Table 1

Plasma amino acid concentration in patients in age cohorts at admission

Amino acid / 0-1 year (n=85) / 1-6 years (n=36) / 6-13 years (n=16) / 13-18 years (n=11) / Statistical significance
Glutamate / 42 (27-65) / 49 (23-91) / 65 (26-84) / 39 (20-92) / ns
Asparagine / 33 ( 33- 44) / 30 (27-42) / 34 (28-47) / 26 (20-30) / ns
Serine / 93 (61-124) / 88 (61-124) / 87 (70-130) / 62 (52-89) / ns
Histidine / 60 (50-75) / 60 (46-78) / 49 (41-67) / 48 (51-58) / ns
Glycine / 208 (132-256) / 187 (140-247) / 251 (176-318) / 171 (87-246) / ns
Threonine / 82 (47-118) / 81 (51-116) / 93 (44-134) / 54 (42-80) / ns
Citrulline / 10 (7-14) / 11 (8-17) / 12 (9-18) / 13 (8-20) / ns
Arginine / 41 (25-58) / 39 (25-66) / 51 (28-76) / 31 (23-43) / ns
Alanine / 166 (115-243) / 173 (120-264) / 163 (122-370) / 103 (94-171) / ns
Taurine / 27 (14-41) / 29 (18-42) / 30 (18-50) / 35 (15-50) / ns
Tyrosine / 9 (7-17) / 11 (8-17) / 12 (6-15) / 8 (6-21) / ns
Valine / 141 (104-183) / 142 (110-187) / 125 (99- 186) / 108 (101-129) / ns
Methionine / 18 (14-24) / 17 (13-29) / 20 (11-31) / 15 (11-21) / ns
Tryptophane / 24 (16-33) / 21 (18-30) / 22 (16-27) / 26 (24-30) / ns
Phenylalanine / 48 (41-68) / 51 (43-64) / 51 (43-70) / 51 (39-60) / ns
Isoleucine / 28 (18-40) / 34 (22-42) / 38 (22-44) / 24 (16-55) / ns
Ornitine / 37 (25-53) / 31 (23-42) / 39 (26-51) / 21 (13-28) / c
Leucine / 65 (48-100) / 73 (55-103) / 64 (52-74) / 55 (48-72) / ns
Lysine / 105 (76-164) / 113 (71-149) / 117 (80-157) / 89 (77-121) / ns
BCAA / 235 (174-318) / 254 (195-326) / 208 (177-304) / 178 (168-261) / ns
Total / 1792 (1327-2244) / 1705 (1286-2349) / 1798 (1346-2566) / 1577 (996-1673) / ns

Values (in µmol/L) are given as median and interquartile range. BCAA: branched chained amino acids. Online alphabets denote statistical significant difference (< 0.05) using one-way ANOVA followed by Turkey’s post-hoc test; (a) between group 0-1 year and 1-6 years (b) between group 0-1year and 6-13 years (c) between group 0-1 year and > 13 years (d) between 1-6 years and 6-13 years (e) between 1-6 years and > 13 years (f) between 6-13 years and > 13 years. ns denotes not significant.

Table 2

Plasma amino acid concentration in patients in age cohorts at day 5

Amino acid / 0-1 year (n=37) / 1-6 years (n=14) / 6-18 years (n=10) / Statistical significance
Glutamate / 110 (63-146) / 99 (65-164) / 63 (46-90) / b
Asparagine / 37 (28-52) / 33 (23-38) / 37 (27-46) / ns
Serine / 140 (107-196) / 140 (118-213) / 109 (75-173) / ns
Histidine / 76 (57-92) / 70 (45-87) / 70 (54-106) / ns
Glycine / 253 (215-319) / 280 (210-349) / 217 (163-270) / ns
Threonine / 181 (112-312) / 138 (110-204) / 141 (113-159) / ns
Citrulline / 14 (8-18) / 12 (9-16) / 14 (12-17) / ns
Arginine / 70 (47-99) / 61 (45-83) / 86 (71-104) / ns
Alanine / 259 (196-332) / 240 (147-283) / 261 (202-315) / ns
Taurine / 30 (18-53) / 16 (10-25) / 19 (8-27) / a
Tyrosine / 13 (9-16) / 14 (10-23) / 23 (16-34) / ns
Valine / 163 (137-212) / 196 (137-248) / 237 (181-254) b / ns
Methionine / 23 (16-29) / 24 (21-35) / 36 (29-40) / b
Tryptophane / 31 (24-42) / 33 (19-40) / 31 (27-36) / ns
Phenylalanine / 55 (43-72) / 74 (48-123) / 85 (79-103) / a
Isoleucine / 41 (32-48) / 62 (40-74) / 61 (52-75) / a+b
Ornitine / 53 (39-79) / 48 (37-57) / 43 (39-50) / ns
Leucine / 99 (86-130) / 91 (71-117) / 121 (101-127) / ns
Lysine / 172 (120-247) / 155 (112-182) / 163 (149-229) / ns
BCAA / 297 (260-399) / 344 (266-438) / 434 (327-461) / ns
Total amino acids / 2439 (1926-2950) / 2345 (1970-2896) / 2307 (2128-2581) / ns

Values (in µmol/L) are given as median and interquartile range. BCAA: branched chained amino acids. Online alphabets denote statistical significant difference (< 0.05) using one-way ANOVA followed by Turkey’s post-hoc test; (a) between group 0-1 year and 1-6 years (b) between group 0-1year and 6-18years (c) between 1-6 years and 6-18 years. ns denotes not significant.

Table 3

Plasma amino acid concentration in the reference group in age cohorts

Amino acid / 0-1 year (n=15) Group 1 / 1-6 years (n=15)
Group 2 / 6-13 years (n=15) Group 3 / 13-18 years (n=15) Group 4 / Statistical significance
Glutamate / 68 (48-95) / 57 (50-71) / 47 (40-65) / 58 (51-75) c / c
Asparagine / 42 (38-52) / 40 (32-42) / 37 (33-41) / 44 (39-47) / ns
Serine / 126 (111-151) / 114 (102-125) / 103 (97-134) / 123 (106-137) / ns
Histidine / 147 (129-201) / 188 (148-207) / 202 (156-230) / 221 (186-258) / c
Glycine / 86 (81-96) / 78 (71-82) / 79 (68-84) / 84 (74-89) / ns
Threonine / 83 (68-104) / 88 (71-92) / 93 (86-119) / 125 (109-157) / c e
Arginine / 66 (56-78) / 59 (47-76) / 60 (51-68) / 81 (73-93) / e f
Alanine / 216 (182-274) / 199 (167-235) / 247 (188-301) / 325 (259-360) / c e f
Taurine / 43 (38-47) / 39 (32-47) / 38 (32-42) / 41 (36-47) / ns
Tyrosine / 20 (16-28) / 26 (21-29) / 19 (15-27) / 23 (21-25) / ns
Valine / 148 (141-174) / 170 (148-188) / 175 (169-192) / 204 (180-211) / c e
Methionine / 17 (13-18) / 15 (13-18) / 17 (15-18) / 21 (18-23) / e f
Tryptophane / 32 (26-35) / 26 (22-32) / 25 (20-27) / 32 (26-34) / b
Phenylalanine / 43 (38-48) / 41 (34-43) / 38 (36-43) / 43 (41-45) / ns
Isoleucine / 44 (39-49) / 43 (37-47) / 42 (41-48) / 57 (48-63) / c e f
Ornitine / 36 (25-48) / 27 (25-36) / 29 (24-38) / 41 (28-42) / ns
Leucine / 76 (65-80) / 85 (73-94) / 90 (82-99) / 107 (98-112) / c e f
Lysine / 99 (74-112) / 116 (108-130) / 123 (101-141) / 153 (138-171) / c e f
BCAA / 252 (226-278) / 299 (262-343) / 304 (291-353) / 366 (327-387) / c e f
Total / 2042 (1928-2318) / 2008 (1887-2170) / 1997 (1866-2162) / 2512 (2123-2555) / c e f

Values (in µmol/L) are given as median and interquartile range. BCAA: branched chained amino acids. Online alphabets denote statistical significant difference (< 0.05); (a) between group 1 and 2 (b) between group 1 and 3, (c) between group 1 and 4 (d) between 2 and 3 (e) between 2 and 4 (f) between 3 and 4. ns denotes not significant.