Appendix 2: Characteristics of Included Studies (Using the Template of Review Manager)

Appendix 2: Characteristics of included studies (using the template of Review Manager)

Akinola 2009

Methods / Prospective
Participants / 50
Interventions / Uterine ArteryLigation
Outcomes / Reintervention risk and VAS
Follow-up: 36 months
Notes / Country where the study was conducted: Nigeria
Journal: Acta Obstetricia et Gynecologica 2009
Funding:notdescribed

Berman 2014

Methods / Prospective
Participants / 135
Interventions / Radio Frequency Volumetric Thermal Ablation
Outcomes / Reintervention risk and SSS, HRQL questionnaires
Follow-up: 36 months
Notes / Country where the study was conducted: United States
Journal: Journal of Minimally Invasive Gynecology 2014
Funding: Halt Medical, Inc., Brentwoord, CA (study sponsor)

Birinyi 2004

Methods / Retrospective
Participants / 58
Interventions / Hysteroscopicmyomectomy
Outcomes / Reintervention risk
Follow-up: 82 months
Notes / Country where the study was conducted: Hungary
Journal: European Journal of Obstetrics and Gynecology and Reproductive Biology 2004
Funding:notdescribed

Brolmann 2016

Methods / Prospective
Participants / 50
Interventions / Radio-frequency volumetric thermal ablation
Outcomes / Reintervention risk and SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: the Netherlands
Journal: Gynecological Surgery 2016
Funding:Gynesonics

Bucek 2006

Methods / Retrospective
Participants / 53
Interventions / Uterine ArteryEmbolisation (Vascular)
Outcomes / Reintervention risk
Follow-up: 36 months
Notes / Country where the study was conducted: Austria
Journal: American Journal of Roentgenology Women's Imaging
Funding:notdescribed

Capmas 2016a

Methods / Retrospectivestudy
Participants / 13
Interventions / Hysteroscopicmyomectomy
Outcomes / Reintervention risk
Follow-up: 36 months
Notes / Country where the study was conducted: France
Journal: European Journal of Obstetrics and Gynecology and Reproductive Biology 2016
Funding:notdescribed

Chang 2010

Methods / Retrospective
Participants / 591
Interventions / Hysteroscopy
Outcomes / Reintervention risk
Follow-up: 60 months
Notes / Country where the study was conducted: Taiwan
Journal: International Journal of Gynecology and Obstetrics 2010
Funding: none

Cho 2014

Methods / Retrospective
Participants / 24
Interventions / Radio Frequency Volumetric Thermal Ablation
Outcomes / Reintervention risk, SSS and HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: Korea
Journal: Journal of Minimally Invasive Gynecology 2014
Funding: Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology

Choi 2013

Methods / Retrospective
Participants / 223
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 25 months
Notes / Country where the study was conducted: Korea
Journal: Journal of Vascular Intervention Radiology 2013
Funding: none

Chrisman 2005

Methods / Prospective
Participants / 111
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 12 months
Notes / Country where the study was conducted: United States
Journal: Journal of Vascular Intervention Radiology 2005
Funding: none

Dobrotwir 2012

Methods / Retrospective
Participants / 100
Interventions / MRgFUS
Outcomes / Reintervention risk and SSS
Follow-up: 12 months
Notes / Country where the study was conducted: Australia
Journal: Journal of Medical Imaging and Radiation Oncology 2012
Funding: The Gandel Charitable Trust and Department of Health New Technologies Program

Duvnjak 2015

Methods / Retrospective
Participants / 350
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 93 months
Notes / Country where the study was conducted: Denmark
Journal: Cardiovascular Interventional Radiology 2015
Funding: none

Edwards 2007

Methods / RandomizedControlled Trial
Participants / 106
Interventions / Uterine ArteryEmbolization
Outcomes / Reinterventionrisk, EQ-5D, SF-36 questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: Scotland/United Kingdom
Journal: New Englang Journal of Medicine 2007
Funding: Chief Scientist Office of the Scottish Executive, Edinburgh

Feng 2002

Methods / Retrospective
Participants / 99
Interventions / Hysteroscopy
Outcomes / Reintervention risk
Follow-up: 72 months
Notes / Country where the study was conducted: China
Journal:Gynaecologic Endoscopy 2002
Funding: Not described

Flyckt 2016

Methods / Retrospectivestudy
Participants / 134 (81 open procedure; 28 laparoscopy; 25 robotic)
Interventions / Myomectomy (different procedures)
Outcomes / Reintervention risk
Follow-up: 96 months
Notes / Country where the study was conducted: USA
Journal: Obstetrics and Gynecology International 2016
Funding: none

Froeling 2013

Methods / Retrospective
Participants / 77 (36 vs. 41)
Interventions / MRgHIFU vs. Uterine Artery Embolization
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 61 months
Notes / Country where the study was conducted: Germany
Journal: European Journal of Radiology 2013
Funding:Notdescribed

Funaki 2009

Methods / Retrospective
Participants / 91
Interventions / MRgFUS
Outcomes / Reintervention risk
Follow-up: 34 months
Notes / Country where the study was conducted: Japan
Journal: Ultrasound in Obstetrics & Gynecology 2009
Funding:Notdescribed

Gabriel-Cox 2007

Methods / Retrospective
Participants / 562
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 57 months
Notes / Country where the study was conducted: United States
Journal: American Journal of Obstetrics and Gynecology 2007
Funding: Women's Health Research Institute, Kaiser Permanente Northern California

Galen 2014

Methods / Retrospective
Participants / 204
Interventions / Radio Frequency Volumetric Thermal Ablation
Outcomes / Reintervention risk and SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: United States
Journal: Journal of the Society of Laparoendoscopic Surgeons 2014
Funding:Notdescribed

GarzaLeal 2011

Methods / Prospective
Participants / 31
Interventions / Radio Frequency Volumetric Thermal Ablation
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: United States
Journal: The Journal of Minimally Invasive Gynecology 2011
Funding: None

Ghezzi 2007

Methods / Prospective
Participants / 25
Interventions / Radio Frequency Volumetric Thermal Ablation
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 24 months
Notes / Country where the study was conducted: Italy
Journal: Surgical endoscopy 2007
Funding: Not described

Glasser 2005

Methods / Retrospective
Participants / 139
Interventions / Myomectomy
Outcomes / Reintervention risk
Follow-up: 60 months
Notes / Country where the study was conducted: United States
Journal: Journal of the American Association of Gynecologic Laparoscopists 2003
Funding: None

Goodwin 2008

Methods / Prospective
Participants / 2112
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 36 months
Notes / Country where the study was conducted: United States
Journal: Obstetrics & Gynecology 2008
Funding: Society for Interventional Radiology Foundation through unrestricted grants from Biosphere Medical, Inc. (Rockland, MA) and Boston Scientific Corporation (Natick, MA).

Hahn 2015

Methods / RandomizedControlled Trial
Participants / 50 (25 vs. 25)
Interventions / Radio Frequency Volumetric Thermal Ablation vs. Myomectomy
Outcomes / Reintervention risk, SSS, HRQL and EQ-5D questionnaires
Follow-up: 60 months
Notes / Country where the study was conducted: Germany
Journal: International Journal of Gynecology and Obstetrics 2015
Funding: Halt Medical Inc (Brentwood, California USA)

Hamoda 2015

Methods / Prospective
Participants / 273
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 134 months
Notes / Country where the study was conducted: United Kingdom
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Funding: Notdescribed

Han 2014

Methods / Prospectivestudy
Participants / 37 patients
Interventions / MRgFUS
Outcomes / Reintervention risk
SSS
Follow-up: 48 months
Notes / Country where the study was conducted: Singapore
Journal: Ann Acad Med Singapore 2014
Funding:notdescribed

Ikink 2014

Methods / Prospective
Participants / 119 (51 vs. 68)
Interventions / MRgFUS vs. Uterine Artery Embolization
Outcomes / Reintervention risk
Follow-up: 15 vs. 24 months
Notes / Country where the study was conducted: the Netherlands
Journal: European Radiology 2014
Funding: None

Jacoby 2015

Methods / RandomizedControlled Trial
Participants / 13
Interventions / MRgFUS
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 24 months
Notes / Country where the study was conducted: United States
Journal: Fertility and Sterility 2015
Funding: intramural grant from the University of California at San Francisco Resource Allocation Program and the Department of Radiology and National Institues of Health grant for MRgFUS device.

Jiang 2014

Methods / Prospective
Participants / 46
Interventions / Radio Frequency Volumetric Thermal Ablation
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: China
Journal: European Journal of Obsterics and Gynecology and Reproductive Biology 2014
Funding: Notdescribed

Joffre 2004

Methods / Prospective
Participants / 85
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 15 months
Notes / Country where the study was conducted: France
Journal: Cardiovascular and Interventional Radiology 2004
Funding: Notdescribed

Kim, H 2011

Methods / Prospective
Participants / 40
Interventions / MRgFUS (Energy)
Outcomes / Reintervention risk, SSS, HRQL
Follow-up: 36 months
Notes / Country where the study was conducted: United States
Journal: Academic Radiolody 2011
Funding: supported in part by NIH InSightec Grant and Gatewoord Foundation Grant

Kramer 2015

Methods / RandomizedControlled Trial
Participants / 51 (26 vs. 25)
Interventions / Radio Frequency Volumetric Thermal Ablation vs. Myomectomy
Outcomes / Reintervention risk, SSS, HRQL and EQ-5D questionnaires
Follow-up: 24 months
Notes / Country where the study was conducted: Germany
Journal: International Journal of Gynecology and Obstetrics 2015
Funding: Halt Medical Inc (Brentwood, California USA)

Kroencke 2008

Methods / Prospective
Participants / 69
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: Germany
Journal: Journal of Vascular and Interventional Radiology 2008
Funding: supported by a grant of Biocompatibles, Farnham, Surrey, UK.

Laios 2014

Methods / Retrospective
Participants / 1178
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 12 months
Notes / Country where the study was conducted: Ireland
Journal:Hippokratia 2014
Funding: none

Lee 2015

Methods / Retrospective
Participants / 272
Interventions / US-HIFU
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: Korea
Journal: Ultra Sonochemistry 2015
Funding: none

Lenard 2008

Methods / Retrospective
Participants / 135
Interventions / MRgFUS
Outcomes / Reintervention risk, SSS questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: United States
Journal: Radiology 2008
Funding: supported in part by InSightec (Haifa, Israel) and by National Institues of Health grants

Liang 2012

Methods / Prospective
Participants / 75
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 24 months
Notes / Country where the study was conducted: Australia
Journal: Australian and New Zealand Journal of Obstetrics and Gynecology 2012
Funding: None

Liu 2016

Methods / Prospectivestudy
Participants / 311
Interventions / Ultrasound-guided percutaneous microwave
Outcomes / SSS
HR-QL
Follow-up: 12 maanden
Notes / Country where the study was conducted: China
Journal: International Journal of Hyperthermia 2016
Funding: Funds from the National Natural Science Foundation of China and Capital Characteristic Clinical APplication Research

Lohle 2008

Methods / Prospective
Participants / 100
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 54 months
Notes / Country where the study was conducted: the Netherlands
Journal: Journal of Vascular and Interventional Radiology 2008
Funding: None

Machtinger 2013

Methods / Prospective
Participants / 122
Interventions / MRgFUS
Outcomes / Reintervention risk, SSS questionnaires
Follow-up: 36 months
Notes / Country where the study was conducted: United States
Journal: Journal of Therapeutic Ultrasound 2013
Funding: personal disclosures of the authors (Insightec, Focused Ultrasound Surgery Foundation etc)

Manyonda 2012

Methods / RandomizedControlled Trial
Participants / 146 (74 vs 73)
Interventions / Uterine Artery Embolization vs. Myomectomy
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: United Kingdom
Journal: Cardiovascular and Interventional Radiology 2012
Funding: None

Mara 2006

Methods / RandomizedControlled Trial
Participants / 63 (30 vs. 33)
Interventions / Uterine Artery Embolization vs. Myomectomy
Outcomes / Reintervention risk
Follow-up: 17 months
Notes / Country where the study was conducted: Czech Republic
Journal: European Journal of Obstetrics and Gynecology 2006
Funding: supported by a grant from the Internal Grant Agency of MInistry of Health of the Czech Republic

Marigliano 2016

Methods / Prospective
Participants / 28
Interventions / MRgFUS
Outcomes / Reintervention
Follow-up: 12 months
Notes / Country where the study was conducted: Italy
Journal:Radiol Med 2016
Funding: none

McLucas 2014

Methods / Retrospective
Participants / 104
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 40 months
Notes / Country where the study was conducted: United States
Journal: Minimally Invasive Therapy & Allied Technologies 2014
Funding: None

Mindjuk 2015

Methods / Retrospective
Participants / 252
Interventions / MRgFUS
Outcomes / Reintervention risk, SSS questionnaires
Follow-up: 19 months
Notes / Country where the study was conducted: Germany
Journal: European Radiology 2015
Funding: None

Mohan 2005

Methods / Prospective
Participants / 20
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 14 months
Notes / Country where the study was conducted: Singapore
Journal: Annals Academy of Medicine 2005
Funding: Notdescribed

Morita 2008

Methods / Prospective
Participants / 48
Interventions / MRgFUS
Outcomes / Reintervention risk
Follow-up: 12 months
Notes / Country where the study was conducted: Japan
Journal: European Journal of Obstetrics & Gynecologu and Reproductive Biology 2008
Funding: Notdescribed

Moss 2011

Methods / RandomizedControlled Trial
Participants / 106
Interventions / Uterine ArteryEmbolization
Outcomes / Reinterventionrisk, EQ-5D, SF-36 questionnaires
Follow-up: 60 months
Notes / Country where the study was conducted: Scotland/United Kingdom
Journal: BJOG 2011
Funding: Chief Scientist Office of the Scottish Executive, Edinburgh

Narayan 2010

Methods / Retrospective
Participants / 185 (87 vs. 98)
Interventions / Uterine Artery Embolization vs. Myomectomy
Outcomes / SSS questionnaires
Follow-up: 66 months
Notes / Country where the study was conducted: United States
Journal: Journal of Vascular and Interventional Radiology 2010
Funding: None

Obed 2011

Methods / Prospective
Participants / 232
Interventions / Myomectomy
Outcomes / Reintervention risk
Follow-up: 65 months
Notes / Country where the study was conducted: Nigeria
Journal:Archies of Gynecology and Obstetrics 2011
Funding: None

Pansky 2009

Methods / Prospective
Participants / 20
Interventions / Cryoablation
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: United States/Israel
Journal: American Journal of Obstetrics and Gynecology 2009
Funding: Notdescribed

Pelage 2003

Methods / Prospective
Participants / 20
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 30 months
Notes / Country where the study was conducted: France
Journal: Journal of Vascular and Interventional Radiology 2003
Funding: research grants fomr Biosphere Medical after completion of this study

Polena 2007

Methods / Retrospective
Participants / 235
Interventions / Hysteroscopy
Outcomes / Reintervention risk
Follow-up: 40 months
Notes / Country where the study was conducted: France
Journal: European Journal of Obstetrics and Gynecology and Resproductive Biology
Funding: Notdescribed

Popovic 2009

Methods / Retrospective
Participants / 39
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 84 months
Notes / Country where the study was conducted: Austria
Journal: American Journal of Radiology - women's imaging 2009
Funding: Notdescribed

Poulsen 2011

Methods / Retrospective
Participants / 96
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 106 months
Notes / Country where the study was conducted: Denmark
Journal: ACTA Obstetricia and GynecologicaScandinavica 2011
Funding: None

Prollius 2004

Methods / Prospective
Participants / 64
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 12 months
Notes / Country where the study was conducted: South Africa
Journal:Britisch Journal of Obstetrics and Gynaecology 2004
Funding: Notdescribed

Quinn 2014

Methods / Retrospective
Participants / 187
Interventions / MRgFUS
Outcomes / Reintervention risk
Follow-up: 60 months
Notes / Country where the study was conducted: United Kingdom
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology 2014
Funding: Funded and supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London.

Radosa 2014

Methods / Retrospective
Participants / 224
Interventions / Myomectomy
Outcomes / Reintervention risk
Follow-up: 108 months
Notes / Country where the study was conducted: Germany
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology 2014
Funding: Notdescribed

Rischbieter 2016

Methods / Retrospective
Participants / 83
Interventions / Uterine ArteryEmbolisation
Outcomes / Reintervention risk
Follow-up: 60 months
Notes / Country where the study was conducted: South Africa
Journal: SA Journal of Radiology 2016
Funding: none

Robles 2013

Methods / Prospective
Participants / 36
Interventions / Radio Frequency Volumetric Thermal Ablation
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 12 months
Notes / Country where the study was conducted: Gutemala
Journal: International Journal of Gynecology and Obstetrics 2013
Funding: sponsored by Halt Medical

Rossetti 2001

Methods / Prospective
Participants / 84
Interventions / Myomectomy
Outcomes / Reintervention risk
Follow-up: 36 months
Notes / Country where the study was conducted: Itlay
Journal: Human Reproduction 2001
Funding: Not described

Salehi 2015

Methods / Retrospective
Participants / 65
Interventions / Uterine ArteryEmbolization
Outcomes / Reinternvention risk
Follow-up: 12 months
Notes / Country where the study was conducted: Iran
Journal: Global Journal of Health Science 2015
Funding: none

Sangha 2016

Methods / Retrospective
Participants / 118
Interventions / Roboticmyomectomy
Outcomes / Reintervention risk
Follow-up: 36 months
Notes / Country where the study was conducted: USA
Journal: J Robotic Surg (2016)
Funding: none

Scheurig-Muenkler 2013

Methods / Prospective
Participants / 380
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk, SSS, HRQL questionnaires
Follow-up: 68 months
Notes / Country where the study was conducted: Germany
Journal: Journal of Vascular and Interventional Radiology 2013
Funding: None

Shiota 2012

Methods / Retrospective
Participants / 250
Interventions / Myomectomy
Outcomes / Reintervention risk
Follow-up: 60 months
Notes / Country where the study was conducted: Japan
Journal: Gynecology and Minimally Invasive Therapy 2012
Funding: None

Sinha 2008

Methods / Prospective
Participants / 505
Interventions / Myomectomy
Outcomes / Reintervention risk
Follow-up: 72 months
Notes / Country where the study was conducted: India
Journal: Journal of Minimally Invasive Gynecology 2008
Funding: None

Siskin 2006

Methods / Prospective
Participants / 77
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 24 months
Notes / Country where the study was conducted: United States
Journal: Journal of Vascular and Interventional Radiology 2006
Funding: grant from Boston Scentific

Sone 2010

Methods / Prospective
Participants / 33
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 33 months
Notes / Country where the study was conducted: Japan
Journal: Journal of Vascular and Interventional Radiology 2010
Funding: supported by the Grant-in-Aid from the Ministry of Health and Welfare of Japan.

Song 2016a

Methods / Prospective
Participants / 30
Interventions / Uterine ArteryEmbolization
Outcomes / SSS
Follow-up: 12 months
Notes / Country where the study was conducted: Korea
Journal: Minimally invasive therapy and allied technologies 2016
Funding: none

Spies 2005

Methods / Prospective
Participants / 200
Interventions / Uterine ArteryEmbolization
Outcomes / Reintervention risk
Follow-up: 60 months
Notes / Country where the study was conducted: United States
Journal: Obstetrics and Gynecology 2005
Funding: Not described

Spies 2005a

Methods / Prospective
Participants / 1701
Interventions / Uterine ArteryEmbolization
Outcomes / Reinterventionrisk
SSS
HR-QOL
Follow-up: 12 months
Notes / Country where the study was conducted: USA
Journal: Obstetrics and Gynecology 2005
Funding: Biosphere Medical, Boston Scientific Corporation and Cordis Endovascular

Spies 2010