Workshop on translational research in“Parkinson’s disease”

Date: May 18, 2015

Venue: Faculté de Médecine, 2 rue de l’Ecole de Médecine, Montpellier

The workshop is organized by the French Neuroscience Society on the occasion of its 12th Meeting, in partnership with ITMO Neurosciences, Sciences Cognitives, Neurologie, Psychiatrie, and the “Club des ganglions de la base”

Coordinators : Abdelhamid BENAZZOUZ (Bordeaux), Wassilios MEISSNER (Bordeaux), VéroniqueSGAMBATO-FAURE(Lyon)

Registration (fees 50€ including lunch) via website:

9:00-9:45Participants welcome and registration

9:45-10:00Welcome adress

Christophe Mulle - President, Société des Neurosciences

Etienne Hirsch - Director, ITMO

10:00-11:30Pathogenesis of Parkinson's disease (PD): Is it all about misfolded alpha-synuclein?

Chair: Pascal Derkinderen (Nantes)

Does it start in the gut? Prion-like propagation of alpha-synuclein

Pascal Derkinderen (Nantes)

Microglial activation: Friend or foe? - StéphaneHunot (Paris)

Mitochondrial dysfunction and progammed cell death - Miquel Vila

(Barcelona, Spain)

11h30-12h00Break

12:00-13:30What is in the treatment pipeline?

Chair:Wassilios Meissner (Bordeaux)

Gene therapy with ProSavin: from bench to bed - Stéphane Palfi (Créteil)

Removing chelatable iron as therapeutic modality - David Devos (Lille)

Targeting alpha-synuclein - Wassilios Meissner (Bordeaux)

13h30-15h00Lunch break

15:00-16:3025 years of deep brain stimulation (DBS): What do we know about the mechanism? What are future developments?

Chair: Abdelhamid Benazzouz (Bordeaux)

The future: adaptive DBS and other innovative approaches - S. Little (Oxford)

Effect of DBS on electrical activity in basal ganglia and related networks

Abdelhamid Benazzouz (Bordeaux)

The molecular signature of DBS in basal ganglia and related networks

Lydia Kerkerian-Le Goff (Marseille)

16h30-17h00Break

17:00-18:30Dyskinesia and behavioral disturbances: implication of dopamine and other systems

Chair: Valérie Cochen de Cock (Montpellier)

When to use L-Dopa and how to face dyskinesia: the clinical perspective - Olivier Rascol (Toulouse)

Dyskinesia: Is it all about dopamine? - Philippe de Deurwaerdere(Bordeaux)

Involvement of cortico-basal ganglia circuits in motivation disorders - Véronique Sgambato-Faure (Lyon)

Journée du Club des Ganglions de la Base

Date: May 19, 2015

Lieu : à confirmer

La journée du Club des Ganglions de la Base est gratuite et ouverte à tout les membres du club (les bulletins d'adhésion peuvent être retirés sur le site du club : . Le montant de l'adhésion est de 10€ pour les étudiants, et 20€ pour les chercheurs).

Coordinateurs : ThomasBORAUD (Bordeaux), Christelle BAUNEZ (Marseille), Léon TREMBLAY (Lyon)

9:30-9:45Accueil

9:45-10:00Introduction : Thomas Boraud, président du Club des Ganglions de la Base

10:00-12:30Student Session (to be done in English)

12h30-14h30Lunch break

14:30-16:45Interaction between basal ganglia and other subcortical structures

Chair: Christelle BAUNEZ (Marseille)

Carole LEVENES

Carine KARACHI

15h45-16h00Break

16:00-17:15Véronique COIZET

ClémentineBOSCH-BOUJU

17:15-18:15Assemblée Générale : Quel Avenir pour le Club ?