Integrating the PGP with having people tell us stuff about their lives: check out curetogether.com –

Jackie – who the potential client is? With pharmacogenomics, the average person can’t do this

JT – act under the assumption that many genomes will be available

Brett – we could do a user facing tool or make something for researchers, put the modeling in a different section

Leibro – the metabolism project, if we are anticipating - would be surprised if we had an advantage

Brett – one advantage is there are 10k people willing to give

Fil – reconstructing networks, standard for reconstructing networks – not just having lots of databases… this is your pathway, here are the parameters – have a way to share and index that – using that as a basis for people to work

JT – with respect to novelty: 1) reconstructing networks is cool, but there has been lots of effort put into this, and it’s gotten so general that there is a project of parsing pubmed abstracts that they have a protein-protein interaction network… the quality of the finds were similar to proteomics. 1) we can’t be absolutely novel 2) reason we cant have novel ideas is we aren’t deep in the field …. If we look at what has been done we can make a tool for researches

Brett – disagrees, would be partial to making a platform on top of PGP – don’t think

Zach – think forward… what kinds of questions are they gong to be asking

Jackie – what would people want . what would you want

Fil – make it research facing then adapt it…

JT – if we want stuff human readable snpcupid might be good…

Fil – an issue of data ordering – step back and think of a larger genomic project about families

Anugraha – nice if it is has a really cool application but we have to focus on something that is a tool.

Fil – SNP cupid would be pretty easy, Could be a very nice patient facing interface. Is kind of ridiculous right now

Brett – would we hard code the genes to look at – if we make something patient facing it doesn't enable other things

Fil – we could do as a class that would be kind of cool, some would say hey we are going to the coding, and hey we are going to do the interface – how are people going to sue this, we don’t need to forego having a rigorous researcher

Leibo – it is something that will be used to full potential once people have this – we could do it on some pats

JT – some traits will be well characterized, a couple people here is the data

Fil – 1) human genome sequence, who would have thought that all these companies would tart up… 2) if you have a lot of people doing this you could do an evolutionary dynamics experiment using this data – let’s just shuffle

JT – something people would pay money for, don’t underestimate how much people would want a service. Parents aren’t just worried about disease – in spain parents avoided passing on a gene – pre-implantation screening has been approved in spain

Alex – wants a cocky idea, mapping families… somebody must have done something

30 second visions for what the project

JT: For various practical reasons, the cupid thing is not the worst idea, an outline of how people could work, could put into practice. Good practical things – not super daring, not super sexy… the things that are sexier require extra work or put us in competition with researchers

Fil: networks might be beyond our scopes – maybe snp cupid in a larger scheme of things – analyze how things change in your family

Anugraha: Strongly in favor of snpcupid

Jackie: attracted to pharmacogenetic tool, but as someone with limited computer science skills – don't’ see a place for myself

Leibo: good compared to all the other projects, wider variety of people can work on – don't’ have a good understanding of how much work it would take. It’s very doable

Zach:

Jackie: if I were a scientist using the too, a more interesting question for me would be – there is this novel protein for some gastrointestinal cancer – what would it do. Ultimately we are limited by the number of adverse drug reactions