Jonathan M. Yuen CV – Page 1

Jonathan M. Yuen

EDUCATION

Washington University, St. Louis, Missouri

Post-Doctoral Research Associate in Chemistry, September 2012 – Present

Advisor: Professor Dewey Holten, Ph.D.

Northwestern University, Evanston, Illinois

Post-Doctoral Fellow in Chemistry and Biomedical Engineering, June 2010 –August 2012

Advisors: Professor Richard P. Van Duyne, Ph.D. and Matthew Glucksberg, Ph.D.

Northwestern University, Evanston, Illinois

Doctor of Philosophy in Biomedical Engineering, June 2010

Dissertation: In Vivo Glucose Detection Using Surface Enhanced Raman Spectroscopy

Advisors: Professor Richard P. Van Duyne, Ph.D. and Matthew Glucksberg, Ph.D.

Northwestern University, Evanston, Illinois

Master of Science in Biomedical Engineering, December 2004

Thesis: A Tissue Perfusion Flow Phantom for Use with Optical Coherence Tomography (OCT)

Advisor: Professor Matthew Glucksberg, Ph.D.

Northwestern University, Evanston, Illinois

Bachelor of Science in Biomedical Engineering, June 2000

ACADEMIC RESEARCH EXPERIENCE

Post-Doctoral Research Associate, Washington University

September 2012 – Present, St. Louis, Missouri

  • Performing photophysical analyses of synthetic chromophores
  • Assessing energy transfer between assemblies and monomeric chromophores

Post-Doctoral Fellow, Northwestern University

June 2010 – August 2012, Evanston, Illinois

  • Developedapplications for Raman Spectroscopy with Baxter Healthcare

Graduate Research Assistant, Northwestern University

Fall 2000 –June 2010, Evanston, Illinois

  • Collected and evaluated first in vivo quantitative transdermal SERS signals using spatially offset Raman
  • Constructed SORS system to allow transdermal operation
  • Designed technique to successfully capture first in vivo SERS measurements
  • Characterized SERS-active surfaces in vitro and in vivo
  • Miniaturized SERS-based sensor
  • Evaluated long-term biocompatibility of SERS-based sensor
  • Created flow phantoms to gauge quantitative capability of OCT
  • Developed quantitative analysis method for studying movement with OCT

VaNTH Educational Outreach Committee, Northwestern University

Fall 2002 – Spring 2002, Evanston, Illinois

  • Founding member of committee
  • Increased awareness of bioengineering through outreach to local schools
  • Designed curriculum with teachers for middle school science students
  • Translated science theories into simple examples and long term-projects for students
  • Created creative back story for long-term project to engage students
  • Taught and oversaw students in classroom during implementation of curriculum
  • Initial project evolved into “Get a Grip” VaNTH educational module

INDUSTRIAL RESEARCH EXPERIENCE

Research Engineer, Whitney Development Corporation

1997 – 2000, Niles, Illinois

  • Developed new manufacturing process for catheters and endotracheal tubes
  • Evaluated thermoplastic materials for use in new process
  • Created prototype of new endotracheal tube design

Research Engineer, PeelMaster Packaging Corporation

1997 – 2000, Niles, Illinois

  • Implemented and conducted reviews of ISO 9000 and GMP quality control standards
  • Evaluated packaging materials and heat sealing technology for use in bags, peel pouches, and lids
  • Designed heat sealing dies to create peel pouches
  • Created custom pouches according to customer specifications

Research Engineer, Whitney Products, Inc.

1997 – 2000, Niles, Illinois

  • Implemented and conducted reviews of ISO 9000 and GMP quality control standards
  • Applied heat sealing technology to develop new medical shoe covers
  • Conducted and analyzedtest survey of 200 medical professionals regarding new shoe covers

LEADERSHIP EXPERIENCE

Executive Committee Member, NU Biomedical Engineering Post-Doc Association

2011 – 2012, Evanston, Illinois

  • Planned and coordinated monthly coffee hours with internal and external speakers

Social Chair, NU Biomedical Engineering Graduate Students Association (BMEGS)

2002 – 2005, Evanston, Illinois

  • Founding member of BMEGS
  • Planned and executed biweekly activities to improve community in the BME Department
  • Coordinated student involvement during 2 yearly recruiting weekends
  • Improved communication between faculty and graduate students by increasing interaction

Keynote Chair, 1stChicagoUniversity Bioengineering Industry Consortium (CUBIC)

2002, Chicago, Illinois

  • Founding member of CUBIC executive committee
  • Identified need for increased interaction between industrial and academic biomedical organizations
  • Planned and coordinated first academic and industrial conference in Chicago area
  • Collaborated with graduate students from 3 universities
  • Acted as liaison with keynote speaker Bill Gantz

SERVICE

Member, NU Biomedical Engineering Post-Doc Association

2010-2012, BME Department, Northwestern University

Outreach Program Volunteer, Nano Scout Day

2010-2012, International Institute for Nanotechnology, Northwestern University

Member, NU Biomedical Engineering Graduate Students Association (BMEGS)

2002 – 2010, BME Department, Northwestern University

TEACHING EXPERIENCE

Teaching Assistant, Northwestern University, Biomedical Engineering Department

Classes: Biochemical Sensors (4 quarters); Cardiac and Pulmonary Systems Physiology (2 quarters); Endocrine, Digestive, and Reproductive Systems Physiology (1 quarter); Transport Fundamentals (1 quarter); Introduction to Biomechanics (1 quarter)

  • Created new test, homework , and lecture materials with professors
  • Conducted weekly discussion sections with up to 45 students
  • Generated review sheets for students
  • Supervised undergraduate and graduate lab sections with up to 30 students
  • Assisted students with time management and problem solving

Guest Lecturer, Northwestern University, BME 317 Biochemical Sensors

Spring 2010

Topic: Surface Enhanced Raman Spectroscopy

Guest Lecturer, Northwestern University, BME 317 Biochemical Sensors

Spring 2009

Topic: Noninvasive Glucose Detection

Guest Lecturer, Northwestern University, BME 317 Biochemical Sensors

Spring 2007

Topic: In Vivo Glucose Detection

SKILLS

Animal Experimentation: Multiple surgery types (rodent) including implantation, cannulation, tracheostomy

Optical /Spectroscopic Characterization: UV-visible, Transient Absorption, Raman, Surface-enhanced Raman (SERS) spectroscopies, and Optical Coherence Tomography (OCT)

Optical Systems: Experience building Raman spectroscopy and optical coherence tomography systems

Software: LabVIEW, MATLAB, Origin, SolidWorks, Inventor, Surface Explorer

Engineering Tools: Familiar with basic machining tools including drill press, lathe, mill (hand), CNC mill, and others.

PUBLICATIONS

Journal Papers:

“In Vivo, Transcutaneous Glucose Sensing Using Surface-Enhanced Spatially Offset Raman Spectroscopy: Multiple Rats, Improved Hypoglycemic Accuracy, Low Incident Power, and Continuous Monitoring for Greater Than 17 Days,” K. Ma, J.M. Yuen, N.C. Shah, J.T. Walsh, M.R. Glucksberg, and R.P. Van Duyne, Anal. Chem.,83, 9146-9152 (2011).

“Trancutaneous Glucose Sensing by Surface-Enhanced Spatially Offset Raman Spectroscopy in a Rat Model,” J.M. Yuen, N.C. Shah, J.T. Walsh, M.R. Glucksberg, and R.P. Van Duyne, Anal. Chem., 82, 8382-8385 (2010).

“Progress Toward an In Vivo Surface-Enhanced Raman Spectroscopy Glucose Sensor,” O.Lyandres, J.M. Yuen, N.C. Shah, R.P. Van Duyne, J.T. Walsh, and M.R. Glucksberg, Diabetes Technol. Ther., 10(4), 255-263 (2008).

“In Vivo Glucose Measurements by Surface-Enhanced Raman Spectroscopy,” D.A. Stuart, J.M. Yuen, N.C. Shah, O. Lyandres, C.R. Yonzon, M.R. Glucksberg, J.T. Walsh, R.P. Van Duyne, Anal. Chem., 78, 7211-7215 (2006).

Book Chapters:

“Surface-Enhanced Raman Spectroscopy for Glucose Analysis,” N.C. Shah, J.M. Yuen, M.R. Glucksberg, J.T. Walsh, R.P. Van Duyne, In In Vivo Glucose Sensing, Stenken, J.A. Cunningham, D.E., Eds., John Wiley & Sons, Inc., pp 421-443 (2010).

PRESENTATIONS

J.M. Yuen, J.W. Springer, D. Niedwiedzki, J. Jiao, O. Mass, J. Jiang, D.F. Bocian, J.S. Lindsey, D. Holten. “Assemblies of Chlorosomal Bacteriochlorophyll Analogs.” Poser presentation at the Light Harvesting Satellite Meeting of The 16th International Congress on Photosynthesis, St. Louis, MO, 2013.

J.M. Yuen, A.I. Henry, B. Sharma, N.C. Shah, M.R. Glucksberg, R.P. Van Duyne. “A Mixed Self-Assembled Monolayer For Small Molecule Sensing Using Surface-Enahnced Raman Spectroscopy Remains Viable In Blood For Up To 10 Days.” Poster presentation at the Annual Meeting of the Biomedical Engineering Society (BMES), Atlanta, GA, 2012.

J.M. Yuen, R.P. Van Duyne, J. T. Walsh, M.R. Glucksberg. “Transdermal SERS Glucose Measurements Using Spatially Offset Raman Spectroscopy.” Poster presentation at the Annual Meeting of the Biomedical Engineering Society (BMES), Austin, TX, 2010.

J.M. Yuen, O. Lyandres, N.C. Shah, R.P. Van Duyne, J. T. Walsh, M.R. Glucksberg. “First Steps Towards Miniaturization of a Surface Enhanced Raman Spectroscopy Glucose Sensor.” Poster presentation at the Annual Meeting of the Biomedical Engineering Society (BMES), St.. Louis, MO, 2008.

J.M. Yuen, N.C. Shah, O. Lyandres, D. Stuart, R.P. Van Duyne, J.T. Walsh, M.R. Glucksberg. “Surface Enhanced Raman Spectroscopy Glucose Measurements in Rats and Steps Towards Transdermal Sensing.” Podium presentation at the Annual Meeting of the Biomedical Engineering Society (BMES), Los Angeles, CA, 2007.

J.M. Yuen, D.A. Stuart, O. Lyandres, N.C. Shah, C.R. Yonzon, R.P. Van Duyne, J.T. Walsh, M.R. Glucksberg. “Surface Enhanced Raman Spectroscopy Measurement of Glucose in Rats.” Poster presentation at the Annual Meeting of the Biomedical Engineering Society (BMES), Chicago, IL, 2006.

J.M. Yuen, D.A. Stuart, O. Lyandres, N.C. Shah, C.R. Yonzon, R.P. Van Duyne, J.T. Walsh, M.R. Glucksberg. “Surface Enhanced Raman Spectroscopy Measurement of Glucose in the Anesthetized Rat.” Poster presentation at the Annual Meeting of the Biomedical Engineering Society (BMES), Baltimore, MD, 2005.

J.M. Yuen, D.A. Stuart, O. Lyandres, N.C. Shah, C.R. Yonzon, R.P. Van Duyne, J.T. Walsh, M.R. Glucksberg. “Surface Enhanced Raman Spectroscopy Measurement of Glucose in the Anesthetized Rat.” Poster presentation at the 5th Annual Diabetes Technology Meeting, San Francisco, CA, 2005

J.M. Yuen, M.R. Glucksberg. “A Tissue Perfusion Flow Phantom for Use With Optical Coherence Tomography.” Poster presentation at the Annual Meeting of the Biomedical Engineering Society (BMES), Philadelphia, PA, 2004.

PATENTS

R.P. Van Duyne, M.R. Glucksberg, K. Shafer-Peltier, C. Hayes, J.T. Walsh, C.R. Yonzon, N.C. Shah, O. Lyandres, D.A. Stuart, J.M. Yuen. “Biosensor for detecting in-vivo and ex-vivo analytes such as glucose in patient, has nano-biosensors that are configured for quantitative detection of analyte.” U.S. Patent Application No. US2009118605-A1.

M.R. Glucksberg, N.C. Shah, R.P. Van Duyne, J.T. Walsh, J.M. Yuen. “Combined surface enhanced and spatially offset Raman spectroscopy for biomolecule detection.” U.S. Patent Application No. WO2012071523 A1

REFERENCES

Matthew R. Glucksberg, PhD.Joseph T. Walsh, Jr., PhD.

ProfessorVice President for Research

Department of Biomedical EngineeringNorthwestern University

Northwestern University633 Clark St

2145 Sheridan RdEvanston, IL60208

Evanston, IL60208847-491-7118

Richard P. Van Duyne, PhD.Dewey Holten, PhD.

ProfessorProfessor

Department of ChemistryDepartment of Chemistry

Northwestern UniversityWashington University

2145 Sheridan RdCampus Box 1134

Evanston, IL 602081 Brookings Dr.

847-491-3516St. Louis, MO 63130

314-935-6502