Areferences Are Numbered As in the Main Text, with the Following Additions

Supplementary Table 1. Nucleotide sequence differences between the cps loci analyzed in this paper and those of other strains of the same serotype. The first column shows the accession numbers of the additional sequences, which are compared to the sequences from strains of the same serotype used in this paper (last column). SNP, single nucleotide polymorphism.

Accession No. / Serotype / Referencea / Number of SNPs
(Accession number)
Z83335 / 1 / S5 / 13 (CR931632)
AF026471 / 2 / S2 / 21 (CR931680)
AE005672 / 4 / 45 / 4 (CR931635)
AF316639 / 4 / 18 / 9 (CR931635)
AY336008 / 5 / Unpublished GenBank entry / 6 (CR931637)
AF246897 / 6B / Unpublished GenBank entry / 162 (CR931639)b
AF316640 / 6B / 18 / 61 (CR931639)
AF316641 / 8 / 18 / 4 (CR931644)
AJ239004 / 8 / 32 / 18 (CR931644)
AF402095 / 9V / 41 / 17 (CR931648)
X85787 / 14 / S3 / 6 (CR931662)
AF316642 / 18C / 18 / 3 (CR931673)
AF094575 / 19A / 30 / 12 (CR931675)
U09239 / 19F / S1 / 27 (CR931678)
AF030373 / 23F / 29 / 74 (CR931685)
AF057294 / 23F / S6 / 40 (CR931685)
AJ006986 / 33F / S4 / 2 (CR931702)

aReferences are numbered as in the main text, with the following additions.

S1. Guidolin, A., J.K. Morona, R. Morona, D. Hansman, and J.C. Paton. 1994. Nucleotide sequence analysis of genes essential for capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 19F. Infect. Immun. 62:5384-5396.

S2. Iannelli, F., B.J. Pearce, and G. Pozzi G. 1999.The type 2 capsule locus of Streptococcus pneumoniae. J. Bacteriol. 181:2652-2654.

S3. Kolkman, M. A., W. Wakarchuk, P. J. Nuijten, and B. A. van der Zeijst. 1997. Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: molecular analysis of the complete cps locus and identification of genes encoding glycosyltransferases required for the biosynthesis of the tetrasaccharide subunit. Mol. Microbiol. 26:197-208.

S4. Llull, D., R. Lopez, E. Garcia, and Muňoz R. 1998. Molecular structure of the gene cluster responsible for the synthesis of the polysaccharide capsule of Streptococcus pneumoniae type 33F. Biochim. Biophys. Acta. 1443:217-224.

S5. Muňoz, R., M. Mollerach., R. Lopez, and E. Garcia. 1997. Molecular organization of the genes required for the synthesis of type 1 capsular polysaccharide of Streptococcus pneumoniae: formation of binary encapsulated pneumococci and identification of cryptic dTDP-rhamnose biosynthesis genes. Mol. Microbiol. 25:79-92.

S6. Ramirez, M., and A. Tomasz. 1998. Molecular characterization of the complete 23F capsular polysaccharide locus of Streptococcus pneumoniae. J. Bacteriol. 180:5273-5278.

bThe cps loci of serotype 6B strains fall into two classes, one very similar to those of 6A and the other more diverged (28). The AF246897 sequence is from the more divergent class and, in addition to the SNPs, includes an extra fragment of a LicD-family phosphotransferase gene.