Microbiology 204
THE T CELL ANTIGEN RECEPTOR (TCR)
Art Weiss ()
October 9, 2017
*Required reading
Historical perspective: Identification of the TCR ab heterodimer
1. Allison, J. P., B. W. McIntyre, and D. Bloch. 1982. Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. J. Immunol. 129:2293.
*2. Meuer, S. C., K. A. Fitzgerald, R. E. Hussey, J. C. Hodgdon, S. F. Schlossman, and E. L. Reinherz. 1983. Clonotypic structures involved in antigen-specific human T cell function: Relationship to the T3 complex. J. Exp. Med. 157:705.
3. Haskins, K., R. Kubo, J. White, M. Migeon, J. Kappler, and P. Marrack. 1983. The major histocompatibility complex-restricted antigen receptor on T cells: I. Isolation with a monoclonal antibody. J. Exp. Med. 157:1149.
The TCR gd heterodimer
4. Brenner, M. B., J. McLean, D. P. Dialynas, J. L. Strominger, J. A. Smith, F. L. Owen, J. G. Seidman, S. Ip, F. Rosen, and M. S. Kragel. 1986. Identification of a putative second T-cell receptor. Nature. 322:145.
5. Asarnow, D. M., W. A. Kuziel, M. Bonyhadi, R. E. Tigelaar, P. W. Tucker, and J. P. Allison. 1988. Limited diversity of gd antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell. 55:837.
6. Bukowski, J.F., C.T. Morita, and M.B. Brenner. 1999. Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity. 11:57.
7. Adams, E.J., Y.H. Chien, and K.C. Garcia. 2005. Structure of a gamma delta T cell receptor in complex with nonclassical MHC T22. Science. 308:227-231.
8. Champagne, Eric. 2011. gd T cell receptor ligands and modes of antigen recognition. Arch. Immunol. Ther. Exp. 59:117-137.
TCR genes
9. Yanagi, Y., Y. Yoshikai, K. Legget, S. P. Clark, I. Aleksander, and T. W. Mak. 1984. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature. 308:145.
*10. Hedrick, S., M., D. I. Cohen, E. A. Nielsen, and M. M. Davis. 1984. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 308:149.
11. Chien, Y., M. Iwashima, K. B. Kaplan, J. F. Elliot, and M. M. Davis. 1987. A new T-cell receptor gene located within the alpha locus and expressed early in T cell differentiation. Nature. 327:677.
Review:
12. Glusman, G., L. Rowen, I. Lee, C. Boysen, J. Roach, A. Smit, K. Wang, B. Koop, and L. Hood. 2001. Comparative genomics of the human and mouse T cell receptor loci. Immunity 15:337.
Structure of the TCR/MHC-peptide complex
13. Garcia, K.C., M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton, and I.A. Wilson. 1996. An ab T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 274:209.
14. Reinherz, E.L., K. Tan, L. Tang, P. Kern, J. Liu, Y. Xiong, et al. 1999. The
crystal structure of a T cell receptor in complex with peptide and MHC Class
II. Science. 286:1913.
15. Reiser, J.-B., C. Gregoire, C. Darnault, T. Mosser, A. Guimezanes, et al.
2002. A T cell receptor CDR3b loop undergoes conformational changes of
unprecedented magnitude upon binding to a peptide/MHC class I complex.
Immunity, 16:345.
16. Reiser, J.B., C. Darnault, C. Gregoire, T., Mosser, G. Mazza, et al., 2003.
CDR3 loop flexibility contributes to the degeneracy of TCR recognition. Nat.
Immunol., 4:241.
17. Colf, L.A., A.J. Bankovich, N.A. Hanick, N.A. Bowerman, L.L. Jones, et al., 2007. How a single T cell receptor recognizes both self and foreign MHC. Cell. 6:135-146.
18. Yin, L., Huseby, E., et al., 2011. A single T cell receptor bound to major histocompatibility complex class 1 and class II glycoproteins reveals switchable TCR conformers. Immunity. 35:23-33.
19. Birnbaum, M.E., Mendoza, J., et al., 2014. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 157:1073-1087.
Review:
*19. Garcia, K.C. Reconciling views on T cell receptor germline bias for MHC. Trends Immunol. 33:429-436.
The TCR a and b genes encode the antigen and superantigen recognition subunit of the TCR
20. Dembic, Z., W. Haas, S. Weiss, J. McCubrey, H. Kiefer, H. von Boehmer, and M. Steinmetz. 1986. Transfer of specificity by murine a and b T-cell receptor genes. Nature. 320:232.
21. Herman, A., J. W. Kappler, P. Marrack, and A. M. Pullen. 1991. Superantigens: Mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745.
22. Li, H., Liera, A., Tsuchiya, D., Leder, L., Yserm, X., Schlievert, P.M., Karjalainen, K., and R.A. Mariuzza. 1998. Three-dimensional structure of the complex between a T cell receptor b chain and the superantigen Staphylococcal Enterotoxin B. Immunity 9:807-816.
23. Posnett, D.N., and A.A. Yarilina. 2001. Sleeping with the enemy-endogenous superantigens in humans. Immunity 15:503.
24. Wu, L.C., D.S. Tout, D.S. Lyons, K.C. Garcia, and M.M. Davis. 2002. Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature 418:552.
The oligomeric TCR
25. Brenner, M. B., I. S. Trowbridge, and J. L. Strominger. 1985. Crosslinking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit. Cell. 40:183.
26. Ohashi, P., T. Mak, P. Van den Elsen, Y. Yanagi, Y. Yasunobu, A. Calman, C. Terhorst, J. Stobo, and A. Weiss. 1985. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature. 316:606.
27. Samelson, L. E., J. B. Harford, and R. D. Klausner. 1985. Identification of the components of the murine T cell antigen receptor complex. Cell. 43:223.
28. Sussman, J. J., J. S. Bonifacino, J. Lippincott-Schwartz, A. M. Weissman, T. Saito, R. D. Klausner, and J. D. Ashwell. 1988. Failure to synthesize the T cell CD3-z chain: Structure and function of a partial T cell receptor complex. Cell. 52:85.
29. Fernandez-Miguel, G., B. Alarcon, A. Iglesias, H. Bluethmann, M. Alvarez-Mon, E. Sanz, and A. de la Hera. 1999. Proc. Natl. Acad. Sci. USA. 96:1547.
30. Call, M.E., J. Pyrdol, M. Wiedmann, and K. Wucherpfennig. 2002. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 111:967.
31. Sun, Z.Y., et al., 2004. Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology. Proc. Natl. Acad. Sci. USA. 101:16867.
Review:
32. Kuhns, M.S., M.M. Davis, and K.C. Garcia. 2006. Deconstructing the form and function of the TCR/CD3 complex. Immunity 24:133-139.
TCR Assembly and internalization:
33. Manolios, N., J. S. Bonifacino, and R. D. Klausner. 1990. Transmembrane helical interactions and the assembly of the T cell receptor complex. Science. 249:274.
34. Tan, L., J. Turner, and A. Weiss. 1991. Regions of the T cell antigen receptor a and b chains that are responsible for interactions with CD3. J. Exp. Med. 173:1247.
35. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
36. D'Oro, U., M.S. Vacchio, A.M. Weissman, and J.D. Ashwell. 1997. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 7:619.
37. Liu, H., Rhodes, M., Wiest, D.L., and D.A. Vignali. 2000. On the dynamics of the TCR:CD3 complex cell surface expression and downmodulation. Immunity. 13:665.
Functional motifs in the CD3 and z chain cytoplasmic domains
38. Reth, M. 1989. Antigen receptor tail clue. Nature. 338:383.
39. Irving, B., and A. Weiss. 1991. The cytoplasmic domain of the T cell receptor z chain is sufficient to couple to receptor-associated signal transduction pathways. Cell. 64:891.
40. Romeo, C., M. Amiot, and B. Seed. 1992. Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor z chain. Cell. 68:889.
41. Wegener, A.-M. K., F. Letourneur, A. Hoeveler, T. Brocker, F. Luton, and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell. 68:83.
42. Irving, B. A., A. C. Chan, and A. Weiss. 1993. Functional characterization of a signal transducing motif present in the T cell receptor z chain. J. Exp. Med. 177:1093.
43. Shores, E.W., T. Tran, A. Grinberg, C.L. Sommers, H. Shen, and P.E. Love. 1997. Role of the multiple T cell receptor (TCR)-z chain signaling motifs in selection of the T cell repertoire. J. Exp. Med. 185:893.
44. Aivazian, D., and LJ. Stern. 2000. Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition. Nat. Struct. Biol. 7:1023.
45. Xu, C., et al., 2008. Regulation of T cell receptor activation by dynamic membrane binding of the CD3 epsilon cytoplasmic tyrosine-based activation motif. Cell. 135:702.
Immature TCR on thymocytes
46. Kishi, H., P. Borgulya, B. Scott, K. Karjalainen, A. Traunecker, J. Kaufman, and H. von Boehmer. 1991. Surface expression of the b T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. EMBO J. 10:93.
47. Shinkai, Y., S. Koyasu, K.-I. Nakayama, K. M. Murphy, D. Y. Loh, E. L. Reinherz, and F. W. Alt. 1993. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science. 259:822.
48. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, J. Fehling, and H. von Boehmer. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science. 266:1208.
49. Fehling, H. J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor a gene in development of ab but not gd T cells. Nature. 375:795.
50. Irving, B.A., F.W. Alt, and N. Killeen. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular immunogloublin domains. Science. 280:905.
51. Saint-Ruf, C., M. Panigada, O. Azogui, P. Debey, and H. von Boehmer. 2000. Different initiation of pre-TCR and gammadelta TCR signalling. Nature. 406:524.
52. Yamasaki, S., Ishikawa, E., et al., 2006. Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat. Immunol. 7:67-75.
53. Pang, S.S., Berry, R., et al. 2010. The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature. 467:844-848.
Review:
54. von Boehmer, H. 2005. Unique features of the pre-TCR alpha-chain: not just a surrogate. Nature Rev. Immunol. 5:571-577.