Protein* / Organism / Regulatory Function † / Regulatory role / Category‡ / References
AarP (P43463) / Providencia stuartii / Regulation of 2'-N-acetyltransferase, capable of acetylating both peptidoglycan and certain aminoglycoside antibiotics / Activator / S / Macinga et al 1995
Ada (P06134) / Escherichia coli / Repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. / Activator / S / Nakabeppu et al 1985
AdaA (P19219) / Bacillus subtilis / Methylphosphotriester-DNA alkyltransferase is one of two genes required for the adaptive response of bacteria to alkylating agents / Activator / S / Morohoshi et al. 1990
AdiY (P33234) / E. coli / Regulation of the arginine decarboxylase system. / Activator / A-R / Gallegos et al 1997
AggR (P43464) / E. coli / Regulator of aggregative adherence fimbria I expression in enteroaggregative E. coli. / Activator / V / Munson et al 2001
AppY (P05052) / E. coli / Induces the synthesis of acid phosphatase (appA) and several other polypeptides (such as appBC) during the deceleration phase of growth. / Activator, Repressor / A-R / Gallegos et al 1997
AraC
(P0A9E0) / E. coli / Regulation of the expression of a regulon involved in the transport and catabolism of L- arabinose. It regulates initiation of transcription of the araBAD operon. / Activator; Repressor / M-C / Schleif 2003
CafR (P26950) / Yersinia pestis / Regulator of the expression of the F1 operon for capsule synthesis / Activator / V / Friedlander et al 1995,
Munson et al 2001
CfaD (P25393) / E. coli / Activator of the CFA/I adhesin (cfaA) gene of enterotoxigenic E. coli / Activator / V / Karlyshev et al 1992
CsvR (P43460) / E. coli / Activator of the fimbrial gene in enterotoxigenic E. coli / Activator / V / Munson et al 2001
EnvY (P10805) / E. coli / Influences the temperature-dependent expression of several envelope proteins, most notably the porins ompF and ompC and the lambda receptor, lamB. / Activator / A-R / Lundrigan et al 1989
EutR (P36547) / E. coli,
S. typhimurium / Activates the transcription of the ethanolamine operon. / Activator / M-C / Troup et al 1994.
ExsA (P26993) / Pseudomonas aeruginosa / Activator of exoenzyme S synthesis above a low basal level. / Activator / V / Frank and Iglewski 1991
FapR (P23774) / E. coli / Positive regulator of the expression of the 987P operon for the fimbrial protein in enterotoxigenic E. coli. / Activator / V / Klaasen and de Graaf 1990
FeaR (Q47129) / E. coli / Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. / Activator / M-N / Yamashita et al 1996
GadW (P63201) / E. coli K12 / Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. / Activator / A-R / Ma et al 2002
GadX (Q9EYV5) / E. coli O127:H6 / Regulates the expression of genes involved in acid resistance. / Activator; Repressor / A-R / Ma et al 2002
HilD (P41782) / S. typhimurium / HilD protein is involved in the expression of the HilA gene, which is encoded on Salmonella pathogenicity island 1 (SPI-1). / Activator / V / Schechter et al 1999.
HrpB (P31778) / Ralstonia solanacearum / Positive regulation of hypersensitive response genes involved in plant pathogenicity. / Activator / V / Genin et al 1992.
InvF (P69343) / S typhimurium / Required for the expression of several genes encoding type III secretion system SPI-1 effector proteins. / Activator / V / Kaniga et al 1994.
LacR (O33813) / Staphylococcus xylosus / Transcriptional regulator of the lacPH genes for lactose utilization. / Activator / M-C / Bassias and Brueckner 1998
LcrF (P28808) / Y. pestis / Activator of the thermally regulated virulent yopE gene. / Activator / V / Goguen et al 1992.
LumQ (Q51872) / Photobacterium leiognathi / Probable transcriptional regulator of riboflavin synthesis genes. / M-G / Lin et al 1995.
MarA (P0ACH5) / E. coli K12 / Transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. / Activator / S / Rhee et al 1998
MelR (P0ACH8) / E. coli K12 / Transcription regulator for the expression of the melAB operon for the melibiose catabolism. / Activator / M-C / Webster et al 1987.
MmsR (P28809) / P. aeruginosa. / Regulatory protein for the mmsAB operon for the valine catabolism. / Activator / M-G / Steele et al 1992.
MsmR (Q00753) / Streptococcus mutans / Regulatory protein for the msm operon for multiple sugar metabolism. / Activator / M-C / Russell et al 1992.
MxiE (P0A2S7) / S. flexneri / Necessary for the secretion of ipa invasins. / Activator / V / Allaoui et al 1993.
OruR (P72171) / P. aeruginosa / Activates the ornithine acetyltransferase related genes. / Activator / M-N / Hebert and Houghton 1997
PchR (P40883) / P. aeruginosa / Regulator of the genes for pyochelin and ferripyochelin receptors. / Activator / M-G / Reimmann et al 1998,
Heinrichs and Poole 1996
PerA (P43459) / E. coli O127 / Involved in regulation of bfp genes for the biosynthesis of a type IV pilus in enteropathogenic E. coli. Activates indirectly the LEE pathogenicity island. / Activator / V / Gomez-Duarte and Kaper 1995
PocR (Q05587) / S. typhimurium / Positive regulatory protein of cobalamin biosynthesis. / Activator / M-G / Chen et al 1994.
PqrA (Q52620) / Proteus vulgaris / Probably confers multidrug resistance in a way similar to that of the SoxS and MarA genes. / Activator / S / Ishida et al 1995.
RafR (P43465) / Pediococcus pentosaceus / Involved in the regulation of the raffinose-operon. / Activator / M-C / Gallegos et al 1997.
RamA (P55922) / Enterobacter cloacae / Probable transcriptional activator that confers a multidrug-resistance phenotype / Activator / S / Komatsu et al 1990.
RhaR (P09378) / E coli K12 / It activates expression of the rhaSR operon in response to L-rhamnose. / Activator / M-C / Tobin and Schleif 1987
RhaS (P09377) / E. coli K12 / Activates expression of the rhaBAD and rhaT operons. Induced by RhaR in response to L-rhamnose. / Activator / M-C / Tobin and Schleif 1987
RhrA (Q9Z3Q6) / Rhizobium meliloti / Transcriptional activator of the rhizobactin regulon / Activator / M-G / Lynch et al 2001.
Rns (P16114 ) / E. coli / Required for the expression of the CS1 and CS2 adhesins of enterotoxigenic E. coli. / Activator / V / Munson et al 2001. Porter et al 1998
Rob (P0ACI0 ) / E. coli K12 / Rob regulates antibiotic resistance, organic solvent tolerance and heavy-metal resistance. / Activator / S / Kwon et al 2000
SirC (Q8Z4A6) / S. typhi / Regulator of the expression of the invasion-associated type III secretion system encoded within SPI-1. / Activator / V / Gallegos et al 1997
SoxS (P0A9E2) / E. coli K12 / Transcriptional activator of the superoxide response regulon / Activator / S / Pomposiello, et al 2001
TcpN (P29492) / Vibrio cholerae / Regulatory protein of the tcp and ctx virulence genes / Activator / V / Ogierman and Manning 1992.
TetD (P28816) / E. coli / Transposon Tn10 regulatory protein. Part of the mar/sox/rob regulon. / Activator / S / Griffith et al 2005
ThcR (P43462) / Rhodococcus erythropolis / Probably involved in the positive regulation of the thc operon for the degradation of the thiocarbamate herbicide EPTC. / Activator / M-G / Nagy et al 1995
UreR (P32326) / E. coli K12 / Positive regulator of the expression of the urease operon. / Activator / M-N / D'Orazio and Collins 1993
VirF (P0A2T1) / S. flexneri / Primary regulator of plasmid-encoded virulence genes. Activates the transcription of icsA (virG) and virB. / Activator / V / Adler et al 1989.
VirF (P13225) / Y. enterocolitica / Transcriptional activator of the thermally-regulated virulent yopE gene. / Activator / V / Porter et al 1998
XylR (P0ACI3) / E. coli K12 / Regulatory protein for the xylBAFGHR operon. / Activator / M-C / Gallegos et al 1997
XylS (P07859) / P. putida / Regulatory protein of the xylXYZLTEGFJQKIH operon required for the degradation of toluene, m- and p-xylene. / Activator / M-C / Spooner et al 1986
Xys1 (Q04710) / P. putida / Regulatory protein of the TOL plasmid pWW53 meta-1 and meta-2 p-toluato / Activator / M-C / Assinder et al 1993
Xys2 (Q05092) / P. putida / xylDLEGF operon transcriptional activator 2 / Activator / M-C / Assinder et al 1992.
Xys3 (Q05335) / P. putida / xylDLEGF operon transcriptional activator 3 / Activator / M-C / Freiberg et al 1997.
Xys4 (Q04713) / P. putida / xylDLEGF operon transcriptional activator 4 / Activator / M-C / Freiberg et al 1997.
Y4Fk (P55449) / Rhizobium sp / Acts in the complex cascade regulation of the nodD3 gene. / Activator / M-G / Quirk et al 1994.
YbbB (P40408) / B. subtilis / Contains one iron siderophore/cobalamin periplasmic-binding domain / Unknown / M-G / Barbeyron et al 1994.
YcgK (P43461) / Alteromonas carrageenovora / Regulates the structural cgkA gene encoding kappa-carrageenase / Activator / M-N / Barbeyron et al 1994.
YdeO (P76135) / E. coli K12 / Induces the expression of gadE and mdtEF. Regulates the expression of other genes involved in acid resistance. / Activator / A-R / Ma 2004

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