Supplemental Table 1 Genes upregulated in cell lines, prostate cancer tissues expressing AR-Vs [modified from Hornberg et al (2011) PloS One 6(4): e19059; Hu et al (2012) Cancer Res 72(14): 3457-62; “Other Aliases”, “Description”, and “Function” from PubMed Gene,

Genes / Other Aliases / Description / Function
CDCA5 / SORORIN / cell division cycle associated 5
BIRC5 / Survivin / baculovirual IAP repeat containing 5 / inhibitor of apoptosis
BUB1 / BUB1A / budding uninhibited by benzimidazoles 1 homolog (yeast) / spindle checkpoint function
KPNA2 / IPOA1 / karyopherin alpha 2 (RAG cohort 1, importin alpha 1) / import of proteins into nucleus
KNTC1 / ROD / kinetochore associated 1 / involved in proper chromosome segregation during cell division
BUB1B / SSK1; MAD3L / budding uninhibited by benzimidazoles 1 homolog beta (yeast) / spindle checkpoint function
CDC25B / RP5-1009E24.3 / cell division cycle 25 homolog B (S. pombe) / activates CDK1/CDC2
MAD2L2 / MAD2B / MAD2 mitotic arrest deficient-like 2 (yeast) / mitotic spindle assembly checkpoint
CENPE / CENP-E / centromere protein E, 312 kDa / accumulates in G2 phase of cell cycle; responsible for mammalian chromosome movement and/or spindle elongation
ESPL1 / ESP1; separase / extra spindle pole bodies homolog 1 (S. cerevisiae) / initates final separation of sister chromatids
KIF2C / KNSL6 / kinesin family member 2C / microtubule-dependent molecular motor involved in anaphase chrosmosome segregation
NEK2 / NEK2A / NIMA (never in mitosis gene a)-related kinase 2 / localized to centrosome and reaches maximal levels in late G2 phase
CIT / CRIK / citron (rho-interacting, serine/threonin kinase 21) / localized to central spindle and midbody, functions to promote efficient cytokinesis
KIF22 / KID; KNSL4 / kinesin family member 22 / role in metaphase chromosome alignment and maintenance
CCNA2 / CCN1; CCNA / cyclin A2 / activates CDC2 or CDK2 kinases to promote G1/S and G2/M transitions
ZWINT / HZwint-1 / ZW10 interactor / localizes to prophase kinetochores, remains on kinetochore until late anaphase
TPX2 / DIL-2 / TPX2, micotubule-associated, homolog (Xenopus laevis)
KIF15 / HKLP2 / kinesin family member 15
MAD2L1 / MAD2 / MAD2 mitotic arrest deficient-like 1 (yeast) / mitotic spindle assembly checkpoint
PKMYT1 / MYT1 / protein kinase, membrane associated tyrosine/threonine 1 / negatively regulates G2/M transition of cell cycle
UBE2C / UBCH10 / ubiquitin-conjugating enzyme E2C / member of E2 ubiquitin-conjugating enzyme family, required for destruction of mitotic cyclins and progression of cell cycle
PLK1 / PLK / polo-like kinase 1
NUSAP1 / LNP; ANKT / nucleolar and spindle associated protein 1 / role in spindle microtubule organization
ETV4 / PEA3 / ets variant 4
FABP5 / E-FABP / fatty acid binding protein 5 (psoriasis-associated) / may play role in fatty acid uptake, transport, and metabolism
HES6 / HES-6 / hairy and enhancer of split 6 (Drosophila) / basic helix-loop-helix transcription repressor that regulates cell differentiation
UGT2B17 / UDPGT2B17 / UDP glucuronosyltransferase 2 family. polypeptide B17 / involved in glucuronidation, an intermediate step in the metabolism of steroids
AR / DHTR / androgen receptor / steroid-hormone activated transcription factor; stimulates transcription of androgen responsive genes
BARD1 / BARD-1 / BRCA1 associated RING domain 1 / interacts with N-terminal region of BRCA1, may be target of oncogenic mutations
CDK1 / CDC2 / cyclin-dependent kinase 1, cell division cycle 2 / essential for G1/S and G2/M transitions
TOP2A / TOP2; TP2A / topoisomerase (DNA) II alpha 170kDa / involved in chromosome condensation, chromatid separation, and relief of torsional stress that occurs during DNA transcription and replication
CDC20 / CDC20A / cell division cycle 20 homolog (S. cerevisiae) / required for two microtubule-dependent processes: nuclear movement prior to anaphase and chromosome separation
SLC7A5 / CD98 / solute carrier family 7 (amino acid transporter light chain, L system), member 5
E2F2 / E2F-2 / E2F transcription factor 2 / binds specifically to pRB in cell-cycle dependent manner; controls cell cycle
MCM7 / CDC47; MCM2 / minichromosome maintenance complex component 7 / essential for initiation of eukaryotic genomic replication
CCNB2 / HsT17299 / cyclin B2 / cyclin B2 is primarily associated with the Golgi region and also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control
HSPB1 / HSP27 / heat shock 27kDa protein 1 / involved in stress resistance and actin organization
TTK / PYT / TTK protein kinase / essential for chromosome alignment at the centromere during mitosis and is required for centrosome;tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles duplication
E2F5 / E2F-5 / E2F transcription factor 5, p130-binding / control of cell cycle; this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB
MCM2 / BM28; CCNL1 / minichromosome maintenance complex component 2 / involved in the initiation of eukaryotic genome replication
MYC / c-MYC / v-myc myelocytomatosis viral oncogene homolog (avian) / transcription factor that regulates cell cycle progression, apoptosis and cellular transformation gene targets
NCAPG / CAP-G / non-SMC condensin I complex, subunit G / encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis
BCL2L12 / BCL2L12 / BCL2-like 12 (proline rich) / member of BCL-2 family, which act as anti- or pro-apoptotic regulators; this protein contains a Bcl-2 homology domain 2 (BH2); the function of this gene has not yet been determined
MELK / HPK38 / maternal embryonic leucine zipper kinase
MCM4 / NKCD / minichromosome maintenance complex component 4 / initiation of eukaryotic genome replication
TUBB / TUBB1 / tubulin, beta class
RECQL4 / RECQ4 / RecQ protein-like 4 / a DNA helicase, which unwinds double-stranded DNA into single-stranded DNAs; may modulate chromosome segregation
MTDH / LYRIC / metadherin
STMN1 / Lag, SMN / stathmin 1/oncoprotein 18 / prevents assembly and promotes disassembly of microtubules
EXO1 / HEX1 / exonuclease 1 / encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity
TUBA1B / K-ALPHA-1 / tubulin, alpha 1b
UHRF1 / Np95 / ubiquitin-like with PHD and ring finger domains 1 / an E3 ubiquitin ligase; plays a major role in the G1/S transition by regulating topoisomerase II alpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint
KIF20A / RAB6KIFL / kinesin family member 20A
ORC6 / ORC6L / origin recognition complex. subunit 6 like (yeast) / part of the origin recognition complex (ORC), it binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins; gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis
PTPRF / LAR / protein tyrosine phosphatase, receptor type, F / functions in the regulation of epithelial cell-cell contacts at adherents junctions and in the control of beta-catenin signaling
RAD21 / HR21 / RAD21 homolog (S. pombe) / highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells
HIST1H4C / H4FG / histone cluster 1, H4c / this gene is intronless and encodes a member of the histone H4 family; transcripts from this gene lack polyA tails but instead contain a palindromic termination element
HSPE1 / HSP10 / heat shock 10kDa protein 1 (chaperonin 10) / gene encodes a major heat shock protein which functions as a chaperonin
PBK / SPK / PDZ binding kinase / encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family; this mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis