RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
KARNATAKA - BANGALORE
COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR
DISSERTATION
“STANDARDIZATION OF BASTI KARMA WITH TWO DIFFERENT METHODS OF MIXING BASTI DRAVYA IN KSHEENA SHUKRA w.s.r.to OLIGOSPERMIA”
BY
Dr. KISHORE
FOR THE DEGREE OF AYURVEDA VACHASPATI
M.D (AYURVEDA) IN PANCHAKARMA
GUIDE CO-GUIDE
Dr.SANTOSH L YADAHALLI Dr.PREMA KUMARI M S
M.D. (AYU) M.D.(AYU)
Dept. of Panchakarma Dept. of Panchakarma
G.A.M.C Bangalore G.A.M.C Bangalore
2011 - 2012
GOVERNMENT AYURVEDIC MEDICAL COLLEGE,
DHANVANTARI ROAD, BANGALORE – 09,
KARNATAKA
From,
Dr.KISHORE,
P.G. SCHOLAR,
Dept. of.P.G.studies in Panchakarma,
G.A.M.C
BANGALORE-09
To,
THE REGISTRAR,
Rajiv Gandhi University of Health Sciences,
Bangalore, Karnataka.
Through,
THE PRINCIPAL AND H.O.D.
OF PG STUDIES IN PANCHAKARMA
G.A.M.C.
BANGALORE-09
Respected Sir,
Sub: Submission of completed proforma for registration of synopsis
for dissertation
I request you to kindly register the below mentioned subject against my name for the submission of dissertation to Rajiv Gandhi University of Health Sciences, Bangalore, for partial fulfillment of M.D. (AYU) in Panchakarma.
TITLE OF DISSERTATION :
“STANDARDIZATION OF BASTI KARMA WITH TWO DIFFERENT METHODS OF MIXING BASTI DRAVYA IN KSHEENA SHUKRA w.s.r.to OLIGOSPERMIA”
Here with i am enclosing completed proforma for registration of subject for dissertation.
Thanking You,
Place: BANGALORE. Yours faithfully,
Date:
(Dr. KISHORE)
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
BANGALORE, KARNATAKA
ANNEXURE-II
PROFORMA FOR REGISTRTION OF SUBJECT FOR DISSERTATION
1) NAME AND ADDRESS OFTHE CANDIDATE / DR.KISHORE
S/O P.K.MAHINDRAKER,
NANAPUR STREET,
POST-GURMITKAL,
DIST-YADGIRI.
2)NAME OF THE
INSTITUTION / GOVERNMENT AYURVEDIC MEDICAL
COLLEGE, DHANVANTARI ROAD
BANGALORE-560009
3)COURSE OF THE STUDY
AND SUBJECT / AYURVEDA VACHASPATI,
1ST YEAR MD (AYU),PANCHAKARMA
4)DATE OF ADDMISSION TO
THE COURSE / 29-10-2011
5)TITLE OF THE TOPIC / “STANDARDIZATION OF BASTI KARMA WITH TWO DIFFERENT METHODS OF MIXING BASTI DRAVYA IN KSHEENA SHUKRA w.s.r.to OLIGOSPERMIA”
6) BRIEF RESUME OF INTENDED WORK:
6.1) Need for the study:-
Ayurveda aims at preventive and curative aspects with various therapeutic measures by means of samshodhana and Samshamana. Among shodhana therapy, the basti karma is claimed as the main radical treatment seeking the absolute cure of disease by eliminating its root cause 1a.Yapanbasti is a type of asthapana basti which is synonym of niruha basti,it is suitable in all seasons1b. Yapana basti is considered to be having particular action on shukra dhatu.
In Āyurveda, sāra of all dhātus is considered as Seventh dhātu i.e. Śhukra. Ksheena shukra is a condition in which there is qualitative and quantitative decrease of shukra charecterised by duarbalya, mukhashosha, pandutva, shrama, klaibya, shukraavisarga, leading to infertility. In Upanishads also mentioned the Putra asina is one of the primary desires of mankind.Charak has described that children (PutraPrapti) are responsible for Dharma (way to reach heaven or divine), Artha (means to earn livelihood), Preeti (way for harmony), Yasha(fame) 1c and this all depend upon Shukra.
Condition Ksheena shukra can be correlated with Oligospermia By definition, the Oligospermia is characterized by the lowered sperm count which is less than 15 million/ml.6
Statistics available over the past 20years reveal that, In approximately 30% of case of infertility, the pathology is found in male alone. In contrast to this, 20% of infertility is due to abnormality present in both man and women. Logically this reveals incidence of 50% of male factor in infertile couples in general. The WHO statistical analysis drawn from 7273 couples revealed that Male factor accounts for 24% of infertility cases, female and male factor accounts 24% further, only female factors were identified in 41% cases of infertility. Also non demonstrable factors of infertility were accounted in remaining 11% of couples.7
In conventional system of medicine management of this condition is been reached to most advance technique i.e. MART(Medical assisted reproductive technique) like Artificial Insemination, In-vitro Fertilization, Intra cytoplasmic sperm injection which are highly expensive and results are not satisfactory.In Ayurvedic Classics, it is explained that Shukra doshas are specially managed by basti karma .1d
Different types of effective Vajikarana basti’s are explained in the management of Ksheena Shukra. Most of these are yet to be explored. Many research works have been done on oligospermia but only few concentrated on standardization of procedure, but those studies were unable to draw a proper conclusion. So an attempt is made to Standardize the procedure of mixing basti dravya prepared from two different methods i.e. khalwa (mechanical) and mixer (instrumental) method and analyse the efficacy of baladi Yapana basti in Ksheena Shukra.w.s.r.to Oligospermia
6.2)Review of literature:
The management of ksheena shukra is explained in detail in brihatrayees.
CHARAKA SAMHITA:
a)“mÉëzÉxiÉzÉÑ¢üSÉåwÉåwÉÑoÉÎxiÉMüqÉïÌuÉzÉåwÉiÉ:”
Basti karma is considered as the best treatment in managing all varieties of
Shukra dosha1d
b)
“SÉæoÉïsrÉqÉÑZÉzÉÉåwɶÉmÉhSÒiuÉxÉSlÉ´ÉqÉ:
YsÉæorÉqÉçzÉÑ¢üÉÌuÉxÉaÉïxcÉ ¤ÉÏhÉzÉÑ¢üxrÉsɤÉhÉ” 1e
Physical symptoms such as weakness, dryness of mouth, pallor, malaise ,tiredness,
loss of libido, obstruction in seminal discharge appears.
c)SUSHRUTA SAMHITA:
zÉÑ¢ü¤ÉrÉåqÉåRíûuÉÚwÉhÉuÉåSlÉÉzÉÌ£üqÉæjÉÑlÉåÍcÉU² mÉëxÉåMü: mÉëxÉåMücÉAsmÉU£üzÉÑ¢üÉSzÉïl É2a
In ksheena shukra there will be pain in phallus & testicles associated with delayed seminal discharge or very less in quantity
d)Sushrutha also considered Ksheena Shukra as one among the 8 Shukra Dushti.and
explained as-“¤ÉÏhÉÇmÉëaÉÑ£üqÉçÌmɨÉqÉÂiÉprÉqÉ”.2b
e)ASHTANG SAMGRAHA Ksheena Shukra lakshanas and its Chikitsa have been
mentioned in Sutrasthana.3 (A.S. Su. 19/9),
f)ASHTANGA HRIDAYA: Ksheena Shukra lakshanas have been mentioned in
Sutrasthana (A.H.Su. 11/20)4a.Shukrakari kriyas have been advised for Ksheena
Shukra 4b(A.H.Sha. 1/14)
g) “oÉsÉÉÌiÉoÉsÉÉmÉqÉÉaÉÉïiqÉaÉÑmiÉÉwOèmÉsÉÉAkÉï¤ÉÑhhÉrÉuÉÉgeÉÍsÉMüwÉÉrÉ:
xÉaÉÑQûbÉÚiÉiÉæsÉsÉuÉhÉrÉÑ£ü:mÉÑuÉïuɯÎxiÉ:xjÉÌuÉUSÒoÉïsɤÉÏhÉzÉÑ¢üÂÍkÉUÉhÉÉÇmÉjrÉiÉqÉ:”1f
Previous work done:
1)Yaswant juneja ;Standardization of procedure of administration of basti w.s.r.to. ksheena shukra(oligospermia);IPGT & RA, Jamnagar. Gujrat Ayurved University, Jamnagar 2009
2)Manerikar shivadatta Viraj;To evaluate effect of Jivantyadi yamaka uttarbasti in ksheena shukra w.s.r.t.oligospermia.GAMC Bangalore RGUHS Bangalore 2006
3)Tike Sachin G;Clinical study on role of sthiradiyapanbasti and erandamoolachurna in management of ksheenashukra w.s.r.t. oligospermia GAMC Bangalore,
RGUHS Bangalore ,2005
4)Prashanth. A.Lande ;Efficacy of Ardha matrika basti in shukrakshaya:S.D.M college of Ayurveda Udupi, RGUHS Bangalore ,2003
6.3) Objective of study:
Aims & Objectives
1)To standardize the Preparation of basti dravya with khalwa (Method I) and
mixer method (Method II).
2) To study the efficacy of Baladi yapanabasti in the patient of ksheena shukra by
Method I and by Method II.
3) To compare the efficacy of Baladi yapanabasti in the patient of ksheena shukra from both above methods.
7) MATERIALS AND METHODS
7.1) Source of data:
30 patients of ksheena shukra (oligospermia) will be selected from OPD IPD of
SRI JAYA CHAMRAJENDRA INSTITUTE OF INDIAN MEDICINE Hospital Bangalore.
7.2) Method of data collection:
For the present study, total 30 patients will be selected from the O.P.D.& I.P.D of
SRI JAYA CHAMRAJENDRA INSTITUTE OF INDIAN MEDICINE Hospital,
Bangalore.
• The patients will be selected irrespective of their religion, socio economic status , fully satisfying the clinical criteria for diagnosis of Ksheena Shukra (Oligspermia)
• A case proforma will be specially designed duly filled with history taking, clinical examination and laboratory investigations.
• The parameters of signs and symptoms will be scored as per the proforma.
Diagnostic criteria:
Ø Mainly based on the signs and symptoms of ksheena shukra and Semen analysis.
Inclusion criteria:
• Age between 25-50 years
• A male complaining of infertility with minimum of 1 year of married life having unprotected sex.
• The patients having classical signs and sympomts of Ksheena Shukra.
• The WHO criteria (2010) for semenogram i.e. sperm count < 15 million/ ml
• Patient fit for basti karma
Exclusion criteria:
• Patients with Absolute Azoospermia.
• Patient with structural abnormality of gonads.
• Patients with major systemic/infectious disorders like Tuberculosis, AIDS, and STD
Which interfere in course of treatment .
• STUDY DESIGN:
It will be a comparative clinical study with pre and post test design
30 patients of Ksheena shukra (oligospermia) who fulfils the inclusion criteria will be
selected and randomly assigned into following 2 groups each comprising of 15 patients.
Group – A
Patients of this group will be given a course of baladi yapan Basti
Dravya Prepared in KhalwaYantra------(Method I)
Group – B
Patients of this group will be given a course of baladi yapan Basti
Dravya Prepared in Mixer ______(Method II)
In both method after preparation of basti dravya,samples are taken for Analysis
in laboratory.
The details of the basti administrative process is as follows.
Patients of both groups are administered Kala Basti1course as mentioned in classics.
GROUP A / GROUP BPURVAKARMA / Ø Previous night 10ml of eranda taila will be given for kosta shodhana
Ø ANUVASANA-
• Abhyanga with murchit taila over abdomen and back followed by nadi sweda
• Laghu ahara
Ø NIRUHA-
• Abhyanga with murchit taila over abdomen and back followed by nadi sweda / Ø Previous night 10ml of eranda taila will be given for kosta shodhana
Ø ANUVASANA-
• Abhyanga with murchit taila over abdomen and back followed by nadi sweda
• Laghu ahara
Ø NIRUHA-
• Abhyanga with murchit taila over abdomen and back followed by nadi sweda
PRADHANA KARMA
ANUVASANA / 96ML / 96ML
NIRUHA / 761ML / 761ML
PASCHAT KARMA / For Anuvasana- Hasta, pada Sphik thadana.
For Niruha- After basti pratya gamana, Mudga Yusha Odana / For Anuvasana- Hasta, pada Sphik thadana.
For Niruha- After basti pratya gamana, MudgaYusha Odana
Ingridients-
A.ANUVASANA
Murchit tila taila-96ml
B.NIRUHA
Guda / 128gmSaindava lavana / 7.5gm
Sneha
Murchit Grhrita
Murchit tila taila / 96ml
96ml
Kalka –Pippali, yastimadhu,, madana / 64gm
Ksheera kashaya
(prepared from Bala, Atibala , Apamarga, Atmagupta , yava ,ksheera, jala) / 370ml
APPROXIMATE TOTAL QUANTITY / 761ML
A-Anuvasanbasti, N-niruhabasti
DAYS / 1 / 2 / 3 / 4 / 5 / 6 / 7 / 8 / 9 / 10 / 11 / 12 / 13 / 14 / 15 / 16BASTI / A / A / N / A / N / A / N / A / N / A / N / A / N / A / A / A
A-Anuvasana Basti(Murchita Tila Taila)
N-Niruha Basti(Baladi Yapana Basti)
During pilot study it is observed that 12 prasrutha dosage of basti mentioned in charaka Samhitha was difficult to administer,so the mamdhyama matra mentioned in sharangadhara Samhitha is taken for present study. 5
DURATION & FOLLOW UP:
After the completion of basti karma, patient reviewed after one month.
STUDY DURATION:50 days
Assessment criteria:
Ø Assessment of Procedural study will be done to know the particle size of final Basti Colloid, pH, Viscosity,Concentration in both the method of preparation by Khalwa (motor pestle) and Mixer.
Ø Assessment of clinical study will be done based on following Subjective and Objective parameters.
SUBJECTIVE PARAMETERS
-Classical laxanas of ksheen shukra.
1.Duarbalya
2.vrashana and medhra vedana
3.Shrama
4.Klaibya
5.Shukraavisarga/alpapraseka
-sexual health parameters like sexual desire, erection, rigidity and orgasm. The
Scoring system developed by Mehra and Singh (1995) will be adopted .
OBJECTIVE PARAMETERS
-Semen Analysis :
(volume, count, pH,viscosity,motility)
TEST OF SIGNIFICANCE
Assessment of the condition will be done based on the detailed proforma adopting standard methods of scoring of subjective parameter which will be analyzed statistically by using Chi-square and Student`s ‘t’ test.
In both the groups assessment is made on 0,18th ,50th day, and conclusion will be drawn
7.3) Investigations needed for the study
· Semen Analysis
· Other investigations will be done where ever necessary.
7.4)Has ethical clearance been obtained from your institution?
YES
8. BIBLIOGRAPHY
1. Agnivesha. Charaka samhita, revised by charaka and Dridhabla with the Ayurveda Dipika commentary of Chakrapanidatta and edited by Vaidya Yadavaji Trikamji Acharya. Reprint 2009. Pub: Chaukambha Surabharati Prakashan; Varanasi; Pp 738
a.cha.si.cha.1/28 pn- 682
b.cha.si.cha.12/16 pn- 731
c.cha.chi.cha. 2/1-3 pn-390.
d. cha.su.cha.17/69 pn-103.
e. cha.chi.30/152 pn-641
f.cha.si.12/16-9
g.Cha.Si.1/47-48
2. Sushruta. Sushruta Samitha with the Nibanda Sangraha commentary of Sri Dalhana Achary and the Naychandrika Panjika of Sri Gayadas Acharya on Nidana Stana, Edited By Vaidya Yadavji Trikamji Acharya, and rest by Narayan Ram Acharya. Pub: Chaukambha Surabharati Prakashan; Varanasi; printed in 2010. Pp 824
a.Su.su 15/9 pn-69.
b.Su.sha.2/4 pn-344.
3. Vagbhata. Astanga Samgraha with sheshilekha Sanskrit commentary by Indu,Edited by Shivprasad Sharma .Reprint 2008. Pub: Chaukamba Sanskrit Series Office; Pp-965 Ast.sam.su.19/9.pn-150.
4.Vagbhata. Astanga hridayam edited with ‘Vidyotini’ hindi commentary by Kaviraja Atrideva Gupta vidyalankara,Bhisagratna edited by Vaidya Yadunandana Upadhya .Reprint 2008.Pub:Chaukamba Prakashan varnasi;Pp-839
a.A.H.Su. 11/20,pn-116
b.A.H.Sha. 1/14, pn-231
5.Sharangadhara. sharangadhar Samhitha ‘Jiwanprada’ Hindi commentary by Dr.Smt.Shailaja Srivastava. Reprint 2011.Pub:Chaukambha Orientalia varnasi;Pp-578
Sha.sam.uttar khanda.6/3 pn-375.
6.en.wikipedia.org/Wikipedia/semen_analysis.
7.Basu SC, Male reproductive Dysfunction,New delhi:1st ed. JaypeeBrothers,Medical Publishers(p)ltd; Pp 290 pn-99
9 / Signature of Candidate:10 / Remark of the Guide:
11 / Name and Designation of:
11.1 / Guide: / Dr.SANTOSH L YADAHALLI
M.D(Ayu)
Dept Of P.G.Studies In Panchakarma, Govt Ayurvedic Medical College,
Bangalore-560009.
11.2 / Signature:
11.3 / Co-Guide / Dr.PREMA KUMARI
M.D(Ayu)
Dept Of P.G.Studies In Panchakarma, Govt Ayurvedic Medical College,
Bangalore-560009.
11.4 / Signature:
11.5 / Head Of The Department: / Dr.Shalini.C.Eli
M.D. (Ayu), DNY Prof. & H.O.D.
Dept Of P.G.Studies In Panchakarma, Govt Ayurvedic Medical College,
Bangalore-560009.
11.6 / Signature:
12.1 / Remark of the chairman and Principal:
12.2 / Signature:
6