Possible Side Effects of Cisplatin, Etoposide, Cyclophosphamide, Vincristine(Table Version Date: August 28, 2014)

COMMON, SOME MAY BE SERIOUS
In 100 people receiving Cisplatin, Etoposide, Cyclophosphamide, Vincristine,
more than 20 and up to 100 may have: /
·  Nausea, vomiting, constipation, diarrhea, loss of appetite
·  Infection, especially when white blood cell count is low
·  Anemia which may require blood transfusions
·  Bruising, bleeding
·  Kidney damage which may cause swelling, may require dialysis
·  Hearing loss including ringing in ears
·  Hair loss
·  Sores in mouth which may cause difficulty swallowing
·  Tiredness
·  Fever, chills
·  Absence of menstrual period which may decrease the ability to have children
·  Blood in urine
·  Pain or redness at the site of injection
·  Numbness and tingling of fingers or toes
·  Headache, jaw pain and/or muscle pain
·  Weakness and difficulty walking
·  Swelling of lower legs
·  Nail damage
OCCASIONAL, SOME MAY BE SERIOUS
In 100 people receiving Cisplatin, Etoposide, Cyclophosphamide, Vincristine, from 4 to 20 may have: /
·  Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat
·  Confusion
·  Difficulty with balance
·  Damage to the heart, heart failure or heart attack which may cause chest pain, shortness of breath, swelling of ankles, and tiredness
·  Severe skin rash with blisters and peeling which can involve inside of mouth and other parts of the body
·  Liver damage which may cause yellowing of eyes and skin, swelling
·  Damage to the bone marrow (irreversible) which may cause infection, bleeding, may require transfusions
·  Loss or absence of sperm which may lead to an inability to father children
·  Stuffy nose
·  Fluid around the heart
·  Drooping eyelids
·  Hoarseness
RARE, AND SERIOUS
In 100 people receiving Cisplatin, Etoposide, Cyclophosphamide, Vincristine, 3 or fewer may have: /
·  A new cancer including cancer of bone marrow (leukemia) caused by chemotherapy later in life
·  Seizure
·  Severe skin rash with blisters and peeling which can involve mouth and other parts of the body
·  Swelling of the body including the brain which may cause dizziness, confusion
·  Scarring of the lungs
·  Brain damage which may cause headache, seizure, blindness (also known as Reversible Posterior Leukoencephalopathy Syndrome)

Page 1 of 2