Title: in Vivo and Rapid Detection of the Malignancy Tumor of Oral Tissues Using Mid-FTIR

Title: In vivo and rapid detection of the malignancy tumor of oral tissues using Mid-FTIR fiber optics spectroscopy

Author(s): Xu YZ, Zhang YF, Yang LM, Peng X, Sun KH, Li QB, Zhou WJ, Wu HZ, Yu GY, Liu Z, Weng SF, Wang J, Ying Z, Xu DF, Wu JG

Source: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 25 (2): 348-350 FEB 2004

Document Type: Letter

Language: Chinese

Cited References: 8 Times Cited: 4

Abstract: Our previous studies show that mid-FTIR spectroscopy can be used to distinguish malignant oral tissue from normal tissue under in vitro condition. Here, an in-situ FTIR spectroscopic measurement was performed to record FTIR spectra of normal and malignant oral tissues including salivary gland, tongue, parotid gland, submandibular gland etc. during clinical examination. The FTIR spectra of various oral tissues were acquired when an ATR probe linked to the FTIR. spectrometer via mid-IR optical fibers was pressed on the tissues of the patients. For example, a patient(male, 76 years old) with tumor on the left parotid and the corresponding normal tissue on the right parotid were measured and obvious differences were observed. The spectral features of normal tissue and tumor are in good agreement with the criteria established in our previous work. (1) 1389 cm(-1) band is quite strong in tumor, while the corresponding band in normal tissue is weaker than 1452 cm(-1) band. (2) In normal tissue, 1250 cm(-1) band is stronger, but the 1250 cm(-1) band disappeared in the skin. of malignant tissue. The above results demonstrate that in vivo FTIR spectra are in good agreement with our previous results obtained under in vitro condition. We believe that in vivo FTIR spectroscopy, providing the first-hand information concerning whether the suspected tissue is cancerous or not, is helpful for doctors in clinical activity.

Author Keywords: Mid-IR fiber optics; FTIR; malignancy tumor of oral tissue; in vivo and in situ detection

KeyWords Plus: MECHANISM

Addresses: Xu YZ (reprint author), Peking Univ, State Key Lab Rare Earth Mat & Applicat, Coll Chem & Mol Engn, Beijing, 100871 Peoples R China
Peking Univ, State Key Lab Rare Earth Mat & Applicat, Coll Chem & Mol Engn, Beijing, 100871 Peoples R China
Peking Univ, Med Sch Stomatol, Beijing, 100081 Peoples R China
Beijing Secondary Opt Instrument Factory, Beijing, 100015 Peoples R China
Chinese Acad Sci, Inst Chem, Beijing, 100080 Peoples R China

E-mail Addresses:

Publisher: HIGHER EDUCATION PRESS, SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA

Subject Category: CHEMISTRY, MULTIDISCIPLINARY

IDS Number: 777PU

ISSN: 0251-0790