Supplemental Table 1. Immune and biochemical parameters in patients before and after radioiodine therapy

CD4+CD25hiFoxp3+ among CD4+ T cells (%) / Proportion variation of Treg among CD4+ T cells (%) / Vα24+Vβ11+CD3+ iNKT cells per mL blood / Proportion variation of iNKT per mL blood (%) / % suppression (Treg:responder 1:1) / Free T4 (pmol/l) / TSHR-Ab (U/L) / ATD pretreatment (weeks)
Before RAI / After RAI / Before RAI / After RAI / Before RAI / After RAI / Before RAI / After RAI
G-no ATD patients / 1,41 / 3826 / 24,3 / 14,8 / 12,3
1,11 / 1,18 / 0,063 / 39 / 41 / 0,051 / 41,9 / 37,4
1,74 / 0,56 / -0,678 / 176 / 182 / 0,034 / 46,8 / 7,3 / 39
2,24 / 2,14 / -0,045 / 72 / 164 / 1,278 / 59 / 16
1,30 / 70 / 41 / 20
0,55 / 703 / 492 / -0,300 / 43 / 16
1,70 / 1,96 / 0,153 / 55 / 19 / -0,655 / 47,5 / 42,3 / 52 / 5,2 / 8
1,70 / 2,06 / 0,212 / 38 / 41,8 / 14
1,11 / 1,75 / 0,577 / 36 / 53 / 0,472 / 48,9 / 49,5 / 36 / 12
1,34 / 2,26 / 0,687 / 48 / 19 / -0,604 / 41,0 / 35,0 / 43 / 26
1,19 / 707 / 76
1,59 / 1237 / 35 / 14
1,70 / 2,01 / 0,182 / 176 / 121 / -0,313 / 50,3 / 35,2 / 27 / 19 / neg
1,08 / 84 / 27
0,82 / 1,26 / 0,537 / 3673 / 1807 / -0,508 / 70,9 / 62,8 / 23 / 23 / neg
51,0 / 27,1 / 31
G-ATD patients / 2,35 / 141 / 23 / 12,3 / 4
1,28 / 1,13 / -0,117 / 3293 / 1650 / -0,499 / 14,4 / 12,2 / 2,34 / 6
2,08 / 73 / 28 / 2,77 / 8
1,06 / 1,03 / -0,028 / 886 / 865 / -0,024 / 44,0 / 39,3 / 17 / 23 / 2,5 / 8
1,92 / 1,93 / 0,005 / 20 / 24 / 0,200 / 53,9 / 50,4 / 36 / 15 / 5
1,37 / 1,18 / -0,139 / 716 / 1093 / 0,527 / 62,5 / 52,1 / 38 / 18 / 6 / 7
1,49 / 303 / 59 / 17 / 4
1,68 / 2,07 / 0,232 / 41 / 30 / -0,268 / 79,9 / 74,4 / 38 / 9 / 6
1,11 / 138 / 82 / 21 / 2
1,47 / 2342 / 38 / 15 / 4
1,56 / 1,81 / 0,160 / 420 / 457 / 0,088 / 52,2 / 45,2 / 79 / 36 / 6,2 / 1
Patients with multi-nodular goiter / 2,18 / 78 / 55,9 / 59,1 / 19
2,22 / 2,29 / 0,032 / 49 / 49 / 0,000 / 53,3 / 56,5 / 13,5 / 29
1,83 / 1,75 / -0,044 / 28 / 31 / 0,107 / 31 / 14
1,72 / 10 / 14
0,99 / 1,06 / 0,071 / 17 / 18 / 0,059 / 35,0 / 36,6 / 11 / 12,8

G: Graves’ disease; G-no ATD: Graves’ disease patients who did not take

ATD before radioiodine therapy; G-ATD: Graves’ disease patients who did take ATD

before therapy; FreeT4: free thyroxine; TSHR-Ab: anti TSH receptor antibodies