Supplemental Table 2: Characteristics of patients with cancer (DCIS or invasive disease) compared to those of patients with no cancer at definitive surgery. Univariate analysis

Cancer
N = 49 (%) / No cancer
N = 155 (%) / P VALUE
Mean age / 60 / 56.5 / 0.03
Age £ 50 years / 8 (16.3) / 41 (26.4) / 0.15
Age > 50 years / 41 (83.7) / 114 (73.5)
Mean age at first menstruation / 13 / 12.7 / 0.16
Mean age at first pregnancy / 24.9 / 24.9 / 0.97
Postmenopausal / 37 (75.5) / 98 (63.2) / 0.21
BI-RADs classification / 0.21
BI-RADs 3 / 0 / 8
BI-RADs 4a / 22 (44.9) / 71 (45.8)
BI-RADs 4b / 12 (24.5) / 50 (32.3)
BI-RADs 4c / 10 (20.4) / 17 (11.0)
BI-RADs 5 / 3 (6.1) / 6 (3.9)
Not assessable / 2 / 3
Mean focus size in mm / 17.4 / 11 / 0.02
Focus size / 0.04
£ 15 mm / 32 (65.3) / 124 (80.0)
> 15 mm / 15 (30.6) / 24 (15.5)
Not assessable / 2 / 7
FEA present / 17 (34.7) / 68 (43.9) / 0.39
ADH present / 28 (57.1) / 82 (52.9) / 0.57
ALH present / 19 (38.8) / 56 (36.1) / 0.76
Lobular carcinoma in-situ present / 15 (30.6) / 32 (20.6) / 0.19
Radial scar / 1 / 9 / 0.49
Papilloma / 5 / 10 / 0.59
Number of biopsy cores / 0.02
1-10 / 32 (65.3) / 122 (78.7)
11-15 / 12 (24.5) / 22 (14.2)
> 15 / 2 (4.1) / 5 (3.2)
Not assessable / 3 / 6
Extension / 0.96
Calcifications in <33% of cores / 6 (12.2) / 25 (16.1)
Calcifications in >33% of cores / 26 (53.1) / 93 (60.0)
Not assessable / 17 / 37
Mean number of biopsy samples with microcalcifications / 3.8 / 4.7 / 0.10
Disappearance of radiological anomalies after biopsy / 0.05
No / 29 (59.2) / 77 (49.7)
Yes / 7 (14.3) / 53 (34.2)
Not assessable / 13 / 25
Mean number of atypical foci / 3.1 / 2.1 / 0.046
Mean size of largest atypical foci (mm) / 2.8 / 2.6 / 0.67
Mean percentage of atypical lobules and ducts / 33.5 / 17.9 / 0.037
Ki67 positive (≥14%) / 2/41 (4.9) / 5/141 (3.5) / 0.66
ALDH1 positive / 2/39 (5.1) / 3/141 (2.1) / 0.29