Institute of Science & Technology in Medicine
Control of Substance Hazardous to Health
COSHH assessment
Student Name: Nawraj Rummun
Title of Experiment/Procedure:Etoposide
Date of Assessment: 03/04/2017 / Names & Status of Worker:Nawraj Rummun. Phd Student IdowuPSSSSsStudentName of hazardous substances to be used / Type of Hazard
Chemical or Biological
Hazards identified / Approximate quantity and the likelihood of exposure, e.g. high, medium, low
Etoposide / Acute toxicity- Harmful if swallowed.
Carcinogenicity- May cause cancer / The storage quantity is 1 g. However, the quantity required to prepare 2 ml volume of 5mg/mlstock solution is 10 mg. Only 20 µl of the stock solution will be used for each experiment. So, the likelihood of exposure is low.
Overall risk assessment of the substances / Very high High Medium Low Carcinogen category
Etoposide / Low (carcinogenic)
Information source: /
Institute of Science & Technology in Medicine
Control of Substance Hazardous to Health
COSHH assessment
Control Measures adopted (personal protective equipment)
Ensure adequate ventilation especially in confined areas. Use personal protective equipment such as safety glasses with side shields, protective gloves and long sleeved laboratory coat. Avoid contact with skin, eyes and clothing. Avoid dust formation. Do not eat, drink or smoke when using this product. Also, remove and wash contaminated clothing before re-use.Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak.
Spillage
Method of Disposal
Collect spillage with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local/national regulations.
Empty containers should be taken to an approved waste handling site for recycling or disposal.
Emergency procedures
In case of fire / Use suitable extinguishing measures that are appropriate to local circumstances and the surrounding environment. Such as water spray and alcohol-resistant foamIn case of water failure / N/A
In case of electricity failure / Adequate ventilation
Description of first aid measures / General advice: if exposed or concerned, get medical advice and attention and show the safety data sheet to the physician
In case of eye contact: Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15minutes.
In case of skin contact: Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes.
If ingested: Clean mouth with water and drink plenty of water.
If inhalation: if breathed in, move the person into fresh air
Emergency contact name / Ying Yang or Pauline Pursglove
Emergency phone number / Ying (+44 (0)1782 674386); Pauline Pursglove (+44 (0)1782 674994)
Signatures
Name and signature DateAssessor / Nawraj Rummun / 03 April 2017
Supervisor or
COSHH Supervisor / Dr Wen Wu Li / 04 04 2017