School of Basic Medical Sciences, FudanUniversity
Final Exam of Cell Biology
MBBS Program, Fall Semester, academic Year 2015- 2016
□B
Name ： Student ID：
section / Ⅰ / Ⅱ / Ⅲ / Total scoresscores
Ⅰ. Multiple choices (Find the best answer to each of the following questions; 2 points each, 20 points total)
1. The major determinant of a cell’s ability to response to a specific signalling molecule correctly is:
A-- The appropriate signal transduction pathway in the cell
B-- Whether there is a appropriate receptor to work with or not
C-- Whether the signalling ligand is membrane-bound or diffusible
D-- The specificity of the signalling molecule itself
E-- None of the above is correct.
2. Nitric Oxide:
A-- can be synthesized by iNOS.
B-- mediates the vasodilatory effects.
C-- can be released from the cell via simple diffusion.
D-- can regulate normal maintenance of vascular tone.
E-- All of the above are correct.
3. A major difference between steroid hormone signaling and other receptor-based signaling mechanisms is:
A--Steroid hormone receptors are themselves transcription factors
B--Steroid hormone receptors expressed on the cell surface do not need to dimerize
C--Steroid hormone signal transduction occurs without the need for a signal transducing cascade of protein kinases
D--A and C
E--All of above
4.When signaling ligand binds to a G protein- coupled receptors (GPCRs) and activate a G protein,which subunit of G protein will be isolated and bind with ATP:
A-- the α subunit B-- the β subunit C-- the γ subunit
D-- the ε subunit E-- the σ subunit
5. Which of the following can works as ligand:
A-- cGMP B-- cAMP C-- DAG D-- acetylcholine E-- IP3
6.Cytokinesis refers to:
A-- Kinetochore/chromosome associations
B-- Cytoplasmic division into daughter cells.
C-- Chromosome movements within the cytoplasm of mitotic cells.
D-- Nuclear division
E-- Two cells fuse each other to form a new one.
7. During S-phase, which of the following feature iscorrect?
A-- chromatins begin to coil and condense B-- nucleolus will disappear
C-- nuclear membrane will disappear D-- cell will divide into two cells
E-- DNA replication/synthesis will begin
8.Which of the following features about CDK-cyclin complexiswrong
A-- the concentration of cyclins always keep same as the cell cycles progress
B-- CDK can be activated by cyclin binding
C--the CDK inhibitor proteins will inhibit CDK’s kinase activaty
D-- MPF is actually CDK-cyclin complex
E-- when DNA is damaged, CDK-cyclin complex will be inhibited to arrest cell cycle progress
9. In the cell cycle, progression through the G1 to S transition is controlled by:
A-- Microtubule disassembly. B-- Sequential activity of CDK4/CDK6.
C-- Activity of Cdk2 . D-- Phosphorylation of CDK1.
E-- None of the above.
10. Which of the following concerningDNA replicationis NOT correct?
A-- The parental DNA strands should be separated at the beginning of the replication.
B-- Replication begins at replication origins.
C-- DNA replication is bidirectional synthesis along the chromosome.
D-- Both parental strands are used as templates.
E-- Both new synthesized strands are synthesized continuously.
Ⅱ. Provide brief descriptions of the following technique terms by using several sentences or simple diagrams (5 pointseach,40 points total)
①-- active transport ②-- Voltage-gated Ion Channel
③--γ-tubulin complex ring ④-- regulated secretory pathway
⑤-- signal recognition partical ⑥--leading strand
⑦--receptor ⑧-- mitosis
Ⅲ. Long answer questions (8 points each,40 points total)
1、Describe the structure and features of cell membrane.
2、How doesmembrane structure in cell such as endoplasmic reticulum bud a vesicle?
3、Describe the structures and functions of the cell nuclear membrane.
4、What is the second messenger? Use an example to explain how the second messenger works.
5、What is the cell cycle? List the cell cyclecheckpoints that stop progression of the cell cycle and at which stage they act.
1