Cognitive impairment and structural brain changes in patients withclinically isolated syndrome at high risk for multiple sclerosis

Journal of Neurology

Eva Hynčicováa, Martin Vyhnáleka,b, Adam Kalinaa, LukášMartinkoviča, TomášNikolaia,b, JiříLisýc, Jakub Horta,b, Eva Meluzínováa, and Jan Laczóa,b

aDepartment of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Czech Republic, V Uvalu 84, Prague 5, 150 06

bInternational Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic, Pekarska 53, Brno, 656 91

cDepartment ofRadiology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Czech Republic, V Uvalu 84, Prague 5, 150 06

Correspondence to:

Jan Laczó, MD, PhD

Department of Neurology

2nd Faculty of Medicine, Charles University and Motol University Hospital

V Úvalu 84

150 06 Prague

Czech Republic

Telephone number: +420224436860

Fax number: +420224436875

Online Resource Table 4 Regional brain volumes increased in the group with clinically isolated syndrome at high risk for multiple sclerosis compared to controls

Structure / Side / Voxel / mm / maxX / maxY / maxZ / p values
Occipital Lobe
Occipital Pole / lh / 383 / 3064 / 55 / 17 / 21 / <0.001
rh / 397 / 3176 / 38 / 17 / 22 / <0.001
Lateral Occipital Cortex inferior division / lh / 421 / 3368 / 58 / 17 / 21 / <0.001
rh / 798 / 6384 / 32 / 17 / 21 / <0.001
Temporal Occipital Fusiform Cortex / lh / 36 / 288 / 50 / 17 / 23 / 0.005
Occipital Fusiform Gyrus / lh / 583 / 4664 / 66 / 26 / 21 / <0.001
rh / 471 / 3768 / 38 / 20 / 21 / <0.001
Supracalcarine Cortex / lh / 37 / 296 / 52 / 15 / 26 / 0.009
rh / 32 / 256 / 41 / 13 / 45 / 0.008
Others
Cerebellum / lh / 3599 / 28792 / 51 / 32 / 4 / <0.001
rh / 3911 / 31288 / 32 / 30 / 4 / <0.001
Putamen / lh / 206 / 1648 / 54 / 66 / 35 / 0.010
rh / 90 / 720 / 30 / 67 / 34 / 0.021
Brain-Stem / 1780 / 14240 / 47 / 36 / 4 / <0.001