Online Resource

Title：High Co-expression of Vascular Endothelial Growth Factor Receptor-1 and Snail is Associated with Poor Prognosis after Curative Resection of Hepatocellular Carcinoma

Journal name: Medical Oncology

Author name: Tao Li, Yu-Hua Zhu, Wanhua Ren, Shifeng Xu, Zhen Yang, Aiju Fang, Chengyong Qin

Affiliation and Email address of the corresponding author:

Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, 324#, Jing 5 Road, Jinan, Shandong Province, 250021, P. R. China

E-mail:


Online Resource 2 Prognostic values of all parameters in recurrent-free survival and overall survival by ROC analysis

Factor / RFS / OS
Area / p / 95%CI / Area / p / 95%CI
TNM stage / 0.720 / 0.016* / 0.554-0.886 / 0.797 / 0.0001* / 0.694-0.900
Cancerous tissues VEGFR-1 / 0.749 / 0.006* / 0.620-0.878 / 0.544 / 0.502 / 0.415-0.674
Cancerous tissues Snail / 0.666 / 0.068 / 0.505-0.827 / 0.722 / 0.001* / 0.606-0.839
Combination of VEGFR-1 and Snail / 0.784 / 0.002* / 0.642-0.927 / 0.685 / 0.005* / 0.567-0.803
HBsAg positive / 0.445 / 0.543 / 0.277-0.612 / 0.608 / 0.103 / 0.478-0.738
Gender / 0.570 / 0.440 / 0.406-0.734 / 0.492 / 0.901 / 0.362-0.622
Liver cirrhosis / 0.403 / 0.287 / 0.249-0.557 / 0.567 / 0.313 / 0.436-0.697
AFP / 0.530 / 0.738 / 0.353-0.708 / 0.59 / 0.175 / 0.463-0.717
Tumor size / 0.726 / 0.013* / 0.570-0.882 / 0.705 / 0.002* / 0.585-0.826
Microvascular invasion / 0.621 / 0.183 / 0.456-0.786 / 0.683 / 0.006* / 0.564-0.803
Tumor number / 0.734 / 0.010* / 0.603-0.866 / 0.757 / 0.0001* / 0.647-0.867
Tumor tissue encapsulation / 0.629 / 0.157 / 0.464-0.793 / 0.694 / 0.003* / 0.575-0.813
Edmondson grade / 0.671 / 0.060 / 0.499-0.843 / 0.609 / 0.101 / 0.483-0.735
Cancerous tissues MMP-9 / 0.557 / 0.530 / 0.383-0.731 / 0.557 / 0.387 / 0.429--.686
Age / 0.492 / 0.929 / 0.314-0.670 / 0.651 / 0.023* / 0.526-0.775
Abbreviations: HBsAg, hepatitis B s antigen; VEGFR-1, vascular endothelial growth factor receptor-1; MMP-9: matrix metalloproteinase-9; RFS, recurrence-free survival; OS, overall survival
*p<0.05 was considered statistically significant.