How to Navigate Research Resources at Penn
Symposium for Early Investigators
Friday, December 11, 2009
Shared Resources
Ian A. Blair, Ph.D. ()
What research cores are available to me and how do I access them?
A. Abramson Cancer Center (ACC)
Center for Cancer Pharmacology (CCP)
Center of Excellence in Environmental Toxicology (CEET)
Institute for Translational Medicine and Therapeutics (ITMAT)
Penn Genome Frontiers Institute (PGFI)
Abramson Cancer Center Proteomics Core:
Shared Resources/Core Facilities
The Cancer Center supports 12 NCI-approved Shared Resources to provide investigators with easy access to state-of-the-art research technology, equipment, and technical support that would otherwise be too difficult or expensive for individual investigat ors or programs to develop. The availability of these core research facilities significantly increases the ease with which cancer-related research can be conducted on the campus.
- Biomedical Imaging Core
Biomedical Informatics Core
Biostatistics Unit
Clinical Cell and Vaccine Production Facility
Clinical Research Unit
DNA Sequencing Facility
Flow Cytometry and Cell Sorting Facility
Histology Service Core
Human Immunology Core
Melanoma Core
Microarray Facility
Molecular Diagnosis & Genotyping Facility
Proteomics Core
Recruitment, Outcomes, and Assessment Resource
Small Animal Imaging Core
Stem Cell and Xenograft Core
Transgenic and Chimeric Mouse Facility
Tumor Tissue Bank
Center for Cancer Pharmacology (CCP) Proteomics Core Facility:
Proteomics Core Facility
The mission of the Proteomics Facility is to provide and disseminate state-of-the-art scientific and technical knowledge in proteomics that will contribute to the research programs of investigators at the University of Pennsylvania and the Children's Hospital of Philadelphia.
This will be accomplished by exploiting and evaluating the impacts of discoveries in proteomics, through focused efforts in:
- instrumentation
- protein separation and detection
- bioinformatics
The Facility is an integral component of the Genomics Institute.
The Proteomics Facility Office
853 BRB II/III
The Proteomics Facility
838 BRB II/III
Philadelphia, PA 19104-6160
215.573.9883 Tel 215.573.9889 Fax
Chao-Xing Yuan, Ph.D. 852 BRB II/III
Christine Busch 838 BRB II/III
Data Processing Room Proteomics Facility 851 BRB II/III
Services provided by the Proteomics Core Facility include:
- 2D gel electrophoresis
- Ettan DIGE analysis
- Applied Biosystems Voyager Pro DE MALDI-TOF mass spectrometer for peptide mass measurement
- LCQ Deca XP Plus mass spectrometer for peptide sequencing
Center of Excellence in Environmental Toxicology (CEET):
Facility Cores
Molecular Profiling Facility Core
The Molecular Profiling Core (MPC) was formed in April 2008 to provide CEET investigators with the resources to conduct integrated “omics” and biomarker research related to toxicant exposure and response. This was accomplished by combining the resources of the existing Toxicogenomics, Toxicoproteomics, and Biomarker Facility Cores into a single Facility Core. Each of these individual areas has a dedicated Technical Director who has considerable expertise in the application of the relevant technology to toxicology research. The MPC provides an integrated systems biology approach to identify molecular fingerprints of exposure and response.
Facility Service
Toxicogenomics
Technical Director, Toxicogenomics : Don Baldwin /Technical Director, Bioinformatics:: John Tobias /
Request Toxicogenomics Consultation (You must indicate whether you are a CEET member in your request to gain priority access ()
The mission of the Toxicogenomics component of the Molecular Profiling Core is to foster both basic and translational research into environmental health science within the CEET. Existing institutionally supported genomics resources have been expanded to provide coordinated, focused support for environmental toxicology projects in the CEET. This is accomplished by providing scientific consultation, instrumentation, and technical expertise for high throughput RNA transcript profiling, high-throughput genotyping, massively parallel sequencing, and toxicogenomic data analysis.
Services Available
- Target Preparation and Sequencing
- Massively Parallel Sequencing
- Quantitative PCR
- Custom Multiplex Genotyping
- Whole Genome Profiling
- Transcript Profiling
- DNA Profiling
- Molecular Diagnosis and Genotyping
- Bioinformatics and Data Analysis
- Quality Control for User Projects
Institute for Translational Medicine and Therapeutics (ITMAT):
Core Facilities
Cores housed within ITMAT are designed to address infrastructural barriers to clinical and translational research. These cores exist to deliver service and typically have a cost sharing structure that enables their expansion and development.
- » Automated Claims and Automated Medical Record Databases (ACARD)
- » Bioinformatics Facility
- » Community Based Research Core (CBRC)
- » Community Outreach using Health System Informatics (COHSI)
- » Dissemination of Translation (DOT)
- » Investigational Drug Service (IDS)
- » Kinetics Modeling and Simulation (KMAS)
- » Office of Human Subject Advocacy and Protection (OHSAP)
- » Outcomes Measurement Methods Core (OMMC)
- » Proteomics Core
- » Recruitment and Coordination Core (RCC)
- » Research Nurse Core (RNC)
- » Study Design and Biostatistics (SDAB)
- » Translational and Clinical Trial Organization (TACTO)
- » Translational Core Lab (TCL)
Penn Genome Frontiers Institute (PGFI):
Proteomics
The Proteomics Facility, an integral component of the Penn Genome Frontiers Institute, provides and disseminates state-of-the-art scientific and technical knowledge in proteomics.
Dr. Ian A. Blair, Scientific Director
853 BRB II/III/ Office
838 BRB II/III/ Facility
421 Curie Blvd.
Philadelphia, PA 19104-6160
215-573-9880
215-573-9889 (fax)
Dr. Chao-Xing Yuan, Technical Director
215-573-9883
215-573-9889