Table e-1. Mixed Models* of APOE e4 Carriers and Noncarriers

Hypercholesterolemia / Cigarette Smoking / Diabetes
Estimate / SE / P / Estimate / SE / P / Estimate / SE / P
Fixed Effects
Intercept / 9.3 / 0.2 / <0.001 / 9.3 / 0.19 / <0.001 / 9.21 / 0.17 / <0.001
Carrieri / -0.19 / 0.31 / 0.56 / -0.37 / 0.3 / 0.22 / -0.32 / 0.27 / 0.24
RiskFactori / -0.24 / 0.32 / 0.46 / -0.11 / 0.34 / 0.76 / -0.071 / 0.51 / 0.89
Agei1-60 / -0.079 / 0.026 / 0.003 / -0.092 / 0.025 / <0.001 / -0.11 / 0.023 / <0.001
Carrieri x (Agei1-60) / -0.0038 / 0.041 / 0.93 / 0.0021 / 0.038 / 0.96 / 0.048 / 0.035 / 0.16
RiskFactori x (Agei1-60) / -0.086 / 0.048 / 0.07 / -0.045 / 0.053 / 0.4 / -0.018 / 0.076 / 0.81
Carrieri x RiskFactori / -0.38 / 0.49 / 0.44 / -0.074 / 0.54 / 0.89 / -0.092 / 1.02 / 0.93
Carrieri x RiskFactori x (Agei1-60) / 0.21 / 0.071 / 0.004 / 0.27 / 0.084 / 0.001 / 0.26 / 0.13 / 0.06
(Agei1-60)2 / 0.0034 / 0.0011 / 0.003 / 0.0031 / 0.0012 / 0.007 / 0.003 / 0.0011 / 0.008
Carrieri x (Agei1-60)2 / 0.0021 / 0.0018 / 0.24 / 0.0022 / 0.0018 / 0.22 / 0.0029 / 0.0018 / 0.1
Ageij-60 / 0.039 / 0.024 / 0.1 / 0.061 / 0.022 / 0.006 / 0.062 / 0.021 / 0.003
Carrieri x (Ageij-60) / -0.05 / 0.036 / 0.17 / -0.061 / 0.033 / 0.07 / -0.083 / 0.031 / 0.008
RiskFactori x (Ageij-60) / 0.074 / 0.041 / 0.07 / 0.011 / 0.047 / 0.81 / 0.0099 / 0.063 / 0.88
Carrieri x RiskFactori x (Ageij-60) / -0.13 / 0.062 / 0.03 / -0.2 / 0.074 / 0.007 / -0.22 / 0.11 / 0.06
(Ageij-60)2 / -0.0025 / 0.001 / 0.01 / -0.0023 / 0.001 / 0.03 / -0.0021 / 0.00097 / 0.03
Carrieri x (Ageij-60)2 / -0.0036 / 0.0016 / 0.02 / -0.0035 / 0.0016 / 0.03 / -0.0041 / 0.0015 / 0.008
Random Effects
Intercept / 6.45 / 0.40 / <0.001 / 6.53 / 0.41 / <0.001 / 6.52 / 0.40 / <0.001
Residual / 3.66 / 0.13 / <0.001 / 3.67 / 0.13 / <0.001 / 3.67 / 0.13 / <0.001
Hypertension / Any CV Risk / Obesity
Estimate / SE / P / Estimate / SE / P / Estimate / SE / P
Fixed Effects
Intercept / 9.25 / 0.2 / <0.001 / 9.29 / 0.25 / <0.001 / 9.33 / 0.22 / <0.001
Carrieri / -0.21 / 0.31 / 0.5 / -0.2 / 0.39 / 0.6 / -0.24 / 0.34 / 0.49
RiskFactori / -0.11 / 0.32 / 0.73 / -0.066 / 0.31 / 0.83 / -0.18 / 0.33 / 0.59
Agei1-60 / -0.11 / 0.029 / <0.001 / -0.1 / 0.035 / 0.004 / -0.08 / 0.027 / 0.003
Carrieri x (Agei1-60) / 0.022 / 0.043 / 0.61 / -0.047 / 0.053 / 0.38 / -0.0059 / 0.041 / 0.89
RiskFactori x (Agei1-60) / 0.012 / 0.047 / 0.8 / -0.003 / 0.049 / 0.95 / -0.066 / 0.048 / 0.17
Carrieri x RiskFactori / -0.3 / 0.5 / 0.55 / -0.29 / 0.48 / 0.55 / -0.28 / 0.58 / 0.63
Carrieri x RiskFactori x (Agei1-60) / 0.13 / 0.073 / 0.07 / 0.2 / 0.073 / 0.007 / 0.21 / 0.079 / 0.008
(Agei1-60)2 / 0.003 / 0.0012 / 0.01 / 0.0028 / 0.0012 / 0.02 / 0.0029 / 0.0012 / 0.01
Carrieri x (Agei1-60)2 / 0.002 / 0.0018 / 0.29 / 0.0014 / 0.0019 / 0.46 / 0.0038 / 0.0019 / 0.04
Ageij-60 / 0.078 / 0.026 / 0.002 / 0.063 / 0.03 / 0.04 / 0.033 / 0.025 / 0.18
Carrieri x (Ageij-60) / -0.078 / 0.037 / 0.04 / -0.039 / 0.044 / 0.38 / -0.036 / 0.037 / 0.33
RiskFactori x (Ageij-60) / -0.037 / 0.04 / 0.34 / 0.00037 / 0.042 / 0.99 / 0.096 / 0.041 / 0.02
Carrieri x RiskFactori x (Ageij-60) / -0.055 / 0.061 / 0.37 / -0.11 / 0.062 / 0.08 / -0.18 / 0.066 / 0.007
(Ageij-60)2 / -0.0019 / 0.001 / 0.06 / -0.0022 / 0.001 / 0.04 / -0.0022 / 0.00099 / 0.03
Carrieri x (Ageij-60)2 / -0.0039 / 0.0016 / 0.01 / -0.0033 / 0.0016 / 0.04 / -0.0044 / 0.0016 / 0.006
Random Effects
Intercept / 6.47 / 0.40 / <0.001 / 6.44 / 0.40 / <0.001 / 6.51 / 0.45 / <0.001
Residual / 3.67 / 0.13 / <0.001 / 3.68 / 0.13 / <0.001 / 3.64 / 0.13 / <0.001

* Table represents six models (one model per risk factor) and each is of the form given in the section titled “Longitudinal Growth Modeling”.