EUROPEAN JOURNAL OF
CLINICAL PHARMACOLOGY
Official organ of the European Association for Clinical Pharmacology and Therapeutics
Supplement to Volume 62 February 2006
Vascular NO: From Bench to Bedside An International Symposium
Hannover, Germany, March 11 - 13, 2004
Roots I:
Festschrift Professor JCirgen C. Frolich 1
Editorial
Tsikas D:
Vascular NO: from bench to bedside 3
Review Articles
Forstermann U:
Endothelial NO synthase as a source of NO and superoxide 5
Landmesser U, Harrison DG, Drexler H:
Oxidant stress—a major cause of reduced endothelial nitric oxide availability in cardiovascular disease 13
Heller R, Werner-Felmayer G, Werner ER: Antioxidants and endothelial nitric oxide synthesis 21
Thum T, Bauersachs J:
Growth hormone regulates vascular function—what we know from bench and bedside 29
Leiper JM, Vallance P:
The synthesis and metabolism of asymmetric dimethylarginine (ADMA) 33
Kielstein JT, Tsikas D, Fliser D:
Effects of asymmetric dimethylarginine (ADMA) infusion in humans 39
Lenzen H, Tsikas D, Boger RH:
Asymmetric dimethylarginine (ADMA) and the risk for coronary heart disease: the multicenter CARDIAC study 45
Tsikas D, Gutzki F-M, Stichtenoth DO:
Circulating and excretory nitrite and nitrate as indicators of nitric oxide synthesis in humans: methods •of analysis 51
Martens-Lobenhoffer J, Bode-Boger SM:
Measurement of asymmetric dimethylarginine (ADMA) in human plasma: from liquid chromatography
estimation to liquid chromatography-mass spectrometry quantification 61
Charakida M, Deanfield JE, Halcox JPJ:
The role of nitric oxide in early atherosclerosis 69
Kofler S, Petrakopoulou R Nickel T, Weis M: Cardiac allograft endothelial dysfunction 79
von der Leyen HE, Chew N:
Nitric oxide synthase gene transfer and treatment of restenosis: from bench to bedside 83
Bode-Boger SM:
Effect of L-arginine supplementation on NO production in man 91
Tousoulis D, Antoniades C, Stefanadis C:
Nitric oxide in coronary artery disease: effects of antioxidants 101
Ritter JM, Ferro A, Chowienczyk PJ:
Relation between p-adreno receptor stimulation and nitric oxide synthesis in vascular control 109
Cooke JP:
Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of angiogenesis 115
Baylis C:
Nitric oxide deficiency in chronic renal disease 123
Zoccali C, Mallamaci F, Tripepi G:
Asymmetric dimethylarginine (ADMA) as a cardiovascular risk factor in end-stage renal disease (ESDR) 131
Haendeler J:
Nitric oxide and endothelial cell aging 137
Napoli R:
Growth hormone, vascular reactivity, and heart failure 141
Bolla M, Momi S, Gresele P, Del Soldato P:
Nitric oxide-donating aspirin (NCX 4016): an overview of its pharmacological properties and
clinical perspectives 145
Abstracts 155 Author Index 173