Which of the Following Antihistamines Is the Most Sedating

· Which of the following antihistamines is the most sedating?

a) loratadine

b) cetirizine

c) fexofenadine

d) azelastine

e) levocarbastine hydrochloride

f) desloratadine

· Which of the following antihistamines will interact with omeprazole? (Don’t use eMIMs)

a) atorvastatin

b) sotalol

c) pioglitazone

d) ethinyloestradiol

e) paracetamol

· Which of the following antiepileptics is first line for partial seizures?

a) carbamazepine

b) gabapentin

c) sodium valproate

d) vigabantrin

e) topiramate

f) lamotrigine

g) phenytoin

· Which of the following antiepileptics is first line to generalised seizures?

a) carbamazepine

b) sodium valproate

c) gabapentin

d) vigabantrin

e) topiramate

f) lamotrigine

g) phenytoin

In pregnant epileptic women, folic acid should be taken

a) for at least 1month before, and for 3months after, conception

b) from conception until birth

c) for at least 1 month before conception until birth

d) from conception and for 6 months after

e) for at least 3 months before, and for 3 months after conception

In pregnant epileptic women, folic acid should be taken at a dose of

a) 0.5mg bd

b) 0.5mg daily

c) 5mg bd

d) 5mg daily

e) 1mg daily

Mrs Cummins has had moderate to severe diarrhoea for the last two weeks. Which of the following of her medications might be causing this?

a) verapamil

b) thyroxine

c) benztropine

d) amitriptyline

e) simvastatin

Which would be an appropriate antiemetic for a patient with Parkinson’s Disease?

a) prochlorperazine

b) metoclopramide

c) domperidone

d) cimetidine

e) omeprazole

Which is the most appropriate antihypertensive for a pregnant woman?

a) ramipril

b) verapamil

c) irbesartan

d) methyldopa

e) metoprolol

Which NSAID is the least irritant on the GIT? Which is the most irritant?

a) naproxen

b) ibuprofen

c) aspirin

d) diclofenac

e) indomethacin

f) mefenamic acid

g) piroxicam

Which of the following drugs will interact with the morning after pill?

a) amoxycilllin

b) carbamazepine

c) azithromycin

d) metoprolol

e) ethinyloestradiol/levonorgestrel

Which of the following combination products is ‘irrational’?

a) paracetamol/codeine

b) dextromethorphan/pseudoephedrine

c) bromhexine/guaphenison

d) guaphenison/pseudoephedrine

e) dextromethorphan/guaphenison

Which (there may be more than one answer) of the following beta-blockers has:
i) beta-1 selective activity
ii) intrinsic sympathomimetic activity
iii) mixed alpha-1 and beta-blocking activities

a) metoprolol

b) bisoprolol

c) carvedilol

d) atenolol

e) propranolol

f) oxprenolol

g) pindolol

h) labetalol

i) sotalol

Which of the following items & doses is correct?

a) tramadol SR 100mg qid

b) oxycodone 5mg qid

c) pravastatin 20mg mane

d) diltiazem SR 60mg tds

e) risedronate 5mg once weekly

Which of the following nasal sprays interacts (theoretically) the most, with blood pressure medication?

a) levocarbastine

b) phenylephrine

c) azelastine

d) budesonide

e) sodium chloride

Which is first line treatment for constipation while on opioid analgesics?

a) Movicol

b) Stimulant laxatives

c) Increase exercise, fluids and dietary fibre

d) Osmotic laxatives

Which of the following beta-blockers is less lipid soluble and therefore less likely to cause sleep disturbances and nightmares

a) propanolol

b) pindolol

c) atenolol

d) metoprolol

e) bisoprolol

When changing from doxepin 10mg to venlafaxine 37.5mg XR, what is the most appropriate action?

a) Stop doxepin and wait 1 week before starting venlafaxine

b) Gradually reduce doxepin dose and wait 1-2 days before starting venlafaxine at a low dose

c) Stop doxepin and wait 2-4 days before starting venlafaxine

d) Gradually reduce doxepin dose and wait 1 week days before starting venlafaxine at a low dose

e) Gradually reduce doxepin dose and wait 2-4 days before starting venlafaxine at a low dose

f) Stop doxepin and wait 1-2 days before starting venlafaxine

Which of the following would not contribute to serotonin syndrome?

a) St John’s Wort

b) Zomitriptan

c) Diethylpropion

d) Lithium

e) Dextropopoxyphene

Which is not a symptom of serotonin syndrome?

a) confusion

b) shivering

c) constipation

d) incoordination

e) agitation

What would be the best advice to give to a young mother concerned about her 2 year old daughter who has been stung by a wasp and now has a rash, and localised swelling around the sting?

a) Do nothing, as the rash and swelling will go by themselves.

b) Do nothing, as the rash and swelling will go by themselves, and antihistamines should not be used in children under 3 years.

c) Give dexchlorpheniramine to reduce allergic reaction, and warn about drowsiness.

d) Give promethazine to reduce allergic reaction, and warn about drowsiness.

e) Give an antiseptic/anaesthetic/anti-inflammatory/soothing product such as Paraderm Plus for symptomatic relief.

f) a) & e)

g) b) & e)

h) c) & e)

i) d) & e)

j) None of the above

A 3 months-pregnant mother has a runny nose and would like an antihistamine, but she doesn’t like nasal sprays. She cannot be drowsy during the day. Which is the SAFEST and most appropriate option?

a) cetirizine 10mg daily

b) loratadine 10mg daily

c) fexofenadine 120mg daily

d) promethazine 25mg nocte

e) dexchlorpheniramine CR 6mg bd

A breastfeeding mother requests some strong pain killers for her backache. What is the best option?

a) paracetamol 2g q4-6h prn

b) aspirin 300mg q4-6h prn

c) paracetamol 500mg/codeine 8mg 2 q4-6h prn

d) ibuprofen 400mg q4-6h prn

e) ibuprofen 400mg/codeine 10mg 2 tds prn

f) None of the above

What other advice would you give?

a) Take dose just before breastfeeding

b) Don’t take medication; use a hot water bottle/heat pack

c) Don’t breast feed while using medication

d) Take dose just after breastfeeding

e) Use a pump to collect and save milk without medication, then give.

Which of the following can you drink milk with?

a) tetracycline

b) risedronate

c) norfloxacin

d) demeclocycline

e) ferrous sulphate

Which sulphonylurea is the most unsafe in elderly patients with renal failure?

a) gliclazide

b) glibenclamide

c) glimepiride

d) glipizide

Which of the following is a selective COX-2 inhibitor at low doses?

a) diclofenac

b) parecoxib

c) meloxicam

d) sulidac

e) mefenamic acid

Which of the following is not a contraindication for using a non-selective NSAID?

a) asthma

b) pregnancy

c) coagulation disorders

d) concurrent low dose aspirin use

e) severe hepatic impairment

Which of the following is the most appropriate first line therapy for a hypertensive patient with acute gouty pain with inflammation?

a) prednisolone

b) colchicine

c) allopurinol

d) diclofenac

e) paracetamol

How is the most appropriate way to take naratriptan?

a) One dose only, at first sign of migraine beginning

b) One dose only, as soon as possible after onset of headache

c) Any time during headache

d) One dose as soon as possible after onset of headache. Repeat after 4 hours if necessary.

e) Take when required