ESM-Table 5: Ophthalmological observations in male and female Wistar Han RCC rats in the 1st and 12th week in the feeding trials A and B

Study A
Male rats
Group / Animal No. / Observations in week 1 / Observations in week 12
control
(33% DKC6666) / 76 / corneal erosion (left eye) / negative
11% GMO
(11% DKC6667-YG + 22% DKC6666) / 19 / membrana pupilaris persistens (right eye) / negative
22 / hemorrhage at the edge of optic nerve / negative
27 / turbidity in the centre of the lens (right eye); whity turbidity in the centre of the cornea (left eye) / negative
28 / white opaque dots on lens (left eye) / negative
31 / corneal erosion in the centre of the cornea (left eye) / negative
33% GMO
(33% DKC6667-YG) / 5 / opacity (right eye) / negative
13 / white infiltration of the cornea, membrana pupilaris persistens (right eye); corneal erosion (left eye) / negative
conventional 1
(33% PR33W82) / 60 / white paracentral corneal opacity (left eye) / negative
conventional 2
(33% SY-NEPAL) / 36 / membrana pupilaris persistens (left eye) / negative
40 / bilaterally reduced eye vascularization / negative
48 / white corneal opacity (right eye) / negative
Female rats
33% GMO
(33% DKC6667-YG) / 134 / fibrae medullares (left eye) / negative
conventional 1
(33% PR33W82) / 148 / vitreous opacity (right eye) / negative
Study B
Male rats
Group / Animal No. / Observations in week 1 / Observations in week 12
11% GMO
(11% PR33D48 + 22% PR32T16) / 222 / white dot opacity at the edge of the cornea (left eye) / hemorrhage (left eye)
33% GMO
(33% PR33D48) / 212 / scar in the lower part of the cornea (left eye) / negative
conventional 1
(33% PR32T83) / 254 / corneal erosion (right eye) / negative
261 / corneal erosion in the centre of the cornea (left eye) / negative
Female rats
conventional 2
(33% DKC6815) / 317
/ scar in the lower part of the cornea (left eye)
/ negative