Project Leader Anthony M. HEAPE, Ph. D., Docent.1
CIVIL STATUS
1Surname :HEAPEFirst names :Martin Anthony
2Date of birth :1st November 1956
Place of birth :Solihull, England
3Nationality :British
4Family status :Married, three children
5Personal AddressProfessional Address
Hanhikaari 12 A2Department of Anatomy & Cell Biology
90240 OuluPL 5000 (Aapistie 7)
FINLAND90014 University of Oulu
FINLAND
Tel. (+358) 08 377665Tel.(+358) 08 537 51 97
E-mail. Fax.(+358) 08 537 51 72
Web.
CURRICULUM VITAE
6. EDUCATION, DIPLOMAS AND TRAINING
YearActivity
1980Diploma of General University Studies (D.E.U.G., option B) in Natural and Life Sciences. University of Bordeaux II (Bordeaux, France).
1981Bachelor of Biochemistry. University of Bordeaux II (Bordeaux, France).
1982Master of Biochemistry. University of Bordeaux II (Bordeaux, France).
1983Licenciate (Diplôme d’Etudes.Approfondies) in Cellular and Molecular Biology Research. University of Bordeaux II (Bordeaux, France).
Research project carried out in the Laboratory of Membrane Biogenesis [Dir.: Professor Claude Cassagne] at the Institut de Biochimie Cellulaire et Neurochimie [I.B.C.N.] of the Centre National de la Recherche Scientifique [C.N.R.S.] (Bordeaux, France).
Theme of the research project: In vivo study of myelin biogenesis in the peripheral nervous system of normal mice. Comparison with the Trembler mutant mouse.
1983 - 1988Research program for Ph.D. degree in Biochemistry carried out in the Laboratory of Membrane Biogenesis [Dir : Professor Claude Cassagne] at the I.B.C.N.-C.N.R.S (Bordeaux, France).
Title of the research program: Biochemical study of myelinogenesis in the peripheral nervous system of normal mice; Pathological modifications in the neurological Trembler mutant. Developmental and in vivo cellular approaches.
Presentation of my Ph.D. thesis on 29th June 1988. University of Bordeaux II (Bordeaux, France).
April 1997Docentship in Biochemistry/Neurochemistry of Oulu University Faculty of Sciences, Dept. of Biochemistry (Oulu, Finland).
GRANTS AWARDED DURING TRAINING
1982 - 1983Study grant from the Academy of Bordeaux (Bordeaux, France).
1983 - 1986Scholarship grant from the Minister of Research and Industry (France).
1988Research grant from the Medical Research Foundation (F.R.M., France) from Jan - Feb 1988.
7. PRESENT POSITION AND FUNDING (Salaries)
1st March 1995-31 July 2004 (9 years 5 months):
Senior Scientist/Senior Assistant (University of Oulu, Finland). Project Leader of The Myelin Group. Funding (salary) during this period was from the following sources:
Mar-Aug 1995:Pathology Dept., Oulu Central Hospital. Senior Scientist.
Aug-Dec 1995:Pathology Dept., Oulu University. Senior Scientist.
1996:Finnish Academy “Returning scientist’s grant”. Senior Scientist.
1997-2001:Pathology Dept., Oulu University. Senior Scientist.
Jan-Apr 2002Pathology Dept., Oulu Central Hospital. Senior Scientist.
May 2002-Aug 2003Pathology Dept. Oulu University. Senior Scientist.
Sept-Dec 2003Anatomy Dept. Oulu University. Senior Assistant.
Jan-Mar 2004Medical Faculty & University of Oulu: Senior Scientist (Anatomy Dept, Oulu).
Apr-Jul 2004Tekes: Project Manager/Principal Investigator (Anatomy Dept, Oulu)
1st Aug 2004 - OngoingResearch Fellow of the Academy of Finland
8a. PRESENT FIELD OF RESEARCH AND PROJECT FUNDING
Research
I am currently Project Leader of The Myelin Group at the Dept. of Anatomy, University of Oulu. The research program of The Myelin Group (see web site at: aims to contribute to our understanding of myelin formation, maintenance and disease through the identification and elucidation of the roles of functional relationships between myelin components and their ligands, on the one hand, and through the identification and analysis of gene expression networks involved in the terminal differentiation of myelinating glial cells, on the other hand. This project thus aims to expand our knowledge of molecular and cellular aspects of myelin formation and maintenance in the nervous system, providing the basis for gaining further insight into the mechanisms involved in the development of human demyelinating diseases. Our research in the first domain (Protein-ligand interactions) is primarily, but not exclusively, focused on MAG, which is one of the few myelin-specific proteins to be expressed in both the CNS and the PNS. The approaches employed include molecular and cell biology, protein chemistry and structural biochemistry. Our research in the second domain (Gene and protein expression networks) exploits our myelinating co-culture model, the availability of numerous, well-defined mouse myelin mutants, as well as cDNA microarray technology, functional proteomics and systems biology, to identify and analyse the differentiation-dependent expression of myelin component functional networks. This second research domain is performed as a cooperative venture with the Myelination & Myelin Disease Consortium (MMDC), of which I am the Coordinator. In collaboration with the Bioworld Oulu Project, Bioforum Oulu and Medipolis GMP (Oulu), I am also establishing a Cell Banking service for the large-scale production and maintenance of Primary Glial Cell Banks in Oulu.
Funding: 1995-2003
The Myelin Group research project and team members have received funding (research appropriations and personal grants) from: the Finnish Academy, Health Research Council, Oulu Central Hospital (k-evo), Maud Kuistila Foundation, Finnish Multiple Sclerosis Foundation, Emil Aaltonen Foundation and Paolo Foundation.
Current Funding
2004-2006:Tekes NeoBio program.
2004-2009:Finnish Academy (Health Research Council)
8b. SUMMARY OF PREVIOUS RESEARCH ACTIVITY
LABORATORY OF MEMBRANE BIOGENESIS OF THE C.N.R.S. (Bordeaux, France). Developmental and in vivo metabolic approaches to myelin biogenesis in the peripheral nervous system and its pathological modifications in the case of a dysmyelinating mutant: the Trembler mouse.
BIOCENTER OULU AND DEPARTMENT OF CLINICAL CHEMISTRY (Oulu, Finland). Effect of the human Prostate-specific Acid Phosphatase on growth factor-dependent tyrosine phosphorylation in androgen-dependent and androgen-insensitive prostate cancer epithelial cell lines.
9. PREVIOUS PROFESSIONAL APPOINTMENTS
1986-1987Assistant in the department of Biochemistry and Cellular Biology of the University of Bordeaux II (Bordeaux, France). (1 year).
1 March 1988Recruited by the C.N.R.S. as scientist (C.R.2, stable position) at the I.B.C.N. (Bordeaux, France).
1988 - 1990Scientist in the Laboratory of Membrane Biogenesis [Dir: Professor Claude Cassagne] at the I.B.C.N.-C.N.R.S. until 15th March 1990. (2 years).
1990 - 1992Detachment from the C.N.R.S. for postdoctoral leave at the Biocenter Oulu and Dept. of Clinical Chemistry (Oulu, Finland), from 1st April 1990 - 30th April 1992. Funding from the Sigrid Jusélius Foundation (Finland). (2 years 1 month).
29 July 1991Promoted to Senior Scientist (C.R.1, stable position) of the C.N.R.S. (France).
1992 - 1995Reintegration of Senior Scientist position in the Laboratory of Membrane Biogenesis at the C.N.R.S-University of Bordeaux (France). (2 years 10 months).
28 Feb 1995Indefinite leave of absence from the C.N.R.S. (renewal on request every two years).
10. TEACHING AND TRAINING EXPERIENCE
In France
1986-1987:Assistant in the department of Biochemistry and Cellular Biology of the University of Bordeaux II (Bordeaux), responsible for Biophysics tutorial and practical work teaching to Masters students, and participating in Biochemistry practical work teaching to B.Sc. students.
1987-1988:Participation in the training of a licenciate (first year of Ph.D. research training) student (Généviève Freyburger, M.D.) studying the correlations between the blood lipid composition and diabetes in Man, in collaboration with the laboratory of Prof. M. Boisseau (Regional Hospital Center, Bordeaux).
1989-1990:Supervisor of the training of a licenciate student (Régis Léonard, M.Sc.) studying in vivo peripheral nerve lipid metabolism in the Laboratory of Membrane Biogenesis (C.N.R.S., University of Bordeaux).
1993-1994:Participation in the training of a licenciate student (Isabelle Bigou, M.Sc.) studying intermembrane lipid transport in peripheral nerves in vitro in the Laboratory of Membrane Biogenesis (C.N.R.S., University of Bordeaux).
In Finland
1995-2000:Supervisor of a doctoral student (Petri Kursula, M.Sc.) studying the role of the Myelin-Associated Glycoprotein in the peripheral nervous system (Myelin Group, Department of Pathology, Oulu University). Ph. D. thesis defended in June 2000.
1996-1997:In collaboration with Professor Frej Stenbäck, I participated in the training of a graduate student (Heikki Ahola) charged with optimizing a PCR-SSCP method for the detection of mutations of the p53 gene in mouse skin tumours (Department of Pathology, Oulu University).
1997-1998:Supervisor of the Pro-graduate Research project of a Biochemistry student (Gitte Tikkanen) studying the homodimerisation domain of the L-MAGCT (Myelin Group, Department of Pathology, Oulu University).
1998:Supervisor of the two-month (1st June-31st July) research project of a SOCRATES exchange medical student (Nosi Owens, Cardiff University, Wales). Study of the human S-MAGCT dimorphism (Myelin Group, Department of Pathology, Oulu University).
2001-2002:Supervisor of the Pro-graduate Research project of a Biochemistry student (Mervi Yliantilla) studying the homodimerisation domain of the L-MAGCT (Myelin Group, Department of Pathology, Oulu University).
2001-ongoing:Supervisor of a doctoral (Ph.D.) student (Satu Päiväläinen, M.Sc.) studying the temporo-spatial expression of the two MAG isoforms and their ligands, and the relevence of the interactions to myelin formation and maintenance (Myelin Group, Depts of Pathology and Anatomy, Oulu University).
2002-ongoing:Supervisor of a doctoral (Ph.D.) student (Outi Lahti, M.Sc.) studying protein functional networks involved in myelination (Myelin Group, Depts of Pathology and Anatomy, Oulu University).
2004-ongoing:Supervisor of a doctoral (Ph.D.) student (Henrika Honkanen, M.Sc.) studying the ligands and roles of the two MAG isoforms (Myelin Group, Dept of Anatomy, Oulu University).
11. RESEARCH AWARDS, HONOURS & MAJOR GRANTS
1983 – 1986:Four-year scholarship grant from the Minister of Research and Industry (France).
1996:Finnish Academy “Returning scientist’s grant” (Health Research Council).
2001 - 2003:Three-year research appropriation from the Finnish Academy (Health Research Council).
2004 - 2005Tekes NeoBio Program.
2006 - 2007Tekes
2004 - 2009Finnish Academy (Health Research Council)
12. MEMBERSHIPS IN SCIENTIFIC SOCIETIES
since 1995:Member of the Societas biochemica, biophysica et microbiologica Fenniae, and the Oulu Biochemists’ Society.
since 1998:Member of the Society for Neurosciences (SfN).
since 2002:Member of the Peripheral Nerve Society (PNS).
since 2005:Member of the Brain Research Society of Finland (BRSF)
since 2005:Member of the Federation of European Neuroscience Societies (FENS)
13. OTHER PROFESSIONAL ACTIVITIES & EXPERT DUTIES
1999:Coordinator of a seven-group European Consortium (Fifth Framework Program 1998-2002, Quality of Life and Management of Living Resources) for the development of a project proposal entitled: “Glycoproteins, glycolipids and associated bioactive molecules in myelination and myelin disorders”.
1999-2001:Participant (Mentor) in the Mentor/Aktor program for undergraduate students of the Biochemistry Department (Oulu University, Finland).
2002 Scientific evaluator for the application of Christine Engblom (Åbo Academy, Finland) for a Docentship in Neurochemistry.
2003-2004Co-chairman of the ESF-sponsored MARIE (Myelin Autoimmunity Research In Europe) Network Steering Committee.
2003-ongoingEditor for the International Journal of Circumpolar Health.
2003-ongoingProject Manager and Chairman of the Steering Committee of the Myelination & Myelin Disease Consortium (MMDC) for studying the expression of protein functional networks during myelin formation, maintenance and disease.
2003-ongoingDirector of a pilot primary cell production and related services project.
2004Reviewer of the Ph.D. thesis (Biochemistry) of Petra Furu (née Nygårdas), Åbo Academy, Finland.
2006-2007Reviewer (active) for the European Science Foundation (ESF).
Referee duties for international science journals: European Journal of Neurochemistry (3), Biochimica et Biophysica Acta, FEBS Letters, Journal of Histochemistry, Journal of Neuroscience Research, Journal of Neurochemistry.
LANGUAGES
English - French:Perfectly bilingual (spoken - written - read). Finnish:Working knowledge (spoken – read)