Appendix1.

The full search strategies for Medline, MMBASE and the Cochrane Central Register of clinical trials

The full search strategy for Medline

#1 Anoxia[MH] OR hypox* OR Acute lung injury[MH] OR acute lung injuries OR acute lung injury OR ALI OR Respiratory distress syndrome,adult[MH] OR ARDS OR acute respiratory distress syndrome OR adult respiratory distress syndrome OR shock lung OR Respiratory insufficiency[MH] OR Respiratory failure OR Respiratory depression OR Ventilatory depression OR Respiratory insufficiency OR Flail chest[MH] OR flail chest OR stove in chest OR rib fracture[MH] OR rib fracture OR rib fractures

#2 Noninvasive ventilation[MH] OR Non invasive ventilation OR Non invasive ventilations OR NIV OR NPPV OR NIPPV OR Noninvasive positive pressure ventilation OR Noninvasive mechanical ventilation OR Noninvasive pressure support ventilation OR Continuous positive airway pressure[MH] OR Continuous positive airway pressure OR Bilevel positive airway pressure OR BiPAP

#3 clinical trial[pt] OR trial[ti] OR randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR clinical trials as topic[MH] OR randomly[tiab] OR groups[tiab]

#4 #1 AND #2 AND #3

#5 (animals[mh]) NOT (animals[mh] AND humans[mh])

#6 #4 NOT #5

Article search was performed at 6 May 2015 and a total of 1,579 articles are scanned.

The full search strategy for EMBASE

#1 (EMB.EXACT("anoxia") OR EMB.EXACT("adult respiratory distress syndrome")) OR EMB.EXACT("acute lung injury") OR EMB.EXACT.EXPLODE("respiratory failure") OR EMB.EXACT("flail chest") OR EMB.EXACT.EXPLODE("rib fracture")

#2 hypox* OR "acute lung injuries" OR "acute lung injury" OR TI,AB(ALI) OR TI,AB(ARDS) OR "acute respiratory distress syndrome" OR "adult respiratory distress syndrome" OR "shock lung" OR "respiratory failure" OR "respiratory depression" OR "ventilatory depression" OR "respiratory insufficiency" OR "flail chest" OR "stove in chest" OR "rib fracture" OR "rib fractures"

#3 #1 OR #2

#4 EMB.EXACT("noninvasive ventilation") OR (EMB.EXACT("positive end expiratory pressure") AND continuous positive airway pressure)

#5 "noninvasive ventilation" OR "noninvasive ventilations" OR "non-invasive ventilation" OR "non-invasive ventilations" OR "non invasive ventilation" OR "non invasive ventilations" OR TI,AB(NIV) OR TI,AB(NPPV) OR TI,AB(NIPPV) OR "noninvasive positive pressure ventilation" OR "noninvasive mechanical ventilation" OR "noninvasive pressure support ventilation" OR "continuous positive airway pressure" OR "bilevel positive airway pressure" OR TI,AB(BiPAP)

#6 #4 OR #5

#7 (EMB.EXACT("controlled clinical trial") OR EMB.EXACT.EXPLODE("clinical trial (topic)") OR EMB.EXACT("randomized controlled trial")) OR (TI,AB(randomized) OR TI,AB(randomly) OR TI(trial) OR TI,AB(placebo) OR TI,AB(groups))

#8 #3 AND #6 AND #7

#9 ANIMAL(YES) NOT (ANIMAL(YES) AND HUMAN(YES))

#10 #8 NOT #9

Article search was performed at 2 June 2015 and a total of 1554 articles were scanned.

The full search strategy for CENTRAL

#1 MeSH descriptor: [Anoxia] explode all trees

#2 hypox*

#3 MeSH descriptor: [Acute Lung Injury] explode all trees

#4 acute lung injuries

#5 acute lung injury

#6 ALI

#7 #1 or #2 or #3 or #4 or #5 or #6

#8 MeSH descriptor: [Respiratory Distress Syndrome, Adult] explode all trees

#9 ARDS

#10 acute respiratory distress syndrome

#11 adult respiratory distress syndrome

#12 shock lung

#13 #8 or #9 or #10 or #11 or #12

#14 MeSH descriptor: [Respiratory Insufficiency] explode all trees

#15 Respiratory failure

#16 Respiratory depression

#17 Ventilatory depression

#18 Respiratory insufficiency

#19 MeSH descriptor: [Flail Chest] explode all trees

#20 Flail chest

#21 stove in chest

#22 MeSH descriptor: [Rib Fractures] explode all trees

#23 Rib fractures or Rib Fracture

#24 #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23

#25 #7 or #13 or #24

#26 MeSH descriptor: [Noninvasive Ventilation] explode all trees

#27 Noninvasive ventilation

#28 NIV or NPPV or NIPPV

#29 noninvasive mechanical ventilation

#30 noninvasive positive pressure ventilation

#31 noninvasive pressure support ventilation

#32 #26 or #27 or #28 or #29 or #30 or #31

#33 MeSH descriptor: [Continuous Positive Airway Pressure] explode all trees

#34 Continuous positive airway pressure

#35 Bilevel positive airway pressure

#36 BiPAP

#37 #33 or #34 or #35 or #36

#38 #32 or #37

#39 #25 and #38 in Trials

Article search was performed at 1 June 2015 and a total of 803 articles were scanned.