Updated in June, 2012

Curriculum Vita

HANLI LIU (Female), Ph.D.

Biomedical Engineering ProgramOffice:(817) 272-2054

The University of Texas at ArlingtonSecretary:(817) 272-2249

Box 19138FAX:(817) 272-2251

Arlington, Texas 76019-0138e-mail:

1. Education and Post-doctoral Training:

University / Degree / Major / Dates
University of Pennsylvania
Philadelphia, PA / Post-doctoral
Fellow / Biomedical Optics and Instrumentation / June 1994 - Aug. 1996
WakeForestUniversity
Winston-Salem, NC / Ph.D. / Applied Physics / May 1994
WakeForestUniversity
Winston-Salem, NC / M.S. / Applied Physics / May 1990
BeijingNormalUniversity
Beijing, P. R. China / B.S. / Physics / July 1983

2. Professional Experience:

Sept. 2006 – presentProfessor of Bioengineering, Bioengineering Department,

The University of Texas at Arlington, Arlington, TX.

Sept. 2001 – Aug. 2006Associate Professor, Biomedical Engineering Program,

The University of Texas at Arlington, Arlington, TX.

Sept. 2000 – presentAffiliate Member of the Institute for Cancer Research, The

University of North Texas Health Science Center, Fort Worth, TX.

Sept. 1996 – present Adjunct Faculty, Joint Program in Biomedical Engineering,

The Univ. of Texas Southwestern GraduateSchool of Biomedical

Sciences, Dallas, TX.

Sept. 1996 – Aug. 2001Assistant Professor, Biomedical Engineering Program,

The University of Texas at Arlington, Arlington, TX.

June 1997-Aug.1997Summer Research Faculty Fellow, Air Force Research lab., Albuquerque, NM

June 1994-Aug.1996Post-doctoral Fellow, Britton Chance’s Laboratory,

Dept. of Biochem.And Biophys., The Univ. of Pennsylvania, Philadelphia, PA

Research Scientist, NIM Incorporated, Philadelphia, PA.

June 1992-Aug.1996Research Associate, University CityScienceCenter, Institute for Biophysical and Biomedical Research (IBBR), Philadelphia.

Sept.1989-May 1992Research assistant, Physics Dept. Wake Forest University, NC

Sept 1987-Aug. 1989Teaching/Research assistant, Physics Dept. Wake Forest Univ.,NC

3. Honors:

Recipient for the following awards:

Sept. 15, 2011invited for an invited presentation on the 7th NIH Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside.September15-16,2011, NIH, Bethesda, Maryland. The title of the presentation was “Translation of fNIRS for clinical applications: objective assessment for pain perception and neuropsychological tests.”

February 2008College of Engineering Excellence in Research Award (one person per year in the college), University of Texas at Arlington

April 2005-

April 2009Annual Research Excellence Award,University of Texas at Arlington

(cash award).

October 2007being selected to be an Associate Editor for Optics Express, which is a fast growing peer-reviewed, International Optics Journal, with an impact factor of 3.8 in 2006.

May 19 2007distinguished speaker to deliver the hooding address in Wait Chapel during the hooding ceremony held by the Graduate School of Wake Forest University.

Jan.-May, 2006Recipient, Faculty Development Award from UT Arlington for Sabbatical in Functional Neuro-imaging.

Jan. 2005Recipient, the STARS program from the University of Texas System to receive $500,000 for equipment fund.

Jan. 6-7, 2005Invited to attend “The Academy of Medicine, Engineering, and Science of

Texas,”Omni Mandalay Hotel at Las Colinas, Texas.

(two faculty members per university within the UT system were invited.)

2004-present, Listed in MarquisWho's Who in the World, 2005 Edition.

April 2004University Outstanding Research Achievement Award, UTA.

2003-present, approved membership for International WHO’S WHO of Professionals

2003-present, Listed in Marquis Who’s Who of American Women.

2002-present,Listed in Marquis Who's Who in America.

October 1999"Chun-Hui" Travel Fund Award for Outstanding Abroad Chinese Scholars, sponsored by Education Ministry of China.

February 1999College of Engineering Outstanding Young Faculty Award, UT Arlington;

April 1998Outstanding Young Scientist Award, Houston Biomedical

Engineering Symposium, Houston, TX.

May 1990Sigma Xi Research Award, WakeForest Chapter, Winston-Salem, NC.

May 1990Graduate Student Association Award for best M. S. thesis, Wake Forest U.

Nominated for the following awards at the level of the University and the State of Texas:

February 2009Nominee for 2008-2009 University Award for Distinguished Record of Research, from College of Engineering to UT Arlington.

May 2006-2008 Nominee for Edith and Peter O'Donnell Awards in Engineering, from UT Arlington to The Academy of Medicine, Engineering and Science of Texas.

Dec. 2006Nomination for Membership to the Academy of Distinguished Scholars,

from College of Engineering to UT Arlington.

4. Memberships in Professional Societies

SPIE, international optical engineering society (since 1992 to now);

APS, American Physical Society (since 1989 to now);

OSA, Optical Society of America (since 2004 to now);

IEEE-LEOS, IEEE Laser and Electro-Optical Society (2004-2006);

IEEE Women in Engineering (2004-2006).

5. Reviewer for Peer-reviewed Journals and the NIH grants:

Associate Editor: Optics Express (Oct. 2007-Oct. 2010);

Journal of Optical Society of America A: Optics and Image Science;

Applied Optics;Applied Spectroscopy;

Optics Letters;Journal of Biomedical Optics;

Optical Engineering;Shock Waves;

Optics Express;NeuroImage;

Physics in Medicine and Biology;Medical Physics;

Photochemistry and Photobiology;Journal of Neural Engineering;

Review of Scientific Instruments;Biomedical Engineering Online.

Committee member for OSA Technical Program Committees (2000-2004).

NIH ad hoc study-section panel member for the NIH grant proposal reviews.

(1)Special emphasis panel: ZRG1 SBIB-V 50 R; Bioengineering Research Partnerships; June 17, 2009.

(2)Special emphasis panel: ZRG1 SBIB-U 53 R; RFA-OD-09-008 BRDG-SPAN and RFA-OD-09-009 Catalyst ARRA Review panel 15; Nov. 5, 2009.

(3)Special emphasis panel:ZRG1 SBIB-U50;Academic Industrial Partnerships;Bahia Hotel, San Diego Feb. 13, 2010.

(4)Special emphasis panel: ZRG1 SBIB-J (80) S;Development Methods of In Vivo Imaging and Bioengineering Research; Oct. 18-19, 2010.

(5)2011/05 ZRG1 DTCS-A (81) S; Cancer and Musculoskeletal Imaging Applications; Feb. 18, 2011 (mail reviewer)

(6)2011/05 ZRR1 BT-7 (01) 1; Biotechnology 2011; Feb. 23-24, 2011.

(7)2011/10 ZRG1 DTCS-U (81) S; Clinical and Translational Imaging Applications; June 13, 2011 (mail reviewer)

(8)2012/01 ZRG1 OTC-X (90) A: Cancer Therapeutics;Internet Assisted Meeting (IAM), September 27-28, 2011.

(9)2012/01 ZRG1 CB-C (02) M: Cell Biology; Internet Assisted Meeting (IAM), Dec. 8-9, 2011

6. Funded or Completed Research Grants:

Currently funded grants:

1)“Near Infrared Brain Imaging for Building Treatment in Children with Cerebral Palsy”

Co-PI: Hanli Liu (PI: George Alexandrakis)

Agency and type: NIBIB/NIH (R01);

Period: 04/01/2011-03/31/2014.

Total Amount: ~$1,180,000.

2)“Feasibility of Prostate Cancer Diagnosis by Transrectal Photoacoustic Imaging”

PI: Hanli Liu (Concept Award)

Agency and type: Department of Defense Prostate Cancer Research Program;

Period: 02/01/2011-01/31/2012.

Total Amount: $112,000.

3)“Transrectal Imaging of Prostate Cancer Using a Globally Convergent Method”

PI: Hanli Liu, Ph.D

Agency and Type:NCI/NIH (R01)

Period: 07/01/2010-08/31/2013.

Total Amount: $958,666.

4)“A Breakthrough Probe Technology for Translating Near-Infrared Brain Imaging into a Routine Clinical Tool for Assessing Motor Deficits in Children with Cerebral Palsy”

co-PI: Hanli Liu, Ph.D

Agency and Type:UT Arlington/UT Dallas/ Texas Instruments Medical Technology Research Program

Period: 01/15/2010-01/14/2011.

Total Amount: $100,000.

5)“Computational Optical Tomography for Anti-stroke Therapy,”

PI: Hanli Liu in collaboration with UNTHSC from Fort Worth.

Agency and type: NINDS/NIH (R33)

Period: 06/2009-05/2012.

Total Amount: ~1,370,646.

6)Equipment fund for purchasing a “High-density NIRS brain imaging system”

PI:Hanli Liu, Ph.D

Agency and type:College of Engineering, UT Arlington

Period:04/01/2009-08/31/2009

Total Amount:$38,000

7)“Development of a Real-Time, Optically Guided Needle Biopsy System for Improved Prostate Cancer Diagnosis”

PI: Hanli Liu, Ph.D

Agency and Type:Texas Ignition Fund from the University of Texas System

Board of Regents

Period: 10/01/2009-01/30/2011.

Total Amount: $50,000.

8)“Development of a Hybrid Optical Biopsy Probe to ImproveProstate Cancer Diagnosis,”

PI: Hanli Liu (Idea Award); in collaboration with UTSW from Dallas

and UNTHSC from Fort Worth.

Agency and type: Department of Defense Prostate Cancer Research Program;

Period: 04/01/2009-03/31/2012.

Total Amount: $518,327.

9)“Computational Optical Tomography for Anti-stroke Therapy,”

PI: Hanli Liu in collaboration with UNTHSC from Fort Worth.

Agency and type: NINDS/NIH(R21)

Period: 06/2007-05/2009.

Total Amount:$368,944 (with supplement of $99,999).

10)“Assessment of Neuroplasticity in children with CP: A multi-source-detector near infrared spectroscopy imaging study,”

PI:Mauricio Delgado, M.D., UTSW from Dallas and Texas

Scottish Rite Hospital for Children

Co-PI:Hanli Liu, Ph.D.

Agency: United Cerebral Palsy Research & Educational Foundation

Period:01/2008 –12/2009.

Total Amount: $100,000

11)Establishment of a Comprehensive Medical Imaging Center, in joint collaboration with UT Southwestern Medical Center at Dallas and The University of Texas at Dallas.

PI:Khosrow Behbehani;

Co-PI(NIR imaging): Hanli Liu, Ph.D.

Agency and type: Congressional “Ear Mark” funding

Period: 2006 – 2009.

Total Amount: $2,400,000 (UTA portion).

12)Establishment of a Comprehensive Medical Imaging Center, in joint collaboration with UT Southwestern Medical Center at Dallas and The University of Texas at Dallas.

PI:Khosrow Behbehani;

Co-PI (NIR imaging): Hanli Liu, Ph.D.

Agency and type: Congressional “Ear Mark” funding

Period: 2006 – 2009.

Total Amount: $579,000.

Completed grants:

13)“Novel Approach to Measurement of Hot Flashes by Near Infrared Spectroscopy”

PI at UTA: Hanli Liu

Source and type:UTA/UNTHSC research seed funding for collaboration.

Period: 01/06-12/06.

Total Amount: $15,000

14)“Microcirculatory Dysfunction: Potential Therapeutic Target of Estrogen Against Ischemic Stroke”

PI at UTA: Hanli Liu

Source and type: UTA/UNTHSC research seed funding for collaboration.

Period: 01/06-12/06.

Total Amount: $12,500

15)“Inter-disciplinary Laboratory for Diffuse Optical Medical Imaging”

PI:Hanli Liu, Ph.D.

Agency and type: The University of Texas System, STARS program for funding

equipment. (It is faculty recruitment and faculty retention fund.)

Period: 02/01/05 – 02/28/06.

Total Amount: $500,000.

16)“Noninvasive Monitoring for Optimization of Therapeutic Drug Delivery by Biodegradable Fiber to Prostate Tumor”

PI: Dan Popa (New Investigator Award);

Co-PI and mentor: Hanli Liu, Ph.D.

Agency and type: Department of Defense Prostate Cancer Research Program;

Period: 04/04-03/07.

Total Amount: $326,756.

17)“Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors under Hyperbaric Oxygen Exposure”

PI: Mengna Xia (BME Ph.D candidate);

Mentor: Hanli Liu, Ph.D.

Agency and type: Department of Defense Breast Cancer Research Program; Pre-

doctoral Traineeship Awards

Period: 04/04-03/08.

Total Amount: $90,000.

18) “Hemodynamic Imaging for Brain Tumor Prognosis”

PI: Hanli Liu, in collaboration with UTSW at Dallas;

Agency and type: NCI/NIH (R21/R33)

Period: 07/01/03 – 06/30/ 08.

Total proved amount: $1,036,516.

19)“Monitoring of Breast Tumor Response to Local Chemotherapeutic Agent Delivered by Biodegradable Fibers,”

PI: Jae G. Kim (BME Ph.D candidate);

Mentor: Hanli Liu, Ph.D.

Agency and type: Department of Defense Breast Cancer Research Program; Pre-

doctoral Traineeship Awards

Period: 06/03-05/07.

Total Amount: $90,000.

20)“Assessing Vascular Oxygen Dynamics for Breast Tumor Prognosis: comparison between MR BOLD and Near Infra-Red method”

PI: Yueqing Gu (post-doctoral fellow);

Mentor: Hanli Liu

Source and type: Department of Defense Breast Cancer Research Program;

Period: 09/01-08/04.

Total Amount: $150,000.

21)"Non-Invasive Monitoring of Breast Tumor Oxygenation: A Key to Tumor Therapy Planningand Tumor Prognosis"

PI:Hanli Liu, Ph.D.

Agency and type: Department of Defense Breast Cancer Research Program.

Period: 9/1/00 – 8/31/04.

Total Amount: $298,104.

22) "A Near-Infrared Probe for Localization in DBS (Deep Brain Stimulation)"

PI: Cole Giller, M.D., Ph.D (UTSW);

Co-PI: Hanli Liu, Ph.D.

Agency and type: NIH, RO-1

Period: 10/00-8/31/04.

Total Amount: $654,330.

23)“Development of a brain spectrometer for guiding brain surgery and in-vivo monitoring of cerebral oxygenation”

PI: Hanli Liu, Ph.D.

Agency and Type: the Whitaker Foundation.

Period: 9/1/97-2/28/01.

Total Amount: $197,301.

24) “In vivo Recording from GFP-labeled Neurons in Freely-behaving Normal and Mutant Mice”

PI: Rolf Joho, Ph.D. (UTSW);

Co-PI:Hanli Liu, Ph.D.

Agency and Type:Haberecht Wildhare-Idea Research Grant, UTSW.

Period: 10/1/99-10/1/01.

Total Amount: $25,000.

25) “An Automated Neuro-Probe for Localization in Deep Brain Stimulation”

PI: Hanli Liu, Ph.D.

Agency and Type: ARRI Research Enhancement Program Grant, UTA

Period: 9/1/99-8/31/01.

Total Amount: $15,000.

26)“A Continuous-Wave Approach to 3-D Imaging through Turbid Media with a Single Planar Measurement”

PI: Hanli Liu, Ph.D.

Agency and Type: AFOSR, Summer Extension Grant

Period: 6/1/98-5/31/99.

Total Amount: $25,000.

27)UTA Research Enhancement Program, 1/1997-8/1997, $10,000.

28)“Electro-Optical Scanner for Detection of Brain Inhomogeneities,”

PI: Hanli Liu, Ph.D.

Agency and Type: NIH, SBIR Phase I grant;

Period: 7/1/94-12/31/94.

Total Amount: $50,000.

29)“Electro-Optical Scanner for Detection of Brain Inhomogeneities,”

PI: Hanli Liu, Ph.D.

Agency and Type: NIH, SBIR Phase II grant;

Period: 10/1/95-9/30/97.

Total Amount: $500,000.

7. U.s. Patents

1)Inventors:Hanli Liu, Vikrant Sharma, and Claus G. Roehrborn;

Title: “Apparatus and MethodsforGuidance of Prostate Needle Biopsy,”

Patent:U.S. patent pending, filedfromUT Arlington in July, 2011.

2)Inventors:Hanli Liu, Edward Livingston, and Boping Wang;

Title: “Porcine Biliary Tract Imaging,”

Patent:U.S. patent pending, filed from UT Arlington on May 21, 2008.

3)Inventors:Hanli Liu, Disha Peswani, and Jeffrey Cadeddu;

Title:“Optical Methods to Intraoperatively Detect Positive Prostateand Kidney

Cancer Margins,”

Patent:U.S. patent pending, filed from UT Arlington on May 21, 2008.

4)Inventors:Britton Chance and Hanli Liu;

Title:“Examination of scattering properties of biological tissue,”

Patent:U. S. patent number: 6957094; issued on October 18, 2005.

5)Inventors:Cole A. Giller and Hanli Liu;

Title:“Method and apparatus for probe localization in brain matter,”

Patent:U.S. patent number: 6,567,690; issued on May 20, 2003.

6)Inventors:Britton Chance and Hanli Liu;

Title:“Examination of biological tissue by monitoring one or more solutes,” Patent: U.S. patent number: 6,493,565; issued on Dec. 10, 2002.

7)Inventors:Britton Chance and Hanli Liu;

Title:“Monitoring one or more solutes in a biological system using optical techniques,”

Patent:U.S. patent number: 5,782,755; issued on July 21, 1998.

  1. Publications in Peer-Reviewed Journals:

(* means corresponding author for the paper)

  1. Yueming Liu, Jianzhong Su, Zi-Jing Lin, Steven Teng, Natee Pantong, and Hanli Liu, “Reconstructions for Continuous-Wave Diffuse Optical Tomography by a Globally Convergent Method,” submitted toJournal of the Optical Society of America A, (April 2012).
  2. Fenghua Tian, F. Andrew Kozel, Amarnath Yennu, Paul E. Croarkin, Shawn M. McClintock, Kimberly S. Mapes, Mustafa M. Husain, Hanli Liu*,“Test-retest reliability of functional near-infrared spectroscopy measurements associated with repetitive Transcranial Magnetic Stimulation,” submitted to Human Brain Mapping (April 2012).
  3. Vikrant Sharma, Shivaranjani Shivalingaiah, Yan Peng, David Euhus, and Hanli Liu*, “Auto-fluorescence lifetime and light reflectance spectroscopy for breast cancer diagnosis:potential tools for intra-operative margin detection,” in pressBiomed. Opt. Express (2012).
  4. Mary Cazzell*, Lin Li, Sonal J. Patel, Zi-Jing Lin, and Hanli Liu*, “Comparison of neural correlates of risk decision making between genders: An fNIRS study of Balloon Analogue Risk Task (BART),” NeuroImagein press (2012).
  5. Venkaiah C. Kavuri, Zi-Jing Lin, Fenghua Tian, and Hanli Liu*, “Sparsity-enhanced Spatial Resolution and Depth Localization in Diffuse Optical Tomography,” Biomed. Opt. ExpressVol. 3(5), 943-957 (2012).
  6. Bilal Khan, Chester Wildey, Robert Francis, Fenghua Tian, Mauricio Delgado, Hanli Liu, Duncan MacFarlane, and George Alexandrakis, “Improving optical contact for functional infrared brain spectroscopy and imaging with brush optodes,”Biomed. Opt. ExpressVol. 3(5), 878–898, (2012).
  7. Ji-Wei He, Fenghua Tian, Hanli Liu*, and Yuan Bo Peng*, “Cerebrovascular Responses of the Rat Brain to Noxious Stimuli as Examined by Functional Near Infrared Whole Brain Imaging,” J Neurophysiol.Vol.107, 2853–2865(2012).
  8. Ronak H. Patel, Aniket S. Wadajkar, Nimit L. Patel, Venkaiah C. Kavuri, Kytai T. Nguyen, Hanli Liu*, “Multifunctionality of indocyanine green-loadedbiodegradable nanoparticles for enhanced optical imaging and hyperthermia intervention of cancer,” J. Biomed.Opt.17(4), 046003 (2012).
  9. Zi-Jing Lin, Haijing Niu, Lin Li, and Hanli Liu*, “Volumetricdiffuse optical tomography for small animals using a CCD-camera-based imaging system,” International Journal of Optics 2012 (276367) 10 pages, (2012). doi:10.1155/2012/276367
  10. Natee Pantong, Aubrey Rhoden, Shao-Hua Yang, Sandra Boetcher, Hanli Liu, and Jianzhong Su, “A Globally Convergent Numerical Method for Coefficient Inverse Problems for Thermal Tomography,” Applicable Analysis90(10),1573-1594 (2011).
  1. Fenghua Tian, Bilal Khan, Haijing Niu, Khosrow Behbehani, George Alexandrakis, and Hanli Liu*, “Enhanced Functional Brain Imaging by Using Adaptive Filtering and a Depth Compensation Algorithm in Diffuse Optical Tomography,” IEEE Transactions on Medical ImagingVol. 30 (6), 1239-1251 (2011).
  1. Haijing Niu, Sabin Khadka, Fenghua Tian, Zijing Lin, Chunming Lu, Chaozhe Zhu, and Hanli Liu*, “Resting-state functional connectivity assessed with two diffuse optical tomographic systems,” J. of Biomed. Opt. Vol. 16(4), 046006 (2011).
  1. Vikrant Sharma Jiwei He, Sweta Narvenkar, Yuan B Peng, and Hanli Liu*, “Quantification of light reflectance spectroscopy and its application: Determination of hemodynamics on the rat spinal cord and brain induced by electrical stimulation,”NeuroImage, Vol. 56, 1316–1328 (2011).
  1. Dawen Zhao, Cheng-Hui Chang, Jae, G. Kim, Hanli Liu, Ralph P. Mason, “In vivo near-infrared spectroscopy and MRI monitoring of tumor response to Combretastatin A4 phosphate correlated with therapeutic outcome,” The International Journal of Radiation Oncology * Biology * Physics Vol. 80(2), 574–581(2011).
  1. Ji-Wei He, Dheerendra Kashyap, Lara A Trevino, Hanli Liu*, Yuan Bo Peng*, “Simultaneous absolute measures of glabrous skin hemodynamics and light scattering change in responses to formalin injection in rats,” Neuroscience Letters, Vol. 492, 59–63 (2011).
  1. Han Zhang, Lian Duan, Yu-Jin Zhang, Chun-Ming Lu, Hanli Liu, Chao-Zhe Zhu, “Test-retest assessment of independent component analysis-derived resting-state functional connectivity based on functional near-infrared spectroscopy,” NeuroImageVol. 55(2), 607-615 (2011).
  1. Fenghua Tian,Mauricio R. Delgado, Sameer Dhamne, Bilal Khan, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Nancy J. Clegg, and Hanli Liu*, “Quantification of diffuse optical tomography for cortical reorganization in children with cerebral palsy,”Optics Express18(25), 25973-25986 (2010).
  1. Christopher E. Hagains, Lara A. Trevino, Ji-Wei He, Hanli Liu, and Yuan B Peng, “Contributions of Dorsal Root Reflex and Axonal Reflex to Formalin-Induced Inflammation,” Brain Research,1359, 90-97(2010).
  1. Fenghua Tian, Haijing Niu, Sabin Khadka, Zi-Jing Lin, and Hanli Liu*, “Algorithmic depth compensationimproves quantification and noise suppression in functional diffuse opticaltomography,” Biomed. Opt. Express,1, 441-452 (2010).
  1. Haijing Niu, Zi-jing Lin, Fenghua Tian, Sameer C. Dhamne, and Hanli Liu*, “Comprehensive investigation of three-dimensional diffuse optical tomography with depth compensation algorithm,” J. of Biomed. Opt.,15(4), 046005(2010).
  1. Michael V. Klibanov, Jianzhong Su, Natee Pantong, Hua Shan,and Hanli Liu, “A globally convergent numerical method for an inverse elliptic problem of optical tomography,” Applicable Analysis, 89(6), 861–891 (2010).
  1. Bilal Khan, Fenghua Tian, Khosrow Behbehani, Mario Romero-Ortega, Mauricio R.