1989)
24- Die Asymmetrische Synthese der cis 4aR,8aR- und cis-4aS,8aS-Dekahydrochinoline
Farghaly Omar und August W. Frahm. Arch. Pharm. (Weinheim) 321, 111-114(1988)
25-Synthesis of 3-(1-Methyl-5-nitro-benzimidazolyl)acrylic Acid Derivatives as expected
Antischistosomal Agents. Nabil M. Omar; Hassan H. Farag and Farghaly A. Omar
Z. Naturforsch 84b, 1427-1430(1979)