Supplement S5: STRING Analysis of the Most Possible Mir-137 Targets

Supplement S5: STRING analysis of the most possible miR-137 targets

Using the STRING v9.05 (Search Tool for the Retrieval of the Interacting Genes/Proteins, 2) database we created the association network based on collected experimental evidences. We examined whether there is any functional association between 17 genes predicted by at least 4 different prediction methods to be the targets of miR-137 and were found to be either differentially expressed (by SAM) or contributed to the core enrichment of the gene sets (GSEA). STRINGin protein mode was used with highest confidence score (0.9) and it included 50 additional white nodes, which represent nodes of higher iterationin order to inspect possible interactions.

FigureS5_1: Network visualization showing the evidences for protein-protein interactions. Each type of predicted functional evidence link (edge) is shown with different color; green: neighborhood, pink:experiments,blue: co-occurrence, purple: homology, black: co-expression, light blue: knowledge (databases), yellow: text-mining. White nodes which were automatically generated by STRING are shown in white.

Figure S4_2: Network visualization showing type of interactions between the input genes and white nodes. Each type of the interaction link (edge) is shown with different color; green: activation, blue: binding, pink: post-translational modification, black: reaction, purple: catalysis fusion, green: neighborhood, blue: co-occurrence, purple: experimental, yellow: text mining, light blue: database, black: co-expression. Grey edges present a suggestion for functional link with confidence score above 0.9. White nodes, which were automatically generated by STRING v9.05 are shown in white.

2. Gene Ontology Enrichment

To examine whether the top possible targets for miR-137 obtained with this study have an effect on neuronal function and as such substantiate the role of miR-137, we re-analyzed the set of 17 genes and included 50 highest iteration nodes using the Gene Ontology enrichment widget included in the STRING (v9.05). We were interested which biological processes are significantly associated with the given set of genes. In the Table S5_1 we present the results of the enrichment analysis with additional data for all the GO terms that had significant P- value after Bonferroni correction1. We excluded annotations inferred by automatic procedures only, and investigated the pre-defined higher level GO annotation categories (GO Slim) and annotation categories pruned for redundant parent terms (GO Specific).

GO Slim
GO id / Biological function / No. of genes* / p-value** / p-value (corrected)** / No. of genes (17)***
GO:0007267 / cell-cell signaling / 43 / 8.25E-40 / 7.95E-36 / 13
GO:0050877 / neurological system process / 40 / 2.72E-35 / 2.62E-31 / 11
GO:0055085 / transmembrane transport / 16 / 4.48E-09 / 0.0000432 / 5
GO:0006810 / transport / 27 / 5.4E-09 / 0.0000521 / 6
GO Specific
GO id / Biological function / No. of genes* / p-value** / p-value (corrected)** / No. of genes (17)**
GO:0007268 / synaptic transmission / 43 / 3.85E-49 / 3.71E-45 / 13
GO:0035637 / multicellular organismal signaling / 42 / 6.73E-46 / 6.49E-42 / 12
GO:0019226 / transmission of nerve impulse / 41 / 1.93E-44 / 1.86E-40 / 11
GO:0007267 / cell-cell signaling / 43 / 8.25E-40 / 7.95E-36 / 13
GO:0003008 / system process / 44 / 2.46E-35 / 2.37E-31 / 11
GO:0050877 / neurological system process / 40 / 2.72E-35 / 2.62E-31 / 11
GO:0032501 / multicellular organismal process / 44 / 2.43E-17 / 2.34E-13 / 10
GO:0006811 / ion transport / 23 / 3.37E-16 / 3.24E-12 / 5
GO:0014047 / glutamate secretion / 8 / 3.79E-16 / 3.66E-12 / 1
GO:0015672 / monovalent inorganic cation transport / 15 / 6.19E-16 / 5.97E-12 / 2
GO:0030001 / metal ion transport / 18 / 3.35E-15 / 3.23E-11 / 2
GO:0006813 / potassium ion transport / 12 / 1.04E-14 / 1E-10 / 1
GO:0006812 / cation transport / 18 / 1.77E-14 / 1.7E-10 / 2
GO:0023052 / signaling / 42 / 2.95E-14 / 2.85E-10 / 12
GO:0007154 / cell communication / 42 / 5.07E-14 / 4,89E-10 / 12
GO:0034220 / ion transmembrane transport / 13 / 8.98E-12 / 8.66E-08 / 3
GO:0071805 / potassium ion transmembrane transport / 8 / 1.63E-11 / 0.000000157 / 1
GO:0055085 / transmembrane transport / 16 / 4.48E-9 / 0.0000432 / 5
GO:0007269 / neurotransmitter secretion / 7 / 4.95E-9 / 0.0000477 / 0
GO:0006810 / transport / 27 / 5.4E-9 / 0.0000521 / 6
GO:0051234 / establishment of localization / 27 / 8.13E-9 / 0.0000783 / 6
GO:0006836 / neurotransmitter transport / 7 / 1.91E-8 / 0.000184 / 0
GO:0044057 / regulation of system process / 10 / 2.26E-8 / 0.000218 / 1
GO:0001505 / regulation of neurotransmitter levels / 7 / 2.49E-8 / 0.00024 / 0
GO:0086091 / regulation of heart rate by cardiac conduction / 4 / 3.51E-8 / 0.000339 / 1
GO:0003001 / generation of a signal involved in cell-cell signaling / 7 / 6.56E-8 / 0.000632 / 0
GO:0023061 / signal release / 7 / 6.56E-8 / 0.000632 / 0
GO:0051179 / localization / 28 / 2.05E-7 / 0.00198 / 6
GO:0061337 / cardiac conduction / 4 / 2.08E-7 / 0.00201 / 1
GO:0008016 / regulation of heart contraction / 6 / 2.29E-7 / 0.00221 / 1
GO:0090257 / regulation of muscle system process / 6 / 4.84E-7 / 0.00467 / 1
GO:0051899 / membrane depolarization / 5 / 7.01E-7 / 0.00676 / 1
GO:0006936 / muscle contraction / 8 / 1.09E-6 / 0.0105 / 2
GO:0055117 / regulation of cardiac muscle contraction / 4 / 1.76E-6 / 0.0169 / 1
GO:0002027 / regulation of heart rate / 4 / 1.76E-6 / 0.0169 / 1
GO:0090072 / positive regulation of sodium ion transport via voltage-gated sodium channel activity / 3 / 1.83E-6 / 0.0177 / 1
GO:0003012 / muscle system process / 8 / 2.06E-6 / 0.0199 / 2

Table S5_1: Results of the enrichment of the functional system obtained with the set of 17 most possible targets of miR-137 and additional 50 white nodes. *- number of the genes contributing to the significant enrichment (17 most possible targets of miR-137 and 50 genes automatically generated by STRING); **- p-value is automatically computed using Hypergeometric test as explained in Franceschiniet al.1, corrected p-value is corrected by Bonferroni method; ***- number of genes (out of 17 genes, which were found to be significantly differentially expressed or contributed to the core enrichment and were predicted by at least 4 different prediction methods as targets of miR-137) contributing to the significant enrichment out of only our set of possible targets.

Node1 / Node2 / Neighborhood / Cooccurence / Homology / Co-expression / Experimental / Knowledge / Textmining / Combined score
KCNQ2 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.751 / 0.973
KCNA4 / KCNQ1 / 0 / 0 / 0.59 / 0 / 0 / 0.9 / 0.61 / 0.923
SYT1 / RAB3A / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.916 / 0.991
CAMK2A / CAMK2B / 0 / 0.525 / 0.962 / 0 / 0.418 / 0.9 / 0.657 / 0.94
KCNA4 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.791 / 0.977
UNC13B / SYT1 / 0 / 0 / 0.527 / 0 / 0 / 0.9 / 0.565 / 0.925
RIMS1 / SNAP25 / 0 / 0 / 0 / 0 / 0.621 / 0.9 / 0.078 / 0.96
KCNA4 / KCNA2 / 0 / 0 / 0.956 / 0 / 0.846 / 0.9 / 0.86 / 0.984
KCNG1 / KCNA1 / 0 / 0.525 / 0.835 / 0 / 0 / 0.9 / 0.508 / 0.915
KCNA2 / KCNV1 / 0 / 0.525 / 0.821 / 0 / 0 / 0.9 / 0.466 / 0.915
KCNF1 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.305 / 0.925
PICK1 / GRIA2 / 0 / 0 / 0 / 0 / 0.867 / 0 / 0.942 / 0.991
FYN / SRC / 0 / 0.525 / 0.958 / 0 / 0.931 / 0.9 / 0.866 / 0.993
ARL6IP5 / SLC1A1 / 0 / 0 / 0 / 0 / 0.621 / 0 / 0.792 / 0.915
KCNQ3 / KCNQ1 / 0 / 0 / 0.868 / 0 / 0 / 0.9 / 0.759 / 0.909
KCNH5 / KCNH2 / 0 / 0 / 0.844 / 0 / 0 / 0.9 / 0.569 / 0.908
KCNQ2 / KCNA1 / 0 / 0 / 0.663 / 0 / 0 / 0.9 / 0.66 / 0.921
KCNG1 / KCNAB3 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.22 / 0.916
MBP / PLP1 / 0 / 0 / 0 / 0.222 / 0.846 / 0 / 0.652 / 0.952
VAMP2 / RAB3A / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.543 / 0.951
GRIN1 / GRIN2A / 0 / 0 / 0.795 / 0 / 0.895 / 0.9 / 0.751 / 0.99
UNC13B / RIMS1 / 0 / 0 / 0.403 / 0 / 0.937 / 0.9 / 0.926 / 0.997
KCNH2 / KCNQ1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.851 / 0.984
RELN / GRIN2A / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.306 / 0.925
KCNG1 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.164 / 0.91
CPLX1 / RIMS1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.22 / 0.916
KCNQ2 / KCNA2 / 0 / 0 / 0.649 / 0 / 0 / 0.9 / 0.655 / 0.922
GRIN3A / GRIN2A / 0 / 0 / 0.758 / 0 / 0.62 / 0.9 / 0.675 / 0.965
KCNAB3 / KCNF1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.506 / 0.947
CAMK2D / CAMK2B / 0 / 0.525 / 0.962 / 0 / 0.846 / 0.9 / 0.236 / 0.984
UNC13B / SLC17A7 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.3 / 0.925
KCNA1 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.778 / 0.976
KCNAB3 / KCNAB2 / 0.137 / 0.525 / 0.959 / 0 / 0 / 0.9 / 0.72 / 0.912
KCNQ2 / KCNA4 / 0 / 0 / 0.591 / 0 / 0 / 0.9 / 0.461 / 0.917
VAMP2 / RIMS1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.332 / 0.928
KCNAB3 / KCNA1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.379 / 0.933
KCNH5 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.069 / 0.9
RIMS1 / SLC32A1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.11 / 0.905
VAMP2 / SYT1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.946 / 0.994
KCNG1 / KCNQ2 / 0 / 0 / 0.619 / 0 / 0 / 0.9 / 0.186 / 0.905
SYT1 / SNAP25 / 0 / 0 / 0 / 0 / 0.846 / 0.9 / 0.57 / 0.992
HSPA4 / TP53 / 0 / 0 / 0 / 0 / 0.937 / 0 / 0.906 / 0.993
SLC1A2 / JUB / 0 / 0 / 0 / 0 / 0.621 / 0 / 0.815 / 0.925
NQO1 / HSPA4 / 0 / 0 / 0 / 0 / 0.621 / 0 / 0.852 / 0.94
KCNV1 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.46 / 0.942
KCNA3 / KCNA2 / 0 / 0.525 / 0.961 / 0 / 0.846 / 0.9 / 0.499 / 0.984
KCNQ3 / KCNA2 / 0 / 0 / 0.623 / 0 / 0 / 0.9 / 0.61 / 0.922
KCNA4 / KCNH5 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.183 / 0.912
GRIA3 / PICK1 / 0 / 0 / 0 / 0 / 0.867 / 0 / 0.527 / 0.933
NFE2L2 / NQO1 / 0 / 0 / 0 / 0 / 0 / 0 / 0.954 / 0.954
KCNA3 / KCNQ1 / 0 / 0 / 0.622 / 0 / 0 / 0.9 / 0.317 / 0.91
KCNA2 / KCNA1 / 0 / 0.525 / 0.966 / 0 / 0.62 / 0.9 / 0.975 / 0.961
KCNH5 / KCNA1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.203 / 0.914
DLG4 / KCNA1 / 0 / 0 / 0 / 0 / 0.937 / 0 / 0.33 / 0.955
CPLX1 / RAB3A / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.341 / 0.929
GRIN2A / PRKCA / 0 / 0 / 0 / 0 / 0.621 / 0.8 / 0.629 / 0.967
RELN / FYN / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.412 / 0.937
KCNA4 / KCNAB3 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.791 / 0.977
NQO1 / TP53 / 0 / 0 / 0 / 0 / 0.621 / 0 / 0.885 / 0.953
KCNQ3 / KCNA4 / 0 / 0 / 0.561 / 0 / 0 / 0.9 / 0.374 / 0.914
KCNQ3 / KCNQ2 / 0 / 0 / 0.911 / 0 / 0.846 / 0.9 / 0.982 / 0.985
CAMK2D / GRIN2A / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.386 / 0.934
CAMK2A / CAMK2D / 0 / 0.525 / 0.969 / 0 / 0.764 / 0.9 / 0.341 / 0.975
KCNQ3 / KCNA1 / 0 / 0 / 0.637 / 0 / 0 / 0.9 / 0.566 / 0.919
RASGRF1 / GRIN2A / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.226 / 0.917
KCNAB3 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.309 / 0.926
SRC / GRIN2A / 0 / 0 / 0 / 0 / 0.937 / 0 / 0.866 / 0.991
KCNA3 / KCNQ2 / 0 / 0 / 0.619 / 0 / 0 / 0.9 / 0.24 / 0.907
CAMK2A / GRIN2A / 0 / 0 / 0 / 0 / 0.621 / 0.9 / 0.265 / 0.968
KCNA4 / KCNV1 / 0 / 0 / 0.829 / 0 / 0 / 0.9 / 0.317 / 0.904
KCNA1 / KCNQ1 / 0 / 0 / 0.652 / 0 / 0 / 0.9 / 0.54 / 0.917
SCN4B / SCN2B / 0 / 0 / 0.802 / 0.104 / 0 / 0.9 / 0.789 / 0.919
KCNQ2 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.308 / 0.926
KCNA2 / KCNAB3 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.374 / 0.933
KCNG1 / KCNA4 / 0 / 0 / 0.826 / 0 / 0 / 0.9 / 0.337 / 0.905
MBP / PRKCA / 0 / 0 / 0 / 0 / 0.937 / 0 / 0.318 / 0.954
KCNA3 / KCNF1 / 0 / 0.525 / 0.846 / 0 / 0 / 0.9 / 0.317 / 0.911
KCNA2 / KCNQ1 / 0 / 0 / 0.656 / 0 / 0 / 0.9 / 0.543 / 0.917
CPLX1 / SNAP25 / 0 / 0 / 0 / 0.097 / 0.938 / 0.36 / 0.309 / 0.97
VAMP2 / CPLX1 / 0 / 0 / 0 / 0 / 0.62 / 0.9 / 0.431 / 0.975
SYT1 / STX1A / 0 / 0 / 0 / 0 / 0.937 / 0.9 / 0.711 / 0.997
GRIA3 / GRIA2 / 0 / 0 / 0.963 / 0 / 0.846 / 0.72 / 0.787 / 0.955
FYN / PRKCA / 0 / 0 / 0.615 / 0 / 0 / 0.9 / 0.317 / 0.91
KCNH5 / KCNA2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.274 / 0.922
KCNA3 / KCNV1 / 0 / 0.525 / 0.817 / 0 / 0 / 0.9 / 0.271 / 0.912
SCN1B / SCN2B / 0 / 0 / 0 / 0 / 0 / 0.72 / 0.793 / 0.938
KCNQ3 / KCNH5 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.38 / 0.933
KCNG1 / KCNV1 / 0 / 0.525 / 0.877 / 0 / 0 / 0.9 / 0.61 / 0.912
KCNA4 / KCNA1 / 0 / 0 / 0.958 / 0 / 0.62 / 0.9 / 0.852 / 0.96
KCNQ3 / KCNA3 / 0 / 0 / 0.59 / 0 / 0 / 0.9 / 0.2 / 0.905
GRIN1 / GRIN3A / 0 / 0 / 0.768 / 0 / 0.846 / 0.9 / 0.675 / 0.986
DTNA / SNTA1 / 0 / 0 / 0 / 0 / 0.858 / 0 / 0.624 / 0.943
KCNH5 / KCNV1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.242 / 0.919
KCNA3 / KCNAB3 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.424 / 0.938
KCNQ2 / KCNF1 / 0 / 0 / 0.623 / 0 / 0 / 0.9 / 0.173 / 0.904
KCNA3 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.529 / 0.949
UNC13B / CPLX1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.245 / 0.919
HSPA4 / KCNQ1 / 0 / 0 / 0 / 0 / 0.621 / 0 / 0.825 / 0.929
KCNH5 / KCNQ1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.217 / 0.916
DLG3 / GRIN2A / 0 / 0 / 0 / 0 / 0.941 / 0 / 0.508 / 0.969
VAMP2 / SNAP25 / 0 / 0 / 0 / 0 / 0.997 / 0.9 / 0.794 / 0.999
KCNG1 / KCNA3 / 0 / 0.525 / 0.818 / 0 / 0 / 0.9 / 0.181 / 0.911
KCNQ3 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.203 / 0.914
RIMS1 / SYT1 / 0 / 0 / 0.604 / 0 / 0.621 / 0.9 / 0.463 / 0.966
UNC13B / SNAP25 / 0 / 0 / 0 / 0 / 0.62 / 0.9 / 0.305 / 0.969
KCNF1 / KCNA1 / 0 / 0.525 / 0.846 / 0 / 0 / 0.9 / 0.521 / 0.914
KCNG1 / KCNF1 / 0 / 0.525 / 0.877 / 0 / 0 / 0.9 / 0.659 / 0.913
KCNG1 / KCNH5 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.22 / 0.916
KCNQ2 / KCNH5 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.372 / 0.932
KCNG1 / KCNQ1 / 0 / 0 / 0.597 / 0 / 0 / 0.9 / 0.261 / 0.908
KCNA3 / KCNA4 / 0 / 0 / 0.948 / 0 / 0.62 / 0.9 / 0.725 / 0.96
PICK1 / PRKCA / 0 / 0 / 0 / 0 / 0.846 / 0 / 0.854 / 0.976
CPLX1 / STX1A / 0 / 0 / 0 / 0 / 0.974 / 0.36 / 0.677 / 0.994
KCNQ3 / KCNAB3 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.273 / 0.922
KCNA4 / DLG4 / 0 / 0 / 0 / 0 / 0.995 / 0 / 0.46 / 0.997
DTNA / DMD / 0 / 0 / 0.758 / 0 / 0.941 / 0 / 0.569 / 0.949
KCNA3 / KCNA1 / 0 / 0.525 / 0.961 / 0 / 0.62 / 0.9 / 0.434 / 0.96
UNC13B / VAMP2 / 0 / 0 / 0 / 0 / 0.62 / 0.9 / 0.466 / 0.976
KCNQ2 / KCNAB3 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.201 / 0.914
KCNA2 / KCNAB2 / 0 / 0 / 0 / 0 / 0.846 / 0.9 / 0.796 / 0.996
KCNV1 / KCNF1 / 0 / 0.525 / 0.868 / 0 / 0 / 0.9 / 0.272 / 0.909
KCNQ3 / KCNG1 / 0 / 0 / 0.576 / 0 / 0 / 0.9 / 0.209 / 0.906
UNC13B / STX1A / 0 / 0 / 0 / 0 / 0.62 / 0.9 / 0.562 / 0.981
KCNQ2 / KCNQ1 / 0 / 0 / 0.881 / 0 / 0.621 / 0.9 / 0.786 / 0.963
KCNA2 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.784 / 0.976
KCNAB3 / KCNQ1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.204 / 0.915
SRC / PRKCA / 0 / 0 / 0.609 / 0 / 0.621 / 0.9 / 0.886 / 0.973
KCNH2 / KCNA1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.786 / 0.977
RIMS1 / RAB3A / 0 / 0 / 0 / 0 / 0.81 / 0.9 / 0.916 / 0.998
KCNG1 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.396 / 0.935
KCNA2 / KCNF1 / 0 / 0.525 / 0.84 / 0 / 0 / 0.9 / 0.18 / 0.909
KCNAB3 / KCNV1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.505 / 0.947
RIMS1 / STX1A / 0 / 0 / 0 / 0 / 0.621 / 0.9 / 0.318 / 0.97
VAMP2 / STX1A / 0 / 0 / 0 / 0 / 0.995 / 0.9 / 0.947 / 0.999
KCNA4 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.752 / 0.973
KCNV1 / KCNQ1 / 0 / 0 / 0.645 / 0 / 0 / 0.9 / 0.145 / 0.903
KCNQ2 / KCNV1 / 0 / 0 / 0.619 / 0 / 0 / 0.9 / 0.24 / 0.907
KCNH2 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.526 / 0.949
CPLX1 / SYT1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.778 / 0.976
ABC17 / SLC1A2 / 0 / 0 / 0 / 0 / 0 / 0 / 0.946 / 0.946
SCN1B / CNTN1 / 0 / 0 / 0 / 0 / 0.621 / 0 / 0.829 / 0.93
KCNV1 / KCNA1 / 0 / 0.525 / 0.83 / 0 / 0 / 0.9 / 0.465 / 0.915
CPLX1 / SLC32A1 / 0 / 0 / 0 / 0.122 / 0 / 0.9 / 0.165 / 0.916
RIMS1 / SLC17A7 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.204 / 0.915
ABC17 / TAP1 / 0 / 0.525 / 0.975 / 0 / 0 / 0.9 / 0.8 / 0.903
KCNG1 / KCNA2 / 0 / 0.525 / 0.832 / 0 / 0 / 0.9 / 0.425 / 0.914
VAMP2 / SLC17A7 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.372 / 0.932
UNC13B / RAB3A / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.514 / 0.948
GRIN2A / CAMK2B / 0 / 0 / 0 / 0 / 0.621 / 0.9 / 0.675 / 0.985
KCNQ3 / KCNV1 / 0 / 0 / 0.591 / 0 / 0 / 0.9 / 0.211 / 0.906
FYN / GRIN2A / 0 / 0 / 0 / 0 / 0.974 / 0.9 / 0.867 / 0.999
SNAP25 / STX1A / 0 / 0 / 0 / 0 / 0.999 / 0.9 / 0.738 / 0.999
RAB3A / SLC17A7 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.305 / 0.925
CPLX1 / SLC17A7 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.374 / 0.933
SRC / CDH2 / 0 / 0 / 0 / 0 / 0 / 0 / 0.906 / 0.906
GRIN1 / DLG4 / 0 / 0 / 0 / 0 / 0.874 / 0.8 / 0.523 / 0.986
KCNF1 / KCNQ1 / 0 / 0 / 0.615 / 0 / 0 / 0.9 / 0.095 / 0.901
SYT1 / SLC32A1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.348 / 0.93
KCNQ3 / KCNH2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.66 / 0.963
VAMP2 / SLC32A1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.274 / 0.922
CDH2 / GRIA2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.227 / 0.917
GRIN2A / DLG4 / 0 / 0 / 0 / 0 / 0.995 / 0 / 0.533 / 0.998
DMD / SNTA1 / 0 / 0 / 0 / 0 / 0.99 / 0 / 0.715 / 0.997
KCNAB2 / KCNQ1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.23 / 0.917
KCNV1 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.623 / 0.959
KCNA3 / KCNH5 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.172 / 0.911
SCN1B / SCN4B / 0 / 0 / 0 / 0 / 0 / 0.72 / 0.724 / 0.917
SYT1 / SLC17A7 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.464 / 0.942
RAB3A / SLC32A1 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.196 / 0.914
TAP1 / SLC1A2 / 0 / 0 / 0 / 0 / 0 / 0 / 0.946 / 0.946
KCNA3 / KCNAB2 / 0 / 0 / 0 / 0 / 0 / 0.9 / 0.264 / 0.921

Table S5_2: Summary of the interaction evidence scores between the set of 17 genes and white nodes, under required confidence score of 0.900 for the association network created by STRING v9.05. Fusion evidence scores were zero for all interactions (omitted from the table).

References:

1.Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 2013; 41(Database issue): 15.

2.Jensen L, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J et al. STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 2009; 37(Database issue): 6.