Supplementary information
Table S1. Gene Set Enrichment Analysis (GSEA)
Gene sets that are downregulated by ResveratrolNAME / SIZE / NES / FDR q-val
REACT_CELL-CELL JUNCTION ORGANIZATION / 35 / -1.9640374 / 0.17952277
WIP_HS_WNT_SIGNALING_PATHWAY / 46 / -1.9137414 / 0.15375544
WIP_HS_HEART_DEVELOPMENT / 31 / -1.9015069 / 0.11680896
NCI_WNT_SIGNALING_PATHWAY / 19 / -1.8745513 / 0.11515321
KEGG_BASAL CELL CARCINOMA / 36 / -1.8339162 / 0.14223292
REACT_GPCR LIGAND BINDING / 187 / -1.8319567 / 0.12096504
REACT_TIGHT JUNCTION INTERACTIONS / 16 / -1.8192871 / 0.11865
WIP_HS_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY / 76 / -1.8176177 / 0.10573168
WIP_HS_ANGIOGENESIS / 23 / -1.7718213 / 0.14905296
REACT_CLASS B_2 (SECRETIN FAMILY RECEPTORS) / 45 / -1.7691889 / 0.13756803
REACT_G ALPHA (S) SIGNALLING EVENTS / 61 / -1.7299539 / 0.17609797
REACT_ADHERENS JUNCTIONS INTERACTIONS / 19 / -1.7108619 / 0.19213966
KEGG_NEUROACTIVE LIGAND-RECEPTOR INTERACTION / 102 / -1.708441 / 0.18119627
REACT_INHIBITION OF INSULIN SECRETION BY ADRENALINE_NORADRENALINE / 19 / -1.7030852 / 0.17522751
REACT_CLASS A_1 (RHODOPSIN-LIKE RECEPTORS) / 141 / -1.690259 / 0.18402019
WIP_HS_GPCRS,_CLASS_A_RHODOPSIN-LIKE / 95 / -1.6858467 / 0.17901707
REACT_SIGNALING BY NOTCH / 16 / -1.6532178 / 0.22045341
KEGG_NOTCH SIGNALING PATHWAY / 44 / -1.6393498 / 0.23263638
WIP_HS_NOTCH_SIGNALING_PATHWAY / 43 / -1.6303889 / 0.23632021
REACT_SIGNALING BY GPCR / 306 / -1.6227005 / 0.23823243
Gene sets that are upregulated by Resveratrol
NAME / SIZE / NES / FDR q-val
KEGG_LYSOSOME / 111 / 2.6043155 / 0
REACT_INTERFERON SIGNALING / 84 / 2.538758 / 0
REACT_INTERFERON GAMMA SIGNALING / 61 / 2.505062 / 0
REACT_CYTOKINE SIGNALING IN IMMUNE SYSTEM / 173 / 2.296378 / 6.55E-04
REACT_INTERFERON ALPHA_BETA SIGNALING / 48 / 2.2798703 / 5.24E-04
KEGG_ANTIGEN PROCESSING AND PRESENTATION / 57 / 2.2517383 / 6.53E-04
KEGG_TUBERCULOSIS / 139 / 2.2092426 / 0.0012973
KEGG_ASTHMA / 19 / 2.1419492 / 0.002947545
KEGG_PHAGOSOME / 117 / 2.1342378 / 0.002917085
KEGG_PATHOGENIC ESCHERICHIA COLI INFECTION / 43 / 2.1341765 / 0.002625376
REACT_HOST INTERACTIONS OF HIV FACTORS / 119 / 2.1311452 / 0.002386706
KEGG_ALLOGRAFT REJECTION / 24 / 2.127537 / 0.002187813
WIP_HS_TYPE_II_INTERFERON_SIGNALING_(IFNG) / 30 / 2.126038 / 0.00201952
KEGG_RHEUMATOID ARTHRITIS / 65 / 2.1176395 / 0.002065492
KEGG_INFLUENZA A / 140 / 2.090036 / 0.002978457
NCI_CD8TCRPATHWAY / 49 / 2.087412 / 0.003036931
REACT_PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS / 21 / 2.0669324 / 0.00411083
REACT_TCR SIGNALING / 62 / 2.043284 / 0.005615118
KEGG_AUTOIMMUNE THYROID DISEASE / 24 / 2.0378587 / 0.005458439
KEGG_OTHER GLYCAN DEGRADATION / 15 / 2.0300682 / 0.00577902
KEGG_STAPHYLOCOCCUS AUREUS INFECTION / 40 / 2.0256584 / 0.006067368
NCI_NFKAPPABCANONICALPATHWAY / 23 / 2.0203152 / 0.006319995
REACT_GENERATION OF SECOND MESSENGER MOLECULES / 32 / 2.0059657 / 0.007239747
REACT_TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE / 19 / 2.0036323 / 0.00704605
REACT_DNA REPLICATION / 160 / 2.0008824 / 0.006973303
REACT_TRAF3-DEPENDENT IRF ACTIVATION PATHWAY / 17 / 1.9974629 / 0.007157057
BIOC_LAIRPATHWAY / 15 / 1.9921861 / 0.007324918
KEGG_LEISHMANIASIS / 59 / 1.981076 / 0.008408328
REACT_GLUCOSE TRANSPORT / 34 / 1.9761 / 0.008390759
REACT_HEXOSE TRANSPORT / 35 / 1.9667088 / 0.008982546
REACT_MITOTIC M-M_G1 PHASES / 143 / 1.9628533 / 0.009029827
NCI_TCR_PATHWAY / 61 / 1.9575642 / 0.009434157
REACT_DOWNSTREAM TCR SIGNALING / 45 / 1.9475203 / 0.010690538
KEGG_INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION / 32 / 1.94027 / 0.011264096
WIP_HS_DNA_REPLICATION / 32 / 1.9335433 / 0.012070825
REACT_VPR-MEDIATED NUCLEAR IMPORT OF PICS / 31 / 1.9326997 / 0.011917895
BIOC_TNFR2PATHWAY / 17 / 1.9304936 / 0.011947127
REACT_PD-1 SIGNALING / 23 / 1.9249855 / 0.012322708
REACT_RIG-I_MDA5 MEDIATED INDUCTION OF IFN-ALPHA_BETA PATHWAYS / 54 / 1.9207956 / 0.012679279
REACT_TRAF6 MEDIATED IRF7 ACTIVATION / 19 / 1.9194654 / 0.012523461
KEGG_B CELL RECEPTOR SIGNALING PATHWAY / 70 / 1.9177427 / 0.012565865
KEGG_MEASLES / 106 / 1.916795 / 0.012297738
KEGG_TYPE I DIABETES MELLITUS / 27 / 1.9119349 / 0.012742362
REACT_REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN / 27 / 1.9110701 / 0.012718243
WIP_HS_B_CELL_RECEPTOR_SIGNALING_PATHWAY / 89 / 1.9051831 / 0.013397985
REACT_INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS / 32 / 1.902015 / 0.013476005
NCI_TNFPATHWAY / 44 / 1.8867021 / 0.015896989
REACT_NUCLEAR IMPORT OF REV PROTEIN / 31 / 1.8718119 / 0.018104104
NCI_BCR_5PATHWAY / 65 / 1.868899 / 0.018269511
WIP_HS_INTERFERON_ALPHA-BETA_SIGNALING / 23 / 1.8472084 / 0.022408692
REACT_REV-MEDIATED NUCLEAR EXPORT OF HIV-1 RNA / 30 / 1.8430605 / 0.023226326
REACT_NEGATIVE REGULATORS OF RIG-I_MDA5 SIGNALING / 33 / 1.8428537 / 0.022856057
REACT_NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS / 50 / 1.8417208 / 0.022722265
REACT_STABILIZATION OF P53 / 49 / 1.8386844 / 0.023217827
REACT_THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS / 25 / 1.8373069 / 0.023079477
REACT_SYNTHESIS OF DNA / 82 / 1.8332423 / 0.023560353
REACT_TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS / 20 / 1.823923 / 0.025790228
NCI_IL8CXCR2_PATHWAY / 32 / 1.8227553 / 0.025731398
KEGG_HERPES SIMPLEX INFECTION / 150 / 1.821615 / 0.02560859
REACT_COSTIMULATION BY THE CD28 FAMILY / 61 / 1.8215075 / 0.025225991
WIP_HS_LEUKOCYTE_TARBASE / 120 / 1.8200104 / 0.02520485
REACT_SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE / 62 / 1.8159913 / 0.025683416
REACT_DNA REPLICATION PRE-INITIATION / 65 / 1.8148302 / 0.025650032
KEGG_HEMATOPOIETIC CELL LINEAGE / 63 / 1.8116652 / 0.026234884
REACT_NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS / 18 / 1.8070898 / 0.02718328
REACT_M_G1 TRANSITION / 65 / 1.8047261 / 0.027458198
REACT_P53-DEPENDENT G1_S DNA DAMAGE CHECKPOINT / 52 / 1.8016477 / 0.027930336
REACT_RECYCLING PATHWAY OF L1 / 33 / 1.7973989 / 0.028898897
REACT_DNA STRAND ELONGATION / 25 / 1.7964914 / 0.02882212
NCI_ATM_PATHWAY / 30 / 1.7947553 / 0.02891435
REACT_AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 / 48 / 1.7863015 / 0.03099602
REACT_MITOTIC PROMETAPHASE / 76 / 1.7849765 / 0.031021843
REACT_INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS / 34 / 1.7823187 / 0.031257793
REACT_ORC1 REMOVAL FROM CHROMATIN / 62 / 1.7788951 / 0.031879775
REACT_REGULATION OF DNA REPLICATION / 62 / 1.7788093 / 0.031472452
REACT_P53-DEPENDENT G1 DNA DAMAGE RESPONSE / 52 / 1.7780813 / 0.031297892
REACT_ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX / 56 / 1.7779014 / 0.030976582
REACT_REMOVAL OF LICENSING FACTORS FROM ORIGINS / 62 / 1.7756778 / 0.031100558
REACT_TRAF6 MEDIATED NF-KB ACTIVATION / 20 / 1.7735611 / 0.031338453
REACT_G1_S DNA DAMAGE CHECKPOINTS / 52 / 1.7677225 / 0.03252063
REACT_M PHASE / 78 / 1.7666134 / 0.03241034
REACT_NF-KB ACTIVATION THROUGH FADD_RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10 / 16 / 1.7577205 / 0.03502061
REACT_ADAPTIVE IMMUNITY SIGNALING / 356 / 1.7492288 / 0.0375443
REACT_CDT1 ASSOCIATION WITH THE CDC6_ORC_ORIGIN COMPLEX / 50 / 1.7489963 / 0.037143838
NCI_BARD1PATHWAY / 26 / 1.7423055 / 0.03894956
BIOC_NKTPATHWAY / 16 / 1.7409289 / 0.039212983
NCI_IL8CXCR1_PATHWAY / 26 / 1.7358813 / 0.04118928
REACT_HIV INFECTION / 178 / 1.7335688 / 0.041387063
REACT_VIF-MEDIATED DEGRADATION OF APOBEC3G / 50 / 1.7328914 / 0.041124776
REACT_EXTENSION OF TELOMERES / 21 / 1.7325041 / 0.040770873
KEGG_GRAFT-VERSUS-HOST DISEASE / 27 / 1.7292174 / 0.04151453
REACT_LAGGING STRAND SYNTHESIS / 18 / 1.7291526 / 0.041120406
REACT_TRANSPORT OF INORGANIC CATIONS_ANIONS AND AMINO ACIDS_OLIGOPEPTIDES / 49 / 1.7225808 / 0.043271977
NCI_RETINOIC_ACID_PATHWAY / 23 / 1.7133322 / 0.046381693
WIP_HS_TNF-ALPHA-NF-KB_SIGNALING_PATHWAY / 179 / 1.7126069 / 0.046153452
KEGG_CARBOHYDRATE DIGESTION AND ABSORPTION / 25 / 1.7080177 / 0.047597196
REACT_P53-INDEPENDENT DNA DAMAGE RESPONSE / 46 / 1.7079753 / 0.047120124
REACT_METABOLISM OF CARBOHYDRATES / 105 / 1.7043953 / 0.04838015
WIP_HS_TRANSPORT_OF_INORGANIC_CATIONS-ANIONS_AND_AMINO_ACIDS-OLIGOPEPTIDES / 17 / 1.7024477 / 0.048752364
KEGG_DNA REPLICATION / 33 / 1.691434 / 0.053566117
BIOC_BCRPATHWAY / 33 / 1.6906419 / 0.05346245
REACT_INFLAMMASOMES / 17 / 1.6888992 / 0.05389844
BIOC_RELAPATHWAY / 16 / 1.6877275 / 0.053921115
REACT_ACTIVATION OF THE PRE-REPLICATIVE COMPLEX / 20 / 1.6784488 / 0.0580823
KEGG_MALARIA / 40 / 1.6782347 / 0.0576163
WIP_HS_DOUBLE-STRAND_BREAK_REPAIR / 15 / 1.6761471 / 0.058247093
KEGG_TOLL-LIKE RECEPTOR SIGNALING PATHWAY / 82 / 1.672359 / 0.059767272
KEGG_TASTE TRANSDUCTION / 22 / 1.6723222 / 0.059225842
REACT_VPU MEDIATED DEGRADATION OF CD4 / 48 / 1.6709341 / 0.059262656
WIP_HS_NOD_PATHWAY / 33 / 1.6676942 / 0.06023468
KEGG_OSTEOCLAST DIFFERENTIATION / 116 / 1.6657169 / 0.06063579
REACT_P53-INDEPENDENT G1_S DNA DAMAGE CHECKPOINT / 46 / 1.6645943 / 0.060722873
REACT_UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A / 46 / 1.6635766 / 0.06068471
REACT_REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION / 46 / 1.6633929 / 0.06029991
REACT_TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES / 241 / 1.6590492 / 0.061905
REACT_DOUBLE-STRAND BREAK REPAIR / 19 / 1.6551774 / 0.06340036
REACT_IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL / 49 / 1.6533375 / 0.06375283
REACT_CELL CYCLE CHECKPOINTS / 94 / 1.6530026 / 0.06341168
KEGG_PRIMARY IMMUNODEFICIENCY / 28 / 1.6489509 / 0.064952575
KEGG_VIBRIO CHOLERAE INFECTION / 44 / 1.6475021 / 0.06530507
REACT_TRANSFERRIN ENDOCYTOSIS AND RECYCLING / 21 / 1.6442571 / 0.06646148
REACT_GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER / 16 / 1.6442459 / 0.06591671
REACT_IRON UPTAKE AND TRANSPORT / 30 / 1.6421721 / 0.06640181
REACT_ANTIGEN PRESENTATION_ FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC / 24 / 1.6393982 / 0.067391984
REACT_G1_S TRANSITION / 82 / 1.6389571 / 0.0670512
REACT_REGULATION OF ORNITHINE DECARBOXYLASE (ODC) / 46 / 1.6386526 / 0.0667488
REACT_S PHASE / 93 / 1.6370424 / 0.06708789
REACT_DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX / 61 / 1.6363872 / 0.06683805
KEGG_CYTOSOLIC DNA-SENSING PATHWAY / 44 / 1.6331836 / 0.06791697
KEGG_NATURAL KILLER CELL MEDIATED CYTOTOXICITY / 94 / 1.6315569 / 0.06844981
REACT_POST-ELONGATION PROCESSING OF INTRONLESS PRE-MRNA / 20 / 1.6312294 / 0.06811608
REACT_GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER / 16 / 1.6259568 / 0.07036466
WIP_HS_TOLL-LIKE_RECEPTOR_SIGNALING_PATHWAY / 82 / 1.6237237 / 0.07088575
REACT_SLC-MEDIATED TRANSMEMBRANE TRANSPORT / 149 / 1.6223332 / 0.07102236
BIOC_TOLLPATHWAY / 32 / 1.6166257 / 0.07393738
BIOC_MEF2DPATHWAY / 16 / 1.6150295 / 0.07445259
REACT_SIGNALING BY WNT / 61 / 1.613268 / 0.07487566
REACT_DESTABILIZATION OF MRNA BY AUF1 (HNRNP D0) / 52 / 1.6124816 / 0.07475818
NCI_CASPASE_PATHWAY / 47 / 1.6123376 / 0.07427649
WIP_HS_CELL_CYCLE / 61 / 1.6117102 / 0.07407592
BIOC_FCER1PATHWAY / 36 / 1.6085298 / 0.075480424
REACT_ION TRANSPORT BY P-TYPE ATPASES / 23 / 1.6080056 / 0.075288884
REACT_SIGNALING BY INTERLEUKINS / 96 / 1.6032853 / 0.07733004
BIOC_STRESSPATHWAY / 24 / 1.6018745 / 0.07778377
KEGG_PROTEASOME / 40 / 1.5998025 / 0.078576736
REACT_REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS / 83 / 1.5984584 / 0.07895616
REACT_CELL CYCLE, MITOTIC / 249 / 1.5984293 / 0.07843707
KEGG_GALACTOSE METABOLISM / 21 / 1.5980651 / 0.07817295
WIP_HS_REGULATION_OF_TOLL-LIKE_RECEPTOR_SIGNALING_PATHWAY / 117 / 1.5968107 / 0.07846697
REACT_FANCONI ANEMIA PATHWAY / 17 / 1.5945443 / 0.07937683
NCI_RAC1_PATHWAY / 48 / 1.5943848 / 0.07892123
REACT_PROCESSING OF CAPPED INTRONLESS PRE-MRNA / 20 / 1.5938104 / 0.0786665
KEGG_T CELL RECEPTOR SIGNALING PATHWAY / 91 / 1.5935053 / 0.078323826
REACT_CELL SURFACE INTERACTIONS AT THE VASCULAR WALL / 79 / 1.5931705 / 0.07806842
KEGG_NOD-LIKE RECEPTOR SIGNALING PATHWAY / 55 / 1.5918957 / 0.078309916
REACT_NOD1_2 SIGNALING PATHWAY / 34 / 1.5835167 / 0.0831918
REACT_E2F MEDIATED REGULATION OF DNA REPLICATION / 15 / 1.582829 / 0.08313004
NCI_ATR_PATHWAY / 31 / 1.5825671 / 0.082844846
WIP_HS_TCR_SIGNALING / 22 / 1.5815668 / 0.08300424
KEGG_GLYCOSAMINOGLYCAN DEGRADATION / 16 / 1.5788784 / 0.08415287
BIOC_AMIPATHWAY / 18 / 1.5783808 / 0.083930284
WIP_HS_T_CELL_RECEPTOR_SIGNALING_PATHWAY / 131 / 1.5770655 / 0.08414915
BIOC_CSKPATHWAY / 18 / 1.5761136 / 0.084131144
NCI_P53REGULATIONPATHWAY / 54 / 1.5757596 / 0.08385922
REACT_ION CHANNEL TRANSPORT / 27 / 1.5748017 / 0.083962746
REACT_GPVI-MEDIATED ACTIVATION CASCADE / 31 / 1.5616349 / 0.091911525
REACT_INSULIN RECEPTOR RECYCLING / 18 / 1.5576 / 0.09420201
BIOC_NFKBPATHWAY / 21 / 1.5571678 / 0.09395175
REACT_CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 / 46 / 1.557011 / 0.09345854
NCI_INTEGRIN2_PATHWAY / 20 / 1.5510597 / 0.097121455
BIOC_HIVNEFPATHWAY / 52 / 1.5451955 / 0.10107193
NCI_IL23PATHWAY / 23 / 1.5442811 / 0.101102315
NCI_SYNDECAN_2_PATHWAY / 30 / 1.5401872 / 0.10366023
KEGG_TOXOPLASMOSIS / 110 / 1.5341787 / 0.10761264
KEGG_RIG-I-LIKE RECEPTOR SIGNALING PATHWAY / 51 / 1.533572 / 0.10746344
WIP_HS_L1CAM_INTERACTIONS / 15 / 1.527342 / 0.11151573
REACT_TRAFFICKING OF AMPA RECEPTORS / 19 / 1.5240461 / 0.11371133
REACT_NRIF SIGNALS CELL DEATH FROM THE NUCLEUS / 16 / 1.5239968 / 0.113094315
WIP_HS_RIG-I-MDA5_MEDIATED_INDUCTION_OF_IFN-ALPHA-BETA_PATHWAYS / 20 / 1.5214586 / 0.11416024
KEGG_PERTUSSIS / 57 / 1.516292 / 0.11746058
REACT_GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY / 19 / 1.5154822 / 0.11748095
REACT_P75 NTR RECEPTOR-MEDIATED SIGNALLING / 76 / 1.5138164 / 0.11828225
REACT_BASE EXCISION REPAIR / 19 / 1.5112092 / 0.11991974
REACT_SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1 / 51 / 1.5085487 / 0.1216214
REACT_AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS / 24 / 1.5079517 / 0.12148109
REACT_DNA REPAIR / 97 / 1.507526 / 0.12119475
REACT_UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D1 / 47 / 1.5039684 / 0.1237145
KEGG_EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION / 60 / 1.5011474 / 0.12564209
KEGG_VIRAL MYOCARDITIS / 54 / 1.5007449 / 0.12534463
BIOC_IL1RPATHWAY / 28 / 1.4965571 / 0.12855749
REACT_G2_M CHECKPOINTS / 27 / 1.4936144 / 0.13066834
NCI_AMB2_NEUTROPHILS_PATHWAY / 34 / 1.4935907 / 0.13003527
NCI_IL12_2PATHWAY / 49 / 1.4931461 / 0.12981477
WIP_HS_MRNA_PROCESSING / 118 / 1.4928987 / 0.12941557
REACT_RESOLUTION OF ABASIC SITES (AP SITES) / 19 / 1.4903538 / 0.1308568
KEGG_AMOEBIASIS / 74 / 1.4888918 / 0.13160814
REACT_UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D / 47 / 1.4888499 / 0.13098638
REACT_RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY / 17 / 1.4819229 / 0.1365708
REACT_REGULATION OF APOPTOSIS / 55 / 1.4808252 / 0.1368437
BIOC_TCRPATHWAY / 41 / 1.4788876 / 0.13808876
BIOC_CALCINEURINPATHWAY / 17 / 1.4775355 / 0.13853645
WIP_HS_PROTEASOME_DEGRADATION / 60 / 1.4745572 / 0.14048529
REACT_CYCLIN A_CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY / 59 / 1.4691283 / 0.14488937
BIOC_RHOPATHWAY / 27 / 1.4685366 / 0.14469941
KEGG_SHIGELLOSIS / 59 / 1.4664499 / 0.14605886
REACT_REMOVAL OF DNA PATCH CONTAINING ABASIC RESIDUE / 17 / 1.4643093 / 0.14768109
NCI_P75NTRPATHWAY / 58 / 1.4632975 / 0.14795235
BIOC_TIDPATHWAY / 16 / 1.4586738 / 0.15175691
NCI_FASPATHWAY / 36 / 1.456148 / 0.15360226
BIOC_ATRBRCAPATHWAY / 16 / 1.454951 / 0.15426725
KEGG_COLLECTING DUCT ACID SECRETION / 18 / 1.4477165 / 0.16088901
NCI_SMAD2_3PATHWAY / 19 / 1.4443939 / 0.16370887
REACT_BASIGIN INTERACTIONS / 19 / 1.4423847 / 0.1652064
REACT_POST-TRANSLATIONAL MODIFICATION_ SYNTHESIS OF GPI-ANCHORED PROTEINS / 23 / 1.4399045 / 0.1674835
KEGG_GASTRIC ACID SECRETION / 46 / 1.4360967 / 0.17099828
NCI_AURORA_B_PATHWAY / 28 / 1.4356253 / 0.17072126
NCI_PLK1_PATHWAY / 29 / 1.4355354 / 0.16998969
REACT_SCF(SKP2)-MEDIATED DEGRADATION OF P27_P21 / 52 / 1.4352839 / 0.16941333
NCI_AR_TF_PATHWAY / 44 / 1.4340653 / 0.16987754
WIP_HS_GENERIC_TRANSCRIPTION_PATHWAY / 15 / 1.4277642 / 0.17614016
REACT_CYCLIN E ASSOCIATED EVENTS DURING G1_S TRANSITION / 57 / 1.4267988 / 0.17643689
KEGG_STARCH AND SUCROSE METABOLISM / 26 / 1.4258044 / 0.1768926
REACT_TRANS-GOLGI NETWORK VESICLE BUDDING / 55 / 1.4164876 / 0.18624902
REACT_METABOLISM OF AMINO ACIDS AND DERIVATIVES / 138 / 1.415408 / 0.18663421
NCI_PI3KCIPATHWAY / 46 / 1.4143054 / 0.18714896
REACT_INTERLEUKIN-1 SIGNALING / 41 / 1.4142264 / 0.18642461
WIP_HS_SQUAMOUS_CELL_TARBASE / 116 / 1.411597 / 0.18864533
KEGG_SPLICEOSOME / 118 / 1.4106534 / 0.18899642
REACT_CLATHRIN DERIVED VESICLE BUDDING / 55 / 1.4070948 / 0.19236675
REACT_MRNA PROCESSING / 117 / 1.4031631 / 0.19629236
REACT_MITOTIC G1-G1_S PHASES / 91 / 1.402922 / 0.19585373
KEGG_HEPATITIS C / 103 / 1.4006637 / 0.1977536
REACT_MRNA SPLICING - MAJOR PATHWAY / 99 / 1.3993171 / 0.19874501
WIP_HS_FAS_PATHWAY_AND_STRESS_INDUCTION_OF_HSP_REGULATION / 36 / 1.3916389 / 0.20769727
KEGG_AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM / 45 / 1.3898996 / 0.20899421
KEGG_NITROGEN METABOLISM / 15 / 1.3896099 / 0.20850843
REACT_PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA / 102 / 1.3856131 / 0.21282496
REACT_APOPTOSIS / 128 / 1.3850399 / 0.21277747
REACT_CDC20_PHOSPHO-APC_C MEDIATED DEGRADATION OF CYCLIN A / 62 / 1.3840266 / 0.21325243
REACT_MRNA SPLICING / 99 / 1.3838096 / 0.2125437
REACT_APC_C_CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS / 61 / 1.3833396 / 0.21222866
WIP_HS_APOPTOSIS_MODULATION_BY_HSP70 / 18 / 1.378157 / 0.2177303
REACT_REPAIR SYNTHESIS OF PATCH ~27-30 BASES LONG BY DNA POLYMERASE / 15 / 1.3759396 / 0.21997452
BIOC_CHEMICALPATHWAY / 20 / 1.3746394 / 0.22087179
REACT_LYSOSOME VESICLE BIOGENESIS / 20 / 1.3733456 / 0.22173093
NCI_FCER1PATHWAY / 57 / 1.3728861 / 0.22136086
REACT_AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE / 17 / 1.3718245 / 0.22183833
REACT_INSULIN SYNTHESIS AND PROCESSING / 101 / 1.3672642 / 0.22696532
REACT_CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION / 212 / 1.3666533 / 0.22697519
REACT_ACTIVATION OF APC_C AND APC_C_CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS / 62 / 1.3627851 / 0.231164
BIOC_FASPATHWAY / 27 / 1.3621032 / 0.23117651
KEGG_SPHINGOLIPID METABOLISM / 32 / 1.3613502 / 0.23133077
NCI_RAC1_REG_PATHWAY / 34 / 1.3600972 / 0.23211163
KEGG_PRION DISEASES / 29 / 1.356441 / 0.23629197
KEGG_CELL ADHESION MOLECULES (CAMS) / 94 / 1.3556136 / 0.23656587
WIP_HS_MUSCLE_CELL_TARBASE / 313 / 1.3529481 / 0.2391989
REACT_POST-ELONGATION PROCESSING OF THE TRANSCRIPT / 38 / 1.3524102 / 0.23906963
REACT_RNA POLYMERASE II TRANSCRIPTION TERMINATION / 38 / 1.3520823 / 0.23865545
BIOC_FMLPPATHWAY / 32 / 1.3518232 / 0.23815072
KEGG_MISMATCH REPAIR / 21 / 1.3489119 / 0.241284
WIP_HS_EBV_LMP1_SIGNALING / 20 / 1.3476769 / 0.24228896
KEGG_APOPTOSIS / 78 / 1.3464121 / 0.24325217
NCI_AVB3_OPN_PATHWAY / 31 / 1.345722 / 0.2433165
REACT_REPAIR SYNTHESIS FOR GAP-FILLING BY DNA POLYMERASE IN TC-NER / 15 / 1.344266 / 0.24445169
REACT_REGULATION OF APC_C ACTIVATORS BETWEEN G1_S AND EARLY ANAPHASE / 69 / 1.3440245 / 0.24387354
REACT_ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS / 25 / 1.3439105 / 0.24311845
NCI_P73PATHWAY / 58 / 1.34279 / 0.24384597
BIOC_VIPPATHWAY / 22 / 1.3426566 / 0.24311198
REACT_CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION / 38 / 1.340817 / 0.24479187
REACT_METABOLISM OF RNA / 206 / 1.3401526 / 0.24480027
NCI_TGFBRPATHWAY / 52 / 1.337808 / 0.24714862
KEGG_FC EPSILON RI SIGNALING PATHWAY / 65 / 1.337542 / 0.24654819
NCI_NFAT_3PATHWAY / 50 / 1.3375131 / 0.24568872
Table S2. Core enriched genes per up- and downregulated pathway after resveratrol supplementation.
Core enriched genes per downregulated pathway after resveratrol supplementationCELL-CELL JUNCTION
Genes / Description / Mean FC / p-value
CADM2 / cell adhesion molecule 2 / -1.15 / 0.011
CDH24 / cadherin 24. type 2 / -1.14 / 0.115
CDH5 / cadherin 5. type 2 (vascular endothelium) / -1.06 / 0.225
CDH6 / cadherin 6. type 2. K-cadherin (fetal kidney) / -1.12 / 0.150
CLDN11 / claudin 11 / -1.04 / 0.459
CLDN12 / claudin 12 / -1.04 / 0.498
CLDN19 / claudin 19 / -1.11 / 0.156
CLDN23 / claudin 23 / -1.06 / 0.378
CLDN5 / claudin 5 / -1.19 / 0.009
CLDN9 / claudin 9 / -1.09 / 0.216
CRB3 / crumbs homolog 3 (Drosophila) / -1.05 / 0.420
CTNND1 / catenin (cadherin-associated protein). delta 1 / -1.02 / 0.626
JUP / junction plakoglobin / -1.07 / 0.157
MLLT4 / myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog. Drosophila) /// translocated to. 4 / -1.08 / 0.177
PARD3 / par-3 partitioning defective 3 homolog (C. elegans) / -1.06 / 0.270
PARD6A / par-6 partitioning defective 6 homolog alpha (C. elegans) / -1.19 / 0.067
PARD6B / par-6 partitioning defective 6 homolog beta (C. elegans) / -1.14 / 0.075
PVR / poliovirus receptor / -1.11 / 0.086
PVRL1 / poliovirus receptor-related 1 (herpesvirus entry mediator C) / -1.07 / 0.197
WNT SIGNALING
Genes / Description / Mean FC / p-value
AXIN2 / axin 2 / -1.10 / 0.115
BMP2 / bone morphogenetic protein 2 / -1.27 / 0.005
CCND1 / cyclin D1 / -1.15 / 0.077
CTBP2 / C-terminal binding protein 2 / -1.09 / 0.108
CTNND1 / catenin (cadherin-associated protein). delta 1 / -1.02 / 0.626
DVL1 / dishevelled. dsh homolog 1 (Drosophila) / -1.12 / 0.075
DVL3 / dishevelled. dsh homolog 3 (Drosophila) / -1.06 / 0.306
FOSL1 / FOS-like antigen 1 / -1.17 / 0.055
FZD10 / frizzled family receptor 10 / -1.11 / 0.043
FZD2 / frizzled family receptor 2 / -1.07 / 0.314
FZD4 / frizzled family receptor 4 / -1.04 / 0.345
FZD5 / frizzled family receptor 5 / -1.07 / 0.205
FZD6 / frizzled family receptor 6 / -1.07 / 0.122
FZD8 / frizzled family receptor 8 / -1.16 / 0.047
FZD9 / frizzled family receptor 9 / -1.07 / 0.346
GLI1 / GLI family zinc finger 1 / -1.06 / 0.349
GLI2 / GLI family zinc finger 2 / -1.08 / 0.228
JUN / jun proto-oncogene / -1.16 / 0.230
KREMEN2 / kringle containing transmembrane protein 2 / -1.13 / 0.080
LDLR / low density lipoprotein receptor / -1.16 / 0.251
LRP5 / low density lipoprotein receptor-related protein 5 / -1.10 / 0.180
LRP6 / low density lipoprotein receptor-related protein 6 / -1.10 / 0.083
MAPK10 / mitogen-activated protein kinase 10 / -1.10 / 0.134
MYC / v-myc myelocytomatosis viral oncogene homolog (avian) / -1.15 / 0.241
NKD1 / naked cuticle homolog 1 (Drosophila) / -1.07 / 0.343
PPP2R1B / protein phosphatase 2. regulatory subunit A. beta / -1.10 / 0.189
PPP2R2A / protein phosphatase 2. regulatory subunit B. alpha / -1.06 / 0.196
PPP2R3B / protein phosphatase 2. regulatory subunit B''. alpha / 1.01 / 0.889
PPP2R5E / protein phosphatase 2. regulatory subunit B'. epsilon isoform / -1.09 / 0.080
PRKD1 / protein kinase D1 / -1.20 / 0.005
SMO / smoothened. frizzled family receptor / -1.07 / 0.305
SFRP4 / secreted frizzled-related protein 4 / -1.20 / 0.150
STK36 / serine/threonine kinase 36 / -1.04 / 0.403
TCF7L1 / transcription factor 7-like 1 (T-cell specific. HMG-box) / -1.11 / 0.117
TCF7L2 / transcription factor 7-like 2 (T-cell specific. HMG-box) / -1.07 / 0.236
WNT1 / wingless-type MMTV integration site family. member 1 / -1.07 / 0.244
WNT6 / wingless-type MMTV integration site family. member 6 / -1.14 / 0.036
ANGIOGENESIS
Genes / Description / Mean FC / p-value
ANGPT1 / angiopoietin 1 / -1.10 / 0.253
FGF2 / fibroblast growth factor 2 (basic) / -1.08 / 0.145
FLT1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / -1.10 / 0.099
KDR / kinase insert domain receptor (a type III receptor tyrosine kinase) / -1.08 / 0.106
NOS3 / nitric oxide synthase 3 (endothelial cell) / -1.06 / 0.316
PDGFB / platelet-derived growth factor beta polypeptide / -1.13 / 0.020
TEK / TEK tyrosine kinase. endothelial / -1.09 / 0.158
TIMP3 / TIMP metallopeptidase inhibitor 3 / -1.05 / 0.170
VEGFA / vascular endothelial growth factor A / -1.09 / 0.125
G PROTEIN COUPLED RECEPTORS
Genes / Description / Mean FC / p-value
ADM / adrenomedullin / -1.16 / 0.023
ADCY4 / adenylate cyclase 4 / -1.07 / 0.320
ADCY6 / adenylate cyclase 6 / -1.12 / 0.098
ADCY9 / adenylate cyclase 9 / -1.11 / 0.054
ADM / adrenomedullin / -1.16 / 0.023
ADRA1D / adrenergic. alpha-1D-. receptor / -1.08 / 0.144
ADRA2A / adrenergic. alpha-2A-. receptor / -1.26 / 0.001
ADRA2C / adrenergic. alpha-2C-. receptor / -1.14 / 0.056
ADRB1 / adrenergic. beta-1-. receptor / -1.28 / 0.004
ADRB2 / adrenergic. beta-2-. receptor. surface / -1.08 / 0.125
ARHGEF17 / Rho guanine nucleotide exchange factor (GEF) 17 / -1.11 / 0.143
AVPR2 / arginine vasopressin receptor 2 / -1.21 / 0.003
CCL16 / chemokine (C-C motif) ligand 16 / -1.14 / 0.099
CHRNB2 / cholinergic receptor. nicotinic. beta 2 (neuronal) / -1.07 / 0.223
CNR1 / cannabinoid receptor 1 (brain) / -1.15 / 0.028
CXCR7 / chemokine (C-X-C motif) receptor 7 / -1.07 / 0.227
DARC / Duffy blood group. chemokine receptor / -1.15 / 0.076
DGKI / diacylglycerol kinase. iota / -1.10 / 0.217
DGKQ / diacylglycerol kinase. theta 110kDa / -1.08 / 0.176
DRD4 / dopamine receptor D4 / -1.13 / 0.141
EDNRB / endothelin receptor type B / -1.09 / 0.237
FZD10 / frizzled family receptor 10 / -1.11 / 0.043
FZD5 / frizzled family receptor 5 / -1.07 / 0.205
FZD6 / frizzled family receptor 6 / -1.07 / 0.122
FZD8 / frizzled family receptor 8 / -1.16 / 0.047
GABRE / gamma-aminobutyric acid (GABA) A receptor. epsilon / -1.07 / 0.223
GALR1 / galanin receptor 1 / -1.19 / 0.053
GLP2R / glucagon-like peptide 2 receptor / -1.13 / 0.269
GNA12 / guanine nucleotide binding protein (G protein) alpha 12 / -1.07 / 0.184
GNAI1 / guanine nucleotide binding protein (G protein). alpha inhibiting activity polypeptide 1 / -1.09 / 0.156
GNAZ / guanine nucleotide binding protein (G protein). alpha z polypeptide / -1.10 / 0.114
GNG10 / glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase / -1.05 / 0.259
GNG2 / guanine nucleotide binding protein (G protein). gamma 2 / -1.07 / 0.160
GPR20 / G protein-coupled receptor 20 / -1.09 / 0.142
GPR4 / G protein-coupled receptor 4 / -1.16 / 0.081
GRID1 / glutamate receptor. ionotropic. delta 1 / -1.17 / 0.007
GRIN2B / glutamate receptor. ionotropic. N-methyl D-aspartate 2B / -1.29 / 0.043
HCAR1 / hydroxycarboxylic acid receptor 1 / -1.15 / 0.137
HCRTR1 / hypocretin (orexin) receptor 1 / -1.09 / 0.088
ITSN1 / intersectin 1 (SH3 domain protein) / -1.07 / 0.203
KALRN / kalirin. RhoGEF kinase / -1.08 / 0.161
LEP / leptin / -1.20 / 0.023
MCF2L / MCF.2 cell line derived transforming sequence-like / -1.10 / 0.073
NET1 / neuroepithelial cell transforming 1 / -1.29 / 0.003
NMUR1 / neuromedin U receptor 1 / -1.12 / 0.078
NPB / neuropeptide B / -1.17 / 0.063
NPFFR1 / neuropeptide FF receptor 1 / -1.07 / 0.250
NPW / neuropeptide W / -1.10 / 0.097
NPY1R / neuropeptide Y receptor Y1 / -1.17 / 0.060
NPY5R / neuropeptide Y receptor Y5 / -1.11 / 0.182
OPN4 / opsin 4 / -1.07 / 0.203
OR10H5 / olfactory receptor. family 10. subfamily H. member 5 / -1.22 / 0.004
OXT / oxytocin. prepropeptide / -1.17 / 0.091
P2RX6 / purinergic receptor P2X. ligand-gated ion channel. 6 / -1.24 / 0.023
P2RY14 / purinergic receptor P2Y. G-protein coupled. 14 / -1.15 / 0.082
PARD3 / par-3 partitioning defective 3 homolog (C. elegans) / -1.06 / 0.270
PDE10A / phosphodiesterase 10A / -1.14 / 0.029
PDE2A / phosphodiesterase 2A. cGMP-stimulated / -1.10 / 0.109
PDE3A / phosphodiesterase 3A. cGMP-inhibited / -1.09 / 0.199
PDE4A / phosphodiesterase 4A. cAMP-specific / -1.07 / 0.313
PLCB4 / phospholipase C. beta 4 / -1.15 / 0.016
PLXNB1 / plexin B1 / -1.09 / 0.202
POMC / proopiomelanocortin / -1.15 / 0.059
PROK1 / prokineticin 1 / -1.17 / 0.051
PROKR1 / prokineticin receptor 1 / -1.15 / 0.045
PTGER3 / prostaglandin E receptor 3 (subtype EP3) / -1.15 / 0.006
PTH1R / parathyroid hormone 1 receptor / -1.09 / 0.207
PTH2 / parathyroid hormone 2 / -1.13 / 0.078
QRFP / pyroglutamylated RFamide peptide / -1.10 / 0.112
RAMP1 / receptor (G protein-coupled) activity modifying protein 1 / -1.09 / 0.248
RAMP3 / receptor (G protein-coupled) activity modifying protein 3 / -1.12 / 0.060
RASGRF2 / Ras protein-specific guanine nucleotide-releasing factor 2 / -1.05 / 0.226
RHOB / ras homolog gene family. member B / -1.09 / 0.127
S1PR2 / sphingosine-1-phosphate receptor 2 / -1.10 / 0.161
SAA1 / sphingosine-1-phosphate receptor 5 / -1.06 / 0.433
SCT / secretin / -1.10 / 0.086
TBXA2R / thromboxane A2 receptor / -1.11 / 0.209
WNT1 / wingless-type MMTV integration site family. member 1 / -1.07 / 0.244
WNT6 / wingless-type MMTV integration site family. member 6 / -1.14 / 0.036
NOTCH SIGNALING
Genes / Description / Mean FC / p-value
CTBP2 / C-terminal binding protein 2 / -1.09 / 0.108
DLL1 / delta-like 1 (Drosophila) / -1.17 / 0.124
DLL4 / delta-like 4 (Drosophila) / -1.18 / 0.069
DVL1 / dishevelled. dsh homolog 1 (Drosophila) / -1.12 / 0.075
HES1 / hairy and enhancer of split 1. (Drosophila) / -1.10 / 0.073
JAG1 / jagged 1 / -1.11 / 0.036
JAG2 / jagged 2 / -1.12 / 0.043
KAT2A / K(lysine) acetyltransferase 2A / -1.09 / 0.154
NOTCH1 / notch 1 / -1.10 / 0.160
NOTCH3 / notch 3 / -1.18 / 0.007
NOTCH4 / notch 4 / -1.16 / 0.046
NUMBL / numb homolog (Drosophila)-like / -1.08 / 0.180
PTCRA / pre T-cell antigen receptor alpha / -1.11 / 0.107
RFNG / RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase / -1.12 / 0.091
Core enriched genes per upregulated pathway after resveratrol supplementation
LYSOSOME
Genes / Description / Mean FC / p-value
ACP2 / acid phosphatase 2. lysosomal / 1.13 / 0.185
ACP5 / acid phosphatase 5. tartrate resistant / 1.42 / 0.233
AGA / aspartylglucosaminidase / 1.04 / 0.272
AP1B1 / adaptor-related protein complex 1. beta 1 subunit / 1.10 / 0.132
AP1S1 / adaptor-related protein complex 1. sigma 1 subunit / 1.06 / 0.423
AP3B1 / adaptor-related protein complex 3. beta 1 subunit / 1.09 / 0.146
AP3S2 / adaptor-related protein complex 3. sigma 2 subunit / 1.05 / 0.298
AP4E1 / adaptor-related protein complex 4. epsilon 1 subunit / 1.07 / 0.299
AP4S1 / adaptor-related protein complex 4. sigma 1 subunit / 1.07 / 0.354
ARSB / arylsulfatase B / 1.10 / 0.173
ATP6AP1 / ATPase. H+ transporting. lysosomal accessory protein 1 / 1.11 / 0.173
ATP6V0A1 / ATPase. H+ transporting. lysosomal V0 subunit a1 / 1.09 / 0.077
ATP6V0B / ATPase. H+ transporting. lysosomal 21kDa. V0 subunit b / 1.07 / 0.220
ATP6V0C / ATPase. H+ transporting. lysosomal 16kDa. V0 subunit c / 1.09 / 0.037
ATP6V0D1 / ATPase. H+ transporting. lysosomal 38kDa. V0 subunit d1 / 1.07 / 0.222
ATP6V1H / ATPase. H+ transporting. lysosomal 50/57kDa. V1 subunit H / 1.09 / 0.156
CD164 / CD164 molecule. sialomucin / 1.07 / 0.178
CD68 / CD68 molecule / 1.19 / 0.246
CLN5 / ceroid-lipofuscinosis. neuronal 5 / 1.07 / 0.278
CLTC / clathrin. heavy chain (Hc) / 1.05 / 0.257
CTNS / cystinosin. lysosomal cystine transporter / 1.13 / 0.065
CTSA / cathepsin A / 1.10 / 0.017
CTSB / cathepsin B / 1.24 / 0.103
CTSC / cathepsin C / 1.16 / 0.041
CTSD / cathepsin D / 1.10 / 0.328
CTSG / cathepsin G / 1.04 / 0.460
CTSH / cathepsin H / 1.13 / 0.202
CTSK / cathepsin K / 1.13 / 0.169
CTSO / cathepsin O / 1.10 / 0.180
CTSS / cathepsin S / 1.25 / 0.092
DNASE2B / deoxyribonuclease II beta / 1.55 / 0.120
ENTPD4 / ectonucleoside triphosphate diphosphohydrolase 4 / 1.08 / 0.152
FUCA1 / fucosidase. alpha-L- 1. tissue / 1.12 / 0.408
GAA / glucosidase. alpha /// acid / 1.10 / 0.368
GALC / galactosylceramidase / 1.07 / 0.289
GALNS / galactosamine (N-acetyl)-6-sulfate sulfatase / 1.06 / 0.253
GBA / glucosidase. beta. acid / 1.17 / 0.030
GGA1 / golgi-associated. gamma adaptin ear containing. ARF binding protein 1 / 1.08 / 0.121
GGA2 / golgi-associated. gamma adaptin ear containing. ARF binding protein 2 / 1.07 / 0.135
GGA3 / golgi-associated. gamma adaptin ear containing. ARF binding protein 3 / 1.05 / 0.251
GLA / galactosidase. alpha / 1.23 / 0.057
GLB1 / galactosidase. beta 1 / 1.13 / 0.081
GM2A / GM2 ganglioside activator / 1.22 / 0.260
GNPTAB / N-acetylglucosamine-1-phosphate transferase. alpha and beta subunits / 1.09 / 0.092
GUSB / glucuronidase. beta / 1.19 / 0.161
HEXA / hexosaminidase A (alpha polypeptide) / 1.15 / 0.017
HEXB / hexosaminidase B (beta polypeptide) / 1.14 / 0.211
LAMP1 / lysosomal-associated membrane protein 1 / 1.03 / 0.415
LAMP2 / lysosomal-associated membrane protein 2 / 1.12 / 0.023
LAPTM4A / lysosomal protein transmembrane 4 alpha / 1.05 / 0.101
LAPTM5 / lysosomal protein transmembrane 5 / 1.20 / 0.060
LIPA / lipase A. lysosomal acid. cholesterol esterase / 1.35 / 0.139
M6PR / mannose-6-phosphate receptor (cation dependent) / 1.16 / 0.022
MAN2B1 / mannosidase. alpha. class 2B. member 1 / 1.15 / 0.092
MANBA / mannosidase. beta A. lysosomal / 1.14 / 0.039
MCOLN1 / mucolipin 1 / 1.13 / 0.036
MFSD8 / major facilitator superfamily domain containing 8 / 1.05 / 0.390
NAGA / N-acetylgalactosaminidase. alpha- / 1.17 / 0.034
NAGPA / N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase / 1.10 / 0.166
NPC1 / Niemann-Pick disease. type C1 / 1.09 / 0.144
NPC2 / Niemann-Pick disease. type C2 / 1.10 / 0.304
PLA2G15 / phospholipase A2. group XV / 1.17 / 0.145
PPT1 / palmitoyl-protein thioesterase 1 / 1.26 / 0.058
PPT2 / palmitoyl-protein thioesterase 2 / 1.03 / 0.652
PSAP / prosaposin / 1.10 / 0.012
SCARB2 / scavenger receptor class B. member 2 / 1.06 / 0.379
SGSH / N-sulfoglucosamine sulfohydrolase / 1.13 / 0.034
SLC11A2 / solute carrier family 11 (proton-coupled divalent metal ion transporters). member 2 / 1.13 / 0.032
SLC17A5 / solute carrier family 17 (anion/sugar transporter). member 5 / 1.12 / 0.067
SORT1 / sortilin 1 / 1.05 / 0.300
TCIRG1 / T-cell. immune regulator 1. ATPase. H+ transporting. lysosomal V0 subunit A3 / 1.07 / 0.379
TPP1 / tripeptidyl peptidase I / 1.14 / 0.039
PHAGOSOME
Genes / Description / Mean FC / p-value
ACTB / actin. beta / 1.06 / 0.086
ACTG1 / actin. gamma 1 / 1.08 / 0.067
ATP6AP1 / ATPase. H+ transporting. lysosomal accessory protein 1 / 1.11 / 0.173
ATP6V0A1 / ATPase. H+ transporting. lysosomal V0 subunit a1 / 1.09 / 0.077
ATP6V0B / ATPase. H+ transporting. lysosomal 21kDa. V0 subunit b / 1.07 / 0.220
ATP6V0C / ATPase. H+ transporting. lysosomal 16kDa. V0 subunit c / 1.09 / 0.037
ATP6V0D1 / ATPase. H+ transporting. lysosomal 38kDa. V0 subunit d1 / 1.07 / 0.222
ATP6V0E1 / ATPase. H+ transporting. lysosomal 9kDa. V0 subunit e1 / 1.03 / 0.314
ATP6V1A / ATPase. H+ transporting. lysosomal 70kDa. V1 subunit A / 1.08 / 0.103
ATP6V1B2 / ATPase. H+ transporting. lysosomal 56/58kDa. V1 subunit B2 / 1.09 / 0.223
ATP6V1C1 / ATPase. H+ transporting. lysosomal 42kDa. V1 subunit C1 / 1.10 / 0.149
ATP6V1D / ATPase. H+ transporting. lysosomal 34kDa. V1 subunit D / 1.13 / 0.053
ATP6V1E1 / ATPase. H+ transporting. lysosomal 31kDa. V1 subunit E1 / 1.03 / 0.555
ATP6V1G1 / ATPase. H+ transporting. lysosomal 13kDa. V1 subunit G1 / 1.02 / 0.597
ATP6V1H / ATPase. H+ transporting. lysosomal 50/57kDa. V1 subunit H / 1.09 / 0.156
C3 / complement component 3 / 1.11 / 0.057
CALR / calreticulin / 1.05 / 0.304
CANX / calnexin / 1.03 / 0.382
CD14 / CD14 molecule / 1.05 / 0.556
CD36 / CD36 molecule (thrombospondin receptor) / 1.02 / 0.507
CLEC7A / C-type lectin domain family 7. member A / 1.29 / 0.243
COLEC12 / collectin sub-family member 12 / 1.09 / 0.205
CORO1A / coronin. actin binding protein. 1A / 1.15 / 0.516
CTSL1 / cathepsin L1 / 1.09 / 0.548
CTSS / cathepsin S / 1.25 / 0.092
CYBA / cytochrome b-245. alpha polypeptide / 1.04 / 0.520
CYBB / cytochrome b-245. beta polypeptide / 1.26 / 0.023
DYNC1I2 / dynein. cytoplasmic 1. intermediate chain 1 / 1.03 / 0.658
DYNC1LI1 / dynein. cytoplasmic 1. light intermediate chain 1 / 1.09 / 0.135
EEA1 / early endosome antigen 1 / 1.04 / 0.510
FCGR3A / Fc fragment of IgG. low affinity IIa. receptor (CD32) / 1.01 / 0.942
HLA-B / major histocompatibility complex. class I. B / 1.09 / 0.068
HLA-C / major histocompatibility complex. class I. C / 1.07 / 0.305
HLA-DMA / major histocompatibility complex. class II. DM alpha / 1.10 / 0.254
HLA-DMB / major histocompatibility complex. class II. DM beta / 1.16 / 0.224
HLA-DOA / major histocompatibility complex. class II. DO alpha / 1.08 / 0.336
HLA-DOB / major histocompatibility complex. class II. DO beta / 1.26 / 0.052
HLA-DPA1 / major histocompatibility complex. class II. DP alpha 1 / 1.15 / 0.057
HLA-DPB1 / major histocompatibility complex. class II. DP beta 1 / 1.09 / 0.235
HLA-DQA1 / major histocompatibility complex. class II. DQ alpha 1 / 1.06 / 0.464
HLA-DQB1 / major histocompatibility complex. class II. DQ beta 1 / 1.12 / 0.105
HLA-DRA / major histocompatibility complex. class II. DR alpha / 1.12 / 0.156
HLA-DRB1 / major histocompatibility complex. class II. DR beta 1 / 1.14 / 0.170
HLA-DRB5 / major histocompatibility complex. class II. DR beta 5 / 1.16 / 0.058
ITGAM / integrin. alpha M (complement component 3 receptor 3 subunit) / 1.16 / 0.195
ITGB2 / integrin. beta 2 (complement component 3 receptor 3 and 4 subunit) / 1.24 / 0.079
ITGB3 / integrin. beta 3 (platelet glycoprotein IIIa. antigen CD61) / 1.16 / 0.363
LAMP1 / lysosomal-associated membrane protein 1 / 1.03 / 0.415
LAMP2 / lysosomal-associated membrane protein 2 / 1.12 / 0.023
M6PR / mannose-6-phosphate receptor (cation dependent) / 1.16 / 0.022
MARCO / macrophage receptor with collagenous structure / 1.04 / 0.582
MRC2 / mannose receptor. C type 2 / 1.05 / 0.468
MSR1 / macrophage scavenger receptor 1 / 1.49 / 0.144
NCF2 / neutrophil cytosolic factor 2 / 1.12 / 0.565
PIK3C3 / phosphoinositide-3-kinase. class 3 / 1.07 / 0.192
PIKFYVE / phosphoinositide kinase. FYVE finger containing / 1.06 / 0.126
RAB7A / RAB7A. member RAS oncogene family / 1.03 / 0.221
SEC61A1 / Sec61 alpha 1 subunit (S. cerevisiae) / 1.03 / 0.486
SEC61A2 / Sec61 alpha 2 subunit (S. cerevisiae) / 1.03 / 0.549
SEC61G / Sec61 gamma subunit / 1.05 / 0.293
TAP1 / transporter 1. ATP-binding cassette. sub-family B (MDR/TAP) / 1.07 / 0.496
TAP2 / transporter 2. ATP-binding cassette. sub-family B (MDR/TAP) / 1.06 / 0.493
TCIRG1 / T-cell. immune regulator 1. ATPase. H+ transporting. lysosomal V0 subunit A3 / 1.07 / 0.379
TFRC / transferrin receptor (p90. CD71) / 1.17 / 0.400
THBS3 / thrombospondin 3 / 1.10 / 0.194
TLR2 / toll-like receptor 2 / 1.33 / 0.209
TLR4 / toll-like receptor 4 / 1.06 / 0.330
TLR6 / toll-like receptor 6 / 1.23 / 0.249
TUBA1A / tubulin. alpha 1a / 1.08 / 0.081
TUBB / tubulin. beta / 1.12 / 0.035
TUBB1 / tubulin. beta 1 / 1.39 / 0.252
TUBB2A / tubulin. beta 2A / 1.03 / 0.514
INFLAMMATION
Genes / Description / Mean FC / p-value
ADAR / adenosine deaminase. RNA-specific / 1.08 / 0.240
ATF2 / activating transcription factor 2 / 1.02 / 0.598
ATM / ataxia telangiectasia mutated / 1.14 / 0.099
B2M / beta-2-microglobulin / 1.07 / 0.211
BIRC2 / baculoviral IAP repeat containing 2 / 1.08 / 0.115
BLNK / B-cell linker / 1.17 / 0.044
BRAF / v-raf murine sarcoma viral oncogene homolog B1 / 1.02 / 0.545
BTK / Bruton agammaglobulinemia tyrosine kinase / 1.33 / 0.009
CALM2 / calmodulin 2 (phosphorylase kinase. delta) / 1.07 / 0.108
CALM3 / calmodulin 3 (phosphorylase kinase. delta) / 1.05 / 0.356
CALR / calreticulin / 1.05 / 0.304
CAMK2A / calcium/calmodulin-dependent protein kinase II alpha / 1.05 / 0.277
CANX / calnexin / 1.03 / 0.382
CBL / Cas-Br-M (murine) ecotropic retroviral transforming sequence / 1.04 / 0.509
CD22 / CD22 molecule / 1.19 / 0.217
CD28 / CD28 molecule / 1.13 / 0.276
CD3D / CD3d molecule. delta (CD3-TCR complex) / 1.23 / 0.289
CD3E / CD3e molecule. epsilon (CD3-TCR complex) / 1.12 / 0.581
CD3G / CD3g molecule. gamma (CD3-TCR complex) / 1.26 / 0.309
CD4 / CD4 molecule / 1.24 / 0.028
CD44 / CD44 molecule (Indian blood group) / 1.13 / 0.044
CD72 / CD72 molecule / 1.12 / 0.265
CD74 / CD74 molecule. major histocompatibility complex. class II invariant chain / 1.09 / 0.136
CD79A / CD79a molecule. immunoglobulin-associated alpha / 1.22 / 0.386
CD79B / CD79b molecule. immunoglobulin-associated beta / 1.19 / 0.146
CD8A / CD8a molecule / 1.29 / 0.086
CD86 / CD86 molecule / 1.25 / 0.038
CHUK / conserved helix-loop-helix ubiquitous kinase / 1.08 / 0.208
CIITA / class II. major histocompatibility complex. transactivator / 1.23 / 0.034
CREB1 / cAMP responsive element binding protein 1 / 1.04 / 0.477
CSK / c-src tyrosine kinase / 1.10 / 0.193
CTSB / cathepsin B / 1.24 / 0.103
CTSS / cathepsin S / 1.25 / 0.092
CXCL10 / chemokine (C-X-C motif) ligand 10 / 1.98 / 0.055
CXCL9 / chemokine (C-X-C motif) ligand 9 / 1.34 / 0.306
CYBB / cytochrome b-245. beta polypeptide / 1.26 / 0.023
CYLD / cylindromatosis (turban tumor syndrome) / 1.08 / 0.313
DAPP1 / dual adaptor of phosphotyrosine and 3-phosphoinositides / 1.26 / 0.237
DBNL / drebrin-like / 1.06 / 0.110
E2F3 / E2F transcription factor 3 / 1.05 / 0.474
EIF2AK2 / eukaryotic translation initiation factor 2-alpha kinase 2 / 1.14 / 0.085
ELK1 / ELK1. member of ETS oncogene family / 1.05 / 0.400
ETS1 / v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) / 1.03 / 0.565
EVL / Enah/Vasp-like / 1.11 / 0.197
FYB / FYN binding protein / 1.22 / 0.332
FYN / FYN oncogene related to SRC. FGR. YES / 1.05 / 0.240
GAB2 / GRB2-associated binding protein 2 / 1.03 / 0.565
GBP2 / guanylate binding protein 2. interferon-inducible / 1.09 / 0.204
GBP3 / guanylate binding protein 3 / 1.09 / 0.157
GBP4 / guanylate binding protein 4 / 1.08 / 0.274
GRAP2 / GRB2-related adaptor protein 2 / 1.18 / 0.462
GRB2 / growth factor receptor-bound protein 2 / 1.11 / 0.073
GSK3A / glycogen synthase kinase 3 alpha / 1.04 / 0.310
GSK3B / glycogen synthase kinase 3 beta / 1.07 / 0.087
GTF2I / general transcription factor IIi / 1.07 / 0.174
HCLS1 / hematopoietic cell-specific Lyn substrate 1 / 1.13 / 0.302
HLA-B / major histocompatibility complex. class I. B / 1.09 / 0.068
HLA-C / major histocompatibility complex. class I. C / 1.07 / 0.305
HLA-DMA / major histocompatibility complex. class II. DM alpha / 1.10 / 0.254
HLA-DMB / major histocompatibility complex. class II. DM beta / 1.16 / 0.224
HLA-DOA / major histocompatibility complex. class II. DO alpha / 1.08 / 0.336
HLA-DOB / major histocompatibility complex. class II. DO beta / 1.26 / 0.052
HLA-DPA1 / major histocompatibility complex. class II. DP alpha 1 / 1.15 / 0.057
HLA-DPB1 / major histocompatibility complex. class II. DP beta 1 / 1.09 / 0.235
HLA-DQB1 / major histocompatibility complex. class II. DQ beta 1 / 1.12 / 0.105
HLA-DRA / major histocompatibility complex. class II. DR alpha / 1.12 / 0.156
HLA-DRB1 / major histocompatibility complex. class II. DR beta 1 / 1.14 / 0.170
HLA-DRB5 / major histocompatibility complex. class II. DR beta 5 / 1.16 / 0.058
HSPA1A / heat shock 70kDa protein 14 / -1.01 / 0.840