Interferon Gamma Release Assay-Selected Bibliography

(updated September, 2010)

Adetifa IM, et al. Commercial Interferon Gamma Release Assays Compared to the Tuberculin Skin Test for Diagnosis of Latent Mycobacterium Tuberculosis Infection in Childhood Contacts in the Gambia. Pediatric Infectious Disease Journal. 29(5):439-43, 2010. Email for reprints:

Adetifa IM, et al. Comparison of Two Interferon Gamma Release Assays in the Diagnosis of Mycobacterium Tuberculosis Infection and Disease in The Gambia. BMC Infectious Diseases. 7:122, 2007. Email for reprints:

Altet-Gómez N, et al. Diagnosing TB Infection in Children: Analysis of Discordances using In Vitro Tests and Tuberculin Skin Test. European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology. [Epub ahead of print], 2010. Article:

American Thoracic Society. Targeted tuberculin testing and treatment of

latent tuberculosis infection. MMWR: Morbidity and Mortality Weekly Report. 49(RR-6):1–51, 2000. Article:

Arend SM, et al. Comparison of Two Interferon-Gamma Assays and Tuberculin Skin Test for Tracing Tuberculosis Contacts. American Journal of Respiratory Critical Care Medicine. 175(6):618–27, 2007. Article:

Bamford AR, et al. Comparison of Interferon-gamma Release Assays and Tuberculin Skin Test in Predicting Active Tuberculosis (TB) in Children in the UK- a Paediatric TB Network Study. Archives of Disease in Childhood. 95(3):180-6, 2010. Email for reprints:

Bakir M, et al. Prognostic Value of a T-Cell–Based, Interferon-Gamma Biomarker in Children with Tuberculosis Contact. Annals of Internal Medicine. 149 (11): 777-787, 2008. Email for reprints:

Bakir M, et al. Use of T Cell–Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts. Clinical Infectious Diseases. 48(3):302–12, 2009. Email for reprints:

Bartu V, et al. QuantiFERON-TB Gold in the Diagnosis of Active Tuberculosis. Journal of International Medical Research. 36(3):434–7, 2008. Email for reprints:

Bennett DE, et al. Prevalence of Tuberculosis Infection in the United States Population: the National Health and Nutrition Examination Survey, 1999–2000. American Journal of Respiratory & Critical Care Medicine. 177:348–355, 2008. Article:

Bergamini BM, et al. Performance of Commercial Blood Tests for the Diagnosis of Latent Tuberculosis Infection in Children and Adolescents.Pediatrics. 123(3):e419-24, 2009. Article:

Beveridge NE, et al. A Comparison of IFNgamma Detection Methods Used in Tuberulosis Vaccine Trails. Tuberculosis. 88(6):631-40, 2008. Emails for reprint:

Bianchi L, et al. Interferon-Gamma Release Assay Improves the Diagnosis of Tuberculosis in Children. The Pediatric Infectious Disease Journal. 28(6):510-14, 2009. Emails for reprints: .

Bocchino M, et al. IFN-Gamma Release Assays in Tuberculosis Management in Selected High-Risk Populations. Expert Review of Molecular Diagnostics.9(2):165-77, 2009. Email for reprints:

Bosshard V, et al. Do Results of the T-SPOT.TB Interferon-Gamma Release Assay Change after Treatment of Tuberculosis? Respiratory Medicine. 103:30–4, 2009. Email for reprints:

Bruzzese E, et al. Gamma Interferon Release Assays for Diagnosis of Tuberculosis Infection in Immune-Compromised Children in a Country Which the Prevalence of Tuberculosis is Low. Journal of Clinical Microbiology. 47(7):2355-7 2009. Emails for reprints:

Chee CB, et al. Comparison of Sensitivities of Two Commercial Gamma Interferon Release Assays for Pulmonary Tuberculosis. Journal of Clinical Microbiology. 46(6):1935–1940, 2008. Email for reprints:

Chun JK, et al. The Role of a Whole Blood Interferon-Gamma Assay for the Detection of Latent Tuberculosis Infection in Bacille Calmette-Guérin Vaccinated Children. Diagnostic Microbiology and Infectious Disease. 62(4):389-94, 2008. Email for reprints:

Connell TG, et al. Early Detection of Perinatal Tuberculosis Using a Whole Blood Interferon-Gamma Release Assay. Clinical Infectious Diseases. 42(11):e82–5, 2006. Email for reprints:

Connell TG, et al. Performance of a Whole Blood Interferon Gamma Assay for Detecting Latent Infection with Mycobacterium Tuberculosis in Children. Thorax, 61(7):616–20, 2006. Email for reprints:

Connell TG, et al. Reversion and Conversion of Mycobacterium Tuberculosis IFN-gamma ELISpot Results during Anti-Tuberculous Treatment in HIV-infected Children. BMC Infectious Diseases. 10:138, 2010. Email for reprints:

Connell TG, et al. A Three-Way Comparison of Tuberculin Skin Testing, QuantiFERON-TB Gold and T-SPOT.TB in Children. PLoS ONE. 3(7):e2624, 2008. Email for reprints:

Connell TG, et al. Indeterminate Interferon-Gamma Release Assay Results in Children. Pediatric Infectious Disease Journal. 29(3):285-6, 2010. Email for reprints:

Davies MA, et al. Detection of Tuberculosis in HIV-Infected Children using an Enzyme-Linked Immunospot Assay. AIDS. 23(8):961-9, 2009. Emails for reprint:

Detjen AK, et al. Interferon-Gamma Release Assays Improve the Diagnosis of Tuberculosis and Nontuberculous Mycobacterial Disease in Children in a Country with a Low Incidence of Tuberculosis. Clinical Infectious Diseases. 45(3):322-8, 2007. Email for reprints:

Diel R, et al. Comparative Performance of Tuberculin Skin Test, QuantiFERON-TB-Gold In Tube Assay, and T-Spot.TB Test in Contact Investigations for Tuberculosis. Chest. 135(4):1010–18, 2009. Email for reprints:

Dogra S, et al. Comparison of a Whole Blood Interferon-Gamma Assay with Tuberculin Skin Testing for the Detection of Tuberculosis Infection in Hospitalized Children in Rural India. Journal of Infection. 54(3):267-76, 2007. Email for reprints:

Domínguez J et al. Comparison of Two Commercially Available Gamma-Interferon Blood Tests for Immunodiagnosis of Tuberculosis. Clinical and Vaccine Immunology: CVI. 15(1):168-71, 2008. Email for reprints:

Ewer K, et al. Comparison of T-Cell-Based Assay with Tuberculin Skin Test for Diagnosis of Mycobacterium Tuberculosis Infection in a School Tuberculosis Outbreak. Lancet. 361(9364):1168–73, 2003. Email for reprints:

Farhat M, et al. False-Positive Tuberculin Skin Tests: What is the Absolute Effect of BCG and Nontuberculous Mycobacteria? International Journal of Tuberculosis and Lung Disease. 10(11):1192–1204, 2006. Article:

Ferrara G, et al. Use in Routine Clinical Practice of Two Commercial Blood Tests for Diagnosis of Infection with Mycobacterium Tuberculosis: a Prospective Study. Lancet. 367:1328–34, 2006. Email for reprints:

Franken WPJ, et al. Interferon-Gamma Release Assays During Follow-Up of Tuberculin Skin Test-Positive Contacts. International Journal of Tuberculosis and Lung Disease. 12(11):1286–94, 2008. Email for reprints:

Gaseitsiwe S, et al. Pattern Recognition in Pulmonary Tuberculosis Defined by High Content Peptide Microarray Chip Analysis Representing 61 Proteins from M. Tuberculosis. PLoS ONE. 3(12):e3840, 2008. Email for reprints:

Goletti D, et al. Accuracy of an Immune Diagnostic Assay Based on RD1 Selected Epitopes for Active Tuberculosis in a Clinical Setting: a Pilot Study. Clinical Microbiology and Infection. 12:544–50, 2006. Email for reprints:

Grare M, et al. QuantiFERON((R))-TB Gold In-Tube as Help for the Diagnosis of Tuberculosis in a French Pediatric Hospital. Diagnostic Microbiology and Infectious Disease. 66(4):366-72, 2010. Email for reprints:

Hansted E, et al. T-Cell-Based Diagnosis of Tuberculosis Infection in Children in Lithuania: a Country of High Incidence Despite a High Coverage with Bacille Calmette-Guerin Vaccination. BMC Pulmonary Medicine. 9:41, 2009. Email for reprints:

Harada N, et al. Comparison of the Sensitivity and Specificity of Two Whole Blood Interferon-Gamma Assays for M. Tuberculosis Infection. Journal of Infection. 56(5):348–353, 2008. Email for reprints:

Hauck FR, et al. Identification and Management of Latent Tuberculosis Infection. American Family Physician.79(10):879-86, 2009. Article:

Haustein T, et al. The Likelihood of an Indeterminate Test Result from a Whole-Blood Interferon-Gamma Release Assay for the Diagnosis of Mycobacterium Tuberculosis Infection in Children Correlates With Age and Immune Status. Pediatric Infectious Disease Journal. 28(8): 669-73, 2009. Email for reprints:

Herrmann JL, et al. Temporal Dynamics of Interferon Gamma Responses in

Children Evaluated for Tuberculosis. PLoS ONE. 4(1):e4130, 2009. Email for reprints:

Hesseling AC, et al. Highly Discordant T-cell Responses in Individuals with Recent Household Tuberculosis Exposure. Thorax. 64:840–846, 2009. Email for reprints:

Heymann SJ, et al. Pediatric tuberculosis: What Needs to be Done to Decrease Morbidity and Mortality. Pediatrics 106:E1, 2000. Email for reprints:

Higuchi K, et al. Use of QuantiFERON®-TB Gold to Investigate Tuberculosis Contacts in a High School. Respirology. 12(1):88–92, 2007. Email for reprints:

Higuchi K, et al. Contact Investigation in a Primary School using a Whole Blood Interferon-Gamma Assay. Journal of Infection 58(5):352-7, 2009. Email for reprints:

Hill PC, et al. Comparison of Enzyme-Linked Immunospot Assay and Tuberculin Skin Test in Healthy Children Exposed to Mycobacterium Tuberculosis. Pediatrics. 117(5):1542-8, 2006. Website for reprints:

Janssens JP, et al. Contribution of a IFN-Gamma Assay in Contact Tracing for Tuberculosis in a Low-Incidence, High Immigration Area. Swiss Medical Weekly.138(39-40):585–93, 2008. Email for reprints:

Janssens JP, et al. Quantitative Scoring of an Interferon-Gamma Assay for Differentiating Active from Latent Tuberculosis. European Respiratory Journal. 30(4):722–728, 2007. Email for reprints:

Kampmann B, et al. Interferon-Gamma Release Assays do not Identify More Children with Active Tuberculosis than the Tuberculin Skin Test. European Respiratory Journal. 33(6):1374-82, 2009 Email for reprints:

Lalvani A, Millington KA. T Cell-Based Diagnosis of Childhood Tuberculosis Infection. Current Opinion in Infectious Diseases. 20(3):264–71, 2007. Email for reprints:

Lange C, Mori T. Advances in the Diagnosis of Tuberculosis. Respirology. 15(2):220-40, 2010. Email for reprints:

Lee JY, et al. Comparison of Two Commercial Interferon-Gamma Assays for Diagnosing Mycobacterium Tuberculosis Infection. European Respiratory Journal. 28(1):24–30, 2006. Email for reprints:

Lew WJ, et al. Combined use of QuantiFERON-TB Gold Assay and Chest Computed Tomography in a Tuberculosis Outbreak. International Journal of Tuberculosis and Lung Disease: the Official Journal of the International Union Against Tuberculosis & Lung Disease. 13(5): 633-9, 2009. Article:

Lewinsohn DA. Embracing Interferon-Gamma Release Assays for Diagnosis of Latent Tuberculosis Infection. Pediatric Infectious Disease Journal. 28(8):674-5, 2009. Email for reprints:

Lewinsohn DA, et al. Interferon-Gamma Release Assays: New Diagnostic Tests for Mycobacterium Tuberculosis Infection, and their Use in Children. Current Opinion in Pediatrics. 22(1):71-6, 2010. Email for reprints:

Lewinsohn DA, et al. Whole Blood Interferon-Gamma Responses to Mycobacterium Tuberculosis Antigens in Young Household Contacts of Persons with Tuberculosis in Uganda. PLoS ONE. 3(10):e3407, 2008. Email for reprints:

Lewinsohn DA, et al. Tuberculosis Immunology in Children: Diagnostic and Therapeutic Challenges and Opportunities. International Journal of Tuberculosis and Lung Disease. 8(5):658–674, 2004. Email for reprints:

Liebeschuetz S, et al. Diagnosis of Tuberculosis in South African Children with a T-cell-Based Assay: a Prospective Cohort Study. Lancet 364(9452):2196–203, 2004. Email for reprints:

Lighter J, et al. Chemokine IP-10: An Adjunct Marker for Latent Tuberculosis Infection in Children. International Journal of Tuberculosis and Lung Disease. 13(6): 731–6, 2009. Email for reprints:

Lighter J, et al. Latent Tuberculosis Diagnosis in Children by Using the QuantiFERON-TB Gold In-Tube Test. Pediatrics.123(1):30-7, 2009. Website for reprints:

Lighter J. Rigaud M., Diagnosing Childhood Tuberculosis: Traditional and Innovative Modalities.Current Problems Pediatric & Adolescent Health Care. 39(3):61-88, 2009. Email for reprints:

Lucas M, et al. A Prospective Large-Scale Study of Methods for the Detection of Latent Mycobacterium Tuberculosis Infection in Refugee Children. Thorax. 65(5):442-8, 2010. Email for reprints:

Magdorf K, et al. T-Cell Responses Against Tuberculin and Sensitin in Children With Tuberculosis and Non-Tuberculosis Mycobacterial Lymphadenopathy. Clinical Microbiology and Infection. 14(11):1079–83, 2008. Email for reprints:

Mandalakas AM, et al. High Level of Discordant IGRA Results in HIV-Infected Adults and Children. International Journal of Tuberculosis and Lung Disease. 12(4):417–23, 2008. Email for reprints:

Mandalakas AM, et al. Interpretation of Repeat Tuberculin Skin Testing in International Adoptees: Conversions or Boosting. Pediatric Infectious Disease Journal. 27(10):913-9, 2008. Email for reprints:

Marais BJ, Pai M. Recent Advances in the Diagnosis of Childhood Tuberculosis. Archives of Disease in Childhood. 92(5):446-52, 2007. Email for reprints:

Mazurek GH, et al. Provisional Guide-lines for use of Interferon Gamma Release Assays (IGRAs) to Detect Mycobacterium Tuberculosis Infection in the United States. National TB Meeting, Atlanta, GA; 18 June 2009. Article:

Molicotti P, et al. Performance of QuantiFERON-TB Testing in a Tuberculosis Outbreak at a Primary School. Journal of Pediatrics. 152(4):585-6, 2008. Email for reprints:

Mori T. Usefulness of Interferon-Gamma Release Assays for Diagnosing TB Infection and Problems with these Assays. Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy. 15(3):143-55, 2009. Email for reprints:

Méndez Echevarría A, et al. Lack of Sensitivity of QuantiFERON-TB Gold Test in Tube in a Child with Tuberculous Meningitis. Pediatric Infectious Disease Journal. 29(7):683-4, 2010. Article:

Nakaoka H, et al. Risk for Tuberculosis Among Children. Emerging Infectious Diseases. 12(9):1383-8, 2006. Email for reprints:

Neira-Munoz E, et al. Extensive Transmission of Mycobacterium Tuberculosis Among Children on a School Bus. Pediatric Infectious Disease Journal. 27(9):835-7, 2008. Email for reprints:

Nelson LJ, Wells CD. Global Epidemiology of Childhood Tuberculosis. International Journal of Tuberculosis and Lung Disease. 8:636–647, 2004. Email for reprints:

Nicol MP, et al. Enzyme-Linked Immunospot Assay Responses to Early Secretory Antigenic Target 6, Culture Filtrate Protein 10, and Purified Protein Derivative Among Children with Tuberculosis: Implications for Diagnosis and Monitoring of Therapy. Clinical Infectious Diseases. 40(9):1301–8, 2005. Email for reprints:

Nicol MP, et al. Comparison of T-SPOT.TB Assay and Tuberculin Skin Test for the Evaluation of Young Children at High Risk for Tuberculosis in a Community Setting. Pediatrics. 123(1):38-43, 2009. Website for Reprints:

Nsutebu E, et al. Use of QuantiFERON-TB Gold Test in the Investigation of Unexplained Positive Tuberculin Skin Tests. Public Health. 122(1):1284-7, 2008. Email for reprints:

Ohno H, et al. A Contact Investigation of the Transmission of Mycobacterium Tuberculosis from a Nurse Working in a Newborn Nursery and Maternity Ward. Journal of Infection and Chemotherapy. 14(1):66–71, 2008. Email for reprints:

Okada K, et al. Performance of an Interferon-Gamma Release Assay for Diagnosing Latent Tuberculosis Infection in Children. Epidemiology and Infection. 136(9)1179-87, 2008. Email for reprints:

Pai M, et al. Systematic Review: T-Cell-Based Assays for the Diagnosis of Latent Tuberculosis Infection: An Update. Annals of Internal Medicine. 149(3):177–184, 2008. Email for reprints:

Pai M, Menzies D. Interferon-Gamma Release Assays: What is their Role in the

Diagnosis of Active Tuberculosis? Clinical Infectious Diseases. 44(1):74–77, 2007. Email for reprints:

Palazzo R, et al.Use of Whole-Blood Samples in In-House Bulk and Single-Cell Antigen-Specific Gamma Interferon Assays for Surveillance of Mycobacterium Tuberculosis Infections. Clinical & Vaccine Immunology: CVI.15:327–337, 2008. Email for reprints:

Paranjothy S, et al. Extensive Transmission of Mycobacterium Tuberculosis from 9 Year Old Child with Pulmonary Tuberculosis and Negative Sputum Smear. British Medical Journal. 337:573-74, 2008. Email for reprints:

Petrucci R, et al. Interferon Gamma, Interferon-Gamma-Induced-Protein 10, and Tuberculin Responses of Children at High Risk of Tuberculosis Infection. Pediatric Infectious Disease Journal. 27(12):1073-7, 2008. Email for reprints:

Powell DA. Interferon Gamma Release Assays in the Evaluation of Children with Possible Mycobacterium Tuberculosis Infection: a View to Caution. Pediatric Infectious Disease Journal. 28(8)676-7, 2009. Email for reprints:

Ruhwald M, et al. Evaluating the Potential of IP-10 and MCP-2 as Biomarkers for the Diagnosis of Tuberculosis. European Respiratory Journal. 32(6):1607–15, 2008. Email for reprints:

Soburg B, et al. Ongoing Tuberculosis Transmission to Children in Greenland. European Respiratory Journal: the Official Journal of the European Society for clinical Respiratory Physiology. [Epub ahead of print] 2010. Email for reprints:

Soysal A, et al. Evaluation of Cut-off Values of Interferon-Gamma-Based Assays in the Diagnosis of M. Tuberculosis Infection. International Journal of Tuberculosis and Lung Disease.12(1):50–6, 2008. Email for reprints:

Stefan DC, et al. Interferon-Gamma Release Assays for the Detection of Mycobacterium Tuberculosis Infection in Children with Cancer. International Journal of Tuberculosis and Lung Disease: the Official Journal of the International Union against Tuberculosis and Lung Disease. 14(6):689-94, 2010. Email for reprints:

Stout JE, Menzies D. Predicting Tuberculosis: Does the IGRA Tell the Tale? American Journal of Respiratory & Critical Care Medicine. 177(10):1055-7, 2008. Article:

Tavast E, et al. IGRA Tests Perform Similarly to TST but Cause No Adverse Reactions: Pediatric Experience in Finland. BMC Research Notes 15;2:9, 2009. Reprints:

Taylor RE, et al. Potential Effect of NICE Tuberculosis Guidelines on Pediatric Tuberculosis Screening. Archives of Disease in Childhood. 93(3):200-3, 2008. Email for reprints:

Tsiouris SJ, et al. Results of a Tuberculosis-Specific IFN-Gamma Assay in Children at High Risk for Tuberculosis Infection. International Journal of Tuberculosis and Lung Disease. 10(8):939–41, 2006. Email for reprints: .

Tsiouris SJ, et al. Sensitivity Analysis and Potential Uses of a Novel Gamma Interferon Release Assay for Diagnosis of Tuberculosis. Journal of Clinical Microbiology. 44(8):2844–2850, 2006. Email for reprints: .

Tsolia MN, et al. Whole Blood Interferon-Gamma Release Assay is a Useful Tool for the Diagnosis of Tuberculosis Infection Particularly among Bacille Calmette Guerin-Vaccinated Children. Pediatric Infectious Disease Journal. [Epub ahead of print]. 2010. Email for reprints:

Tuuminen T, et al. Feasibility of Commercial Interferon-Gamma-Based Methods for the Diagnosis of Latent Mycobacterium Tuberculosis Infection in Finland, a Country of Low Incidence and High Bacille Calmette-Guérin Vaccination Coverage. Clinical Microbiology and Infection: the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 13(8):836-8, 2007. Email for reprints:

Warier A, et al. T-cell Assay as a Diagnostic Tool for Tuberculosis. Indian Pediatrics. 47(1):90-2, 2010. Article:

Whittaker E, et al. Is IP-10 a Better Biomarker for Active and Latent Tuberculosis in Children than IFN gamma? PLoS ONE. 3(12):e3901, 2008. E-mail for reprints:

Winje BA, et al. School Based Screening for Tuberculosis Infection in Norway: Comparison of Positive Tuberculin Skin Test with Interferon-Gamma Release Assay. BMC Infectious Diseases. 8:140, 2008. Article:

Wright CA, et al. Fine Needle Aspiration Biopsy: an Undervalued Diagnostic Modality in Paediatric Mycobacterial Disease. International Journal of Tuberculosis and Lung Disease: the Official Journal of the International Union against Tuberculosis and Lung Disease. 13(12):1467-75, 2009. Email for reprints: