HEXAPEPTIDE N-ter HD HOMEODOMAIN C-ter HD
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labial
Esplab YQWMRVKR GPQSL- NNTGRTAFNTKQLTELEKEFHFNKYLTRARXIEIASALSLNETQVKIWFQNRRMKQKKRM KEGQRDK-SI
Ngrlab YQWMRVKR GPQSLN NNTGRTAFNTKQLTELEKEXHYNKYLTRARRIEIASALSLNETQVKIWFQNRRMKQKKRM KESQREKPSL
Dmelab YKWMQLKR SLSSNT NNSGRTNFTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRRMKQKKRV KEG-LI-PAD
Amelab YKWMQVKR AGIGSF NNTGRTNFTNKQLTELEKEFHFNKYLTRARRIEIAS-LQLNETQVKIWFQNRRMKQKKRM KEG-LI-PAE
Psclab KWMQVKR -GGGFG GGTGRTNFTTKQLTELEKEFHFNKYLTRARRIEIASALQLNETQVKIWFQNRR
Alolab PNTGRTNFTTNQLTELEKEFHFNKYLTRARRIEIATALQLNETQVKIWFQNRRMKQKKRM KEG-LI-PSD
Csalab YKWMQVKR VSNGGS NGSGRTNFTTKQLTELEKEFHYNKYLTRARRIEIATALQLNETQVKIWFQNRRMKQKKRM KEG-LLV-TD
Latlab HFNKYLTRARRIEIATALQLNETQVKIWFQNRRMKQKKRL KEGSILV-SE
Akalab HFNKYLTRARRIEIATALQLNETQVKIW
Esclab FRWMQIRR LGAGGG NSTGRTNFTNKQLTELEKEFHFNKYLTRARRIEIAAA------KIWFQNRRMKQKKRL KEAQGTPGLG
BflHox1 YDWMKLKR GFTTSG PNNGRTNFTTKQLTELEKEFHYNKYLTRARRVEIAAALNLNETQVKIWFQNRRMKQKKRE KENGFSTPGS
MmuHoxa1 FDWMKVKR GYV-GQ PNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKRE KEGLLPISPA
proboscipedia
Esppb YPWMKEKK VGENGL PRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMRHKRQS NGKSADDKGS
Ngrpb VGENGL PRRLRTAYTNNQLLELEKEFHFNKYLCRPRRIEIAASLELTERQVKVWFQNRRMKHXRQS TGKSGDDKGS
Dmepb YPWMKEKK VPENGL PRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQT LSK-TDD---
Amepb YPWMKEKK VAENGL PRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQT LSK--ED-G-
Pscpb WMKEKK SSENGM PRRLRTAYTNTQLLELEKEFHFNKXLCRPRRIXXAASLDLTERQVKVWF
Alopb GENGM PRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKHKRQS
Csapb KRARTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKYKK
Latpb LLELEKEFHFNKYLCRPRRIEIAASLDLAERQVKVWFQNRRMKHKRQT MGKGSDD-GG
Akapb FNKYLCRPRRIEIAASLDLTERQVKVW
Nvipb TGTGSN PRRLRTAYTNTQLLELEKEFHFNKYLCRPRRIEIAASLDLTERQVKVWFQNRRMKFKRQT QTKGLPDGNS
BflHox2 FPWVKLKK TDQVNS SRRLRTVFTNTQLLELEKEFHYNKYVCKPRRKEIASYLDLNERQVKIWFQNRRMRQKRRD -TKGRSEIGT
MmuHoxa2 YPWMKEKK DGSGGG SRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQT QCKENQNSEG
Hox3/zen
EspHox3 HFNRYLCRPRRVEMANLLNLSERQIKIW
Dmezen DSQRVK LKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDI QGHREPKSNA
AmeHox3 GGNQKK TKRSRTAYTSVQLVELEKEFTVTKYLCRPRRIELAIALSLTERQIKIWFQNRRMKYKKEQ QQTR
AloHox3 AKRARTAYTSSQLVELEKEFHTSRYLCRPRRIEMASLLKLSERQIKIWFQNRRMKFKKEQ
CsaHox3 YPWMVDSR FLGEQP AKRARTAYTSAQLVELEKEFHFNRYLCRPRRIEMANLLNLSERQIKIWFQNRRMKYKKEQ KSKGLYIQQS
LatHox3 SAQLVELEKEFHFNRYLCRPRRVELAKQLGLTDRQIKIWFQNRRMKYKKEL KHREGCQTAP
EscHox3 YPWMKETR IPCEQP AKRARTAYTSAQLVELEKEFHFNQYLCRPRRIEMAALLNLSERQIKIWFQNRRMRFKKEK KLKVNMDKSG
BflHox3 YPWMKESR GLGGAA GKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMAAMLNLTERQIKIWFQNRRMKYKKEQ KVKGGGSGGG
MmuHoxa3 FPWMKESR PPGQAS SKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQ KGKGMLTSSG
Deformed
EspDfd YPWMRKVH SCGGVE PKRHRTNYNKIQSLELEKEFHFNRYVTRRRRIEIAHALCLPERQIKIWFQNRRMRYKKDN NQPNTKNVRK
DmeDfd YPWMKKIH YQPGME PKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDN KLPNTKNVRK
AmeDfd YPWMKKIH YQPGME PKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDN KLPNTKNVRR
AfrDfd FQPGME PKRQRTAYTRHQILELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDN KLPNTKNVRR
AloDfd F-AGME PKRQRTAYTRHQILELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDN KLPNTKNVKK
CsaDfd YPWMKKVH F-PGIE PKRQRTAYTRHQILELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDN KLPNTKNVKK
LfoDfd FQAGSE PKRQRTAYTRQQILELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDN KLPNTKNVRR
AkaDfd YNRYLTRRRRIEIAHTLVLSERQIKIW
NviDfd Y--GTD SKRTRTAYTRHQVLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KLPNTKN-RL
BflHox4 YPWMKKVH YN-GQD TKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHSLGLTERQIKIWFQNRRMKWKKDN RLPNTK-TRS
MmuHoxa4 YPWMKKIH YN-GGE PKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDH KLPNTK-MRS
Sex Combs Reduced
EspScr YPWMRKVH -SNGME TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKEH KQLPGSMAAGQIPGM
NgrScr YPWMRKVH -SNGME TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKEH KQLPGSMSSAQIPGI
DmeScr YPWMKRVH NANG-E TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH K-----MASMNIVPY
AmeScr YSWMKRVH NANG-E VKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH K-----MASMNIVPY
AfrScr NANG-E TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKEH K-----IATMNMMQH
AloScr NAMG-E TKRQRTSYTRYQTLXLEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKEH K-----MQS
LfoScr NGVE TKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKEH K-----IPSVNQVPG
AkaScr YPWMRRAH --NGME AKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH K-----MSSSTPPQT
EscScr YPWMRRMQ DPDG-E SKRSRTSYTRHQTLELEKEFHYNKYLTRRRRIEIAHALNLTERQIKIWFQNRRMKWKKEH K-----LSHIAKNMN
BflHox5 AGTG-D NKRTRTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN K-----LKSLSQCQQ
MmuHoxa5 YPWMRKLH NIGGPE GKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDN K-----LKSMSMAAA
HEXAPEPTIDE N-ter HD HOMEODOMAIN C-ter HD
111111111122222222223333333333444444444455555555556
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fushi-tarazu
Espftz YPWMKSYT -DNSSG PKRTRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALGLSERQIKIWFQNRRMKAKKEN -LQGMNSTLS
Dmeftz FNW--SHI ASDCKD SKRTRQTYTRYQTLELEKEFHFNRYITRRRRIDIANALSLSERQIKIWFQNRRMKSKKDR -LDSSPEHCG
Ameftz SNNNG QKRTRQTYTRYQTLELEKEFHFNRYLTRNRRLEIARALHLTERQVKIWFQNRRMKAKKFN K-DAE
Afrftz TIPMPG QKRTRQTYTKYQTLELEKEFLYNRYLTRVRRMDISSKLQLTERQIKIWFQNRRMKAKKEN K-NETNFRSS
Aloftz FPWMKSYT -DSGQG PKRTRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHSLGLTERQIKIWFQNRRMKAKKEN KIKVDPNSAE
Csaftz YPWMKSHG -DTTPG PKRSRQTYTRYQTLELEKEFHFNQYLTRRRRIEIAHTLGLTERQIKIWFQNRRMKAKKEN KFPISSSNSL
Latftz HFNRYLTRRRRIEIAHALGLTERQIKIWFQNRRMKAKKEN KLQNGQTSPE
Akaftz YPWMRSYT -DNGFG PKRTRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALGLTERQIK
EscLox5 YPWMRPVN IETAYE QKRTRQTYTRFQTLELEKEFHFNRYLTRRRRIEIAHSLGLSERQIKIWFQNRRMKWKKEN NVSKLTGPDK
BflHox6 FPWMRKGS TAMGEE KKRGRQTYTRYQTLELEKEFHFNKYLTRKRRIEIAHLLGLTERQIKIWFQNRRMKWKKEN KIPSLNATTI
MmuHoxa6 YPWMQRMN AVYGSH GRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKEN KLINSTQASG
Antennapedia
EspAntp YPWMRSQ- ----FE RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KPKTEGPNGE
NgrAntp YPWMRSQ- ----FE RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KPKTEGPNGE
DmeAntp YPWMRSQ- ----FE RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KTKGEPGSGG
AmeAntp YPWMRSQ- ----FE RKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KSKGTPGSG-
AfrAntp YPWMKSQ- ----FE RKRGRQTYTRFQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KSKVDSGCLD
AloAntp RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEI RTR
CsaAntp YPWMRSQ- ----FE RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KAK-EPAAGF
LfoAntp1 RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KAKLEGAGGD
AkaAntp YQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIW
EscAntp YPWMRSQY ----PH RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KAEMPGTENG
BflHox7 PE RKRGRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEN KLESLKQQPA
MmuHoxa7 YPWMRSSG ----PD RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEH KDESQAPTAA
Ultrabithorax
EspUbx YPWMALA- GANGL- RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEI QAIKELNDQE
DmeUbx YPWMAIAG GTNGL- RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEI QAIKELNEQE
AmeUbx YPWMAIAG GANGM- RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHSLCLTERQIKIWFQNRRMKLKKEI QAIKELNEQE
AfrUbx YPWMAIA- GANGL- RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHSLCLTERQIKIWFQNRRMKLKKEI QAIKELNEQD
AloUbx ANGL- RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHSLCLTERQIKIWFQNRRMKLKKEI QAIKELNEQE
CsaUbx1 ANGL- RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEI QAIKELNEQE
LatUbx HTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEI QAIKELNEQE
AkaUbx YPWMNVA- GANGLQ RKRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEM QTIKDLNEQE
EscLox4 YPWMGIV- GPNSSQ RRRGRQTYSRFQTLELEKEFQYNNYLTRKRRIEVAHALNLSERQVKIWFQNRRMKLKKEK QQIREMNGAC
BflHox8 PE--- RRRGRQTYSRYQTLELEKEFHFNKYLTRRRRIEIAHALGLTERQIKIWFQNRRMKLKKEA AMLCPPKAET
MmuHoxa8 FPWMRP-- -QAAAG RRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKEN NKDKFPSSKC
abdominal-A
Ngrabd-A YPWISGS- -S-GFL KKKGRQTYTRFQTLELEKEFRFNNYLTSRRRQDLSGMLELSERQIKIWFQNRRMKMKREI RLVEQINHQV
Dmeabd-A YPWMTLT- GPNGCP RRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKEL RAVKEINEQA
Ameabd-A YPWMSIT- GPNGCP RRRGRQTYTRFQTLELEKEFHYNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKEL RAVKEINEQA
Afrabd-A PNGCP RRRGRQTYTRYQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKEL RAVKEINEQA
Csaabd-A YPWMSIA- GPNGCP RRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKEM RAVKEINEQA
Lfoabd-A TRFQTLELEKVFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKLKKEM RAVKEINEQA
Akaabd-A TNGCP RRRGRQTYTRYQTLELEKEFHFNHYLTRRRRIEIAHVLCLTERQIKIWFQNRRMKLKKEL RAVKEINEQA
EscLox4 YPWMGIV- GPNSSQ RRRGRQTYSRFQTLELEKEFQYNNYLTRKRRIEVAHALNLSERQVKIWFQNRRMKLKKEK QQIREMNGAC
BflHox8 PE--- RRRGRQTYSRYQTLELEKEFHFNKYLTRRRRIEIAHALGLTERQIKIWFQNRRMKLKKEA AMLCPPKAET
MmuHoxa8 FPWMRP-- -QAAAG RRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKEN NKDKFPSSKC
Abdominal-B
EspAbd-B ------WTGNVT IRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWESARNLNLSERQVKIWFQNRRMKNKKNS QRNS-DQISN
NgrAbd-B LFNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKNKKNS QRNSSDGLNS
DmeAbd-B ------WTGQVS VRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLQLTERQVKIWFQNRRMKNKKNS QRQANQQNNN
AmeAbd-B ------WTGQVT VRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKNKKNS QRQ--QQNNN
AfrAbd-B T VRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLNLTERQVKIW
AloAbd-B HHVS VRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKSKKTS QRNSD
CsaAbd-B ------WTGTVT VRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKSKKTS QRNA-ENNQN
LatAbd-B LFNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKNKKNS QRNTADTTAS
AkaAbd-B YSKFQTLELEKEFLFNAYVSKQKRWELARNLNLTERQVKIW
EscPost2 ------GSHETK GRKKRKPYTRYQTMVLENEFLNSSYITRQKRWEISCKLQLTERQVKVWFQNRRMKRKKLN ERAKARLRED
BflHox9 ------WMNNHS SRKKRCPYTRFQTLELEKEFLYNMYLTRERRYEISQHVNLTERQVKIWFQNRRMKMKKMS KQRQEQQQSP
MmuHoxa9 ------WLHARS TRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKIN KDRAKDE