Supplementary Figure 1. Risk Ratio of 50% responder rate for 2 mg perampanel (reported in one study only [13])

CI, confidence intervals; M-H, Mantel-Haenszel

Supplementary Figure 2. Risk Ratio of seizure freedom for 2 mg and 4 mg perampanel (reported in one study only [13])

CI, confidence intervals; M-H, Mantel-Haenszel

Supplementary Table 1. Assessment of risk of bias in accordance to Cochrane Collaboration’s tool*

Study / Sequence generation / Allocation concealment / Blinding / Incomplete outcome data / Selective outcome reporting / Other sources of bias
French 2012 [11]
(study 304) / Yes / Yes / Yes / Yes
(low risk of bias) / Unclear / Yes
(low risk of bias)
French 2013 [12]
(study 305) / Yes / Yes / Yes / Yes
(low risk of bias) / Unclear / Yes
(low risk of bias)
Krauss 2012a [13]
(study 306) / Yes / Yes / Yes / Yes
(low risk of bias) / Unclear / Yes
(low risk of bias)
Krauss 2012b [10] (study 206) / Unclear / Unclear / Yes / Yes
(low risk of bias) / Unclear / Unclear
Krauss 2012b [10] (study 208) / Unclear / Unclear / Yes / Yes
(low risk of bias) / Unclear / Unclear

*Yes: low risk of bias, No: high risk of bias, Unclear: unclear risk of bias

Supplementary Table 2. Sensitivity analysis (excluding or moving study 208 [10]) of risk ratios of 50% response rates

Dose of perampanel / Original model / Exclusion of study 208 / Moved study 208 to 8 mg subgroup / Moved study 208 to 4 mg subgroup
Sample size
(perampanel
/placebo) / Risk ratio
[95% CI†] / I2 / Sample size
(perampanel
/placebo) / Risk ratio
[95% CI] / I2 / Sample size
(perampanel
/placebo) / Risk ratio
[95% CI†] / I2 / Sample size
(perampanel
/placebo) / Risk ratio
[95% CI] / I2
2 mg bid / 180/184 / 1.15
[0.75, 1.75] / - / N/C / N/C / N/C / N/C / N/C / N/C / N/C / N/C / N/C
4 mg bid / 273/235 / 1.54
[1.11, 2.13] / 0% / N/C / N/C / N/C / N/C / N/C / N/C / 311/244 / 1.55
[1.13, 2.13] / N/C
8 mg bid / 431/441 / 1.80
[1.38, 2.35] / 25% / N/C / N/C / N/C / 469/450 / 1.79
[1.43,2.24] / 0% / N/C / N/C / N/C
12 mg bid / 292/266 / 1.72
[1.17, 2.52] / 31% / 254/257 / 1.74
[1.04, 2.90] / 66% / 254/257 / 1.74
[1.04, 2.90] / 66% / 254/257 / 1.74
[1.04, 2.90] / 66%

CI, confidence intervals; N/C, no change comparing to the original model