UCSF Lab Standard Operating Procedure
Chemical Process, Name or Hazard Class:
Trisodium Arsenate Heptahydrate
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Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class
Purpose
Trisodium arsenate heptahydrate is a toxic chemical that may cause cancer. It is toxic if inhaled or ingested. It may also be harmful if absorbed through the skin. It may cause irritation to the respiratory tract, gastrointestinal tract, skin, and eyes. Exposure to this chemical may cause symptoms of arsenic poisoning.
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 64070-83-3
Class: Carcinogen, toxic
Molecular Formula: Na3AsO4 ∙ 7H2O
Form (physical state): Solid
Color: White
Boiling point: N/A
Potential Hazards/Toxicity
Trisodium arsenate heptahydrate is toxic if inhaled or ingested. It may be harmful if absorbed through the skin. It may cause respiratory tract, gastrointestinal tract, skin, and eye irritation. Symptoms of exposure include burning, dry nose, dry mouth, muscle cramps/spasms, nausea, vomiting, diarrhea, shock, coma, and death. It may cause cancer. Inorganic arsenic-containing compounds have a permissible exposure limit (PEL) of 10 μg/m3.
Engineering Controls
Chemical fume hood. Adequate exhaust and capture filtration.
Personal Protective Equipment (PPE)
Respirator Protection
If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)
Hand Protection
Handle with gloves. Nitrile gloves are recommended.
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with trisodium arsenate heptahydrate.
Refer to glove selection chart from the links below:
http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf
OR
http://www.allsafetyproducts.biz/page/74172
OR
http://www.showabestglove.com/site/default.aspx
OR
http://www.mapaglove.com/
Eye Protection
ANSI approved, tight-fitting safety glasses/goggles. Face shields are recommended.
Skin and Body Protection
Appropriately-fitting lab coat, long pants, and closed-toe shoes.
Hygiene Measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
First Aid Procedures
If inhaled
Move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water for at least 15 minutes while removing contaminated clothing. Take victim immediately to hospital.
In case of eye contact
Flush eyes with plenty of water for at least 15 minutes. Consult a physician.
If swallowed
Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Special Handling and Storage Requirements
Precautions for safe handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation and ingestion. Avoid dust formation. Provide adequate exhaust ventilation. Ensure normal measures for preventative fire protection. Open and handle container with care.
Conditions for safe storage: Keep container tightly closed in a cool, dry, and well-ventilated area. Incompatible with strong oxidizing agents.
Spill and Accident Procedure
Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only)
Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only) for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.
Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885-7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays).
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).
Decontamination/Waste Disposal Procedure
Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste.
Safety Data Sheet (SDS) Location
Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html
Protocol/Procedure
Quantities covered by this SOP:
______(g , ml) to ______(g, ml)
Temperature range covered by this SOP:
__ °C – __ °C
General Overview and Purpose:
Enter the experimental purpose
Procedure:
Enter experimental procedure. You can copy procedure from your lab notebook or from literature.
NOTE
Any deviation from this SOP requires approval from the Principal Investigator.
Trisodium Arsenate Heptahydrate 4 Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)