London Cardiovascular Device Innovation Summit

August 28th, 2015

Presented by

Yale University School of Medicine

University College London

Queen Mary University

The National Institute for Health Research Biomedical Research Unit and Centre at Barts and University College London NHS Trust

Program Chairs

Mark Caulfield – Alexandra Lansky – Anthony Mathur

Program Co-Chairs

Andreas Baumbach – Mark De Belder

Charles Knight – Andrew Taylor

London Cardiovascular Device Innovation Summit

Friday August 28th, 2015

The Derek Willoughby Lecture Theatre,

The National Institute for Health Research Biomedical Research Unit at Barts Heart Centre and

The William Harvey Research Institute, Queen Mary University of London,

Charterhouse Square London EC1M 6BQ.

8:00 amCheck-In and Breakfast

8:50 amWelcome and Introduction

Mark Caulfield

Co-Director, William Harvey Research Institute

Alexandra Lansky

Director, Yale Heart and Vascular Clinical Research Program

Session ICardioVascular Innovation Trends and Commissioning

Moderator: Anthony Mathur

Session Goals:

  • To discuss trends in CV device innovation
  • To discuss how UK and European reimbursement can be streamlined in early device evaluation
  • To discuss the roles and interface of academia and the private sector in innovation

9:00 amDevice Innovation Trends in Interventional Cardiovascular Therapeutics

Alexandra Lansky

Director, Yale Heart and Cardiovascular Clinical Research

9:15 amThe Interface of Industry and Academia in Innovation: The Unique Perspective of a Clinician in Industry

Martin Rothman

Chief Medical Officer, Medtronic

9:30 am Streamlining the Commissioning Process: Aiming for an Early and Efficient Integrated Clinical, Regulatory and Reimbursement Pathway

Mark De Belder

9:45 amDiscussion: Integrating Value Based Healthcare into Innovation and the Role of Academia

Moderator: Anthony Mathur

Panel: Mark De Belder, John Martin, Martin Rothman, Alexandra Lansky, Krishna Sudhir

10:15 amCoffee Break- The Norfolk Cloister of the Charterhouse

Session IIDigital Health Care and Big Data in Cardiovascular Innovation and Health Care Delivery

Session Goals:

  • To discuss the goals of digital health to increase access, improve quality and compliance and reduce cost
  • To discuss the status and impact of digital monitoring on health care
  • To explore the full potential of national databases in the innovation cycle
  • To discuss the impact of health informatics and big data on population health and innovation

Moderator: Mark Caulfield and Andrew Taylor

Panel: Bart Segers, Peter Ludman, Adam Timmis, Mark De Belder, Semih Oktay, Adi Livneh, John Deanfield

10:45 amNICOR in the UK Cardiovascular Innovation Life Cycle: Role of National Databases for Cardiovascular Interventions in Streamlining Device Evaluation and Outcomes Assessment

Peter Ludman

11:00 am Population Genomics and Opportunities for Innovation in Cardiovascular Diseases

Mark Caulfield

11:15 amNon invasive Hemodynamic Monitoring: Bringing Value to HealthCare

Adi Livneh

11:30 am3D Printing in Entrepreneurship and Cardiovascular Device Innovation

Andrew Taylor

11:45 amComputational Modeling in Device Development: Case Examples

Silvia Schievano

12:00 pm Hilbert Paradox: A Unique Way of Worldwide Capturing and Correlating Digital Health Data

Bart Segers

12:15 pmDiscussion: Integrating Information Technology into Health Care: Ready for Prime Time?

Moderator: Mark Caulfield and Andrew Taylor

Panel: Peter Ludman, Semih Oktay, Gunnar Brandrup-Wognsen, Adi Livneh, John Deanfield, Bart Segers, Krishna Sudhir

12:30 pmLunch- The Charterhouse and Gardens

Session IIICoronary Interventions, Stents and Scaffolds: The Next Generation

Session Goals:

  • To discuss remaining challenges in coronary intervention
  • To discuss limitations of current stent technology
  • To explore stents and scaffolds as delivery vehicles for biologics
  • To discuss regulatory considerations and challenges in delivery of biologics

Moderator: Andreas Baumbach

Panel: Anthony Mathur, Todd Brinton, Semih Oktay, Martin Rothman, Albert Sinusas, Krishna Sudhir, Gunnar Brandrup-Wognsen, Alvaro Mata

1:30 pmUnmet Clinical Need in Coronary Interventions, Stenting and Scaffolds

Andreas Baumbach

1:45 pm Lithoplasty for Calcified Vessels and Degenerative Valve Disease: In Situ Vascular Remodeling

Todd Brinton

CMO, Shockwave Medical

2:00 pm Smart Stents and Scaffolds: Targeted Delivery Vehicles

Anthony Mathur

2:15 pmAdvanced Imaging Techniques in Device Design and Targeted Biologic Therapies: The Role of Imaging in the Balance of Injury, Inflammation and Healing

Albert Sinusas

2:30 pmA Practical US Regulatory Roadmap for Combination Products: How to Get There?

Semih Oktay

3:00 pmDiscussion: The Bright Future of Percutaneous Vascular Intervention-Next Frontiers

Moderator: Andreas Baumbach

Panel: Anthony Mathur, Todd Brinton, Semih Oktay, Martin Rothman, Albert Sinusas, Krishna Sudhir, Gunnar Brandrup-Wognsen, Alvaro Mata

3:30 pmTea in the Norfolk Cloister of the Charterhouse

Session VIAdvances in Regenerative Medicine For the Heart

Session Goals:

  • To review current status of Stem Cell and pluripotent cell therapy in AMI
  • To discuss novel tissue engineering applications
  • To discuss different applications of gene therapy
  • To discuss the role of nanotechnology and nanomaterial in regenerative medicine

Moderator: John Martin

Panel: Anthony Mathur, Alvaro Mata, Ken Suzuki, Semih Oktay, Alexander Seifalian, Martin Rothman

4:00 pmAutologous Stem Cell Therapy in Acute Myocardial Infarction: Lessons learned

Anthony Mathur

4:15 pmNanocomposite Polymeric Percutaneous Aortic Valve: Design and Durability Features

Alexander Seifalian

4:30 pmBiomaterial-Mediated Epicardial Placement of Stem Cells for Cardiac Repair

Ken Suzuki

4:45 pmLocal Intrauterine Delivery of Gene Therapy in Growth Retardation

John Martin

5:00 pm Smart Nanomaterials for Regenerative Medicine

Alvaro Mata

Director, Institute of Bioengineering

5:15 pmDiscussion

Moderator: John Martin

Panel: Anthony Mathur, Alvaro Mata, Ken Suzuki, Semih Oktay, Alexander Seifalian, Martin Rothman

5:45 pmClosing remarks:

Charles Knight

6:00 pmReception in the Great Chamber of the Masters Court of the Charterhouse