MOLECULAR
______PHARMACOLOGY
April 2004Volume 65Number 4 0026-895X
MINIREVIEW
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Computational Lipidomics: A Multiplexed Analysis of Dynamic Changes in Membrane Lipk Composition during Signal. Transduction
Jeffrey S. Forrester, Stephen B. Milne, Paulina T. Ivanova, and H. Alex Brown813
PERSPECTIVE
Scaffolds Direct Src-Specific Signaling in Response to Angiotensin II: New Roles for Cas and GIT1
Kanchana Natarajan, Guoyong Yin, and Bradford C. Berk H822
ACCELERATED COMMUNICATION
An Active and Water-Soluble Truncation Mutant of the Human UDP-Glucuronosyltransferase 1A9
Mika Kurkela, Saila Morsky, Jouni Hirvonen, Risto Kostiainen, and Moshe Finel826
ARTICLES
I Src and Cas Are Essentially but Differentially Involved in Angiotensin II-Stimulated Migration of Vascular Smooth Muscle Cells via Extracellular Signal-Regulated Kinase 1/2 and c-Jun NH2-Terminal Kinase Activation
Moe Kyaw, Masanori Yoshizumi, Koichiro Tsuchiya, Shoji Kagami, Yuki Izawa, Yoshiko Fujita,
Nermin AH, Yasuhisa Kanematsu, Kazunori Toida, Kazunori Ishimura, and Toshiaki Tamaki832
Differential Roles of Arg97, Asp293, and ArglO8 in Enzyme Stability and Substrate Specificity of
CYP2C9
Leslie J. Dickmann, Charles W. Locuson, Jeffrey P. Jones, and Allan E. Rettie842
Nitric Oxide (NO) Scavenging and NO Protecting Effects of Quercetin and Their Biological Significance in Vascular Smooth Muscle
Gustavo Lopez-Lopez, Laura Moreno, Angel Cogolludo, Milagros Galisteo, Manuel Ibarra,
Juan Duarte, Federica Lodi, Juan Tamargo, and Francisco Perez-Vizcaino851
Crystal Structures of the Mitochondrial Deoxyribonucleotidase in Complex with Two Specific Inhibitors
Agnes Rinaldo-Matthis, Chiara Rampazzo, Jan Balzarini, Peter Reichard, Vera Bianchi, and
Par Nordlund860
Potent Cyclic Antagonists of the Complement C5a Receptor on Human Polymorphonuclear Leukocytes. Relationships between Structures and Activity
Darren R. March, Lavinia M. Proctor, Martin J. Stoermer, Robert Sbaglia, Giovanni Abbenante,
Robert C. Reid, Trent M. Woodruff, Khemar Wadi, Natalii Paczkowski, Joel D. A. Tyndall,
Stephen M. Taylor, and David P. Fairlie868
Rapamycin Effects Transcriptional Programs in Smooth Muscle Cells Controlling Proliferative and Inflammatory Properties
Dietlind Zohlnhofer, Thomas G. Nilhrenberg, Franz-Josef Neumann, Thomas Richter,
Andreas E. May, Roland Schmidt, Katja Denker, Matthias A. Clauss, Albert Schomig, and
Patrick A. Baeuerle ' v°^ ' ■ " ■"880
■
Inhibition of Tumor Necrosis Factor-a-Converting Enzyme by a Selective Antagonist Protects Brain from Focal Ischemic Injury in Rats
Xinkang Wang, Giora Z. Feuerstein, Lin Xu, Hugh Wang, William A. Schumacher,
Martin L. Ogletree, Rebecca Taub, James J.-W. Duan, Carl P. Decicco, and Rui-Qin Liu890
Glutathione S-Transferase Ml and Multidrug Resistance Protein 1 Act in Synergy to Protect Melanoma Cells from Vincristine Effects
Philippe Depeille, Pierre Cuq, Sophie Mary, Isabelle Passagne, Alexandra Evrard, Didier Cupissol,
and Laurence Vian897
CCAAT/Enhancer-Binding Protein /3 (Nuclear Factor for Interleukin 6) Trans activates the Human
MDR1 Gene by Interaction with an Inverted CCAAT Box in Human Cancer Cells
G. Kevin Chen, Sanja Sale, Thomas Tan, Ralph P. Ermoian, and Branimir I. Sikic906
Atrial Natriuretic Peptide-C Receptor-Induced Attenuation of Adenylyl Cyclase Signaling Activates
Phosphatidylinositol Turnover in A10 Vascular Smooth Muscle Cells
Rima Mouawad, Yuan Li, and Madhu B. Anand-Srivastava917
Interactions of Nucleoside Analogs, Caffeine, and Nicotine with Human Concentrative Nucleoside
Transporters 1 and 2 Stably Produced in a Transport-Defective Human Cell Line
Thack T, Lang, James D. Young, and Carol E. Cass925
Aryl Hydrocarbon Receptor Activation and Cytochrome P450 1A Induction by the Mitogen-Activated Protein Kinase Inhibitor U0126 in Hepatocytes
Lise Andrieux, Sophie Langouet, Alain Fautrel, Frederic Ezan, Joel A. Krauser, Jean F. Savouret,
F. Peter Guengerich, Georges Baffet, and Andre Guillouzo934
Analogs of a-Conotoxin Mil Are Selective for a6-Containing Nicotinic Acetylcholine Receptors
J. Michael Mclntosh, Layla Azam, Sarah Staheli, Cheryl Dowell, Jon M. Lindstrom,
Alexander Kuryatou, James E, Garrett, Michael J. Marks, and Paul Whiteaker944
Coordinate Regulation of the Human UDP-Glucuronosyltransferase 1A8, 1A9, and 1A10 Genes by
Hepatocyte Nuclear Factor la and the Caudal-Related Homeodomain Protein 2
Philip A. Gregory, Rikke H. Lewinsky, Dione A. Gardner-Stephen, and Peter I. Mackenzie953
Dexamethasone Promotes Toxicity in U937 Cells Exposed to Otherwise Nontoxic Concentrations of
Peroxynitrite: Pivotal Role for Lipocortin 1-Mediated Inhibition of Cytosolic Phospholipase A2
Ilaria Tommasini and Orazio Cantoni964
The Two-Step Model of Prostaglandin Signal Termination: In Vitro Reconstitution with the
Prostaglandin Transporter and Prostaglandin 15 Dehydrogenase
Teruhisa Nomura, Run Lu, Michael L. Pucci, and Victor L. Schuster973
Functional Regulation of P2X6 Receptors by ^-Linked Glycosylation: Identification of a Novel, a/3-Methylene ATP-Sensitive Phenotype
Clare A. Jones, Catherine Vial, Lynda A. Sellers, Pat P. A. Humphrey, Richard J. Evans, and
Iain P. Chessell979
Temporal Characteristics of cAMP Response Element-Mediated Gene Transcription: Requirement for Sustained cAMP Production Jillian G. Baker, Ian P. Hall, and Stephen J. Hill
Cultured Rat Microglial Cells Synthesize the Endocannabinoid 2-Arachidonylglycerol, Which Increases Proliferation via a CB2 Receptor-Dependent Mechanism
Erica J. Carrier, Christopher S. Kearn, Andrew J. Barkmeier, Nicole M. Breese, Wenqi Yang,
Kasem Nithipatikom, Sandra L. Pfister, William B. Campbell, and Cecilia J. Hillard999
Characterization of Novel L-£/ira?-/3-Benzyloxyaspartate Derivatives, Potent Blockers of the Glutamate Transporters
Keiko Shimamoto, Ryuichi Sakai, Kiyo Takaoka, Noboru Yumoto, Terumi Nakajima,
Susan G. Amara, and Yasushi Shigeri1008
Differential Susceptibilities of Murine Hepatoma Iclc7 and Tao Cells to the Lysosomal Photosensitizer
NPe6: Influence of Aryl Hydrocarbon Receptor on Lysosomal Fragility and Protease Contents
Joseph A. Caruso, Patricia A. Mathieu, Aby Joiakim, Brendan Leeson, David Kessel,
Bonnie F. Sloane, and John J. Reiners, Jr.1016
Regulation of NAD(P)H:Quinone Oxidoreductase 1 Gene Expression by CYP1A1 Activity
A Marchand, R. Barouki, and M. Garlatti1029
Circumvention of Nuclear Factor KB-Induced Chemoresistance by Cytoplasmic-Targeted Anthracyclines Jennifer D. Bilyeu, Ganesh R. Panta, Lakita G. Cavin, Christina M. Barrett, Eddie J. Turner,
Trevor W. Sweatman, Mervyn Israel, Leonard Lothstein, and Marcello Arsura1038
ERRATA
Correction to "8R-Lisuride is a potent stereospecific histamine Hl-receptor partial agonist"1048
Correction to "Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-
administration of nicotine: disproportionate increase of the a6 subunit"1049