Renal
Supplemental Instruction
IowaStateUniversity / Leader: / Kristina
Course: / AnS 214
Instructor: / Keating
Date: / 10/27/2014
  1. Where is the filtration membrane located and what is is its function?
  1. Using the diagram to the right, label the 3 main parts of the filtration membrane and indicate what the green arrows are pointing to:

1:

2:

3:

Green arrow:

  1. What is the function of the mesangial cells within the glomerulus?
  1. What are the 3 pressures involved with the net filtration pressure in the glomerulus and how do they act on each other?
  1. Define the glomerular filtration rate:
  1. The ______mechanism of intrinsic control reflects the tendency of vascular smooth muscle to ______when stretched. Increasing blood pressure causes the ______arterioles to ______, restricting blood flow to the glomerulus and preventing damage. Declining ______causes the ______arterioles to dilate, raising glomerular ______pressure.
  1. The ______mechanism of intrinsic control is directed by ______cells of the JGA. These cells respond to the concentration of ______in the filtrate. When GFR is ______there is little time for reabsorption, so concentration of ______remains ______, causing the ______cells to release ______which constricts the afferent arteriole. This then ______the GFR. On the other hand, if GFR is low, ______release is ______, causing vasodilation of the afferent arteriole. This then ______the GFR.
  1. Which extrinsic GFR control mechanism is active under extreme stress?

What is released at this time, and from where?

What is the outcome of this release?

  1. When does the renin-angiotensin mechanism of extrinsic GFR control become active?

What is the pathway of activated substances involved with this mechanism?

What are the effects of angiotensin II?

  1. T/F: Tubular reabsorption during urine formation involves active transport, but not passive.
  1. What are the two routes used in tubular reabsorption?
  1. What is needed for Na+ transport out of the tubule cell?
  1. What aids transport of glucose, amino acids, vitamins, and ions out of the tubule cell?
  1. What mechanism is used in water reabsorption?

What aids this process?

  1. Where in the nephron does most reabsorption occur?
  1. Indicate which substances are reabsorbed in each of the following nephron structures:

Proximal Convoluted tubule:

Descending limb of Loop of Henle:

Ascending limb of Loop of Henle:

Distal Covoluted tubule:

Collecting duct:

  1. What hormones come into play in the DCT and the CD, and what materials do they regulate the reabsorption of?
  1. What is the function of tubular secretion in the process of urine formation?
  1. Using the diagram to the right, indicate which part of the nephron the letter is indicating and what substance is moving in/out there:

A: ______D: ______

Moving in: Moving in:

Moving out: Moving out:

B: ______E: ______

Moving in: Moving in:

Moving out: Moving out:

C: ______

Moving in:

Moving out:

  1. What is the purpose of the vasa recta in regards to tubular reabsorption/secretion?
  1. What effect does ADH have at the collecting duct?
  1. What is an example of an ADH inhibitor? What would the outcome be then if the inhibitor was present?