C83MLP Dissertations – Tobias Bast
Dissertation Academic / Tobias BastDissertation Code and title / TB1. Memory and beyond . . . Functional differentiation within the hippocampus.
Suggested reading / Quick start:
BastT (2011)The hippocampal learning-behaviour translation and the functional significance of hippocampal dysfunction in schizophrenia. Curr Opin Neurobiol, 21,492-501.
Some additional reading:
Bast T (2007) Toward an integrative perspective on hippocampal function: from the rapid encoding of experience to adaptive behavior. Rev Neurosci, 18, 253-281.
Moser MB, Moser EI (1998) Functional differentiation in the hippocampus. Hippocampus, 8, 608-619.
Brief description / The hippocampus is commonly associated with specific types of memory, namely declarative, especially episodic, and place memory. Other behavioural functions outside the realm of memory, including emotional, motivational, and sensorimotor processes, have been less in the spotlight, although there is now convincing evidence that the hippocampus is critically involved. In this dissertation, you will discuss the relevant evidence for functional differentiation within the hippocampus (focusing on differentiation along the longitudinal axis) and potential implications (e.g., for the translation of hippocampus-dependent learning into adaptive behaviour).
Dissertation Academic / Tobias Bast
Dissertation Code and title / TB2. Hippocampal dysfunction in schizophrenia and the contribution of such dysfunction to symptom generation.
Suggested reading / Quick start:
BastT (2011)The hippocampal learning-behaviour translation and the functional significance of hippocampal dysfunction in schizophrenia. Curr Opin Neurobiol, 21,492-501.
Some additional reading:
Heckers S & Konradi C (2010) Hippocampal pathology in schizophrenia. Curr Top Behav Neurosci, 4, 529-553.
Lisman et al (2008) Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neursosci, 31, 234-242.
Brief description / Hippocampal dysfunction has emerged as a key feature of schizophrenia pathophysiology. In this dissertation, you will discuss relevant evidence from clinical and animal model studies and consider the possible role of hippocampal dysfunction in symptom generation.
Dissertation group:
4248092 / Thynne / Imogen Amelia / / TB14247028 / Palfreyman / Hannah / / TB1
4252668 / Dudka / Katarzyna / / TB1
4253668 / Leow / Karen / / TB1
4248726 / Bell / Sophie / / TB1
2123038 / Lim / Wei Seng / / TB1
4246336 / Colley / Peyton Leigh / / TB1
4253134 / Thayaparan / Avithaa / / TB2
4249902 / Deshmukh / Rose / / TB2
4254421 / Sonola-Jones / Olivia / / TB2
4252538 / Coll / Emily / / TB2
4251662 / Chapman / Nicholas / / TB2
4262886 / Wilkey / Oluwatoni / / TB2
4248464 / Shrivastava / Muskan / / TB2
Schedule for dissertation tutorials
Monday26Feb 2018,16-18h, A29
To do in preparation of meeting:
- Everybody reads the ‘quick start’ paper suggested for both topics.
- Everybody reads at least one of the papers suggested as additional reading for their topics. You may also already have a look ahead at the papers suggested for presentation at the next meeting (list of papers is on p. 4).
During meeting:
- Identify key topics/papers for presentation and discussion during next tutorial.
- Discuss any general or specific questions you may have.
Monday5 March 2017, 16--18h, Room A29
To do in preparation of meeting:
- Everybody carefully reads the papers for their topic that have been suggested for discussion at the previous meeting.
- Everybody at least skim reads the papers for the other topic that have been suggested for discussion at the previous meeting.
- In the previous meeting, students will have been divided into four groups of three to four students each. Each group will prepare one joint 10- to 15-min presentation on key points relevant to their topic, i.e. there will be four presentations.
During meeting:
- Four 10- to 15-min presentations on key papers by groups of 3 students, followed by discussion.
- Discuss any general or specific questions you may have.
Monday12March 2018, 16-18h, Room A29
To do in preparation of meeting:
- Some general reading may have been suggested during the previous meeting.
- Everybody does individual reading and works hard on their dissertation.
During meeting:
- Everybody raises any issues that require clarification.
(- Potentially, one presentation may “spill” over to this meeting from the previous meeting).
Monday19March 2018, 16-18 h, Office B26
Drop-in sessions in my officefor any specific questions concerning the dissertation topic.
Dissertations are due on Wed, 9 May,2018!
Suggested papers for presentationsonTuesday 14March
Topic TB1
1. Hippocampal role in learning and memory – some key ideas
Suggested literature:
H Eichenbaum, 2004, Neuron
H Eichenbaum, 2000, Nature Rev Neurosci
H Eichenbaum et al., 1999, Neuron
RG Morris et al., 2003, Phil Trans Roy Soc London
Presenters: TBD
2. Functional differentiation in the hippocampus
Suggested literature:
T Bast, 2007, Rev Neurosci
T Bast et al., 2009, PLoS Biol
T Bast, 2011, Curr Opin Neurobiol
M Fanselow & Dong, 2010, Neuron
E Moser & M Moser, 1998, Hippocampus
Presenters: TBD
Topic TB2
1. Hippocampal pathology in SZ – overview of key findings
Suggested literature:
S Heckers & C Konradi, 2010, Curr Top Behav Neurosci (also see Heckers & Konradi, 2015, Schizophr Res)
C Tamminga et al., 2010, Am J Psychiatry (also see Tamminga et al., 2012, Schizophr Bull)
S Schobel et al., 2009, Arch Gen Psychiatry (also see S Schobel et al., 2013, Neuron)
J Lisman et al., 2008, Trends Neurosci
Presenters: TBD
2. Aberrant hippocampal modulation of dopamine systems and psychosis
Suggested literature:
J Lisman et al., 2008, Trends Neurosci
D Lodge & A Grace, 2007, J Neurosci
D Lodge et al., 2009, J Neurosci
D Lodge & A Grace, 2011, Trends Pharmacol Sci
SN Mitchell et al., 2000, Eur J Pharmacol
Presenters: TBD
1