Supplementarytable 1. Multivariate Analyses Identifying Factors Associated with Chronic

SupplementaryTable 1. Multivariate analyses identifying factors associated with chronic

Waist circumference ≦90 cm
(n=858) / LDL≦ 130 mg/dL
(n=595)
OR(95% CI) / P value / OR(95% CI) / P value
Erosive esophagitis / 2.07(1.16-3.69) / 0.014 / 2.41(1.19-4.86) / 0.015
Age, year / 0.99(0.97-1.01) / 0.307 / 0.99(0.97-1.01) / 0.425
Sex, Male=1 / 1.03(0.62-1.72) / 0.911 / 0.77(0.42-1.42) / 0.405
BMI, kg/m2 / 1.04(0.95-1.14) / 0.378 / 1.01(0.94-1.10) / 0.725
Fasting blood glucose, mg/dL / 1.01(1.00-1.02) / 0.006 / 1.00(0.99-1.01) / 0.996
Total cholesterol, mg/dL / 0.99(0.98-1.00) / 0.021 / 0.99(0.98-1.00) / 0.239
AST, IU/L / 1.02(1.00-1.04) / 0.067 / 1.01(0.99-1.04) / 0.268
ALP, IU/L / 1.02(1.00-1.03) / 0.006 / 1.03(1.02-1.04) / <0.001
Platelet, K/μl / 0.99(0.99-1.00) / 0.014 / 0.99(0.99-1.00) / 0.007

HBV infection with waist circumference ≦90 cm or serum LDL ≦ 130 mg/dL

Multivariate logistic regression model was used. Use HBsAg (+) as reference and dependent variable, and age, sex, BMI, fasting blood glucose, total cholesterol, AST, ALP, platelet and erosive esophagitis as independent variables. P < 0.05 is considered as statistical significance.

SupplementaryTable 2. Multivariate analyses identifying factors associated with chronic

Fasting blood glucose ≧ 100 mg/dL (n=328) / HDL < 50 mg/dL in females or
HDL < 40 mg/dL in males
(n=305)
OR(95% CI) / P value / OR(95% CI) / P value
Erosive esophagitis / 2.88(1.25-6.61) / 0.013 / 3.44(1.36-8.70) / 0.009
Age, year / 0.96(0.93-1.00) / 0.050 / 0.99(0.96-1.02) / 0.517
Sex, Male=1 / 1.50(0.65-3.45) / 0.337 / 1.01(0.43-2.34) / 0.990
BMI, kg/m2 / 0.87(0.77-0.98) / 0.018 / 0.98(0.87-1.11) / 0.766
Fasting blood glucose, mg/dL / 1.01(1.00-1.02) / 0.014 / 1.01(1.00-1.02) / 0.254
Total cholesterol, mg/dL / 0.99(0.98-1.00) / 0.083 / 0.99(0.98-1.00) / 0.083
AST, IU/L / 1.01(0.98-1.03) / 0.583 / 0.98(0.93-1.02) / 0.313
ALP, IU/L / 1.01(0.99-1.03) / 0.363 / 1.02(1.00-1.04) / 0.046
Platelet, K/μl / 1.00(0.99-1.00) / 0.453 / 0.99(0.99-1.00) / 0.086

HBV infection with fasting blood glucose ≧ 100 mg/dL or lower serum HDL levels

Multivariate logistic regression model was used. Use HBsAg (+) as reference and dependent variable, and age, sex, BMI, fasting blood glucose, total cholesterol, AST, ALP, platelet and erosive esophagitis as independent variables. P < 0.05 is considered as statistical significance.

SupplementaryTable 3. Multivariate analyses identifying factors associated with chronic

Without use of aspirin or non-steroidal anti-inflammatory drugs (n=959) / Without alcohol consumption (n=825)
OR(95% CI) / P value / OR(95% CI) / P value
Erosive esophagitis / 1.70(0.99-2.91) / 0.054 / 1.80(0.97-3.34) / 0.063
Age, year / 0.99(0.97-1.01) / 0.313 / 0.99(0.97-1.01) / 0.325
Sex, Male=1 / 1.12(0.69-1.81) / 0.654 / 1.17(0.69-2.00) / 0.551
BMI, kg/m2 / 1.00(0.94-1.07) / 0.963 / 0.99(0.91-1.07) / 0.787
Fasting blood glucose, mg/dL / 1.01(1.00-1.02) / 0.010 / 1.01(1.00-1.01) / 0.067
Total cholesterol, mg/dL / 0.99(0.99-1.00) / 0.042 / 0.99(0.99-1.00) / 0.080
AST, IU/L / 1.01(0.99-1.03) / 0.395 / 1.01(0.99-1.03) / 0.298
ALP, IU/L / 1.01(1.00-1.02) / 0.033 / 1.01(1.00-1.02) / 0.076
Platelet, K/μl / 1.00(0.99-1.00) / 0.022 / 0.99(0.99-1.00) / 0.008

HBV infection without use of aspirin or non-steroidal anti-inflammatory drugs, or alcohol consumption

Multivariate logistic regression model was used. Use HBsAg (+) as reference and dependent variable, and age, sex, BMI, fasting blood glucose, total cholesterol, AST, ALP, platelet and erosive esophagitis as independent variables. P < 0.05 is considered as statistical significance.

SupplementaryTable 4. Multivariate analyses identifying factors associated with erosive esophagitis (n=996)

OR(95% CI) / P value
Sex, Male=1 / 2.43(1.63-3.64) / <0.001
HbA1c, % / 1.21(1.00-1.46) / 0.050
HDL, mg/dL / 1.02(1.00-1.03) / 0.008
HBsAg, +ve=1 / 1.61(0.95-2.73) / 0.077
LDL, mg/dL / 1.01 (1.00-1.01) / 0.011
Alcohol drinking, Yes=1 / 1.65(1.09-2.50) / 0.019
Waist circumference, cm◎ / 1.02(1.00-1.04) / 0.031

Stepwise estimation with backward-selection logistic regression model was used. Use the presence of erosive esophagitis (yes or no) as reference and dependent variable, and age, sex, BMI, waist circumference, SBP, DBP, HBsAg, triglyceride, total cholesterol, HbA1c, LDL, HDL level, AST, ALT, ALP levels, history of DM, hypertension, smoking, alcohol consumption and APRI as independent variables. P ≥ 0.2 is the significant level for removal from the model, and P < 0.1 is the significant level for addition to the model.

◎Three non-HBV enrollers did not have waist circumference data, and two without HbA1c.

Supplementary Table 5. Demographic, biochemical features, and components of metabolic syndrome of enrolled subjects

Characteristics / Erosive esophagitis a / OR(95% CI) / P value
No (n=835) / Yes (n=166)
Mean ± S.D. or n (%)
Age, year / 51.7 ± 11.1 / 53.7± 13.2 / 1.02(1.00-1.03) / 0.041
Male, n (%) / 361(43.2) / 112 (67.5) / 2.72(1.91-3.87) / <0.001
BMI (kg/m2) / 23.3 ± 3.2 / 24.0 ± 3.8 / 1.06(1.01-1.11) / 0.021
Waist circumference (cm) b / 80.0 ± 9.3 / 83.4± 10.1 / 1.04(1.02-1.05) / <0.001
SBP (mmHg) / 121.4 ± 16.4 / 123.8± 18.7 / 1.01(1.00-1.02) / 0.091
DBP (mmHg) / 75.1 ± 11.7 / 77.8± 13.5 / 1.02(1.00-1.03) / 0.010
Fasting blood glucose, mg/dL / 99.3 ± 24.8 / 103.8 ± 29.0 / 1.01(1.00-1.01) / 0.037
HbA1c, % b / 5.5 ± 0.7 / 5.7± 1.0 / 1.25(1.05-1.49) / 0.008
Diabetes Mellitus, yes=1, n (%) / 36(4.3) / 9 (5.4) / 1.27(0.60-2.69) / 0.528
Hypertension, yes=1, n (%) / 132 (15.8) / 36 (21.7) / 1.47(0.98-2.23) / 0.064
Alcohol, yes=1, n (%) / 126(15.1) / 50(30.1) / 2.43(1.66-3.55) / <0.001
Smoking, yes=1, n (%) / 61 (7.3) / 24 (14.5) / 2.14(1.29-3.55) / 0.003
NSAID user, yes=1, n (%) c / 24 (2.9) / 4 (2.4) / 0.83(0.29-2.44) / 0.740

Supplementary Table 5. Demographic, biochemical features, and components of metabolic

Aspirin user, yes=1, n (%) / 15(1.8) / 2(1.2) / 0.67(0.15-2.94) / 0.590
AST, IU/L / 24.3 ± 10.6 / 25.7 ± 11.1 / 1.01(1.00-1.02) / 0.133
ALT, IU/L / 26.6 ± 20.7 / 30.1 ± 22.2 / 1.01(1.00-1.01) / 0.051
Platelet, K/ul / 245.4 ± 59.9 / 239.3± 61.9 / 1.00(1.00-1.00) / 0.236
Triglyceride, mg/dL / 130.7± 95.5 / 136.0 ± 77.4 / 1.00(1.00-1.00) / 0.508
Total cholesterol, mg/dL / 194.2± 37.3 / 202.4 ± 35.5 / 1.01(1.00-1.01) / 0.010
LDL, mg/dL / 123.2± 32.3 / 132.0 ± 31.4 / 1.01(1.00-1.01) / 0.001
HDL, mg/dL / 53.2 ± 14.6 / 52.6± 15.7 / 1.00(0.99-1.01) / 0.594
Chronic HBV infection, yes=1, n (%) / 70(8.4) / 23(13.9) / 1.76(1.06-2.91) / 0.027
Metabolic syndrome / 173(20.7) / 46(27.7) / 1.47(1.00-2.14) / 0.047
APRI c / 0.28±0.43 / 0.28±0.14 / 0.99(0.64-1.53) / 0.967

syndrome of enrolled subjects (cont.)

Data are shown by mean ± standard deviation or proportion of the character.

aThe severity of erosive esophagitis was graded from A to D according to the LA classification. However, only 20 subjects were graded as B and one as C, so we collapsed the grading and the presence of erosive esophagitis defined as yes/or no was used.

b Three non-HBV enrollers did not have waist circumference data, and two without HbA1c.

c NSAID, nonsteroidal anti-inflammatory drug; APRI, aspartate aminotransferase to platelet ratio index