SUPPLEMENTAL MATERIAL

Supplemental Table 1. Multivariable-adjusted estimated relative risks* (and 95% confidence intervals) of coronary heart disease for every 0.5% increase in Hemoglobin A1c in different subgroups during 14 years of follow in the Nurses’ Health Study and 10 years of follow-up of the Health Professionals Follow-up Study

Women / Men
Subgroup / Cases /
Controls / RR / P trend / Cases /
Controls / RR / P trend
Overweight
No (BMI <25 kg/m2) / 190 / 496 / 1.35 (0.97-1.88) / 0.08 / 152 / 394 / 0.92 (0.65-1.30) / 0.62
Yes (BMI ≥ 25 kg/m2) / 180 / 336 / 1.25 (0.91-1.72) / 0.17 / 244 / 449 / 1.54 (1.18-1.99) / 0.001
P interaction / 0.53 / 0.11
Hypertension
No / 205 / 621 / 1.38 (1.02-1.85) / 0.04 / 260 / 603 / 1.32 (1.02-1.70) / 0.03
Yes / 166 / 211 / 1.16 (0.78-1.70) / 0.47 / 136 / 240 / 1.29 (0.90-1.86) / 0.17
P interaction / 0.38 / 0.87
CRP levels
≤ 3.0 mg/L / 207 / 553 / 1.42 (1.04-1.94) / 0.03 / 314 / 710 / 1.28 (1.03-1.60) / 0.03
> 3.0 mg/L / 155 / 255 / 1.18 (0.82-1.70) / 0.39 / 81 / 133 / 1.33 (0.76-2.32) / 0.31
P interaction / 0.42 / 0.61
Parental history of early
myocardial infarction†
No / 280 / 716 / 1.29 (1.01-1.66) / 0.04 / 333 / 747 / 1.29 (1.03-1.61) / 0.03
Yes / 91 / 116 / 1.70 (0.94-3.05) / 0.08 / 63 / 96 / 1.69 (0.90-3.19) / 0.11
P interaction / 0.46 / 0.45
Age at diagnosis
<65 years / 122 / 289 / 1.72 (1.10-2.71) / 0.02 / 141 / 313 / 1.16 (0.82-1.63) / 0.41
≥ 65 years / 249 / 543 / 1.22 (0.93-1.60) / 0.15 / 255 / 530 / 1.38 (1.06-1.78) / 0.02
P interaction / 0.37 / 0.52
Smoking status‡
Never / 124 / 300 / 1.05 (0.70-1.56) / 0.82 / 167 / 351 / 1.26 (0.92-1.75) / 0.15
Past / 142 / 310 / 1.53 (1.04-2.27) / 0.03 / 173 / 386 / 1.32 (0.96-1.82) / 0.09
Current / 105 / 222 / 1.24 (0.79-1.95) / 0.35 / 36 / 74 / 1.13 (0.40-3.17) / 0.82
P interaction / 0.56 / 0.92

*Adjusted for matching factors (age, smoking status, month of blood drawing, fasting status), body mass index, family history of myocardial infarction before age of 60 years, alcohol intake, physical activity, NSAID use, the total cholesterol / HDL cholesterol ratio, and hormone replacement therapy use among women.

†Multivariable not adjusted for family history of myocardial infarction before age of 60 years

‡Subjects with missing/unknown smoking were excluded from this analysis