APPENDIX
Multivariable Cox Regression Models for 90-day Mortality According ST-recovery Measures
(n=4780; 86 pts excluded for missing data)
Table A1. Single-lead ST-E (50%)
Wald / HR / 95%CI / p-valueAge (10 years) / 109.90 / 2.21 / 1.91 / 2.56 / <0.001
History of diabetes / 1.82 / 1.28 / 0.89 / 1.83 / 0.177
Systolic BP (10mmHg) / 41.26 / 0.74 / 0.68 / 0.81 / <0.001
Heart rate (10bpm, >70bpm) / 27.85 / 1.39 / 1.23 / 1.57 / <0.001
Heart rate (10bpm, ≤70bpm) / 0.24 / 1.07 / 0.81 / 1.42 / 0.621
Killip>2 on admission / 13.75 / 2.70 / 1.60 / 4.56 / <0.001
Baseline ∑ST-deviation (10mm) / 12.15 / 1.30 / 1.12 / 1.51 / <0.001
Inferior MI / 4.80 / 1.48 / 1.04 / 2.11 / 0.028
Major cardiac rhythm disturbances prior to PCI / 19.09 / 2.36 / 1.61 / 3.48 / <0.001
Shock or CHF prior to PCI / 8.93 / 2.35 / 1.34 / 4.13 / 0.003
Pre-PCI TIMI 0/1 / 5.45 / 1.71 / 1.09 / 2.67 / 0.020
Sx onset to PCI (1h, ≤3h) / 7.18 / 1.82 / 1.18 / 2.83 / 0.007
Sx onset to PCI (1h, >3h) / 1.30 / 1.06 / 0.96 / 1.17 / 0.254
Post-PCI TIMI Flow 2/3 / 20.85 / 0.30 / 0.18 / 0.50 / <0.001
Single-lead ST-E (ref:≥50%) / 23.07 / 2.24 / 1.61 / 3.12 / <0.001
Table A2. Single-lead ST-E (30%, 70%)
Wald / HR / 95%CI / p-valueAge (10 years) / 107.44 / 2.19 / 1.89 / 2.53 / <0.001
History of diabetes / 2.02 / 1.30 / 0.91 / 1.86 / 0.155
Systolic BP (10mmHg) / 39.35 / 0.75 / 0.68 / 0.82 / <0.001
Heart rate (10bpm, >70bpm) / 26.16 / 1.37 / 1.22 / 1.55 / <0.001
Heart rate (10bpm, ≤70bpm) / 0.35 / 1.09 / 0.82 / 1.44 / 0.556
Killip>2 on admission / 14.36 / 2.77 / 1.64 / 4.69 / <0.001
Baseline ∑ST-deviation (10mm) / 11.55 / 1.30 / 1.12 / 1.50 / 0.001
Inferior MI / 5.44 / 1.52 / 1.07 / 2.17 / 0.020
Major cardiac rhythm disturbances prior to PCI / 18.83 / 2.36 / 1.60 / 3.47 / <0.001
Shock or CHF prior to PCI / 8.25 / 2.28 / 1.30 / 3.99 / 0.004
Pre-PCI TIMI 0/1 / 5.72 / 1.73 / 1.10 / 2.71 / 0.017
Sx onset to PCI (1h, ≤3h) / 7.39 / 1.84 / 1.19 / 2.85 / 0.007
Sx onset to PCI (1h, >3h) / 1.22 / 1.06 / 0.96 / 1.16 / 0.270
Post-PCI TIMI Flow 2/3 / 20.87 / 0.30 / 0.18 / 0.50 / <0.001
Single-lead ST-E (ref:≥70%) / 18.52 / <0.001
<30% / 2.26 / 1.51 / 3.39
30% to <70% / 1.03 / 0.72 / 1.47
Table A3. ∑ST-E (50%)
Wald / HR / 95%CI / p-valueAge (10 years) / 101.21 / 2.15 / 1.85 / 2.50 / <0.001
History of diabetes / 1.34 / 1.24 / 0.86 / 1.77 / 0.247
Systolic BP (10mmHg) / 40.24 / 0.74 / 0.68 / 0.81 / <0.001
Heart rate (10bpm, >70bpm) / 29.07 / 1.40 / 1.24 / 1.58 / <0.001
Heart rate (10bpm, ≤70bpm) / 0.30 / 1.08 / 0.82 / 1.43 / 0.583
Killip>2 on admission / 18.26 / 3.11 / 1.85 / 5.22 / <0.001
Baseline ∑ST-deviation (10mm) / 12.63 / 1.31 / 1.13 / 1.52 / <0.001
Inferior MI / 4.11 / 1.43 / 1.01 / 2.03 / 0.043
Major cardiac rhythm disturbances prior to PCI / 17.21 / 2.26 / 1.54 / 3.33 / <0.001
Shock or CHF prior to PCI / 7.06 / 2.15 / 1.22 / 3.77 / 0.008
Pre-PCI TIMI 0/1 / 4.72 / 1.65 / 1.05 / 2.59 / 0.030
Sx onset to PCI (1h, ≤3h) / 6.08 / 1.74 / 1.12 / 2.71 / 0.014
Sx onset to PCI (1h, >3h) / 0.84 / 1.05 / 0.95 / 1.16 / 0.360
Post-PCI TIMI Flow 2/3 / 33.73 / 0.36 / 0.26 / 0.51 / <0.001
∑ST-E <50% (ref:≥50%) / 15.72 / 1.92 / 1.39 / 2.65 / <0.001
Table A4. ∑ST-E (30%, 70%)
Wald / HR / 95%CI / p-valueAge (10 years) / 107.64 / 2.19 / 1.89 / 2.54 / <0.001
History of diabetes / 1.89 / 1.29 / 0.90 / 1.85 / 0.169
Systolic BP (10mmHg) / 38.98 / 0.75 / 0.68 / 0.82 / <0.001
Heart rate (10bpm, >70bpm) / 25.93 / 1.37 / 1.21 / 1.55 / <0.001
Heart rate (10bpm, ≤70bpm) / 0.28 / 1.08 / 0.82 / 1.43 / 0.598
Killip>2 on admission / 14.19 / 2.74 / 1.62 / 4.62 / <0.001
Baseline ∑ST-deviation (10mm) / 13.70 / 1.33 / 1.14 / 1.55 / <0.001
Inferior MI / 4.60 / 1.48 / 1.03 / 2.12 / 0.032
Major cardiac rhythm disturbances prior to PCI / 19.55 / 2.39 / 1.63 / 3.52 / <0.001
Shock or CHF prior to PCI / 7.76 / 2.25 / 1.27 / 3.97 / 0.005
Pre-PCI TIMI 0/1 / 5.82 / 1.74 / 1.11 / 2.73 / 0.016
Sx onset to PCI (1h, ≤3h) / 7.33 / 1.83 / 1.18 / 2.84 / 0.007
Sx onset to PCI (1h, >3h) / 1.28 / 1.06 / 0.96 / 1.16 / 0.258
Post-PCI TIMI Flow 2/3 / 20.29 / 0.30 / 0.18 / 0.51 / <0.001
∑ST-E (ref:≥70%) / 12.78 / 0.002
<30% / 2.07 / 1.37 / 3.15
30% to <70% / 1.19 / 0.81 / 1.73
Table A5. ∑ST-D (30%, 70%)
Age (10 years) / 105.86 / 2.18 / 1.88 / 2.53 / <0.001
History of diabetes / 1.91 / 1.29 / 0.90 / 1.85 / 0.167
Systolic BP (10mmHg) / 39.07 / 0.75 / 0.68 / 0.82 / <0.001
Heart rate (10bpm, >70bpm) / 26.16 / 1.37 / 1.22 / 1.55 / <0.001
Heart rate (10bpm, ≤70bpm) / 0.20 / 1.07 / 0.81 / 1.41 / 0.655
Killip>2 on admission / 13.97 / 2.70 / 1.61 / 4.56 / <0.001
Baseline ∑ST-deviation (10mm) / 14.94 / 1.34 / 1.16 / 1.56 / <0.001
Inferior MI / 4.22 / 0.69 / 0.48 / 0.98 / 0.040
Major cardiac rhythm disturbances prior to PCI / 19.79 / 2.39 / 1.63 / 3.51 / <0.001
Shock or CHF prior to PCI / 8.32 / 2.31 / 1.31 / 4.08 / 0.004
Pre-PCI TIMI 0/1 / 5.70 / 1.73 / 1.10 / 2.71 / 0.017
Sx onset to PCI (1h, ≤3h) / 7.22 / 1.83 / 1.18 / 2.84 / 0.007
Sx onset to PCI (1h, >3h) / 1.69 / 1.06 / 0.97 / 1.17 / 0.193
Post-PCI TIMI Flow 2/3 / 20.15 / 0.30 / 0.18 / 0.51 / <0.001
∑ST-D resolution (ref:≥70%) / 20.16 / <0.001
<30% / 2.46 / 1.63 / 3.71
30% to <70% / 1.24 / 0.85 / 1.80
Table A6. Worst-lead residual ST-E
Wald / HR / 95%CI / p-valueAge (10 years) / 107.69 / 2.20 / 1.89 / 2.55 / <0.001
History of diabetes / 1.49 / 1.25 / 0.87 / 1.80 / 0.222
Systolic BP (10mmHg) / 39.05 / 0.75 / 0.68 / 0.82 / <0.001
Heart rate (10bpm, >70bpm) / 23.85 / 1.35 / 1.20 / 1.53 / <0.001
Heart rate (10bpm, ≤70bpm) / 0.33 / 1.09 / 0.82 / 1.44 / 0.563
Killip>2 on admission / 16.42 / 2.96 / 1.75 / 5.00 / <0.001
Baseline ∑ST-deviation (10mm) / 3.67 / 1.16 / 1.00 / 1.36 / 0.055
Inferior MI / 2.97 / 1.38 / 0.96 / 1.98 / 0.085
Major cardiac rhythm disturbances prior to PCI / 20.46 / 2.44 / 1.66 / 3.59 / <0.001
Shock or CHF prior to PCI / 6.79 / 2.12 / 1.20 / 3.72 / 0.009
Pre-PCI TIMI 0/1 / 5.17 / 1.69 / 1.08 / 2.65 / 0.023
Sx onset to PCI (1h, ≤3h) / 6.75 / 1.80 / 1.16 / 2.81 / 0.009
Sx onset to PCI (1h, >3h) / 1.55 / 1.06 / 0.97 / 1.17 / 0.214
Post-PCI TIMI Flow 2/3 / 22.99 / 0.28 / 0.17 / 0.47 / <0.001
Worst-lead residual ST-E (ref:<1mm) / 15.72 / <0.001
1-<2mm / 1.23 / 0.74 / 2.03
≥2mm / 2.22 / 1.35 / 3.65
Multivariable Cox Regression Models for 90-day Death/CHF/Shock for ST-recovery Measures
(n=4691; 78 pts excluded missing data)
Table A7. Single-lead ST-E (50%)
Wald / HR / 95%CI / p-valueAge (10 years) / 122.46 / 1.86 / 1.67 / 2.08 / <0.001
Female / 7.63 / 1.40 / 1.10 / 1.77 / 0.006
Prior MI / 7.89 / 1.53 / 1.14 / 2.05 / 0.005
History of diabetes / 4.82 / 1.34 / 1.03 / 1.73 / 0.028
Heart rate (10 bpm, >70bpm) / 46.26 / 1.37 / 1.25 / 1.49 / <0.001
Heart rate (10 bpm, ≤70bpm) / 0.18 / 1.05 / 0.84 / 1.30 / 0.669
Systolic BP (10mmHg) / 18.53 / 0.85 / 0.79 / 0.92 / 0.000
Killip>2 on admission / 11.57 / 2.28 / 1.42 / 3.67 / 0.001
Baseline ∑ST-deviation (10mm) / 35.57 / 1.35 / 1.23 / 1.50 / <0.001
MCRD prior to PCI / 4.54 / 1.47 / 1.03 / 2.10 / 0.033
LAD-IRA / 37.01 / 2.16 / 1.69 / 2.77 / <0.001
Multivessel disease / 11.40 / 1.47 / 1.17 / 1.83 / 0.001
Pre-PCI TIMI 0/1 / 11.86 / 1.69 / 1.25 / 2.27 / 0.001
Sx onset to PCI (1h, ≤3h) / 7.42 / 1.53 / 1.13 / 2.07 / 0.006
Sx onset to PCI (1h, >3h) / 0.49 / 1.03 / 0.95 / 1.11 / 0.483
Post-PCI TIMI Flow 2/3 / 7.15 / 0.51 / 0.31 / 0.83 / 0.008
Single-lead ST-E (ref:≥50%) / 14.55 / 1.60 / 1.26 / 2.04 / <0.001
Table A8. Single-lead ST-E (30%, 70%)
Wald / HR / 95%CI / p-valueAge (10 years) / 120.69 / 1.85 / 1.66 / 2.07 / <0.001
Female / 8.34 / 1.42 / 1.12 / 1.80 / 0.004
Prior MI / 8.30 / 1.54 / 1.15 / 2.07 / 0.004
History of diabetes / 4.61 / 1.33 / 1.03 / 1.72 / 0.032
Heart rate (10 bpm, >70bpm) / 43.80 / 1.35 / 1.24 / 1.48 / <0.001
Heart rate (10 bpm, ≤70bpm) / 0.19 / 1.05 / 0.85 / 1.30 / 0.664
Systolic BP (10mmHg) / 17.98 / 0.85 / 0.79 / 0.92 / <0.001
Killip>2 on admission / 11.16 / 2.25 / 1.40 / 3.63 / 0.001
Baseline ∑ST-deviation (10mm) / 38.08 / 1.37 / 1.24 / 1.51 / <0.001
MCRD prior to PCI / 4.66 / 1.48 / 1.04 / 2.11 / 0.031
LAD-IRA / 34.85 / 2.13 / 1.66 / 2.74 / <0.001
Multivessel disease / 11.16 / 1.46 / 1.17 / 1.82 / 0.001
Pre-PCI TIMI 0/1 / 11.88 / 1.69 / 1.25 / 2.28 / 0.001
Sx onset to PCI (1h, ≤3h) / 7.15 / 1.52 / 1.12 / 2.05 / 0.008
Sx onset to PCI (1h, >3h) / 0.41 / 1.03 / 0.95 / 1.11 / 0.520
Post-PCI TIMI Flow 2/3 / 6.83 / 0.51 / 0.31 / 0.85 / 0.009
Single-lead ST-E (ref:≥70%) / 23.28 / <0.001
<30% / 1.97 / 1.47 / 2.65
30% to <70% / 1.04 / 0.81 / 1.34
Table A9. ∑ST-E (50%)
Wald / HR / 95%CI / p-valueAge (10 years) / 120.91 / 1.86 / 1.66 / 2.07 / 0.000
Female / 7.11 / 1.38 / 1.09 / 1.76 / 0.008
Prior MI / 8.72 / 1.56 / 1.16 / 2.09 / 0.003
History of diabetes / 4.38 / 1.32 / 1.02 / 1.70 / 0.036
Heart rate (10 bpm, >70bpm) / 45.89 / 1.36 / 1.25 / 1.49 / 0.000
Heart rate (10 bpm, ≤70bpm) / 0.12 / 1.04 / 0.84 / 1.29 / 0.731
Systolic BP (10mmHg) / 17.22 / 0.86 / 0.80 / 0.92 / 0.000
Killip>2 on admission / 13.06 / 2.39 / 1.49 / 3.84 / 0.000
Baseline ∑ST-deviation (10mm) / 40.87 / 1.39 / 1.26 / 1.53 / 0.000
MCRD prior to PCI / 4.42 / 1.46 / 1.03 / 2.09 / 0.035
LAD-IRA / 31.70 / 2.06 / 1.60 / 2.64 / 0.000
Multivessel disease / 11.93 / 1.48 / 1.18 / 1.84 / 0.001
Pre-PCI TIMI 0/1 / 11.71 / 1.68 / 1.25 / 2.27 / 0.001
Sx onset to PCI (1h, ≤3h) / 7.23 / 1.52 / 1.12 / 2.06 / 0.007
Sx onset to PCI (1h, >3h) / 0.41 / 1.03 / 0.95 / 1.11 / 0.522
Post-PCI TIMI Flow 2/3 / 6.49 / 0.52 / 0.32 / 0.86 / 0.011
∑ST-E <50% (ref:≥50%) / 19.97 / 1.70 / 1.35 / 2.14 / 0.000
Table A10. ∑ST-E (30%, 70%)
Wald / HR / 95%CI / p-valueAge (10 years) / 122.37 / 1.86 / 1.67 / 2.08 / <0.001
Female / 7.88 / 1.41 / 1.11 / 1.79 / 0.005
Prior MI / 9.58 / 1.59 / 1.19 / 2.13 / 0.002
History of diabetes / 4.02 / 1.30 / 1.01 / 1.69 / 0.045
Heart rate (10 bpm, >70bpm) / 44.84 / 1.36 / 1.24 / 1.49 / <0.001
Heart rate (10 bpm, ≤70bpm) / 0.14 / 1.04 / 0.84 / 1.30 / 0.707
Systolic BP (10mmHg) / 17.73 / 0.86 / 0.80 / 0.92 / <0.001
Killip>2 on admission / 12.21 / 2.32 / 1.45 / 3.73 / <0.001
Baseline ∑ST-deviation (10mm) / 42.54 / 1.40 / 1.27 / 1.55 / <0.001
MCRD prior to PCI / 4.74 / 1.48 / 1.04 / 2.11 / 0.029
LAD-IRA / 29.07 / 2.02 / 1.56 / 2.60 / <0.001
Multivessel disease / 11.98 / 1.48 / 1.19 / 1.85 / 0.001
Pre-PCI TIMI 0/1 / 11.15 / 1.66 / 1.23 / 2.24 / 0.001
Sx onset to PCI (1h, ≤3h) / 6.98 / 1.51 / 1.11 / 2.04 / 0.008
Sx onset to PCI (1h, >3h) / 0.51 / 1.03 / 0.95 / 1.11 / 0.477
Post-PCI TIMI Flow 2/3 / 6.17 / 0.53 / 0.32 / 0.88 / 0.013
∑ST-E (ref:≥70%) / 18.44 / <0.001
<30% / 1.86 / 1.67 / 2.08
30% to <70% / 1.41 / 1.11 / 1.79
Table A11. ∑ST-D (30%, 70%)
Wald / HR / 95%CI / p-valueAge (10 years) / 119.52 / 1.85 / 1.66 / 2.06 / <0.001
Female / 7.85 / 1.41 / 1.11 / 1.78 / 0.005
Prior MI / 9.15 / 1.57 / 1.17 / 2.11 / 0.002
History of diabetes / 3.93 / 1.30 / 1.00 / 1.68 / 0.047
Heart rate (10 bpm, >70bpm) / 44.30 / 1.36 / 1.24 / 1.48 / <0.001
Heart rate (10 bpm, ≤70bpm) / 0.14 / 1.04 / 0.84 / 1.30 / 0.710
Systolic BP (10mmHg) / 16.95 / 0.86 / 0.80 / 0.92 / <0.001
Killip>2 on admission / 11.49 / 2.27 / 1.41 / 3.64 / 0.001
Baseline ∑ST-deviation (10mm) / 42.75 / 1.40 / 1.27 / 1.55 / <0.001
MCRD prior to PCI / 4.44 / 1.46 / 1.03 / 2.08 / 0.035
LAD-IRA / 30.81 / 2.05 / 1.59 / 2.63 / <0.001
Multivessel disease / 11.56 / 1.47 / 1.18 / 1.84 / 0.001
Pre-PCI TIMI 0/1 / 11.21 / 1.67 / 1.24 / 2.25 / 0.001
Sx onset to PCI (1h, ≤3h) / 6.98 / 1.51 / 1.11 / 2.05 / 0.008
Sx onset to PCI (1h, >3h) / 0.63 / 1.03 / 0.96 / 1.11 / 0.428
Post-PCI TIMI Flow 2/3 / 6.29 / 0.53 / 0.32 / 0.87 / 0.012
∑ST-D (ref:≥70%) / 23.45 / <0.001
<30% / 2.06 / 1.53 / 2.77
30% to <70% / 1.26 / 0.97 / 1.64
Table A12. Worst-lead residual ST-E
Wald / HR / 95%CI / p-valueAge (10 years) / 120.58 / 1.85 / 1.66 / 2.06 / <0.001
Female / 8.41 / 1.42 / 1.12 / 1.81 / 0.004
Prior MI / 9.94 / 1.60 / 1.20 / 2.15 / 0.002
History of diabetes / 4.15 / 1.31 / 1.01 / 1.69 / 0.042
Heart rate (10 bpm, >70bpm) / 41.76 / 1.35 / 1.23 / 1.47 / <0.001
Heart rate (10 bpm, ≤70bpm) / 0.24 / 1.06 / 0.85 / 1.31 / 0.626
Systolic BP (10mmHg) / 18.44 / 0.85 / 0.79 / 0.92 / 0.001
Killip>2 on admission / 13.48 / 2.44 / 1.52 / 3.92 / <0.001
Baseline ∑ST-deviation (10mm) / 16.21 / 1.24 / 1.12 / 1.38 / <0.001
MCRD prior to PCI / 4.85 / 1.49 / 1.05 / 2.13 / 0.028
LAD-IRA / 23.44 / 1.89 / 1.46 / 2.45 / <0.001
Multivessel disease / 11.03 / 1.46 / 1.17 / 1.82 / 0.001
Pre-PCI TIMI 0/1 / 9.07 / 1.59 / 1.18 / 2.14 / 0.003
Sx onset to PCI (1h, ≤3h) / 6.22 / 1.48 / 1.09 / 2.01 / 0.013
Sx onset to PCI (1h, >3h) / 0.78 / 1.04 / 0.96 / 1.12 / 0.378
Post-PCI TIMI Flow 2/3 / 6.40 / 0.53 / 0.32 / 0.87 / 0.011
Worst-lead residual ST-E (ref:<1mm) / 22.22 / <0.001
1-<2mm / 1.55 / 1.06 / 2.26
≥2mm / 2.33 / 1.59 / 3.41
1