Breathing pattern and chest wall volumes during exercise in patients with cystic fibrosis, pulmonary fibrosis and COPD before and after lung transplantation
H. Wilkens, B. Weingard, A. Lo Mauro, E. Schena,
A. Pedotti, G.W. Sybrecht, A. Aliverti
ONLINE SUPPLEMENT
Table 1-S –Ventilatory pattern at rest in patients with pulmonary fibrosis, cystic fibrosis, chronic obstructive pulmonary disease (COPD), healthy control subjects and transplanted patients.
Pulmonary Fibrosis(PF) / Cystic Fibrosis (CF) / COPD / Healthy controls (HC) / Transplanted (T)
N / 9 / 9 / 21 / 10 / 16
VT (liters) / 0.60 / ± / 0.09 / 0.55 / ± / 0.04 / 0.82 / ± / 0.05 / 0.74 / ± / 0.11 / 0.80 / ± / 0.08
DVRC (%VT) / 43.8 / ± / 8.9 / 43.3 / ± / 4.3 / 52.3 / ± / 3.8 / 55.8 / ± / 3.9 / 51.6 / ± / 3.3
DVAB (%VT) / 56.2 / ± / 8.9 / 56.7 / ± / 4.3 / 47.7 / ± / 3.8 / 44.2 / ± / 3.9 / 48.4 / ± / 3.3
TTOT (sec) / 2.02 / ± / 0.39 / *** vs COPD,HC, T / 2.51 / ± / 0.20 / *** vs COPD,HC
** vs T / 3.91 / ± / 0.22 / 4.58 / ± / 0.46 / ** vs T / 3.56 / ± / 0.30
TI (sec) / 0.81 / ± / 0.13 / *** vs HC,T
** vs COPD / 0.97 / ± / 0.06 / *** vs HC,T / 1.16 / ± / 0.05 / *** vs HC
** vs T / 1.66 / ± / 0.13 / 1.44 / ± / 0.09
TE (sec) / 1.20 / ± / 0.26 / *** vs COPD,HC
** vs T / 1.54 / ± / 0.15 / *** vs COPD,HC
* vs T / 2.75 / ± / 0.19 / ** vs T / 2.91 / ± / 0.33 / 2.12 / ± / 0.23
Duty Cycle (TI/ TTOT, %) / 41.7 / ± / 1.4 / * vs HC / 39.1 / ± / 1.6 / 30.4 / ± / 1.1 / *** vs PF,CF, HC,T / 37.3 / ± / 1.2 / * vs T / 41.7 / ± / 1.4
Breath. frequency (min-1) / 35.0 / ± / 3.6 / *** vs COPD,HC,T
** vs CF / 25.4 / ± / 1.9 / ** vs COPD,HC
* vs T / 16.3 / ± / 0.8 / 14.4 / ± / 1.3 / 18.5 / ± / 1.4
Min. Ventilation (L/min) / 19.4 / ± / 2.7 / 13.5 / ± / 0.4 / 13.0 / ± / 0.8 / 9.8 / ± / 0.9 / 13.9 / ± / 1.3
Mean Insp. Flow (VT/TI, L/sec) / 0.77 / ± / 0.10 / 0.58 / ± / 0.02 / 0.72 / ± / 0.04 / 0.44 / ± / 0.04 / 0.57 / ± / 0.05
Borg Breath / 1.94 / ± / 0.67 / (N=8) / 2.21 / ± / 0.83 / (N=7) / 0.83 / ± / 0.34 / 0.10 / ± / 0.10 / 0.13 / ± / 0.13 / (N=8)
Borg Leg / 1.00 / ± / 0.42 / (N=8) / 0.57 / ± / 0.57 / (N=7) / 1.50 / ± / 0.79 / 0.10 / ± / 0.10 / 0.63 / ± / 0.63 / (N=8)
*: p<0.05
**: p<0.01
***: p<0.001
VT, tidal volume; DVRC, percentage contribution of rib cage to tidal volume; DVAB, percentage contribution of abdomen to tidal volume; TTOT, total respiratory cycle time; TI, inspiratory time; TE, expiratory time
FIGURE LEGENDS
Figure 1-S
Anthropometric characteristics of patients with pulmonary fibrosis (PF), cystic fibrosis (CF) and COPD on the waiting list and transplanted patients (assessed before transplantation): age (top panel), weight (left-middle panel), height (right-middle panel) and Body Mass Index (bottom panel). Data are expressed as mean (SE). NS, not significant.
Figure 2-S
Pulmonary function of patients with pulmonary fibrosis (PF), cystic fibrosis (CF) and COPD on the waiting list and transplanted patients (assessed before transplantation): forced vital capacity (FVC, top-left panel), FVC percentage of predicted values (top-right panel), forced expiratory volume in one second (FEV1, left-middle panel), FEV1 percentage of predicted values (right-middle panel) and FEV1/FVC (bottom panel). Data are expressed as mean (SE). NS, not significant.
Figure 3-S
Subdivision of lung volumes of patients with pulmonary fibrosis (PF), cystic fibrosis (CF) and COPD on the waiting list and transplanted patients (assessed before transplantation): total gas volume (TGV, top-left panel), TGV percentage of predicted values (top-right panel), total lung capacity (TLC left-middle panel), TLC percentage of predicted values (right-middle panel), residual volume RV (bottom-left panel) and RV percentage of predicted values (bottom-right panel). Data are expressed as mean (SE). NS, not significant
Figure 1-S
Figure 2-S
Figure 3-S