Professor Onn Min Kon MD FRCP

Curriculum Vitae

Professor Onn Min Kon MD FRCP

Consultant Respiratory Physician,

Head of ServiceTuberculosis Service Imperial College Healthcare NHS Trust,

Chest and Allergy Clinic,St Mary’s Hospital, Imperial College Healthcare NHS Trust,

Praed Street, LondonW2 1NY

Tel: 0207 886 1344 Fax: 0207 886 1613

e-mail:

Consultant Physician, TB Clinic, HammersmithHospital

Adjunct Professor and Reader,National Heart and Lung Institute, Imperial College

Date of birth:26th March 1964

General Medical Council: Full registration No: 3290497

Undergraduate education:

UniversityCollege and MiddlesexHospitalSchool of Medicine 1983-1988

Qualifications:

• MBBS 1988 (UniversityCollege and MiddlesexHospitalSchool of Medicine)
• MRCP 1992 (London)
• FRCP2003 (London)
• CCST in Respiratory and General Internal Medicine January 1999
• MD 2000 University London - ‘Immunosuppressants in Asthma’ (supervisors Professor Barry Kay and Professor Neil Barnes)

Committee Work

• Lead Clinician for Tuberculosis Service since 2008
• Lead Clinician Respiratory Medicine and TB service St Mary’s Hospital 1999-2008

External Committees

• National TB Oversight Group
• Joint Tuberculosis Committee UK – Chair from 2016
• British Thoracic Society –Ex -Chair Specialist Advisory Group for Tuberculosis till 2015
• British Thoracic Society and Royal College of Physicians – Regional Specialty Adviser for North West London since Dec 2011
• Clinical lead for TB - North West London Sector
• Find and Treat Steering Committee – Department of Health till 2011

PhD/MDstudent supervision:

Name of student / Date registered / Sponsor / Funding Body / Co supervisor(s) / Date degree obtained
Helen Neighbour
Matthew Berry
Annie Sykes
Jonathon MacIntyre
David Connell
Hannah Jarvis
Aula Abbara / 2006
2007
2008
2008
2011
2015
2015 / Pharmaceutical
MRC/ Dana Foundation
Wellcome Trust
MRC
Wellcome Trust
BRC / Trevor Hansel
Anne O’Garra
Sebastian Johnston
Sebastian Johnston
Ajit Lalvani
Ajit Lalvani / 2009
2010
2011
2014

Grants:

Medical Research Council / Mechanisms of Deficient Innate Immune Responses in Asthma / 2008 / £1.2 million / Co-investigator / Sebastian Johnston (PI) and Michael Edwards
Wellcome Trust Strategic Award / Centre for Respiratory Infection Core support / 2008-2011 / £3.39 million / Principal Investigator / Professor Peter Openshaw – Chief Investigator
NIHR HTA 08/106/02 / IGRAs in Diagnostic Evaluation of Active TB
(IDEA) / 2010 / £1.9 million / Co-Lead Principal Investigator / Ajit Lalvani (Co-Lead Principal Investigator)
NIHR – HTA
08/68/01 / Prognostic value of interferon gamma release assays in predicting active tuberculosis among individuals with, or at risk of, latent tuberculosis infection / 2010 / £2.65 million / Co-Investigator / Professor Ibrahim Abubakar
NIHR- DEC / NIHR Diagnostic Evidence Co-operatives / 2013 / £993,690 / Principal Investigator / Professor George Hanna
NIHR – EME
12/65/27 / VANTDET - ‘Validation of New Technologies for Diagnostic Evaluation of Tuberculosis’ / 2014 / £1.2 million / Co-Investigator / Professor Ajit Lalvani
BRC grant / RESPISAM study / 2014 / £200,000 / Lead Principal Investigator

Teaching /Training commitments:

Associate UTD Respiratory Medicine

OSCE examiner /Finals Examiner

Chair and Examiner MSc Respiratory Medicine, ImperialCollege till 2011

New Drugs and Targets in Asthma and COPD course ImperialCollege – Regular Lecturer

Advanced Respiratory Medicine lecturer – RoyalBromptonHospital

Invited lectures to the Royal Society of Medicine, Ceylonese College of Physicians, Royal College of Physicians Pulmonary Infections series, British Thoracic Society

Lecturer - Allergy MSc, Infection Control MSc, Respiratory BSc at Imperial College, London

London Advanced TB Course – organiser, chair and lecturer:

I have developed an annual national and international TB course in collaboration with Public Health England - the London Advanced TB course - this is now regarded as a premier TB course and continues to be highly popular and attracts delegates from abroad as well as nationally.

Previous appointments

Specialist Registrar in Respiratory and General Medicine

Academic Department of Medicine

Charing CrossHospitalApril 1998 – May1999

Specialist Registrar in Respiratory Medicine,

RoyalBromptonHospital,

London SW3 6LYOct 1996-March 1998

Research Fellow and Honorary Registrar

National Heart and Lung Institute and the LondonChestHospital

September 1994 - September 1996

Registrar in General and Respiratory Medicine

St. Mary's Hospital, London

July 1993-Aug 1994

Selected Publications:

Nooredinvand HA, Connell DW, Asgheddi M, Abdullah M, O'Donoghue M, Campbell L,

Wickremasinghe MI, Lalvani A, Kon OM, Khan SA. Viral hepatitis prevalence in

patients with active and latent tuberculosis. World J Gastroenterol. 2015 Aug

7;21(29):8920-6. doi: 10.3748/wjg.v21.i29.8920.

Footitt J, Mallia P, Durham AL, Ho WE, Trujillo-Torralbo MB, Telcian AG, Del

Rosario A, Chang C, Peh HY, Kebadze T, Aniscenko J, Stanciu L, Essilfie-Quaye S,

Ito K, Barnes PJ, Elkin SL, Kon OM, Wong WS, Adcock IM, Johnston SL. Oxidative

and nitrosative stress and histone deacetylase-2 activity in exacerbations of

Chronic Obstructive Pulmonary Disease. Chest. 2015 Mar 19.

Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley

C, Ito M, Tunstall T, Elkin S, Kon OM, Hansel TT, Paul-Clark MJ. Protocol for a

human in vivo model of acute cigarette smoke inhalation challenge in smokers with

COPD: monitoring the nasal and systemic immune response using a network biology

approach. BMJ Open. 2015 Jan 28;5(1):e005750.

Jackson DJ, Makrinioti H, Rana BM, Shamji BW, Trujillo-Torralbo MB, Footitt J,

Jerico Del-Rosario, Telcian AG, Nikonova A, Zhu J, Aniscenko J, Gogsadze L,

Bakhsoliani E, Traub S, Dhariwal J, Porter J, Hunt D, Hunt T, Hunt T, Stanciu LA,

Khaitov M, Bartlett NW, Edwards MR, Kon OM, Mallia P, Papadopoulos NG, Akdis CA,

Westwick J, Edwards MJ, Cousins DJ, Walton RP, Johnston SL. IL-33-dependent type

2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J

Respir Crit Care Med. 2014 Dec 15;190(12):1373-82.

Gielen V, Sykes A, Zhu J, Chan B, Macintyre J, Regamey N, Kieninger E, Gupta

A, Shoemark A, Bossley C, Davies J, Saglani S, Walker P, Nicholson SE, Dalpke AH,

Kon OM, Bush A, Johnston SL, Edwards MR. Increased nuclear suppressor of cytokine

signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of

innate interferons. J Allergy Clin Immunol. 2015 Jul;136(1):177-188.e11. doi:

10.1016/j.jaci.2014.11.039. Epub 2015 Jan 25.

Dhariwal J, Tennant RC, Hansell DM, Westwick J, Walker C, Ward SP, Pride N,

Barnes PJ, Kon OM, Hansel TT. Smoking cessation in COPD causes a transient

improvement in spirometry and decreases micronodules on high-resolution CT

imaging. Chest. 2014 May;145(5):1006-15.

Telcian AG, Zdrenghea MT, Caramori G, Laza-Stanca V, Message SD, Kebadze T,

Kon OM, Groh V, Papi A, Johnston SL, Mallia P, Stanciu LA. Soluble major

histocompatibility complex class I-related chain B molecules are increased and

correlate with clinical outcomes during rhinovirus infection in healthy subjects.

Chest. 2014 Jul;146(1):32-40.

Hingley-Wilson SM, Connell D, Pollock K, Hsu T, Tchilian E, Sykes A, Grass L,

Potiphar L, Bremang S, Kon OM, Jacobs WR Jr, Lalvani A. ESX1-dependent

fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in

humans. Tuberculosis (Edinb). 2014 May;94(3):262-70.

Boshier PR, Mistry V, Cushnir JR, Kon OM, Elkin SL, Curtis S, Marczin N, Hanna

GB. Breath metabolite response to major upper gastrointestinal surgery. J Surg

Res. 2015 Feb;193(2):704-12.

Jackson DJ, Makrinioti H, Rana BM, Shamji BW, Trujillo-Torralbo MB, Footitt J,

Jerico Del-Rosario, Telcian AG, Nikonova A, Zhu J, Aniscenko J, Gogsadze L,

Bakhsoliani E, Traub S, Dhariwal J, Porter J, Hunt D, Hunt T, Hunt T, Stanciu LA,

Khaitov M, Bartlett NW, Edwards MR, Kon OM, Mallia P, Papadopoulos NG, Akdis CA,

Westwick J, Edwards MJ, Cousins DJ, Walton RP, Johnston SL. IL-33-dependent type

2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J

Respir Crit Care Med. 2014 Dec 15;190(12):1373-82.

Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley

C, Ito M, Tunstall T, Elkin S, Kon OM, Hansel TT, Paul-Clark MJ. Protocol for a

human in vivo model of acute cigarette smoke inhalation challenge in smokers with

COPD: monitoring the nasal and systemic immune response using a network biology

approach. BMJ Open. 2015 Jan 28;5(1):e005750.

Footitt J, Mallia P, Durham AL, Ho WE, Trujillo-Torralbo MB, Telcian AG, Del

Rosario A, Chang C, Peh HY, Kebadze T, Aniscenko J, Stanciu L, Essilfie-Quaye S,

Ito K, Barnes PJ, Elkin SL, Kon OM, Wong WS, Adcock IM, Johnston SL. Oxidative

and nitrosative stress and histone deacetylase-2 activity in exacerbations of

Chronic Obstructive Pulmonary Disease. Chest. 2015 Mar 19

.

Singanayagam A, Manalan K, Sridhar S, Molyneaux PL, Connell DW, George PM,Kindelerer A, Seneviratne S, Lalvani A, Wickremasinghe M, Kon OM. Evaluation ofscreening methods for identification of patients with chronic rheumatologicaldisease requiring tuberculosis chemoprophylaxis prior to commencement of TNF-αantagonist therapy. Thorax. 2013 Oct;68(10):955-61.

Pollock KM, Whitworth HS, Montamat-Sicotte DJ, Grass L, Cooke GS, Kapembwa MS,

Kon OM, Sampson RD, Taylor GP, Lalvani A. T-cell immunophenotyping distinguishes

active from latent tuberculosis. J Infect Dis. 2013 Sep;208(6):952-68.

Hingley-Wilson SM, Casey R, Connell D, Bremang S, Evans JT, Hawkey PM, Smith

GE, Jepson A, Philip S, Kon OM, Lalvani A. Undetected multidrug-resistanttuberculosis amplified by first-line therapy in mixed infection. Emerg InfectDis. 2013 Jul;19(7):1138-41.

Thillai M, Eberhardt C, Lewin AM, Potiphar L, Hingley-Wilson S, Sridhar S,Macintyre J, Kon OM, Wickremasinghe M, Wells A, Weeks ME, Mitchell D, Lalvani A. Sarcoidosis and tuberculosis cytokine profiles: indistinguishable inbronchoalveolar lavage but different in blood. PLoS One. 2012;7(7):e38083.

Pareek M, Bond M, Shorey J, Seneviratne S, Guy M, White P, Lalvani A, Kon OM.

Community-based evaluation of immigrant tuberculosis screening using interferon γ

release assays and tuberculin skin testing: observational study and economicanalysis. Thorax. 2013 Mar;68(3):230-9.

Singanayagam A, Sridhar S, Dhariwal J, Abdel-Aziz D, Munro K, Connell DW,

George PM, Molyneaux PL, Cooke GS, Burroughs AK, Lalvani A, Wickremasinghe M, Kon

OM. A comparison between two strategies for monitoring hepatic function during

antituberculous therapy. Am J Respir Crit Care Med. 2012 Mar 15;185(6):653-9.

George PM, Mehta M, Dhariwal J, Singanayagam A, Raphael CE, Salmasi M, Connell

DW, Molyneaux P, Wickremasinghe M, Jepson A, Kon OM. Post-bronchoscopy sputum:

Improving the diagnostic yield in smear negative pulmonary TB. Respir Med. 2011

Aug 12.

Navani N, Molyneaux PL, Breen RA, Connell DW, Jepson A, Nankivell M, Brown JM,

Morris-Jones S, Ng B, Wickremasinghe M, Lalvani A, Rintoul RC, Santis G, Kon OM,

Janes SM. Utility of endobronchial ultrasound-guided transbronchial needleaspiration in patients with tuberculous intrathoracic lymphadenopathy: amulticentre study. Thorax. 2011 Aug 3.

Sturdy A, Goodman A, José RJ, Loyse A, O'Donoghue M, Kon OM, Dedicoat MJ,Harrison TS, John L, Lipman M, Cooke GS. Multidrug-resistant tuberculosis(MDR-TB) treatment in the UK: a study of injectable use and toxicity in practice.J Antimicrob Chemother. 2011 Aug;66(8):1815-20.

Montamat-Sicotte DJ, Millington KA, Willcox CR, Hingley-Wilson S, Hackforth S,Innes J, Kon OM, Lammas DA, Minnikin DE, Besra GS, Willcox BE, Lalvani A. Amycolic acid-specific CD1-restricted T cell population contributes to acute andmemory immune responses in human tuberculosis infection. J Clin Invest. 2011 Jun 1;121(6):2493-503.

Pareek M, Watson JP, Ormerod LP, Kon OM, Woltmann G, White PJ, Abubakar I,Lalvani A. Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis. Lancet Infect Dis. 2011Jun;11(6):435-44.

McNab FW, Berry MP, Graham CM, Bloch SA, Oni T, Wilkinson KA, Wilkinson RJ,

Kon OM, Banchereau J, Chaussabel D, O'Garra A. Programmed death ligand 1 is

over-expressed by neutrophils in the blood of patients with active tuberculosis.

Eur J Immunol. 2011 Jul;41(7):1941-7.

Millington KA, Fortune SM, Low J, Garces A, Hingley-Wilson SM, Wickremasinghe

M, Kon OM, Lalvani A. Rv3615c is a highly immunodominant RD1 (Region of

Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis

infection. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5730-5.

Casey R, Blumenkrantz D, Millington K, Montamat-Sicotte D, Kon OM,

Wickremasinghe M, Bremang S, Magtoto M, Sridhar S, Connell D, Lalvani A.

Enumeration of functional T-cell subsets by fluorescence-immunospot defines

signatures of pathogen burden in tuberculosis. PLoS One. 2010 Dec

14;5(12):e15619.

Connell DW, Singanayagam A, Charif R, George PM, Molyneaux PL, McCrudden C,

Magtoto M, Harden E, Seneviratne SL, Duncan ND, Kon OM. A comparison between

interferon gamma release assays and the tuberculin skin test in the contact

tracing of patients with chronic kidney disease. Thorax. 2011 Aug;66(8):729-30.

Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T, Wilkinson KA,

Banchereau R, Skinner J, Wilkinson RJ, Quinn C, Blankenship D, Dhawan R, Cush JJ,

Mejias A, Ramilo O, Kon OM, Pascual V, Banchereau J, Chaussabel D, O'Garra A. An

interferon-inducible neutrophil-driven blood transcriptional signature in human

tuberculosis. Nature. 2010 Aug 19;466(7309):973-7.

Hawkey CR, Yap T, Pereira J, Moore DA, Davidson RN, Pasvol G, Kon OM, Wall RA, Wilkinson RJ. Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis. Clin Infect Dis. 2005 May 1;40(9):1368-71.