Fig. 1 Visual Predictive Check for Baseline Model with Observed ABPM Data

Appendix

Fig. 1 Visual predictive check for baseline model with observed ABPM data.

Fig. 2a Global sensitivity analysis: Fixed effect parameters vs. Fraction of patients with |deviation| > 10 mm Hg

Fig. 2b Global sensitivity analysis: Inter-individual variability vs. Fraction of patients with |deviation| > 10 mm Hg

Fig. 2c Global sensitivity analysis: Inter-occasion variability vs. Fraction of patients with |deviation| > 10 mm Hg

Figure 3a: Global sensitivity analysis: Fixed effect parameters vs. Fraction of patients with BP misclassification

Figure 3b: Global sensitivity analysis: Inter-individual variability vs. Fraction of patients with BP misclassification

Figure 3c: Global sensitivity analysis: Inter-occasion variability vs. Fraction of patients with BP misclassification

Table 1 Uncertainty distribution in the parameter estimates of the baseline model on analysis endpoints.

Population Parameters / 95% CI / |dev| > 10 mm Hg (without measurement error) / |dev| > 10 mm Hg (with measurement error)
24-h mean BP (mm Hg) / 145.5 ~ 157.1 / 9.5% ~ 11.3% / 26% ~ 27.5%
Amplitude, first cosine term / (-)0.087~ (-) 0.048 / 8% ~ 13.7% / 24% ~ 30%
amplitude, second cosine term / 0.011 ~ 0.046 / 10% ~ 12.5% / 26% ~ 29%
phase shift, second cosine term / (-)9.13 ~ (-)8.50 / 9.5% ~ 12% / 26% ~ 29%
inter-individual variability in mean BP (variance) / 0.002~ 0.015 / 10% ~ 11.5% / 26.5% ~ 27.8%
inter-individual variability on amplitude of 1st and 2nd cosine term (variance) / 0.11 ~ 0.82 / 9.5% ~ 13% / 26% ~ 29.5%
inter-individual variability on clock time (h) (variance: hr^2) / 3.59 ~ 28.47 / 7% ~15% / 24.5% ~ 30%
inter-occasion variability in baseline (variance: mm Hg^2) / 39.24 ~ 97.91 / 10.50% / 27%
inter-occasion variability on clock time (h) (variance: hr^2) / 1.12 ~ 2.64 / 10.50% / 27%
SD of measurement error (mm Hg) / 3 ~ 7 / 15.5% ~ 38.3%