CURRICULUM VITAE
MATHEW NINAN MD, FRCS(C-Th), FETCS
May 3, 2004
PERSONAL DETAILS
Last Name NINAN
First NameMATHEW
Work AddressVanderbilt University Medical Center
Department of Thoracic Surgery
2971 The Vanderbilt Clinic
Nashville, TN 37232-5734
Date of Birth : 4 July 1962
TelephoneWork (615) 322-0064
Medical Registration:Tennessee Full License MD0000034573
Pennsylvania Full License MD059 598L
Family: Wife : Annie
Daughter : Rebekah
POSITIONS:
July 2000 to presentAssistant Professor (tenure track), Thoracic Surgery
Surgical Oncologist, Vanderbilt-IngramCancerCenter
Surgical Director, Lung Transplant Program
VanderbiltUniversityMedicalCenter
Nashville, Tennessee
July 2002 to present Master of Science in Clinical Investigation
VanderbiltUniversity
TRAINING
January 1999 to June 2000Senior Registrar and Thoracic Transplantation Fellow, University of Leeds, Leeds, U.K.
July 1995 to November 1998Resident Fellow, Cardiothoracic Surgery
University of PittsburghMedicalCenter
Pittsburgh, Pennsylvania
May 1990 to June 1995Resident, General Surgery
St. Thomas’and Harefield Hospital and The BasildonUniversityHospitals,University of London, U.K.
1982 - 1989J.N. Medical College, KarnatakUniversity, and MedicalCollegeHospital, Trivandrum, Kerala, India
GENERAL THORACIC ONCOLOGY SPECIALIST EXPERIENCE
- Thoracic oncology surgeon, VanderbiltUniversity, 2000 to 2004. Was responsible for thoracic surgical care of referrals to VanderbiltUniversityHospital and the VanderbiltIngramCancerCenter, responsible for the Division of Thoracic Surgery as the only thoracic surgeon in Year 2003.
- Special focus on pneumonectomy sparing bronchial and vascular sleeve resections, thoracoscopic lobectomies for early stage lung cancer, minimally invasive esophagectomy.
- Responsible for establishing the Vanderbilt Lung Volume Reduction Surgery Program, the Photodynamic Therapy Program concentrating on treatment of early stage bronchial and esophageal lesions and the Thoracoscopic Lobectomy program
THORACIC TRANSPLATATION EXPERIENCE
- Primary Lung Transplant Surgeon of VanderbiltUniversity. Surgical leadership of the program with major operating responsibilities including chairing weekly assessment meetings, chairing protocol sessions, etc. Survival Statistics – 95% operative 30 day survival for the last 24 transplant operations.
- University of Pittsburgh and University of Leeds: 18 months dedicated thoracic transplantation fellowship training with the transplantation team headed by Dr. Robert Kormos and Dr. Robert Keenan.
- HarefieldHospital: 6 months training with all transplant operations both recipient and donor) at the busiest thoracic transplant center in Europe, with Professor Sir Magdi Yacoub and team
Board Certifications: Cardiothoracic Surgery, Intercollegiate Board, RoyalCollege of Surgeons 1999
Cardiothoracic Surgery, European Board, 2000
Royal College of Surgeons, UK 1992
OPERATIVE EXPERIENCE
Attending Thoracic Surgeon – VanderbiltUniversityMedicalCenter, Nashville, Tennessee – over 950operative cases in three years
ONGOING CLINICAL RESEARCH PROJECTS
Principal Investigator ECOG THO E5597 – A Phase 3 Chemoprevention Trial of Selenium supplementation in persons with resected Stage 1 Non Small Cell Lung Cancer
Principal Investigator ECOG THO S9900 – A Randomized Phase 3 Trial of Surgery Alone or Surgery plus pre-operative Paclitaxel/Carboplatin in Clinical Stage 1B, 2, and selected 3A Non Small Cell Lung Cancer
Co-Principal Investigator COX2 inhibitors and lung cancers (VCC THO 0055) to the National Institutes of Health (NIH).
Principal Investigator ASCOG THO 0177 Detection of Pleural Micrometastasis in Surgically Treated Non Small Cell Lung Cancer
Principal Investigator : Role of Isoprostanes and Isofurans in Post-operative Acute Lung Injury. Scientific project for the MSCI Program, VanderbiltUniversity.
Principal Investigator : Iron Metabolism in Post-operative Acute Lung Injury. Scientific Project for the GCRC, VanderbiltUniversity.
Two outstanding grant applications to HRSA, DHSS (announcement date July 30, 2004)
Principal Investigator CIOP 12560 “Establishment of a non-heart beating lung donor protocol in a tertiary care hospital: an evidence based approach”. Budget: $1,000,000 over 3 years.
Co-Principal Investigator CIOP 12562 “A multimodality approach to transform and salvage lungs determined to be non-transplantable: a prospective randomized controlled study. Budget: $ 1,000,000 over 3 years
AWARDS AND CITATIONS
Awarded the $ 100,000 Discovery Grant at VanderbiltUniversityMedicalCenter, 2002
Awarded the $ 25,000 GCRC Pilot Grant, VanderbiltUniversityMedicalCenter, 2002
Awarded the $150,000 VanderbiltIngramCancerCenter Lung Cancer Surgery Award, 2000 to 2003.
Resident Award – University of PittsburghMedicalCenter. Award financed a six week transplantation fellowship at Harefield Hospital, U.K. 1997
Best Outgoing Student and First Rank Holder 1988J.N.MedicalCollege, Belgaum, India and Karnatak University, India
First Rank Holder 2 MBBS examination, J.N.MedicalCollege and Karnatak University, India
First Class in all Undergraduate Examinations in MedicalSchool
Pearce Memorial Gold Medal for the Best Outstanding Student, LaidlawMemorialHigh School, Ketti, India 1978
MEMBERSHIPS AND ASSOCIATIONS
Fellow, Intercollegiate Board in Cardiothoracic Surgery
Member, American Thoracic Society
Member, American College of Cardiology
Member, American College of Chest Physicians
Member, International Society of Heart and Lung Transplantation
Fellow, Royal College of Surgeons of Edinburgh
BIBLIOGRAPHY
TEXTBOOK CHAPTERS
Roberts JR, Ninan M. Thoracoscopic Resection of Lung Cancer in Atlas of Cancer. Marka, M (ed) Current Medicine 2002.
Ninan M, Myers J. Revision of the Fontan-Kreutzer procedure to total cavopulmonary connection. Pediatric Cardiac Surgery Annual: 182-5, 1997
Ninan M, Luketich JD. Management of bronchopleural, oesophageal and aortic fistulae of the thoracic cavity. In: Oxford Textbook of Critical Care. Eds. Webb A, Shapiro MJ, Singer M, Suter P, 1997
Ninan M, Venn GE, Goldstraw P. Surgical Management of Bullous Lung Disease. In: Textbook of Thoracic surgery. Ed. Goldstraw P., 429-17, 1995
OTHER BIBLIOGRAPHY
Pierre P. Massion, Peter M. Taflan, Yu Shyr, S. M. Jamshedur Rahman, Pinar Yildiz,
Bashar Shakthour, Mary E. Edgerton, Mathew Ninan, Adriana L. Gonzalez: PIK3CA gene copy number and downstream phosphorylated Akt protein expression are involved in lung tumor development. Accepted for publication Am J Resp Crit Care Med, 2004
Carl R. Schmidt, John L. Tarpley, John R. Roberts, MD, A. Scott Pearson, Mark C. Kelley, MD, Mathew Ninan, R. Daniel Beauchamp, Nipun B. Merchant. Complete Response to Neoadjuvant Chemoradiation Therapy forEsophageal Cancer Does Not Improve Survival. Accepted for publication Annals of Surgical Oncology, 2004
Carsten Schröder, Frank Scholl, Emmanuel Daon, Andrea Goodwin, William H. Frist, John R. Roberts, Karla G. Christian,Aaron P. Milstone, Mathew Ninan, James E. Loyd .Modified bronchial anastomosis technique for lung transplantation,The Annals of Thoracic Surgery, Volume 75, Issue 6; 1697-1704, June 2003
Ninan M, et al. Long term outcome following aortocoronary connection for anomalous left coronary artery arising from the pulmonary artery – a twenty four year experience. J Amer. Coll. Cardiology 31(2) Spl. 190A, 1998
Ninan M et al. Standarized exercise oximetry predicts postpneumonectomy outcome.
Annals of Thoracic Surgery 64:328-333, Aug. 1997
Ninan M, Devita M, et al. Novel critical care strategies following minimally invasive lung reduction surgery. J Pennsylvania Ass. Thorac. Surg 8:122-125, 1997
Devita M, Sirio C, Ninan M, Keenan R. Ethical issues in the delivery of ICU care in a managed care era: lessons learned from minimally lung reduction surgery. Am. J. Res. Crit. Care Med. 155(4): 2(2) 1997
O’Keefe PA, Ninan M et al. Aortic valve replacement with the Jyros bileaflet prosthetic valve: early echocardiographic and radiological evaluation. J. Heart Valve Disease. 4 Suppl. 1: S77-9. July 1995
Ninan M. Minimally Invasive strategies for esophageal cancer staging. J Kerala Chapter Ass. Surg. India 15:207-210, Dec 1995
Ninan M, Hunter S, Parker DJ. Aortobronchial fistulae following aortic valve surgery. J Royal Soc. Med. 87(9):558-9, Sept. 1994
Ninan M, Treasure T. Pericardiectomy using ultrasonic dissector. Annals of Thoracic Surgery 58(1):233-5, July 1994
Ninan M, Treasure T. New strategies for coronary revascularization in the nineties. World J Cardiothoracic. Surg., 15:66-69, Feb 1993
Ninan M. Patterns of injury and surgical management of major hepatic injury in South Kerala, 1991. Dissertation accepted by the University of Kerala in partial fulfillment of the Master of Surgery degree
ABSTRACTS
Roman CD, Ninan M, Roberts JR. Parenchymal Sparing Sleeve Resection in Patients with Poor Pulmonary Function. Submitted to Southern Thoracic Surgical Association Annual Meeting, November 2004.
ACADEMIC PRESENTATIONS
Dummer S, Lazariashvili N, Barnes J, Milstone A, Ninan M. Antifungal Management after lung transplantation: survey of 37 Lung Transplant Centers. Presented to the International Society of Heart and Lung Transplantation Annual Meeting, ViennaAustria, 2003
Simian Virus-40 infection causing nephropathy and renal failure following lung transplantation. Milstone A, Vilchez RA, Geiger X, FogoAB, Ninan M, Dummer S. presented to the International Society of Heart and Lung Transplantation Annual Meeting, Vienna, Austria, 2003
Ninan M et al. Ethical issues in the delivery of ICU care in a managed care era: lessons learned from lung reduction surgery. Presented to the Annual Meeting of the American Thoracic Society. San Francisco 1997
Ninan M, Myers JL, et al. Long term outcome following aortocoronary connection for anomalous left coronary artery from the pulmonary artery – a twenty four year experience. Presented to the Annual Meeting of the American College of Cardiology, Atlanta, Georgia, March 1998
Ninan M. et al. Standardized exercise oximetry predicts postpneumonectomy outcome.
Presented to the Southern Thoracic Surgical Association Annual Meeting at Cancun, Mexico. November 1996
Ninan M, et al. Novel critical issues in minimally invasive lung reduction surgery. Presented to the Annual Conference of the Pennsylvania Association of Thoracic Surgery. Quebec City, Canada, 1997
Ninan M, Ferson P. A new minimally invasive staging protocol for esophageal cancer. Presented to the Pittsburgh Cardiothoracic Surgical Forum, Jan 1996
Ninan M, Hunter S, Parker DJ. Aortobronchial fistulae following aortic valve surgery. Presented to the Royal Society of Medicine, London, May 1994
Ninan M. Minimally invasive lung reduction surgery, the Pittsburgh experience. Presented to the faculty and students, Respiratory Care Program, Western School of Health, Pittsburgh, Pennsylvania, April 1996
Ninan M, Ferson P. Minimally invasive strategies for the treatment of lung cancer. Presented to the faculty and students, Respiratory Care Program, Western School of Health, Pittsburgh, Pennsylvania, May 1997
Ninan M, Thomas PA. Immunosuppressive strategies for heart transplantation. Presented to the Faculty of Surgery, Kerala University, India, April 1989
Ninan M. A strategy for minimally invasive cardiac and thoracic surgery in the next decade. Presented to the Medical Faculty, Medical Trust Hospital, Cochin, India, Nov. 1997
Ninan M. Minimally invasive staging criteria for esophageal cancer – early results.
Presented to the Oncology and Surgical Faculty, Regional Cancer Centre, Trivandrum, India, Nov. 1997
Ninan M, Thomas PA. Surgery for intrahepatic biliary lithiasis. Presented to the Annual Meeting of the Kerala Chapter of the Association of Surgeons of India, Sept. 1989
Ninan M. Outcome of patients after minimally invasive lung reduction surgery, the Pittsburgh experience. Presented to the Surgical Faculty, Medical College Hospital, University of Kerala, India, Nov. 1997
O’Keefe PA, Ninan M, et al. Early results of the Jyros valve. Presented to the Heart Valve Replacement – The Second Sheffield Symposium. Oct. 1994
O’Keefe PA, Ninan M, et al. The Jyros bileaflet prosthetic valve: clinical echocardiographic and radiological evaluation. Presented to the Cardiac Surgical Research Club, Nov. 1994
Roberts JR, Ninan M. Minimally invasive thoracoscopic management of empyema thoracis. Presented to the Annual Conference of the Southern Thoracic Surgical Association, San Antonio, Texas. 8 – 12 November 2001.
MAJOR INTERNATIONAL CONFERENCES ATTENDED
European Society of Cardiothoracic Surgery, October 1994, Amsterdam, The Netherlands.
Brompton Cardiothoracic Conference and Course, organized by Sir Magdi Yacoub, London, England, May 1995
The Toronto General Hospital Cardiac Course, Toronto, Canada, April 1996
Southern Thoracic Surgical Association Annual Conference, Cancun, Mexico, November 1996
Annual Conference of the American Thoracic Society, San Francisco, November 1997
Annual Conference of the PA Association of Thoracic Surgery, Quebec City, Canada, 1997
Annual Conference of the AmericanCollege of Cardiology, Atlanta, GA, March 1998.
Hellenic Lung Cancer Conference, Nicosia, Republic of Cyprus, April 1999.
Thoracic Conference of the University of Padua, Italy, March 2000
Annual conference of the American Association of Thoracic Surgery, Toronto, Canada May 2000
Toronto Thoracic Surgical Conference, Toronto, Canada, May 2001
International Society of Heart and Lung Transplantation, WashingtonD.C., April 2002
Society of Thoracic Surgeons Annual Meeting, 2003
Society of Thoracic Surgeons Annual Meeting, Feb 2004, San Antonio, TX