Department of Nutritional Sciences and Toxicology Fall, 2007
University of California, Berkeley
NST 110: Toxicology (3 units)
(CCN:64635)
General Information
Class Hours: Tuesday and Thursday, 9:30-11:00, 101 LSA
Instructors: Len Bjeldanes, 217 Morgan Hall
Phone: 510-642-1601
Email:
Office Hours: Wednesday 2-3:00, or by appointment
Wally Wang, 315 Morgan Hall
Phone: 510-643-1039
Email:
Office hours: Wednesday 2-3:00, or by appointment
Nygerma Dangleben, 27 Morgan Hall
Email:
Office Hours: Thursday 11-1
Ashley Kagel, 27 Morgan Hall
Email:
Office Hours: Mon 11–12, or by appointment
Evening Discussion Sections: 9/6, 9/20, 10/4, 10/25, 11/8, 11/29, before final
Prerequisites: Organic chemistry, biochemistry and a course in biology
Required Text: Casarett & Doull’s Toxicology - the Basic Science of Poisons, 6th ed. C.D. Klaassen, editor.
Course website: https://bspace.berkeley.edu/portal
Course Objectives:
1. To become familiar with basic chemical and biological aspects of toxicology.
2. To describe and evaluate the toxicology of certain natural and manmade environmental substances.
3. To appreciate certain current research issues important to toxicology.
Examinations:
Exams: Two exams on the following dates: 9/27 and 11/13
Final Exam: SATURDAY, DECEMBER 15, 2007 8-11AM
Grading:
Grading is based on points earned from two midterms (100 pts. each) and a final (100 pts.), for a total of 300 points. Grades are assigned by the following percentages based on the highest score in the class:
“A” range ……………. 90% - 100%
“B” range ……………..80% - 89%
“C” range …………….. 70% - 79%
“D” range …………….. 50% - 69%
Students may improve their midterm scores as follows. Students may provide correct responses along with a summary of a primary research paper (not a review) that relates to the topic of the examination question. Summaries should be double-spaced, approximately one page in length, and should clearly explain how the material relates to the topic of the exam question. As much as 50% of the maximum points for each exam question may be obtained in this manner. The deadline for turning in the revised examinations is one week following receipt of the graded examination. Group discussions of graded exams are encouraged, but the summaries of published papers are to be prepared individually. The instructors will not provide the exam key until after the exam re-writes have been turned in. A good resource for finding primary articles is http://www.pubmed.com
Student Liaison Committee (SLC):
Members of three SLCs are chosen from volunteers in the class to serve for the several week periods before each examination. The primary function of the SLC is to serve as the voice of the class to communicate to the instructors any problems related to course instruction. In addition, the SLC may choose to organize groups and activities for the class, as they wish.
Course Website on Berkeley bspace:
All students are required to sign up for the course website on Berkeley bspace at https://bspace.berkeley.edu/portal as soon as possible. All powerpoint and PDF format lectures and handouts, as well as any class announcements will be posted on bspace. It is highly recommended that you print out and bring the lectures to class.
Also, bspace can be used to post named or anonymous comments and suggestions about the class to other students or to the instructors. The GSIs will respond to any comments posted.
Department of Nutritional Sciences and Toxicology NST 110 Fall 2007
University of California, Berkeley Lecture: T,Th 9:30-11:00
Room 101 LSA
Toxicology, Fall 2006
COURSE OUTLINE
Lecture # Date Topic Required reading2
LB 1 Tues Aug 28 Introduction, description of the course, Ch 1,2,5
Principles of toxicology-1 / Absorption and Distribution
LB 2 Thurs Aug 30 Absorption and Distribution Ch 5
LB 3 Tues Sept 4 Excretion/Metabolism Phase I Ch 5, 6
LB 4 Thurs Sept 6 Metabolism—Phase I Ch 6
LB 5 Tues Sept 11 Metabolism—Phase II Ch 6
LB 6 Thurs Sept 13 Bioactivation and gene induction Ch 6, 8 (p.243-244)
LB 7 Tues Sept 18 Bioactivation/Toxicokinetics Ch 6, 7
LB 8 Thurs Sept 20 Risk assessment/Testing Ch 4
LB 9 Tues Sept 25 Reproductive/Developmental toxicity Ch 9, 10
10 Thurs Sept 27 EXAM #1
DN 11 Tues Oct 2 Neurotoxicology Ch 16
DN12 Thurs Oct 4 Pesticide Toxicology-1 Ch 22
DN13 Tues Oct 9 Pesticide Toxicology-2 Ch 22
LB 14 Thurs Oct 11 Mechanisms of Toxicity-1 Ch 3
LB 15 Tues Oct 16 Mechanisms of Toxicity-2 Ch 8
LB 16 Thurs Oct 18 Carcinogenesis-1 Ch 8
LB 17 Tues Oct 23 Carcinogenesis-2 Ch 8
Department of Nutritional Sciences and Toxicology NST 110
University of California at Berkeley Toxicology
Lecture Day Date Topic Required reading*___
WW18 Thurs Oct 25 Food and Color Additives p.1049-1064 (Ch30)
WW19 Tues Oct 30 Metal Toxicity-1 Ch 23
WW20 Thurs Nov 1 Metal Toxicity-2 Ch 23
WW21 Tues Nov 6 Fungal toxins-1 Ch 30
WW22 Thurs Nov 8 Fungal toxins-2
23 Tues Nov 13 EXAM #2
WW24 Thurs Nov 15 Marine toxins Ch 30
WW25 Tues Nov 20 Natural toxins in plant foods-1
Thurs Nov 22 Thanksgiving Holiday
WW26 Tues Nov 27 Natural toxins in plant foods-2
WW27 Thurs Nov 29 (WW to choose topic)
LB28 Tues Dec 4 Diet and cancer-1.
LB29 Thurs Dec 6 Diet and cancer-2.
1 Readings are from Casarett & Doull’s Toxicology - the Basic Science of Poisons, 6th ed. C.D. Klaassen, editor. (http://www.knovel.com/knovel2/Toc.jsp?BookID=956)