Curriculum Vitae

Associate Professor David Andrew Osborn

Current Position

1999 - 2007Neonatologist - Staff Specialist in Neonatal Medicine

Royal PrinceAlfredHospital

University appointment

2007Clinical Associate Professor, Faculty of Medicine and the Central Clinical School, The University of Sydney

University Degrees and Qualifications

1984MB, BSBachelor of Medicine and Bachelor of Surgery

University of Sydney

1999 MMed (Clin Epi)Masters of Medicine (Clinical Epidemiology)

University of Sydney

1998FRACPAdvanced training in Neonatal/Perinatal Medicine with the

RoyalAustralasianCollege of Physicians

1998FRACPFellow of the RoyalAustralasianCollege of Physicians:

Division of Paediatrics

2006PhDDoctor of Philosophy

University of Sydney

Medical registration

1984 NSW Medical Board

Registration number: MPO 201007

Postgraduate examinations

1987RACS Primary examination

1995RACP Paediatrics Fellowship Examination

Clinical activities

Current clinical responsibilities

Full time Staff Specialist Neonatologist Royal PrinceHospital including responsibilities for:

  • Neonatal intensive care, neonatal high dependency unit and special care nursery comprising total of 9 ventilated level 3 cots and 24 non-ventilated level 2 cots.
  • Developmental follow up of high risk infants including all infants born <30 weeks gestation, <1000g, birth weight <3rd percentile or neurological concern.
  • Neonatal consultant for RPA Women and Babies for any referred newborn infants born at Royal PrinceAlfredHospital.
  • Perinatal consultant RPA Women and Babies for any referred pregnant women at Royal PrinceAlfredHospital.
  • Neonatologist on call roster 24 hours / 7 days a week, one week in four at Royal PrinceAlfredHospital.

Clinical experience

1984 Intern - Royal PrinceAlfredHospital

1985 - 1986Resident Medical Officer - Royal PrinceAlfredHospital

1987 – 1988Surgical Registrar - Royal PrinceAlfredHospital

1989Anaesthetic Registrar - WestmeadHospital

1990 - 1993Paediatric Registrar - WestmeadHospital

1994 - 1995Paediatric Registrar - RoyalAlexandraHospital for Children,

Camperdown, and the Children’s Hospital, Westmead

1996Neonatal Fellow - Westmead Hospital Department of Neonatology

1997 - 1998Neonatal Fellow - Royal PrinceAlfredHospital

1999 – 2006Research fellow - Royal PrinceAlfredHospital and

RoyalNorthShoreHospital

2000 - CurrentStaff Specialist Neonatologist – Royal PrinceAlfredHospital

Clinical skills

Perinatologist and Neonatologist - Advanced training in Neonatal / Perinatal Medicine, RoyalAustralasianCollege of Physicians.

Paediatrician -Fellowship of the RoyalAustralasianCollege of Physicians

Developmental assessment - Advanced training in Neonatal / Perinatal Medicine, RoyalAustralasianCollege of Physicians.

Accredited to perform the Griffith’s Mental Development Scales.

Echocardiography -Research and development of functional echocardiography in the newborn

Evidence Based Medicine -Masters in Medicine (Clinical Epidemiology), University of Sydney.

Tutor in Evidence Based Medicine, Postgraduate Training, RPA Newborn Care.

Tutor in Evidence Based Medicine, Postgraduate Medical Course, University of Sydney 2000-2001.

Reviewer Cochrane Collaboration –24 reviews

Teaching activities

I have extensive experience over the last decade in educational activities of many groups including:

  • Supervisor Perinatal / Neonatal training, RoyalAustralasianCollege of Physicians, currently primary supervisor one fellow and co-supervisor 2 fellows.
  • University of Sydney undergraduate medical students,
  • University of Sydney postgraduate medical students resident
  • Registrar medical officers undertaking basic and advanced training in Paediatrics and Perinatal / Neonatal training for the RoyalAustralasianCollege of Physicians,
  • Postgraduate multidisciplinary education involving medical, nursing and allied health workers at Royal PrinceAlfredHospital,
  • Residents and registrars in Obstetrics and Gynaecology at Royal PrinceAlfredHospital undertaking fellowship training with the RANZCOG, and
  • Perinatal Services Network Outreach educational workshops in NSW level 2 Neonatal Services for staff involved in the care of newborn infants.
  • International educational initiatives for Doctors and Nurses in the Republic of Macedonia.
  • Neonatal educator with HOC MÃI, 2007 - The Australia Vietnam Medical Foundation, The University of Sydney – an international educational effort between the University of Sydney and the Ministry for Health, Vietnam. This involves developing and conducting week long perinatal workshops conducted in Hanoi, with the goal of ‘training the trainer’ and improving perinatal health and mortality in Vietnam.
  • Co-investigator and member of the Australian based Cochrane Collaboration Activities – Neonatal Review Group Support Group. This group provides support for Australasian reviewers for the Cochrane Collaboration including outreach workshops.

I am skilledin, and intensively conduct, opportunistic teaching in a clinical setting and integrate Evidence Based Practice into clinical teaching and practice.

I have had an extensive involvement in and understanding of Problem Based Learning, use of educational methods such as workshops and SCORPIO, and teaching of multidisciplinary groups.

I have developed and run regular courses in Evidence Based Medicine for postgraduate medical and nursing staff at RPA Newborn Care, and as a consultant for an International Educational Initiative for the Republic of Macedonia both at RPA Women and Babies and the Republic of Macedonia. I organise and facilitate monthly critical appraisals by Obstetric and Gynaecology and Neonatal Trainees at RPA Women and Babies.

I am Chair of the Neonatal Examination Committee for the Graduate Medical Programme, University of Sydney – responsible for the development of Neonatal Assessments and development of a new Neonatal Curriculum Grid, 2006-2007. I have contributed to the development of assessments including OSCE’s, Short Answer Questions and Modified Essay Questions and I am a regular examiner using these tools.

University of SydneyPostgraduate Medical Program

1997 – 2000Tutor in Evidence Based Medicine for Postgraduate Medical

Students from 1997 to 2000. Small group tutorials for Year 1 and

2 University of Sydney GMP Medical Students in Evidence Based

Medicine.

1998 – 2000Clinical tutor in Paediatrics for Postgraduate Medical students. Bedside tutorials in paediatrics for Year 1 University of Sydney Graduate Medical Program Students at Royal PrinceAlfredHospital

2000Developed OSCEs, Short Answer Questions and Modified Essay Questions for the formative assessment of the Perinatal and Women Health Rotation

2004Developed Problem Based Learning Tutorial for the Perinatal and Women Health Rotation (Cynthia’s Problem)

2005 - 2007Chair, Neonatal committee for redevelopment of current year 4 neonatal assessments including short answer questions, OSCEs and MEQs.

2000 - 2007Problem Based Learning tutor for Central Clinical School Perinatal and Women’s Health Rotation at Royal PrinceAlfredHospital

2000 - 2007Bedside tutorials for Central Clinical School Perinatal and Women’s Health Rotation at Royal PrinceAlfredHospital

2000 – 2007Educator in SCORPIO sessions for Central Clinical School Perinatal and Women’s Health Rotation at Royal PrinceAlfredHospital.

2000 – 2007Examiner for OSCE at Central Clinical School Perinatal and Women’s Health Rotation at Royal PrinceAlfredHospital.

2000-2007Marking of Short Answer Questionsat Central Clinical School Perinatal and Women’s Health Rotation at Royal PrinceAlfredHospital.

University of Sydney Medical Science Program

2000 – 2006 Annual half day workshops for undergraduate Medical Science

Students on applied neonatal cardiovascular and respiratory physiology

2006 Lecture to undergraduate Medical Science Studentsapplied

neonatal cardiovascular and respiratory physiology

University of Sydney Undergraduate Medical Program

1997 – 1999Clinical tutor for Undergraduate Medical students from 1997 to 1999 incorporatingProblem Based Learning into clinical tutorials – Women’s and Children’s Health,RPAHospital and the University of Sydney.

1997 – 1999Tutor in neonatal SCORPIO teaching sessions for the

Women’s and Children’s Health rotation.

1998 – 1999 Clinical assessor in neonatal OSCE formative assessments for the

Undergraduate Medical Course, Women’s and Children’s Health rotation.

1997 – 1999Tutor in epidemiology for Undergraduate Medical students from

1997 to 1998. Small group tutorials for Year 3 Medical Students,

University of Sydney, in Epidemiology and Evidence Based Medicine.

1996Clinical tutor in Neonatology for Year 5 Undergraduate Medical

Students, University of Sydney.

Royal PrinceAlfredHospital Postgraduate Education

1997 – 2007Tutor and supervisor in Postgraduate Education Program for Postgraduate Trainees (Resident Medical Officers and Basic and Advanced Registrars Trainees for RACP) in Paediatrics and Neonatalology at Royal Prince Alfred Hospital.

1999 – 2007Developed and run Evidence Based Medicine tutorials run twice yearly for Postgraduate Trainees in RPA Newborn Care, Royal PrinceAlfredHospital.

1997 – 2007Tutor in SCORPIOs for Postgraduate Trainees in Paediatrics and Neonatalology, and nursing Staff, at Royal PrinceAlfredHospital.

2005 – 2007Tutor in Postgraduate Education Program for RANZCOG Obstetric Trainees in RPA Women and Babies, Royal PrinceAlfredHospital.

2000 - 2007Supervisor, advanced trainees RACP for Perinatal / Neonatal Training at Royal PrinceAlfredHospital.

NSW Perinatal Services Outreach Education Program

2000 – 2007Tutor in NSW Perinatal Services Outreach Program resuscitation training workshops in level 2 Neonatal Centres (urban and rural) including Broken Hill, Eden, Wagga Wagga, HornsbyHospital, Cooma and Moruya.

2006Tutor in NSW Perinatal Services Outreach Program Neonatal Abstinence Syndrome in Broken Hill.

International Education Initiative Postgraduate Education Program for the Republic of Macedonia

1999-2000Educator for an International Educational Initiative to improve

perinatal and infant health in the Republic of Macedonia. Developed and ran a course in Evidence Based Practice in Perinatal Health for medical and nursing staff conducted for separate groups at RPA Women and Babies and in Macedonia.

2007Educator in short perinatal and evidence based medicine course in Malaysia.

Cochrane Neonatal Review Group Australasian Reviewer Support Group

2003 – 2007Tutor for the Cochrane Neonatal Review Group Australasian

Reviewer Support Group. All day workshops conducted at JohnHunterHospital, RoyalNorthShoreHospital, NepeanHospital, and NSW Neonatal Emergency Transport Service, Westmead.

2006 – 2007 Co-investigator for the Australasian Co-ordinating Network for Cochrane Neonatal Review Group. The function is to provide education and support for authors of Cochrane reviews for the Neonatal Review Group. This is funded by the Commonwealth Department of Health and Aging - through the School of Public Health, University of Sydney (7 years funding June 2001 - June 2008, $280,000; 3 grants - 2001-2003, 2003 -2005, 2005-2008). Mentor for the Cochrane Neonatal Review Group Australasian

Reviewer Support Group – providing support for NSW

neonatal reviewers.

Cochrane workshops

2005One day workshop – Systematic reviews, JohnHunterHospital,

Newcastle

2005One day workshop – Systematic reviews, NepeanHospital, Penrith

2005Cochrane Systematic Reviews Workshop – NETS, Westmead

Sydney South West Area Health Service education

2000 – 2006Division of General Practice education: newborn examination.

2005 – 2006 Division of General Practice education: management of neonatal abstinence syndrome.

2006Early Childhood Centre Education: Care of the pregnant substance using mother.

2007Foster Carer Education: Babies Experiencing Neonatal Abstinence Syndrome. SCORPIO.

Department of Community Services education

2006DOCS Legal Officers Conference: Effects of drugs and alcohol in pregnancy and on parenting. Sydney.

2006Foster Carer Education: Babies Experiencing Neonatal Abstinence Syndrome. SCORPIO.

2007Foster Carer Education: Babies Experiencing Neonatal Abstinence Syndrome. SCORPIO.

Research / Scholarship

Publications in Refereed Journals

  1. Osborn DA, Lockley C, Jeffery HE, Lloyd J, Lazarus R. Interobserver reliability of the click test: a rapid bedside test to determine surfactant function. Journal of Paediatrics and Child Health 1998;34:544-7.
  1. Osborn DA, Lui K, Pussell P, Jana AK, Desai AS, Cole M. T and Tk antigen activation in necrotising enterocolitis: manifestations, severity of illness, and effectiveness of testing. Archives of Disease in Childhood Fetal Neonatal Ed 1999;80:F192-7.
  1. Osborn DA, Lau KC, Uther JB, Coughtrey H, Rochefort MJ. Radiofrequency catheter ablation in a haemodynamically compromised premature neonate with hydrops fetalis. Journal of Paediatrics and Child Health 1999;35:406-8.
  1. Osborn DA, Jeffery HE, Bredemeyer SL, Polverino JM, Reid S. Targeted early rescue surfactant in ventilated preterm infants using the click test. Pediatrics 2000;106:E30.
  1. Henderson-Smart DJ, Osborn DA. Kinesthetic stimulation for preventing apnea in preterm infants. Cochrane Database of Systematic Reviews 2000:CD000373.
  1. Osborn DA, Henderson-Smart DJ. Kinesthetic stimulation for treating apnea in preterm infants. Cochrane Database of Systematic Reviews 2000:CD000499.
  1. Osborn DA, Henderson-Smart DJ. Kinesthetic stimulation versus theophylline for apnea in preterm infants. Cochrane Database of Systematic Reviews 2000:CD000502.
  1. Osborn DA. Thyroid hormones for preventing of neurodevelopmental impairment in preterm infants. Cochrane Database of Systematic Reviews 2000:CD001070.
  1. Osborn DA, Evans N. Early volume expansion versus inotrope for prevention of morbidity and mortality in very preterm infants. Cochrane Database of Systematic Reviews 2001:CD002056.
  1. Osborn DA. Thyroid hormones for preventing neurodevelopmental impairment in preterm infants. Cochrane Database of Systematic Reviews 2001:CD001070.
  1. Osborn DA, Evans N. Early volume expansion for prevention of morbidity and mortality in very preterm infants. Cochrane Database of Systematic Reviews 2001:CD002055.
  1. Osborn D, Evans N, Kluckow M. Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow. Journal of Pediatrics 2002;140:183-91.
  1. Evans N, Kluckow M, Simmons M, Osborn D. Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants. Archives of Disease in Childhood Fetal Neonatal Ed 2002;87:F181-4.
  1. Loh M, Osborn DA, Lui K. Outcome of very premature infants with necrotising enterocolitis cared for in centres with or without on site surgical facilities. Archives of Disease in Childhood Fetal Neonatal Ed 2001;85:F114-8.
  1. Henderson-Smart DJ, Osborn DA. Kinesthetic stimulation for preventing apnea in preterm infants. Cochrane Database of Systematic Reviews 2002:CD000373.
  1. Osborn DA, Jeffery HE, Cole MJ. Sedatives for opiate withdrawal in newborn infants. Cochrane Database of Systematic Reviews 2002:CD002053.
  1. Osborn DA, Cole MJ, Jeffery HE. Opiate treatment for opiate withdrawal in newborn infants. Cochrane Database of Systematic Reviews 2002:CD002059.
  1. Hunt R, Osborn D. Dopamine for prevention of morbidity and mortality in term newborn infants with suspected perinatal asphyxia. Cochrane Database of Systematic Reviews 2002:CD003484.
  1. Osborn DA, Sinn J. Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants. Cochrane Database of Systematic Reviews 2003:CD003664.
  1. Osborn DA, Evans N, Kluckow M. Effect of early targeted indomethacin on the ductus arteriosus and blood flow to the upper body and brain in the preterm infant. Archives of Disease in Childhood Fetal Neonatal Ed 2003;88:F477-82.
  1. Osborn DA, Evans N. Randomized trial of high-frequency oscillatory ventilation versus conventional ventilation: effect on systemic blood flow in very preterm infants. Journal of Pediatrics 2003;143:192-8.
  1. Osborn DA, Evans N, Kluckow M. Hemodynamic and antecedent risk factors of early and late periventricular/intraventricular hemorrhage in premature infants. Pediatrics 2003;112:33-9.
  1. Osborn DA, Sinn J. Soy formula for prevention of allergy and food intolerance in infants. Cochrane Database of Systematic Reviews 2004:CD003741.
  1. Osborn DA, Evans N. Early volume expansion for prevention of morbidity and mortality in very preterm infants. Cochrane Database of Systematic Reviews 2004:CD002055.
  1. Paradisis M, Osborn DA. Adrenaline for prevention of morbidity and mortality in preterm infants with cardiovascular compromise. Cochrane Database of Systematic Reviews 2004:CD003958.
  1. Lacey JL, Rudge S, Rieger I, Osborn DA. Assessment of neurological status in preterm infants in neonatal intensive care and prediction of cerebral palsy. Australian Journal of Physiotherapy 2004;50:137-44.
  1. Osborn DA, Evans N, Kluckow M. Clinical detection of low upper body blood flow in very premature infants using blood pressure, capillary refill time, and central-peripheral temperature difference. Archives of Disease in Childhood Fetal Neonatal Ed 2004;89:F168-73.
  1. Doggett C, Burrett S, Osborn D. Home visits during pregnancy and after birth for women with an alcohol or drug problem. Cochrane Database of Systematic Reviews. 2005;4:CD004456. .
  1. Osborn DA, Jeffery H, Cole M. Sedatives for opiate withdrawal in newborn infants. Cochrane Database of Systematic Reviews 2005:CD002053.
  1. Osborn DA, Jeffery H, Cole M. Opiate treatment for opiate withdrawal in newborn infants. Cochrane Database of Systematic Reviews 2005:CD002059.
  1. Osborn DA, Sinn J. Soy formula for prevention of allergy and food intolerance in infants. (Substantial update) Cochrane Database of Systematic Reviews 2006:CD003741.
  1. Osborn DA, Sinn J. Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants. (Substantial update) Cochrane Database of Systematic Reviews 2006:CD003664.
  1. Osborn DA, Paradisis M, Evans N. Inotropes for reducing morbidity and mortality in preterm infants with low systemic or organ blood flow. Cochrane Database of Systematic Reviews 2006. CD005090.
  1. Osborn DA, Evans N, Kluckow M, Rieger I. Low SVC flow, inotropes and neurodevelopment to 3 years in preterm infants. Pediatrics. 2007;120;372-80.
  1. Osborn DA, Hunt RW. Postnatal thyroid hormones for preterm infants with transient hypothyroxinaemia. Cochrane Database of Systematic Reviews 2007. CD005945.
  1. Osborn DA, Hunt RW. Postnatal thyroid hormones for respiratory distress in preterm infants. Cochrane Database of Systematic Reviews 2007. CD005946.
  1. Osborn DA, Hunt RW. Prophylactic postnatal thyroid hormones for prevention of morbidity and mortality in preterm infants. Cochrane Database of Systematic Reviews 2007. CD005948.
  1. Paradisis M, Jiang X, McLachlan AJ, Evans N, Kluckow M,Osborn D. Population pharmacokinetics and dosing regimen design of milrinone in preterm infants.Archives of Disease in Childhood Fetal & Neonatal Edition. 92(3):F204-9, 2007.
  1. Osborn DA, Evans N, Kluckow M. Left ventricular contractility in extremely premature infants in the first day and response to inotropes. Pediatric Research. 2007;61:335-40.
  1. Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database of Systematic Reviews. (4):CD006475, 2007.
  1. Osborn DA, Sinn JK. Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database of Systematic Reviews. (4):CD006474, 2007.
  1. Osborn DA, Sinn JK. The Cochrane Library and dietary prevention of allergy and food hypersensitivity in children; an umbrella review. BMJ Evid Based Child Health 2007;2:541–52.
  1. de Waal KA, Evans N, Osborn DA, Kluckow M. Cardiorespiratory effects of changes in end expiratory pressure in ventilated newborns. Archives of Disease in Childhood Fetal & Neonatal Edition. 92(6):F444-8, 2007.
  1. Osborn DA, Paradisis M, Evans N. The effect of inotropes on morbidity and mortality in preterm infants with low systemic or organ blood flow. Cochrane Database of Systematic Reviews. (1):CD005090, 2007.

Invited Publications in Journals

  1. Henderson-Smart DJ, Osborn D, Evans N, Beeby P, Jeffery H. Do we practice evidence-based care in our neonatal intensive care units? Clin Perinatol 2003;30:333-42.
  1. Osborn DA, Evans N, Kluckow. Diagnosis and treatment of low systemic blood flow in preterm infants. Neoreviews 2004;5;e109-22.
  1. Kluckow N, Evans N, Osborn D. Low systemic blood flow and brain injury in the preterm infant. Neoreviews 2004;5;e98-108.
  1. Evans N, Malcolm G, Osborn D, Kluckow M. Diagnosis of patent ductus arteriosus in preterm infants. Neoreviews 2004;5;e86-97.
  1. Osborn DA. Diagnosis and treatment of preterm transitional circulatory compromise. Early Human Development2005;81:413-22.
  1. Osborn DA, Sinn JK. The Cochrane Library and dietary prevention of allergy and food hypersensitivity in children; an umbrella review. BMJEvidence Based Child Health 2007. Accepted for publication (peer reviewed).

Invited Publications in Textbooks

1.Osborn D, Burrell T. Neonatal abstinence syndrome. In: Evidence Based Pediatrics and Child Health. 2nd edition. Eds: MoyerVA, Elliott EJ. BMJ Books. 2004.

2.Osborn DA. Chapter 6. Evidence-based evaluation of the management of neonatal shock. In: Cardiovascular Series.Eds: Klienman and SeriI. 2007Accepted for publication.

3.Osborn DA, Sinn J. What evidence supports dietary interventions to prevent infant food hypersensitivity and allergy? Questions and Controversies in Neonatology. 2007. Accepted for publication.

Letters to peer reviewed journals

  1. Evans N, Osborn D, Kluckow M. Compensated shock and dopamine. Journal of Pediatrics 1999;135:135-6.
  1. Evans N, Osborn D, Kluckow M. Mechanism of blood pressure increase induced by dopamine in hypotensive preterm neonates. Archives of Disease in Childhood Fetal Neonatal Ed 2000;83:F75-6.
  1. Evans N, Osborn D, Kluckow M. Preterm circulatory support is more complex than just blood pressure. Pediatrics 2005;115:1114-5.

Grants

Dr Martin Kluckow, A/Prof Nick Evans Dr David Osborn. Randomised trial of systemic circulatory support: completed 1999. Co-investigator. Supported by the National Health and Medical Research Council of Australia and NorthShore Heart Research Foundation. $50000 per year 1988-1999.

Dr Martin Kluckow, A/Prof Nick Evans, Dr David Osborn. Prevention of low systemic blood flow and brain injury in very preterm babies using Milrinone. Co-investigator. Supported by the NorthShore Heart Research Foundation. $50000 per year. 2003-2006.