The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
November 2007
Vol. 323, No. 2
Contents
PERSPECTIVES IN PHARMACOLOGY
Serotonin (5-HT) in Veins: Not All in Vain
A. Elizabeth Under, Wei Ni, 415
Jessica L. Diaz, Theodora Szasz, Robert Burnett, and Stephanie W. Watts
BEHAVIORAL PHARMACOLOGY
k Agonist-Induced Reinstatement of Cocaine Seeking in Squirrel Monkeys: A Role for Opioid and Stress-Related Mechanisms
Drug and Reinforcement History as Determinants of the Response-Maintaining Effects of Quinpirole in the Rat
CARDIOVASCULAR
Platelet-Endothelial Cell Adhesion Molecule-1 -Directed Endothelial Targeting of Superoxide Dismutase Alleviates Oxidative Stress Caused by Either Extracellular or Intracellular Superoxide
B-9972 (D-Arg-[Hyp3,Igls,Oic7,Igl8]-bradykinin) Is an Inactivation-Resistant Agonist of the Bradykinin B2 Receptor Derived from the Peptide Antagonist B-9430 (D-Arg- [Hyp3,Igr,D-lgl7,Oics] -bradykinin): Pharmacologic Profile and Effective Induction of Receptor Degradation
The Cytochrome P450 Inhibitor Ketoconazole Potentiates 5-Hydroxytryptamine-Induced Contraction in Rat Aorta
Af-Benzyladriamycin-14-valerate (AD 198): A Non-Cardiotoxic Anthracycline That Is Cardioprotective through PKC-e Activation
Glenn R. Valdez, Donna M. Platt, 525
James K. Rowlett, Daniela Ruedi-Bettschen, and Roger D. Spealman
Gregory T. Collins and James H. Woods 599
Vladimir V. Shuvaev, Samira Tliba, 450
Marian Nakada, Steven M. Albelda, and Vladimir R. Muzykantov
Marie-Therese Bawolak, Lajos Gera, 534
Guillaume Morissette, John M. Stewart, and Francois Marceau
Kevin K. Ogden, John R. Falck, and 606
Stephanie W. Watts
Polly A. Hofmann, Mervyn Israel, 658
Yoshihiro Koseki, Jeffrey Laskin,
Joshua Gray, Aleksandra Janik,
Trevor W. Sweatman, and Leonard Lothstein
CELLULAR AND MOLECULAR
The Endogenous Cannabinoid Anandamide Inhibits Cromakalim-Activated K+ Currents in Follicle-Enclosed Xenopus Oocytes
Conversion of Phosphodiesterase-5 (PDE5) Catalytic Site to Higher Affinity by PDE5 Inhibitors
Murat Oz, Keun-Hang Yang, Meral Dine, 547
and Toni S. Shippenberg
Mitsi A. Blount, Roya Zoraghi, 730
Emmanuel P. Bessay, Alfreda Beasley, Sharron H. Francis, and Jackie D. Corbin
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY Activation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 via Extracellular Signal-Regulated Kinase 1/2 Mitogcn-Activated Protein Kinase Revealed a Isochaihulactone-Triggered Apoptotic Pathway in Human Lung Cancer A549 Cells
Yi-Lin Chen, Po-Cheng Lin, Shee-Ping Chen, Chai-Ching Lin, Nu-Man Tsai, Yeung-Leung Cheng, Wen-Liang Chang, Shinn-Zong Lin, and Horng-Jyh Harn
746
ENDOCRINE AND DIABETES
HI Identification of Novel Orally Available Small Molecule Insulin Mimetics
A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents
Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, 579
Ashok Pai, Ling Zhong, Michael C. Pirrung, and Nicholas J. G. Webster
Aslrid A. Ortiz, Lucinda F. Milardo, 692
Lynn B. DeCarr, Thomas M. Buckholz, Michelle R. Mays, Thomas H. Claus, James N. Livingston, Cathy D. Mahle, and Kevin J. Lumb
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL Inhibition of Renal Dipeptidyl Peptidase IV Enhances Peptide YYj_3fi-Induced Potentiation of Angiotensin H-Mediated Renal Vasoconstriction in Spontaneously Hypertensive Rats
Differential Down-Regulation of Aquaporin-2 in Rat Kidney Zones by Peripheral Nociceptin/Orphanin FQ Receptor Agonism and Vasopressin Type-2 Receptor Antagonism
Influence of Estrogen and Xenoestrogens on Basolateral Uptake of Tetraethylammonium by Opossum Kidney Cells in Culture
3- [5-(3,4-Dichloro-phenyl)-1 -(4-methoxy-phenyl)- \H -py razol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a Novel, Potent, and Selective Cholecystokinin 1 Receptor Antagonist: In Vitro and in Vivo Pharmacological Comparison with Dexloxiglumide
Edwin K. Jackson, Mingdi Zhang, Weili Liu, 431
and Zaichuan Mi
Niels Hadrup, J0rgen S. Petersen, 516
S0ren Windfeld, Lotte Risom, Claus B. Andersen, S0ren Nielsen, Slen Christensen, and Thomas E. N. Jonassen
Ryan M. Pelis, Randall C. Hartman, 555
Stephen H. Wright, Theresa M. Wunz, and Carlotta E. Groves
Magda F. Morton, Terrance D. Barrett, 562
Wen Yan, Jamie M. Freedman, Guy Lagauci,
Clodagh E. Prendergast, Veronica Moreno,
Jayashree Pyati, Katherine Figueroa, Lina Li,
Xiaodong Wu, Michele Rizzolio,
James G. Breitenbucher, Kelly McChire, and
Nigel P. Shankley
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis
Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-l-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs
Modulation of Airway Responses to Influenza A/PR/8/34 by A9-Tetrahydrocannabinol in C57BL/6 Mice
Carolyn A. Foster, Laurence M. Howard, 469
Alain Schweitzer, Elke Persohn, Peter C. Hiestand, Balazs Balatoni, Roland Reuschel, Christian Beerli, Manuela Schwartz, and Andreas Billich
Anindya Bhattacharya, Brian P. Scott, 665
Nadia Nasser, Hong Ao, Michael P. Maher, Adrienne E. Dubin, Devin M. Swanson, Nigel P. Shankley, Alan D. Wickenden, and Sandra R. Chaplan
John P. Buchweitz, Peer W. F. Karmaus, 675
Jack R. Harkema, Kurt J. Williams, and Norbert E. Kaminski
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
Human Renal Cortical and Medullary UDP-Glucuronosyltransferases (UGTs): Immunohistochemical Localization of UGT2B7 and UGT1A Enzymes and Kinetic Characterization of S-Naproxen Glucuronidation
Paraskevi Gaganis, John O. Miners, James S. Brennan, Anthony Thomas, and Kathleen M. Knights
422
CYP2A13: Variable Expression and Role in Human Lung Microsomal Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone
Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4a; and Pregnane X Receptor
Xiiiling Zhang, Jaime D'Agostino,
Hong Wu, Qing-Yu Zhang,
Linda von Weymarn, Sharon E. Murphy, and
Xinxin Ding
Hai-Lin Fang, Stephen C. Strom, Ewa Ellis, Zhengbo Duanmu, Jiaqi Fu, Zofia Duniec-Dmuchowski, Charles N. Falany, Josie L. Falany, Thomas A. Kocarek, and Melissa Runge-Morris
570
586
NEUROPHARMACOLOGY
Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model
Prolonged Attenuation of Amygdala-Kindled Seizure Measures in Rats by Convection-Enhanced Delivery of the N-Type Calcium Channel Antagonists o>-Conotoxin GVIA and w-Conotoxin MVIIA
3,4-Methylenedioxymethamphetamine- and 8-Hydroxy-2-di-«-propylamino-tetralin-Induced Hypothermia: Role and Location of 5-Hydroxytryptamine 1A Receptors
Cyclooxygenase Inhibition Limits Blood-Brain Barrier V Disruption following Intracerebral Injection of Tumor Necrosis Factor-a in the Rat
Expression of Cannabinoid CB, Receptors in Models of Diabetic Neuropathy
A Select Set of Opioid Ligands Induce Up-Regulation by Promoting the Maturation and Stability of the Rat K-Opioid Receptor in Human Embryonic Kidney 293 Cells
The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors
Regulator of G-Protein Signaling 4 Interacts with Metabotropic Glutamate Receptor Subtype 5 in Rat Striatum: Relevance to Amphetamine Behavioral Sensitization
Ethanol Sensitivity of GABAergic Currents in Cerebellar Granule Neurons Is Not Increased by a Single Amino Acid Change (R100Q) in the a6 GABAA Receptor Subunit
jx-Opioid Receptor Up-Regulation and Functional Supersensitivity Are Independent of Antagonist Efficacy
Pharmacological Characterization of a Novel, Potent Adenosine At and A3A Receptor Dual Antagonist, 5-[5-Amino-3-(4-fluorophenyl)py razin-2-y 1] -1 -isopropylpy ridme-2(lH)-one (ASP5854), in Models of Parkinson's Disease and Cognition
Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter
Methylphenidate Administration Alters Vesicular Monoamine Transporter-2 Function in Cytoplasmic and Membrane-Associated Vesicles
Inna Vulih-Shultzman, Albert Pinhasov, 438
Shmuel Mandel, Nikolaos Grigoriadis, Olga Touloumi, Zipora Pittel, and Illana Gozes
Maciej Gasior, Natalie A. White, and 458
Michael A. Rogawski
Daniel E. Rusyniak, Maria V. Zaretskaia, 477
Dmitry V. Zaretsky, and Joseph A. DiMicco
Eduardo Candelario-Jalil, Saeid Taheri, 488
Yi Yang, Rohit Sood, Mark Grossetete, Eduardo Y. Estrada, Bernd L. Fiebich, and Gary A. Rosenberg
Fan Zhang, Shuangsong Hong, Vicki Stone, 508
and Paula J. W. Smith
Kenneth M. Wannemacher, Prem N. Yadav, 614
and Richard D. Howells
Rochelle P. Coelho, Shawn G. Payne, 626
Robert Bittman, Sarah Spiegel, and Carmen Sato-Bigbee
Marek Schwendt and Jacqueline F. McGinty 650
Paolo Botta, Manuel Mameli, 684
Kirsten L. Floyd, Richard A. Radcliffe, and C. Fernando Valenzuela
Sunil Sirohi, Priyank Kumar, and 701
Byron C. Yoburn
Takuma Mihara, Kayoko Mihara, 708
Junko Yarimizu, Yasuyuki Mitani,
Ritsuko Matsuda, Hiroko Yamamoto,
Satoshi Aoki, Atsushi Akahane,
Akinori Iwashita, and
Nobuya Matsuoka
John N. Mason, Darlene C. Deecher, 720
Rhonda L. Richmond, Gary Stack, Paige E. Mahaney, Eugene Trybulski, Richard C. Winneker, and Randy D. Btakely
Trent J. Volz, Sarah J. Farnsworth, 738
Jill L. King, Evan L. Riddle, Glen R. Hanson, and Annette E. Fleckenstein
TOXICOLOGY
Mitochondrial Complex I Inhibitor Rotenone-Elicited Dopamine Redistribution from Vesicles to Cytosol in Human Dopaminergic SH-SY5Y Cells
Masahiko Watabe and Toshio Nakaki
499
Mitochondrially Targeted Effects of Berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(£)-l,3-benzodioxolo(5,6-a)quinolizinium] on K1735-M2 Mouse Melanoma Cells: Comparison with Direct Effects on Isolated Mitochondria! Fractions
Goncalo C. Pereira, Ana F. Branco, Julio A. C. Matos, Sandro L. Pereira, Donna Parke, Edward L. Perkins, Teresa L. Serafim, Vilma A. Sardao, Maria S. Santos, Antonio J. M. Moreno, Jon Holy, and Paulo J. Oliveira
636
ERRATUM
Correction to "Lysophosphatidic Acid Decreases Epidermal Growth Factor Receptor Binding in Airway Epithelial Cells"
757