Table S1 Complete Linear Regression Analyis

Linear Regression Analysis
dv / Time / Iv T1 / Estimate / 95% CI / p-value
OPG / T2 / OPG / 6.7440 / 4.2705 / - / 10.6502 / 0.0000 / ***
T2 / RANKL / 0.8829 / 0.7843 / - / 0.9938 / 0.0395 / *
T2 / Leptin / 0.8039 / 0.7208 / - / 0.8966 / 0.0002 / ***
T2 / ZLSC / 1.6038 / 0.8018 / - / 3.2081 / 0.1777
T2 / treat / 1.0144 / 0.9231 / - / 1.1147 / 0.7632
OPG / T3 / OPG / 4.4971 / 2.6737 / - / 7.5641 / 0.0000 / ***
T3 / treat / 1.0048 / 0.9024 / - / 1.1189 / 0.9286
OPG / T4 / OPG / 4.2085 / 2.7040 / - / 6.5500 / 0.0000 / ***
T4 / treat / 1.0486 / 0.9569 / - / 1.1490 / 0.3040
OPG / T5 / OPG / 1.9338 / 1.0195 / - / 3.6680 / 0.0437 / *
T5 / RANKL / 0.7966 / 0.6780 / - / 0.9360 / 0.0067 / **
T5 / OC / 1.4312 / 0.9985 / - / 2.0514 / 0.0509 / ,
T5 / OPN / 0.8604 / 0.7532 / - / 0.9829 / 0.0277 / *
T5 / treat / 0.9880 / 0.8662 / - / 1.1268 / 0.8539
RANKL / T2 / RANKL / 1.9704 / 1.1413 / - / 3.4019 / 0.0159 / *
T2 / Leptin / 0.6633 / 0.3961 / - / 1.1108 / 0.1163
T2 / PTH / 4.7904 / 1.2051 / - / 19.0426 / 0.0268 / *
T2 / ZLSC / 0.0037 / 0.0002 / - / 0.0876 / 0.0008 / ***
T2 / treat / 1.0825 / 0.7088 / - / 1.6532 / 0.7092
RANKL / T3 / OC / 2.6942 / 0.8311 / - / 8.7343 / 0.0970 / ,
T3 / ACTH / 1.5376 / 1.1176 / - / 2.1155 / 0.0091 / **
T3 / treat / 0.9048 / 0.5874 / - / 1.3937 / 0.6447
RANKL / T4 / ACTH / 1.5530 / 1.0421 / - / 2.3142 / 0.0311 / *
T4 / treat / 0.8812 / 0.5139 / - / 1.5110 / 0.6405
RANKL / T5 / OPG / 0.2659 / 0.0370 / - / 1.9115 / 0.1835
T5 / ACTH / 1.8484 / 1.3570 / - / 2.5177 / 0.0002 / ***
T5 / treat / 0.8933 / 0.5796 / - / 1.3769 / 0.6029
OR / T2 / OR / 2.3536 / 1.3608 / - / 4.0708 / 0.0028 / **
T2 / OPG / 5.2055 / 0.5291 / - / 51.2176 / 0.1539
T2 / PTH / 0.2200 / 0.0544 / - / 0.8905 / 0.0343 / *
T2 / ZLSC / 646.0558 / 24.1830 / - / 17259.4340 / 0.0002 / ***
T2 / treat / 0.8994 / 0.5731 / - / 1.4113 / 0.6391
OR / T3 / OPG / 9.5713 / 1.2583 / - / 72.8062 / 0.0298 / *
T3 / OC / 0.3880 / 0.1213 / - / 1.2415 / 0.1086
T3 / ACTH / 0.6311 / 0.4624 / - / 0.8611 / 0.0044 / **
T3 / treat / 1.0678 / 0.6967 / - / 1.6365 / 0.7596
OR / T4 / OPG / 7.8330 / 0.4986 / - / 123.0697 / 0.1401
T4 / OC / 0.3174 / 0.0655 / - / 1.5393 / 0.1510
T4 / ACTH / 0.6512 / 0.4270 / - / 0.9931 / 0.0465 / *
T4 / treat / 1.1970 / 0.6704 / - / 2.1371 / 0.5370
Ratio / T5 / OR / 1.7918 / 1.0186 / - / 3.1518 / 0.0432 / *
T5 / ACTH / 0.5766 / 0.4039 / - / 0.8231 / 0.0031 / **
T5 / treat / 1.2110 / 0.7514 / - / 1.9518 / 0.4243
OC / T3 / OC / 5.7422 / 3.5017 / - / 9.4162 / 0.0000 / ***
T3 / RANKL / 0.7524 / 0.5951 / - / 0.9513 / 0.0184 / *
T3 / Leptin / 0.7224 / 0.5840 / - / 0.8936 / 0.0034 / **
T3 / OPN / 0.8289 / 0.6898 / - / 0.9959 / 0.0453 / *
T3 / PTH / 2.2066 / 1.2438 / - / 3.9145 / 0.0077 / **
T3 / ACTH / 1.1156 / 0.9646 / - / 1.2901 / 0.1374
T3 / treat / 0.9721 / 0.8096 / - / 1.1673 / 0.7577
OC / T4 / OC / 4.7021 / 3.2468 / - / 6.8097 / 0.0000 / ***
T4 / treat / 0.9900 / 0.8681 / - / 1.1290 / 0.8790
OC / T5 / OC / 5.0226 / 2.8702 / - / 8.7891 / 0.0000 / ***
T5 / treat / 0.9214 / 0.7498 / - / 1.1321 / 0.4286
Leptin / T3 / Leptin / 6.0336 / 4.2828 / - / 8.5004 / 0.0000 / ***
T3 / RANKL / 0.6218 / 0.4218 / - / 0.9164 / 0.0172 / *
T3 / treat / 0.8402 / 0.6209 / - / 1.1368 / 0.2537
Leptin / T4 / Leptin / 6.3794 / 4.8159 / - / 8.4507 / 0.0000 / ***
T4 / RANKL / 0.7587 / 0.5519 / - / 1.0430 / 0.0877 / ,
T4 / treat / 0.9720 / 0.7584 / - / 1.2456 / 0.8194
Leptin / T5 / Leptin / 6.4184 / 3.7080 / - / 11.1102 / 0.0000 / ***
T5 / OPN / 0.6271 / 0.3969 / - / 0.9907 / 0.0457 / *
T5 / PTH / 3.2295 / 0.6908 / - / 15.0984 / 0.1331
T5 / treat / 0.9169 / 0.5721 / - / 1.4694 / 0.7132
OPN / T3 / OPN / 2.3000 / 1.5401 / - / 3.4348 / 0.0001 / ***
T3 / RANKL / 0.6904 / 0.4156 / - / 1.1467 / 0.1492
T3 / ACTH / 0.8275 / 0.6019 / - / 1.1378 / 0.2387
T3 / treat / 1.1248 / 0.7522 / - / 1.6820 / 0.5605
OPN / T4 / OPN / 2.3853 / 1.5623 / - / 3.6419 / 0.0001 / ***
T4 / RANKL / 0.6833 / 0.3975 / - / 1.1747 / 0.1647
T4 / Leptin / 1.4061 / 0.8728 / - / 2.2654 / 0.1578
T4 / treat / 1.0406 / 0.6832 / - / 1.5848 / 0.8506
OPN / T5 / RANKL / 0.5020 / 0.2977 / - / 0.8465 / 0.0108 / *
T5 / PTH / 3.0912 / 0.8427 / - / 11.3391 / 0.0873 / ,
T5 / treat / 1.1143 / 0.7285 / - / 1.7045 / 0.6115
PTH / T3 / PTH / 2.7576 / 1.2546 / - / 6.0614 / 0.0125 / *
T3 / treat / 1.0251 / 0.7935 / - / 1.3243 / 0.8473
PTH / T4 / PTH / 2.5099 / 1.6122 / - / 3.9073 / 0.0001 / ***
T4 / RANKL / 0.8648 / 0.7219 / - / 1.0359 / 0.1126
T4 / Leptin / 0.8582 / 0.7261 / - / 1.0144 / 0.0723 / ,
T4 / ACTH / 1.1220 / 1.0059 / - / 1.2515 / 0.0392 / *
T4 / ZLSC / 2.3375 / 0.8440 / - / 6.4736 / 0.1005
T4 / treat / 1.0917 / 0.9473 / - / 1.2582 / 0.2204
PTH / T5 / PTH / 3.7164 / 1.9765 / - / 6.9880 / 0.0001 / ***
T5 / OPG / 0.4465 / 0.1796 / - / 1.1100 / 0.0813 / ,
T5 / RANKL / 0.6917 / 0.5376 / - / 0.8899 / 0.0050 / **
T5 / OC / 1.6167 / 0.9692 / - / 2.6968 / 0.0651 / ,
T5 / Leptin / 0.8487 / 0.6598 / - / 1.0917 / 0.1964
T5 / ZLSC / 3.5065 / 0.7958 / - / 15.4506 / 0.0954 / ,
T5 / treat / 1.1042 / 0.9073 / - / 1.3440 / 0.3152
ACTH / T3 / ACTH / 1.7882 / 1.3280 / - / 2.4079 / 0.0002 / ***
T3 / OC / 2.4955 / 0.8442 / - / 7.3767 / 0.0966 / ,
T3 / OPN / 0.6647 / 0.4478 / - / 0.9866 / 0.0429 / *
T3 / treat / 0.7924 / 0.5345 / - / 1.1747 / 0.2414
ACTH / T4 / ACTH / 2.5111 / 1.3523 / - / 4.6630 / 0.0043 / **
T4 / RANKL / 2.3338 / 0.8417 / - / 6.4706 / 0.1015
T4 / OC / 172.0165 / 19.8209 / - / 1492.8573 / 0.0000 / ***
T4 / Leptin / 2.5854 / 1.0126 / - / 6.6014 / 0.0471 / *
T4 / PTH / 0.0587 / 0.0048 / - / 0.7226 / 0.0276 / *
T4 / treat / 0.7963 / 0.3556 / - / 1.7830 / 0.5734
ACTH / T5 / ACTH / 4.3291 / 1.5825 / - / 11.8419 / 0.0052 / **
T5 / RANKL / 0.0709 / 0.0130 / - / 0.3863 / 0.0029 / **
T5 / OC / 383.6189 / 15.4082 / - / 9551.9201 / 0.0005 / ***
T5 / Leptin / 0.1826 / 0.0419 / - / 0.7944 / 0.0243 / *
T5 / OPN / 0.1773 / 0.0473 / - / 0.6649 / 0.0114 / *
T5 / ZLSC / 13455.5049 / 0.5776 / - / 313474927.0604 / 0.0633 / ,
T5 / treat / 0.8515 / 0.2419 / - / 2.9970 / 0.7983
ZLSC / T2 / ZLSC / 6.1633 / 3.9219 / - / 9.6856 / 0.0000 / ***
T2 / RANKL / 1.0693 / 0.9939 / - / 1.1504 / 0.0715 / ,
T2 / OC / 1.1274 / 0.9546 / - / 1.3315 / 0.1543
T2 / OPN / 0.9407 / 0.8837 / - / 1.0014 / 0.0551 / ,
T2 / PTH / 1.2479 / 1.0377 / - / 1.5008 / 0.0195 / *
T2 / treat / 1.0136 / 0.9557 / - / 1.0750 / 0.6471
ZLSC / T3 / ZLSC / 6.9661 / 4.3292 / - / 11.2093 / 0.0000 / ***
T3 / OPN / 0.9416 / 0.8814 / - / 1.0058 / 0.0731 / ,
T3 / treat / 1.0278 / 0.9649 / - / 1.0947 / 0.3884
ZLSC / T4 / ZLSC / 6.2492 / 3.5756 / - / 10.9220 / 0.0000 / ***
T4 / OPN / 0.9376 / 0.8677 / - / 1.0132 / 0.1015
T4 / treat / 1.0156 / 0.9432 / - / 1.0937 / 0.6763
ZLSC / T5 / ZLSC / 4.7736 / 2.7090 / - / 8.4117 / 0.0000 / ***
dv dependent variable, iv independent variable, CI confidence interval,
OPG Osteoprotegerin, RANKL receptor activator of nuclear κB ligand, OC osteocalcin, OPN osteopontin. PTH parathyroid hormone, ACTH adrenocorticotropic hormone, ZLSC Zerssen`s list of somatic complaints
Treat treatment (placebo or radon)
T1,T2,T3,T4,T5 timepoints,T1=day0, T2=day6, T3=day60, T4=day63, T5=day 240
Significance codes: *** <0.001, ** <0.01, *< 0.05, ,< 0.1. n.s. not significant

2