Curriculum Vitae for Meenhard Herlyn, D.V.M., D.Sc.
Meenhard Herlyn, D.V.M, D.Sc.
Updated: 3/1/14
Home Address
1223 Knox Road
Wynnewood, PA 19096
Office Address
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104 USA
Tel.: 215-898-3950
Fax: 215-898-0980
Email:
Web: http://www.wistar.org/lab/meenhard-herlyn-dvm-dsc
EDUCATION
1970 D.V.M., Veterinary Medical School, Hannover, Germany
1976 D.Sc., Medical Microbiology, University of Munich, Germany
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS
1971-1972 / Fellowship in Immunology and Virology, University of Munich, Germany1972-1976 / Assistant at the Institute of Medical Microbiology, Infectious and Epidemic Diseases, Veterinary Faculty, Maximillian University, Munich, Germany
1976-1979 / Associate Scientist, The Wistar Institute, Philadelphia, PA
1979-1981 / Research Associate, The Wistar Institute, Philadelphia, PA
1981-1985 / Assistant Professor, The Wistar Institute, Philadelphia, PA
1986-1990 / Associate Professor, The Wistar Institute, Philadelphia, PA
1991-present / Professor, The Wistar Institute, Philadelphia, PA
1991-1993 / Chairman, Program of Experimental Therapeutics, The Wistar Institute, Philadelphia, PA
1993-1998 / Chairman, Program of Molecular and Cellular Biology, The Wistar Institute, Philadelphia, PA
1998-2002 / Chairman, Tumor Biology Program, The Wistar Institute, Philadelphia, PA
2002-2012 / Leader, Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA
2008-2011 / Associate Director for Translational Research, The Wistar Institute
2010-present / Director, Melanoma Research Center, Philadelphia, PA
2011-present / Caspar Wistar Professor in Melanoma Research, Philadelphia, PA
FACULTY APPOINTMENTS
1982-1996 / Consultant, Adjunct Associate Professor of Gynecology, Adjunct Professor of Gynecology, Dept. of Gynecology, Division of Surgery, University of Texas, MD Anderson Cancer Center, Houston, TX1989-1991 / Wistar Institute Associate Professor of Dermatology and Wistar Institute Associate Professor of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
1989-present / Member, Cellular and Molecular Biology Graduate Program (CAMB), University of Pennsylvania, Philadelphia
1991- present / Member, University of Pennsylvania Comprehensive Cancer Center, Philadelphia
1992-present / Wistar Institute Professor of Dermatology and Wistar Institute Professor of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
1995-2002 / Member, Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia
2007-present
2011-present / Member, Bioengineering Graduate Group, University of Pennsylvania, Philadelphia
Member, Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia
AWARDS AND HONORS
2004 / Wings of Hope, Melanoma Research Foundation Award2004 / Diana Ashby Award for Excellence in Melanoma Research
2005 / American Skin Association Annual Skin Cancer/Melanoma Achievement Award
2006 / Scientific Research Award for Outstanding Contributions in Melanoma Research, American Cancer Society, Southeast Region, Pennsylvania Division
2006 / 7th Annual Wallace H. Clark, Jr., M.D. Lectureship in Cutaneous Oncology, University of Pennsylvania, Philadelphia, PA
2007 / Pan American Pigment Cell Society Achievement Award
2007 / Lifetime Achievement Award in Melanoma Research, Society of Melanoma Research
2008 / 28th Alfred-Marchioni Memorial Award, Hamburg, Germany
2008 / Joseph-von-Plenck Award, Austrian Society for Dermatology and Venereology, Vienna Austria
2010 / Award for Lifetime Achievement in Melanoma Research, Society for Melanoma Research
2013 Rod and Ceil Mortel Visiting Scholar in Cancer Research, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA
2013 Founders Award, Society for Melanoma Research
MEMBERSHIPS IN: PROFESSIONAL AND SCIENTIFIC SOCIETIES (including offices held):
1982-present / American Association for Cancer Research1996-2002, Pennsylvania Steering Committee
1997, Program Committee Chair, Biology
2004-2005, Stem Cell Initiative
1984-2010 / American Association for Investigative Pathology
1995-present / Society for Investigative Dermatology
1999-present / Pan American Society for Pigment Cell Research
1999-2002, Council Member
1999-2002, Melanoma Group Chair
2000-2002, Membership Committee
1999-present / International Federation of Pigment Cell Societies
1999-2003, Special Interest Group on ‘Biology of Melanoma’ Chair
1985-present / American Association for the Advancement of Science
2000-present / Metastasis Research Society
2004-present / Society for Melanoma Research
2004-2007, Founder and President
2004-2007, Ex officio member of Executive Committee, Steering Committee (Chair), Meeting Committee, Finance Committee, Election Committee, Membership Committee
2007-2010, Past President, Member Steering Committee
2006-2011
2010-present / Society for Stem Cell Research
American Society for Clinical Oncology
EDITORIAL POSITIONS
1986-1988 / Editorial Board, The Journal of Clinical Laboratory Analysis1990-present / Associate Editor, Melanoma Research
1992-1998 / Editorial Board, Cell Growth and Differentiation
1994-1999 / Associate Editor, Pigment Cell Research
1995-2003 / Associate Editor, Journal of Experimental Therapeutics and Oncology
1995-2002 / Editorial Board, Pathology Oncology Research
1997-2004 / Editorial Board, American Journal of Pathology
1998-2000 / Editorial Board, Tumor Targeting
2000-2007 / Editorial Board, Cancer Research
2001-present / Editorial Board, Cancer Biology and Therapy
2002-present / Editorial Board, Cancer and Metastasis Review, 2005 Guest Editor
2002-2007 / Associate Editor, Journal of Investigative Dermatology
2005-present / Associate Editor, Pigment Cell and Melanoma Research
2005-present / Editorial Board, International Journal of Cancer
2007-present / Section Editor, Journal of Investigative Dermatology
2007-present / Scientific Advisory Board, Journal of Cell Communication and Signaling
2007-present / Consulting Editorial Board, Journal of Clinical Investigation
2007-present / Editorial Board, Open Dermatology Journal
2008-present / Editorial Board, Journal of Oncology
2008-present / Editorial Board, Experimental Dermatology
2009-present / Editorial Board, Genes & Cancer
2010-2011 / Editorial Board, PLoS One
2012-present Editorial Board, Cancer Biomarkers
2013-present Editorial Board, Melanoma Management
2013-present Editorial Board, Precision Oncology
2013-present Advisory Board, International CCN Society
MANUSCRIPT REVIEWER
With major support from laboratory members, review of 110-170 manuscripts per year (2000-present) for the American Journal of Pathology, Archives of Dermatology, Cancer, Cancer Cell, Cancer Research, Cell, Clinical Cancer Research, Experimental Cell Research, International Journal of Cancer, Journal of Cell Science, Journal of Clinical Investigations, Journal of Investigative Dermatology, Journal of Immunology, Journal of Experimental Medicine, Laboratory Investigation, Melanoma Research, Molecular Carcinogenesis, Nature, Nature Cell Biology, Nature Medicine, Nature Review Cancer, Oncogene, Pigment Cell Melanoma Research, Proceedings National Academy of Sciences (USA), and Science.
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Curriculum Vitae for Meenhard Herlyn, D.V.M., D.Sc.
LECTURES BY INVITATION (past 5 years)
2009 / Feb. 23 / Melanoma Research AllianceApril 18 / American Association for Cancer Research, Denver, CO
April 29 / University of Wisconsin, Madison, WI
May 12 / World Congress of Melanoma, Vienna, Austria, Keynote Lecture
May 20 / Australian Congress of Dermatology, Brisbane, Australia, Honorary Lecture
May 27 / Rutgers University, Cancer Center Retreat, Keynote Lecture
June 23 / University of Heidelberg, Germany
July 17 / Mayo Clinic, Rochester, MN
Sept. 18 / NCI, Frederick, MD
Oct. 9 / European Academy for Dermatology and Venereology, Berlin, Germany
Nov. 2 / SMR 4th International Congress, Boston, MA
Nov.18 / MD Anderson Cancer Center, Houston, TX
Nov. 20 / Cancer Therapy, Havana, Cuba
2010 / Jan. 11 / University of Vienna, Vienna, Austria
Jan. 14 / L’Oreal, Paris, France
Feb. 23 / University of North Carolina, Chapel Hill, NC
March 2 / University of Pittsburgh, Pittsburgh, PA
March 31 / University of California at Irvine, Irvine, CA
April 30 / Moffitt Cancer Center, Tampa, FL
May 28 / Schering-Plough, Kenilworth, NJ
June 2 / MD Anderson Cancer Center, SPORE Symposium, Houston, TX
June 24 / GenoMEL, University of Leeds, Leeds, GB
June 26 / Human Skin Carcinogenesis Symposium, Collegeville, PA
August 2 / Roswell Park Memorial Institute, Buffalo, NY
Sept. 12 / AACR TME and Metastasis, Philadelphia, PA
Nov. 2 / Centenary Institute, University of Sydney, Sydney, Australia
Nov. 5 / SMR 7th International Conference, Sydney, Australia
Nov. 9 / Melanoma Symposium, Western Australia Institute for Medical Research, Perth, Australia
Dec. 14 / University of Ohio, Cincinnati, OH
2011 / Jan. 12 / MD Anderson Cancer Center, Science Park, TX
Jan. 28 / L’Oreal, Paris, France
Feb. 2 / Adelson Medical Research Foundation, Las Vegas, NV
Feb. 18 / Melanoma Research Alliance, Washington, DC, Session Chair
March 7 / AACR Special Conference on Stem Cells, Differentiations and Cancer, Vancouver, Canada, Session Chair
March 23 / Banbury Meeting on Curing Melanoma, Cold Spring Harbor Laboratory, NY, Session Chair
April 2-4 / AACR Annual Meeting, Orlando, FL
April 27 / CSHL Symposium on Tumor Microenvironment, Cold Spring Harbor, NY
May 5 / Tetralogic, Malvern, PA
May 25 / World Congress of Dermatology, Seoul, Korea
June 27 Engineered Tissue Models for Environmental Health Science Research, NIEHS, Research Triangle Park, Chapel Hill, NC
July 10 European Post-ASCO Meeting, Munich, Germany
Nov. 29 National Cancer Institute, Bethesda, MD
Dec. 8 L’Oreal Inc., Paris, France
Dec. 16 Expert Forum on Malignant Melanoma, Los Angeles, CA
2012 / Jan. 19 / Virginia Commonwealth University, Richmond, VAFeb. 2
Feb. 21
April 1 / Dartmouth School of Medicine, Dartmouth, NH
German Cancer Congress, Berlin, Germany, Keynote Lecture
American Association for Cancer Research, Annual Meeting, Major Symposium Speaker
May 10 / AACR Special Conference on Resistance Mechanisms to Targeted Therapy, San Diego, CA
June / Melanoma Research Foundation Breakthrough Consortium, Chicago, IL
June 12 / Genentech, San Francisco, CA
June 18 / GenoMEL Annual Symposium, Leiden, Netherlands
June 22 / Pigment Cell and Melanoma Research Symposium, NCI, Bethesda, MD
July 27 / SPORE in Skin Cancer, Yale University, New Haven, CT
August 13 / University of Cologne, Cologne, Germany
Sept. 5 / L’Oreal Inc., Paris, France
2013 / Jan. 25 / Sandford-Burnham Institute, La Jolla, CA
March 22 / German Cancer Society, Heidelberg, Germany
May 2 / Hershey Medical Center, Hershey, PA, Award Lecture
May 8 / International Melanoma Congress, Dublin, Ireland
Sept. 5 / Brazilian Workshop on Melanoma, São Paulo, Brazil, Keynote Lecture
Sept. 10 / European Organization of Pigment Cell Research, Lisbon, Portugal, Keynote Lecture
Sept. 17 / L’Oreal Inc., Paris, France
Sept. 27 / Temple University, Philadelphia, PA
Nov. 20 / SMR 10th International Congress, Philadelphia, PA
ADVISORY ROLES (past 5 years):
2008-2011 / MRF, Board of Managers, Member2009 / Jan., Southwestern Melanoma SPORE, Denver, CO, External Advisor
Jan., PO1 Biotherapy of Metastatic Melanoma: Biology and Systemic Delivery of MDA7/IL-24, (E. Grimm, PI), MD Anderson Cancer Center, Houston, TX, External Advisor
Feb., Oct., NCI Study Sections, Tumor Microenvironment (TME), Ad Hoc
May, NCI Intramural Review, Laboratory of Cancer Prevention
July, NCI, Stage II Challenge Grant Review Committee, Ad Hoc
Oct., Utah Skin SPORE, External Advisor
Feb.-Dec., Grant Reviews for Funding Agencies in Netherlands, Austria, Australia, Germany, Israel, Great Britain
Australia, Germany, Israel, Great Britain
2010 / Joanna M. Nikolay Melanoma Foundation, Advisory Board
NDRI, Board of Directors, Chair
NCI, Feb., Oct., TME Study Section, Member
NCI, Special Emphasis Panel, Chair
MRA, Grant Review Committee, Co-Chair
Roche, Washington, DC, Advisor
Moffitt Cancer Center, Tampa, FL, SPORE Advisor
MRF Breakthrough Consortium, Board of Directors
MRF Breakthrough Consortium, Secretary Treasurer
2011 / Melanoma Research Alliance, Scientific Review Committee Co-Chair
June, Tumor Microenvironment Network Study Section, NCI, Chair
Sept., SPORE Study Section, Ad Hoc
Oct., TME NCI Study Section, Member
Jan.-Dec., Grant reviews from Austria, Germany, New Zealand, Israel, Ireland, Netherlands, Norway
Grant Reviews for the Melanoma Research Foundation, Joanna Nicolay Melanoma Foundation
NDRI, Board of Directors, Chair
MRF Breakthrough Consortium, Board of Directors
2013 / Feb., Melanoma Research Alliance, Scientific Review Committee, Member
May, NCI, Special Emphasis Panel, Ad Hoc Reviewer
June, Melanoma Research Alliance, Reviewer
August, Melanoma Research Foundation
NDRI, Board of Directors, Chair
MD Anderson, Skin SPORE
MRF Breakthrough Consortium, Board of Directors
SMR Congress 2013, Co-Organizer
Program Project, MD Anderson, L. Chin
FUNDING
Targeted Therapies in Melanoma
Principal Investigator: Meenhard Herlyn
Agency: National Cancer Institute
Type: PO1 (CA114046-03)
Years 5-10, Period: May 16, 2008 to Oct. 1, 2018
Subproject 1: Senescence as an endpoint in melanoma therapy
Human Melanoma: Etiology, Progression, and Therapy
Principal Investigator: Meenhard Herlyn
Agency: NIH/NCI
Type: P01-Program Project (CA25874),
Years 30-34, Period: May 1, 2011 to April 30, 2016
Subproject on grant: Cellular mechanisms of therapy resistance
Biology of Melanoma Metastasis
Principal Investigator: Meenhard Herlyn
Agency: National Cancer Institute
Type: R01 (CA47159)
Years 21-25, 2011-2016
Cell-Cell Communication During Melanoma Progression
Principal Investigator: Meenhard Herlyn
Agency: National Cancer Institute
Type: R01 (CA76674)
Years 15-19, Period: April 1, 2011 to March 31, 2016
Mechanisms of Esophageal Carcinogenesis
Principal Investigator: Anil Rustgi; Co-Principal Investigator: Meenhard Herlyn
Agency: NIH/NCI
Type: P01-CA098101
Years 6-10, Period: July 1, 2009 – June 30, 2014
Subproject on grant: The tumor microenvironment in human esophageal squamous cell carcinoma
The Role of Genetic Susceptibility in Melanoma Development
Principal Investigator: Meenhard Herlyn
Agency: National Cancer Institute
Type: R01 (CA182890)
Years 1-5, Period: Dec. 1, 2013 to Nov. 30, 2018
CORE ACTIVITIES
1. Administrative Core A for Human Melanoma – Etiology, Progression & Therapy (CA025874)
2. Administrative Core A for Targeted Therapies in Melanoma (CA114046)
3. Cell Biology Core C for Targeted Therapies in Melanoma (CA114046)
2013: Sponsored Agreements With industry (GSK, Novartis, Plexxikon, Tetralogic)
2013: Funding from Miriam and Sheldon Adelson Foundation for Medical Research, Melanoma Research Alliance (Team Award), Melanoma Research Foundation
BIBLIOGRAPHY
Research Publications, Peer Reviewed
1. Buschmann H, Herlyn M. Stimulation of phagocytic activity by dextran. Z Immunitatsforsch Exp Klin Immunol. 1972;143:209-210. PMID4282799
2. Mayr A, Streitferdt U, Herlyn M, Jaeger O. Vaccination of dogs against rabies. Die Kleintierpraxis. 1973;18:91-96.
3. Danner K, Herlyn M, Gerbermann H, Mayr A. Oral immunization against pox. 5: effectiveness of drinking water vaccination against fowl pox. Zentralbl Veterinärmed B. 1975;22:274-284. PMID169653
4. Mahnel H, Herlyn M. Stability of Teschen, HCC, ND and vaccinia viruses against 5 disinfectants. Zentralbl Veterinärmed B. 1976;23:403-411. PMID183417
5. Mahnel H, Ottis K, Herlyn M. Stability in drinking and surface water of nine virus species from different genera (author’s transl). Zentralbl Bakteriol [Orig B]. 1977;164:64-84. PMID14460
6. Danner K, Luthgen K, Herlyn M, Mayr A. Comparative studies on the demonstration and formation of serum antibodies against the Borna virus. Zentralbl Veterinärmed B. 1978;25:345-355. PMID358683