CINRYZE TEST

This test evaluates the infusion nurse’s knowledge of HAE and Cinryze ™ C1 inhibitor.

A score of 80% or better is required for all nurses providing home infusion services.

Five questions on Reconstitution :

1) CINRYZE™ C1 inhibitor:

a) must be kept frozen until reconstituted

b) must be kept in a refrigerator between 36oF and 40oF until reconstituted

c) can be stored between 36oF - 77oF up to the expiration date listed on the vial

d) must be kept in a refrigerator between 36oF and 40oF after reconstitution

2) CINRYZE™ C1 inhibitor must be protected from direct sunlight prior to reconstitution.

True False

3) After reconstitution, CINRYZE™ C1 inhibitor must be given within:

a) 1 hour

b) 3 hours

c) 5 hours

d) a day

4) Aseptic technique should be adhered to at all times when reconstituting CINRYZE™ C1 inhibitor? True False

5) Reconstituted CINRYZE™ C1 inhibitor is safe to administer if it:

a) is clear and colorless

b) is clear and colorless or clear and pale blue

c) is turbid

d) contains particulate matter

Questions on Administration:

1) A standard dose of CINRYZE™ C1 inhibitor is :

a) 1000 units in 10 mL from one vial

b) 500 units in 5 mL from one vial

c) 1000 units in 10 mL from two 500 unit vials

d) 500 units in 10 mL from two vials

2) CINRYZE™ C1 inhibitor is FDA approved for:

a) routine prophylaxis against angioedema attacks in adolescent and adult

patients with Hereditary Angioedema (HAE)

b) treatment of an acute attack of angioedema in adolescent and adult patients

with Hereditary Angioedema (HAE)

c) both

d) neither

3) The infusion rate for administering CINRYZE™ C1 inhibitor is:

a) 5 milliliters per minute for a total time of 2 minutes

b) 1 milliliter per minute for a total time of 5 minutes

c) 10 milliliters per minute for a total time of 1 minute

d) 1 milliliter per minute for a total time of 10 minutes

4) In addition to IV injection, CINRYZE™ C1 inhibitor can also be administered via

indwelling catheter or implanted infusion port.

True False

5) Preparations for administering CINRYZE™ C1 inhibitor require all of the following EXCEPT:

a) availability of epinephrine for acute allergic reactions

b) refrigerator to keep CINRYZE™ cold until it is administered

c) sharps container for disposal of all hazardous material

d) aseptic technique throughout administration

6) Preparations for reconstituting CINRYZE™ C1 inhibitor with the Mix2™ vial system require all of the following EXCEPT:

a) wipe the top of each vial with an alcohol swab and allow to dry

b) remove the protective covering from the Mix2 transfer device and remove the device from the packaging

c) place the vial of CINRYZE™ C1 inhibitor on a flat surface

d) after reconstitution, gently swirl the vial of CINRYZE™ C1 inhibitor until powder is dissolved

I have received instructional information on HAE and on Cinryze administration.

Signature: ______

Name (printed): ______

Agency Name:______

Agency City/State:______

Test Score: ______

PRIOR TO 1ST PATIENT VISIT,

CONTACT RN AT 972-619-8127 FOR TELEPHONIC REVIEW.

*** FAX COMPLETED FORM TO: 1-888-281-8206 ***